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| Product | Description | |
|---|---|---|
| BMS-345541 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| BMS-345541 hydrochloride | BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK ( IKK-2 IC 50 =0.3 μM, IKK-1 IC 50 =4 μM). BMS-345541 binds at an allosteric site of IKK. Uses: Scientific research. Group: Signaling pathways. CAS No. 547757-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10518. |  |
| BMS 345541 trifluoroacetate salt | BMS 345541 is a cell-permeable inhibitor of the IκB kinases IKKα with IC50s of 4 uM and IKKβ with IC50s of 0.3 μM, which binds at allosteric site of the enzyme and displays ~10-fold greater selectivity at IKK-2 over IKK-1. It exhibits no effect against a panel of 15 other kinases. BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-κB signaling. Synonyms: IKK Inhibitor III. Grade: ≥98%. CAS No. 547757-23-3. Molecular formula: C14H17N5·2CF3COOH. Mole weight: 483.4. |  |
| BMS-347070 | BMS-347070 is a COX-2 inhibitor, initially developed for the treatment for Colorectal cancer. Synonyms: (3Z)-3-[(4-bromophenyl)-(4-methylsulfonylphenyl)methylidene]oxolan-2-one; BMS-347070; BMS 347070; BMS347070; UNII-0CKM4H090C; 0CKM4H090C; SCHEMBL6882900; SCHEMBL6882905. Grade: >98%. CAS No. 197438-73-6. Molecular formula: C18H15BrO4S. Mole weight: 407.28. | |
| BMS-351 | BMS-351 is a selective and nonsteroidal CYP17A1 lyase inhibitor with good selectivity over steroidogenic CYPs 21A2 and 11B1. BMS-351 has become a preclinical candidate to treat Castration-resistant prostate cancer (CRPC) and is likely to minimize the side effects of current therapies because of its exceptional selectivity. Uses: Castration-resistant prostate cancer. Synonyms: BMS-351; BMS 351; BMS351; 4-(4-methylpyridin-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzo[d]imidazole. Grade: 98%. CAS No. 1370001-71-0. Molecular formula: C15H12F3N3. Mole weight: 291.28. | |
| BMS-354326 | BMS-354326 is a tryptase inhibitor with IC50 value of 1.8 nM. It has excellent selectivity against trypsin and most other related serine proteases. Synonyms: BMS-354326; BMS 354326; BMS354326; CHEMBL306448; BDBM50144532.(2S,3R)-4-oxo-1-((4-(1-oxo-6-phenylhexyl)-1-piperazinyl)carbonyl)-3-(2-(3-piperidinyl)ethyl)- 2-Azetidinecarboxylic acid. Grade: 98%. CAS No. 708258-16-6. Molecular formula: C28H40N4O5. Mole weight: 512.65. | |
| BMS358233 | BMS358233 is a potent Lck inhibitor. It has excellent cellular activities against T-cell proliferation. Uses: Bms358233 has excellent cellular activities against t-cell proliferation. Synonyms: BMS-358233; BMS 358233; 6-Benzothiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-((6-methyl-2-((((2R)-tetrahydro-2-furanyl)methyl)amino)-4-pyrimidinyl)amino)-. Grade: 98%. CAS No. 601519-75-9. Molecular formula: C25H25ClN6O2S. Mole weight: 509.02. | |
| BMS-36313 | BMS-363131 is very potent inhibitor of human tryptase with inhibitory activity against bovine trypsin. Uses: Tryptase inhibitor. Synonyms: BMS-363131; BMS 363131; BMS363131. (2S,3R)-3-[[(3R)-1-carbamimidoylpiperidin-3-yl]methyl]-4-oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]azetidine-2-carboxylic acid. Grade: ≥98%. CAS No. 384829-65-6. Molecular formula: C28H40N6O5. Mole weight: 540.66. | |
| BMS-378806 | BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus. Synonyms: BMS-378806; BMS 378806; BMS378806; BMS-806; BMS806; Bms 806. Grade: >98%. CAS No. 357263-13-9. Molecular formula: C22H22N4O4. Mole weight: 406.43. | |
| BMS-394136 | BMS-394136 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: BMS-394136; BMS 394136; BMS394136; UNII-M694U7167K. [(7R)-7-(3,4-dichlorophenyl)-5-methyl-1,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanone. Grade: ≥98%. CAS No. 343246-73-1. Molecular formula: C24H21Cl2FN4O. Mole weight: 471.35. | |
| BMS-419437 | BMS-419437 is a synthetic organic bio-active chemical. Uses: A synthetic organic bio-active chemical. Synonyms: BMS-419437; BMS419437; BMS 419437; UNII-09RR39UU4V; CHEBI:34550; AC1NQZWA; BMS-387032 analog 2. N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-2-[4-[(1,3-dihydroxypropan-2-ylamino)methyl]phenyl]acetamide. Grade: ≥98%. CAS No. 333389-24-5. Molecular formula: C23H30N4O4S2. Mole weight: 490.64. | |
| BMS 433771 | BMS 433771 is a potent inhibitor of RSV replication in vitro with an average EC of 20nM. Uses: Viral fusion protein inhibitor. Synonyms: BMS 433771; BMS433771; BMS-433771; BMS-433771 HCl hydrate; BMS-433771 HCl; BMS-433771 hydrochloride. 1-cyclopropyl-1,3-dihydro-3-((1-(3-hydroxypropyl)-1H-benzimidazol-2-yl)methyl)-2H-Imidazo(4,5-c)pyridin-2-one. Grade: ≥98%. CAS No. 380603-10-1. Molecular formula: C20H21N5O2. Mole weight: 363.41. | |
| BMS-433771 bis-hydrochloride monohydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMS-433796 | BMS-433796 is a γ-secretase inhibitor. Chronic dosing of BMS-433796 in Tg2576 mice suggested a narrow therapeutic window and Notch-mediated toxicity at higher doses. Uses: Gamma secretase inhibitors and modulators. Synonyms: BMS433796; BMS-433796; BMS 433796. (2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(5S)-3-methyl-4-oxo-5H-2,3-benzodiazepin-5-yl]propanamide; BMS-433796; UNII-R1E8M783K2; 935525-13-6; CHEMBL247361; R1E8M783K2; ZINC28899741; (alphaS)-N-[(1S)-2-[[(5S)-4,5-Dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide; (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide; Benzeneacetamide, N-((1S)-2-(((5S)-4,5-dihydro-3-methyl-4-oxo-3H-2,3-benzodiazepin-5-yl)amino)-1-methyl-2-oxoethyl)-3,5-difluoro-alpha-hydroxy-, (alphaS)-. CAS No. 935525-13-6. Molecular formula: C21H20F2N4O4. Mole weight: 430.15. | |
| BMS453 | BMS453 (BMS-189453), a synthetic retinoid, is a RAR? agonist and a RAR?/RAR? antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGF?[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-189453. CAS No. 166977-43-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100608. | |
| BMS 453 | BMS 453. Group: Biochemicals. Grades: Purified. CAS No. 166977-43-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| BMS 453 | BMS 453 is a synthetic retinoid that acts as an RARβ agonist in vivo, and also an RARα and RARγ antagonist in vitro. It inhibits the proliferation of breast cells by inducing active transforming growth factor β (TGFβ) and causes G1 arrest. Synonyms: BMS453; BMS 453; BMS-453; BMS 189453; BMS-189453; BMS189453. 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid. Grade: ≥98% by HPLC. CAS No. 166977-43-1. Molecular formula: C27H24O2. Mole weight: 380.48. | |
| BMS 470539 dihydrochloride | BMS 470539 dihydrochloride is a potent and selective melanocortin MC1 receptor agonist (IC50 = 120 nM) with anti-inflammatory activity. It also inhibits leukocyte trafficking. Synonyms: BMS 470539 dihydrochloride; BMS470539 dihydrochloride; BMS-470539 dihydrochloride; 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride. Grade: ≥98% by HPLC. Molecular formula: C32H41N5O4.2HCl. Mole weight: 632.62. | |
| BMS 470539 dihydrochloride | BMS 470539 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 457893-92-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-470539 dihydrochloride | BMS 470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC1) agonist with an IC50 of 120 nM, an EC50 of 28 nM. It exhibits anti-inflammatory properties. Synonyms: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride; BMS 470539 dihydrochloride. CAS No. 2341796-82-3. Molecular formula: C32H43Cl2N5O4. Mole weight: 632.63. | |
| BMS480404 | BMS480404 is a potent small molecule inhibitor. It bounds to human keratinocyte fatty acid-binding protein. Synonyms: BMS-480404; BMS 480404; (S)-2-(2,3-bis(2-chlorobenzyloxy)phenyl)-2-hydroxyacetic acid. Grade: 98%. CAS No. 533889-36-0. Molecular formula: C22H18Cl2O5. Mole weight: 433.28. | |
| BMS 488043 | BMS-488043 is a small-molecule HIV fusion inhibitor. Uses: Hiv fusion inhibitor. Synonyms: BMS-488043; 452296-83-2; BMS 043; BMS 488043; 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione; BMS043; BMS-043; CHEMBL238103; MKS21EJ435; 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)-; 1-Benzoyl-4-(2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)-2-oxoacetyl]piperazine; 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)ethane-1,2-dione; UNII-MKS21EJ435; DBPMWRYLTBNCCE-UHFFFAOYSA-N; 1-BENZOYL-4-(2-(4,7-DIMETHOXY-1H-PYRROLO(2,3-C)PYRIDIN-3-YL)-2-OXOACETYL)PIPERAZINE; BMS488043; SCHEMBL2688411; DTXSID501006367; GLXC-15766; BDBM50228465; AKOS040750864; DB05532; HY-14135; TS-08685; CS-0003220; NS00071850; Q27284087; n-(benzoyl)-n'-[(4,7-dimethoxy-6-azaindol-3-yl)-oxoacetyl]-piperazine; n-(benzoyl)-n'-[(4,7-dimethoxy-6-azaindol-3-yl)-oxoacetyl]piperazine; 1-(4-benzoyl-1-piperazinyl)-2-(4,7-dimethoxy-1H-pyrrolo(2,3-c)pyridin-3-yl)-1,2-ethanedione; 1-[4-(benzoyl)piperazin-1-yl]-2-(4,7-dimethoxy-1h-pyrrolo[5,4-c]pyridin-3-yl)ethane-1,2-dione; 857500-24-4; Piperazine, 1-benzoyl-4-[2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-1,2-dioxoethyl]-. Grade: ≥98%. CAS No. 452296-83-2. Molecular formula: C22H15NO7. Mole weight: 405.4. | |
| BMS493 | BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation[1][2]. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 215030-90-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108529. | |
| BMS 493 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMS 493 | BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Synonyms: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic Acid; BMS-493; BMS493; (E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid; Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-. Grade: 97%. CAS No. 215030-90-3. Molecular formula: C29H24O2. Mole weight: 404.50. | |
| BMS 493 | BMS 493. Group: Biochemicals. Grades: Purified. CAS No. 215030-90-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-5 | BMS-5, a LIMK inhibitor, has been found to restrain the cofilin phosphorylation in MDA-MB-231 breast cancer cells. Synonyms: LIMKi 3; N-(5-(1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2-yl)isobutyramide; N-{5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-1,3-thiazol-2-yl}-2-methylpropanamide; BMS 5; BMS5. Grade: 98%. CAS No. 1338247-35-0. Molecular formula: C17H14Cl2F2N4OS. Mole weight: 431.29. | |
| BMS-5 | BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LIMKi 3. CAS No. 1338247-35-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18305. | |
| BMS-502 | BMS-502 is an inhibitor of diacylglycerol kinase α (DGK-α), DGK-ζ, and DGK-Ι with IC50s of 0.0046, 0.0021, and 0.0026 μM, respectively. BMS-502 induces immune responses in human and mouse T cells and blocks intracellular checkpoint signaling in T cells. Synonyms: BMS 502; BMS502. CAS No. 2407854-18-4. Molecular formula: C27H22F2N6O3. Mole weight: 516.50. | |
| BMS-505130 | BMS-505130 is a selective serotonin transport inhibitor with Ki of 0.18 nM. Ki value for binding to the norepinephrine is 4.6 mM and for dopamine transporters is 2.1 mM. Synonyms: BMS-505130; BMS 505130; BMS505130; UNII-E892TW82D9; E892TW82D9; 1H-Indole-5-carbonitrile, 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-, (2Z)-2-butenedioate (1:1). Grade: 98%. CAS No. 859230-84-5. Molecular formula: C19H21N3O4. Mole weight: 355.39. | |
| BMS-505130 Free base | BMS-505130 is a potent and selective serotonin transport inhibitor with K(I) of 0.18 nM. Uses: A potent and selective serotonin transport inhibitor. Synonyms: BMS-505130; BMS 505130; BMS505130; 3-((1S,2S)-2-((dimethylamino)methyl)cyclopropyl)-1H-Indole-5-carbonitrile. Grade: ≥98%. CAS No. 468715-83-5. Molecular formula: C15H17N3. Mole weight: 239.32. | |
| BMS 509744 | BMS 509744. Group: Biochemicals. Grades: Purified. CAS No. 439575-02-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BMS-509744 | BMS-509744 is a potent, selective and ATP competitive Itk inhibitor with an IC50 of 19 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 439575-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11092. | |
| BMS-509744 | BMS-509744 is a selective Itk inhibitor. It is useful for treatment of inflammatory and autoimmune diseases. Synonyms: BMS-509744; BMS 509744; BMS509744; CHEMBL209148. Grade: >98%. CAS No. 439575-02-7. Molecular formula: C32H41N5O4S2. Mole weight: 623.83. | |
| BMS-512148 | BMS-512148 Inhibitor. Uses: Scientific use. Product Category: T2389. CAS No. 461432-26-8. |  |
| BMS-520 | This active molecular is a selective S1P1 receptor agonist that originated by Bristol-Myers Squibb. BMS-520 shows really good efficacy in animal models of arthritis as well as in a mouse EAE (experimental autoimmune encephalomyelitis) model of multiple sclerosis. Agonism of S1P1 has been known to play an important role in lymphocyte trafficking from the thymus and secondary lymphoid organs, resulting in immunosuppression. Uses: Haematological malignancies; solid tumours. Synonyms: BMS-520; BMS 520; BMS520. 1-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid. Grade: 98%. CAS No. 1236188-38-7. Molecular formula: C23H17F3N4O4. Mole weight: 470.41. | |
| BMS 536924 | BMS 536924. Group: Biochemicals. Grades: Purified. CAS No. 468740-43-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BMS-536924 | BMS-536924 is a potent small molecule inhibitor of IGF-IR, which shows antitumor activity in multiple tumor models, including sarcoma. Synonyms: BMS536924; BMS 536924; Insulin-like Growth Factor-1 Receptor Inhibitor; (S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one. Grade: 98%. CAS No. 468740-43-4. Molecular formula: C25H26ClN5O3. Mole weight: 479.96. | |
| BMS-536924 | BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC 50 s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 468740-43-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10262. | |
| BMS-536924 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMS538158 | BMS538158 is a bio-active chemical compound developed by Bristol-Myers Squibb. Synonyms: BMS-538158; BMS 538158; Acetamide, 2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)-N-((4-fluorophenyl)methyl)-N-methoxy-. Grade: 98%. CAS No. 543730-36-5. Molecular formula: C15H16FNO5. Mole weight: 309.29. | |
| BMS-538203 | BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent. Synonyms: BMS-538203; BMS 538203; BMS538203. Grade: >98%. CAS No. 543730-41-2. Molecular formula: C12H12FNO5. Mole weight: 269.23. | |
| BMS-554417 | BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, with the IC50 for proliferation ranged from 120 nmol/L (Colo205) to >8.5 micromol/L (OV202). Uses: A novel inhibitor of igf-ir. Synonyms: BMS-554417; BMS 554417; BMS554417; 3-[4-[(2Z)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperazin-1-yl]propanenitrile. Grade: ≥98%. CAS No. 468741-42-6. Molecular formula: C28H30ClN7O2. Mole weight: 532.04. | |
| BMS561392 | BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction of TNF alpha, such as rheumatoid arthritis (RA). It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms561392 has the potential treatment of diseases characterized by overproduction of tnf alpha, such as rheumatoid arthritis (ra). Synonyms: BMS-561392; BMS561392; BMS 561392; DPC-333; DPC 333; DPC333. (αR,?3R)?-3-Amino-N-hydroxy-α-(2-methylpropyl)?-3-[4-[(2-methyl-4-quinolinyl)?methoxy]?phenyl]?-2-oxo-1-pyrrolidineacetamide?; BMS-561392; DPC-333; (2R)-2-[(3R)-3-amino-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]-N-hyd. Grade: 98%. CAS No. 611227-74-8. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| BMS-561392 formate | BMS-561392 formate is the formate form of BMS-561392 (HY-19667). BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DPC 333 formate. CAS No. 2922280-85-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-19667A. | |
| BMS-564929 | BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 627530-84-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-12111. | |
| BMS-564929 | BMS-564929 is a novel androgen receptor (AR) modulator (Ki= 2.11 nM) which has been advanced to clinical trials for the treatment of age-related functional decline. Uses: Androgen receptor (ar) modulator. Synonyms: BMS-564929; BMS 564929; BMS564929. 4-[(7R,7aS)-7-hydroxy-1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-2-chloro-3-methylbenzonitrile. Grade: ≥98%. CAS No. 627530-84-1. Molecular formula: C14H12ClN3O3. Mole weight: 305.71. | |
| Bms 566394 | Bms 566394. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2H-Pyran-3-carboxamide, tetrahydro-N-hydroxy-4-[[4-[[2-(trifluoromethyl)-1H-benzimidazol-1-yl]methyl]benzoyl]amino]-, (3R,4R)-;BMS 566394;(3R,4R)-N-hydroxy-4-(4-((2-(trifluoroMethyl)-1H-benzo[d]iMidazol-1-yl)Methyl)benzaMido)tetrahydro-2H-pyran-3-carboxaMide. Product Category: Heterocyclic Organic Compound. CAS No. 503166-51-6. Molecular formula: C22H21F3N4O4. Mole weight: 0. Product ID: ACM503166516. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BMS-566419 | Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Synonyms: BMS 566419; BMS566419; N-(1-(6-(4-Ethyl-1-piperazinyl)-3-pyridinyl)-1-methylethyl)-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide. Grade: >98%. CAS No. 566161-24-8. Molecular formula: C28H30FN5O2. Mole weight: 487.57. | |
| BMS582949 | BMS582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 value of 13nM, which plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1β. It is used for the treatment of rheumatoid arthritis. It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms582949 is used for the treatment of rheumatoid arthritis. Synonyms: 4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide; BMS-582949; PS-540446; BMS 582949; PS 540446; BMS582949; PS540446. Grade: 98%. CAS No. 623152-17-0. Molecular formula: C22H26N6O2. Mole weight: 406.49. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC 50 of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912806-16-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14305A. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grade: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
| BMS-585248 | BMS585248 is a highly potent and novel human immunodeficiency virus type 1 (HIV-1) attachment inhibitor with 4-fluoro-6-azaindole core heterocycles. It targets the viral envelope protein gp120. It showed much improved in vitro potency and pharmacokinetic properties than the previous clinical candidate BMS488043. Uses: Bms585248 targets the viral envelope protein gp120. Synonyms: BMS-585248; 619331-12-3; UNII-CIO2TZZ9H1; CIO2TZZ9H1; 1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-(4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo(2,3-C)pyridin-3-yl)-; BMS 585248; 1-(4-benzoylpiperazin-1-yl)-2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione; Piperazine, 1-benzoyl-4-((4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo(2,3-C)pyridin-3-yl)oxoacetyl)-; 1-(4-Benzoylpiperazin-1-yl)-2-(4-fluoro-7-(1,2,3)triazol-1-yl-1H-pyrrolo(2,3-c)pyridin-3-yl)ethane-1,2-dione; CHEMBL236995; SCHEMBL2628937; AKOS040750870; BMS-585428; DA-71584; HY-13829; CS-0007961; Q27275484; 1-(4-benzoyl-piperazin-1-yl)-2-(4-fluoro-7-(1,2,3)triazol-1-yl-1H-pyrrolo(2,3-c)pyridin-3-yl)-ethane-1,2-dione; Piperazine, 1-benzoyl-4-[2-[4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-. Grade: 98%. CAS No. 619331-12-3. Molecular formula: C26H21Cl2N3O6S. Mole weight: 574.4. | |
| BMS587101 | BMS-587101 is an LFA-1 small-molecule antagonist. It could reduce inflammation and joint destruction in murine models of arthritis. It inhibited LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production in vitro. It is developed by Bristol Myers Squibb research. It is used for the treatment of moderate to severe psoriasis. It was in phase II clinical trials, but has been terminated. Uses: Bms-587101 is used for the treatment of moderate to severe psoriasis. Synonyms: BMS-587101; BMS 587101; BMS587101; UNII-5V7E4UQL93. 5-[[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl]thiophene-3-carboxylic acid. Grade: 98%. CAS No. 509083-77-6. Molecular formula: C26H20Cl2N4O4S. Mole weight: 555.43. | |
| BMS-593214 | BMS-593214 is an active-site, direct FVIIa inhibitor. It displayed direct, competitive inhibition of human FVIIa in the hydrolysis of a tripeptide substrate with Ki of 5 nM. Synonyms: BMS593214; BMS 593214; 2'-(2-Carbamimidoyl-5,6a,7,11b-tetrahydro-6H-indeno[2,1-c]quinolin-6-yl)-5'-hydroxy-4'-methoxy-biphenyl-4-carboxylic acid. Grade: >98%. CAS No. 1004551-40-9. Molecular formula: C31H27N3O4. Mole weight: 505.56. | |
| BMS 599626 | BMS 599626. Group: Biochemicals. Alternative Names: N-[4-[[1-[(3-Fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic acid (3S)-3-morpholinylmethyl ester. Grades: Highly Purified. CAS No. 714971-09-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C27H27FN8O3. US Biological Life Sciences. | Worldwide |
| BMS-599626 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMS 599626 dihydrochloride | BMS 599626 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BMS 599626 dihydrochloride | BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor (IC50 = 22 nM and 32 nM, respectively), and also inhibits HER4 (IC50 = 190 nM). BMS 599626 displays 100-fold selectivity for EGFR and ErbB2 over VEGFR2, c-Kit, Lck, MET etc MEK and Lck. It can be used as an antiproliferative agent in vitro and anti-tumorigenic agent in vivo. Synonyms: BMS599626 dihydrochloride; BMS-599626 dihydrochloride; AC480 dihydrochloride; AC 480 dihydrochloride; AC-480 dihydrochloride; (3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamate dihydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:2); (3S)-3-Morpholinylmethyl (4-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1781932-33-9. Molecular formula: C27H27FN8O3.2HCl. Mole weight: 603.48. | |
| BMS-599626 Hydrochloride | BMS-599626 Hydrochloride is a selective and efficacious orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases with potential antineoplastic activity. It inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: AC480 hydrochloride; AC 480 hydrochloride; AC-480 hydrochloride; BMS-599626 HCl; BMS-599626 monohydrochloride; BMS 599626 Hydrochloride; BMS599626 hydrochloride; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, hydrochloride (1:1); Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)imino)-5-methyl-1,4-dihydropyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate hydrochloride. Grade: >98%. CAS No. 873837-23-1. Molecular formula: C27H28ClFN8O3. Mole weight: 567.01. | |
| BMS-599626 Hydrochloride | BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC 50 s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC 50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AC480 Hydrochloride. CAS No. 873837-23-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12010. | |
| BMS-604992 dihydrochloride | BMS-604992 dihydrochloride is a selective and orally active growth hormone secretagogue receptor (GHSR) agonist with high-affinity binding (Ki = 2.3 nM) and strong functional activity (EC50 = 0.4 nM). It stimulates feeding in rodents. Synonyms: EX-1314 dihydrochloride; Carbamic acid, N-(2-amino-2-oxoethyl)-N-methyl-, [3-[(1S)-1-[(2-amino-2-methyl-1-oxopropyl)amino]-2-(phenylmethoxy)ethyl]-1,2,4-triazolo[4,3-a]pyridin-5-yl]methyl ester, dihydrochloride (1:2). CAS No. 1469750-46-6. Molecular formula: C24H33Cl2N7O5. Mole weight: 570.47. | |
| BMS-604992 free base | BMS-604992 free base is a selective and orally active growth hormone secretagogue receptor (GHSR) agonist with high-affinity binding (Ki = 2.3 nM) and strong functional activity (EC50 = 0.4 nM). It stimulates feeding in rodents. Synonyms: EX-1314 free base; Carbamic acid, (2-amino-2-oxoethyl)methyl-, [3-[(1S)-1-[(2-amino-2-methyl-1-oxopropyl)amino]-2-(phenylmethoxy)ethyl]-1,2,4-triazolo[4,3-a]pyridin-5-yl]methyl ester; (3-{(1S)-2-(Benzyloxy)-1-[(2-methylalanyl)amino]ethyl}[1,2,4]triazolo[4,3-a]pyridin-5-yl)methyl (2-amino-2-oxoethyl)methylcarbamate. Grade: ≥95%. CAS No. 760944-56-7. Molecular formula: C24H31N7O5. Mole weight: 497.55. | |
| BMS 605541 | BMS 605541 is a potent and ATP-competitive VEGFR-2 inhibitor (IC50 = 23 nM) displaying >10-fold selectivity for VEGFR-2 over VEGFR-1. It exhibits antitumor activity in human lung and colon tumor xenograft models. Synonyms: BMS-605541; BMS 605541; BMS605541. N-Cyclopropyl-2,4-difluoro-5-[[[2-(2-pyridinylamino)-5-thiazolyl]methyl]amino]benzamide. Grade: ≥98% by HPLC. CAS No. 639858-32-5. Molecular formula: C19H17F2N5OS. Mole weight: 401.43. | |
| BMS-626529 | BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529, a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. The activity of BMS-626529 is virus dependent, due to heterogeneity within gp120. Research result suggest that BMS-626529 should be active against the majority of HIV-1 viruses and support the continued clinical development of the compound. Synonyms: BMS626529; BMS 626529; BMS-626529; Temsavir. Grade: 98%. CAS No. 701213-36-7. Molecular formula: C24H23N7O4. Mole weight: 473.493. | |
| BMS639623 | BMS639623 is a CCR3 antagonist with picomolar inhibition potency against eosinophil chemotaxis. It may be used for the treatment of asthma. Uses: Bms639623 may be used for the treatment of asthma. Synonyms: BMS-639623; BMS 639623; Urea, N-((1R,2S)-3-((3S)-3-((4-fluorophenyl)methyl)-1-piperidinyl)-2-hydroxy-1-methylpropyl)-N'-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)-. Grade: 98%. CAS No. 675122-44-8. Molecular formula: C25H32FN7O2. Mole weight: 481.57. | |
| BMS-641988 | BMS-641988 is a nonsteroidal androgen receptor (AR) antagonist with anti-androgenic and potential antineoplastic activities. BMS-641988 binds to ARs in target tissues and prevents AR activation, which may result in the inhibition of AR-mediated transcriptional activity and tumor cell death in susceptible tumor cell populations. Synonyms: BMS641988; BMS 641988; Ethanesulfonamide, N-((3aR,4R,5R,7R,7aS)-2-(4-cyano-3-(trifluoromethyl)phenyl)octahydro-4,7-dimethyl-1,3-dioxo-4,7-epoxy-1H-isoindol-5-yl)-. CAS No. 573738-99-5. Molecular formula: C20H20F3N3O5S. Mole weight: 471.45. | |
| BMS-645737 | BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. Synonyms: BMS645737; BMS 645737; 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine. Grade: >98%. CAS No. 651744-16-0. Molecular formula: C20H20N8O. Mole weight: 388.43. | |
| BMS-646786 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BMS-663068 | BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. It is a prodrug for BMS-626529, which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Synonyms: Fostemsavir; BMS-663068; BMS 663068; BMS663068. Grade: >98%. CAS No. 864953-29-7. Molecular formula: C25H26N7O8P. Mole weight: 583.49. | |
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