A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
DSPE-PEG(2000) Carboxy NHS is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an active ester group. Uses: Dspe-peg(2000) carboxy nhs is often used in targeted drug delivery with the lipid bilayer to improve drug solubility. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000, NHS ester] (sodium salt). Grades: >99%. Molecular formula: C135H260N2NaO57P. Mole weight: 2877.490.
DSPE-PEG(2000) Carboxy NHS
DSPE-PEG(2000) Carboxy NHS, a pegylated lipid, plays a pivotal role in drug delivery systems, particularly in the innovation of liposomal nanoparticles designed for precise targeted drug distribution. Its versatile application in combinatory conjugation with diverse pharmaceutical agents or targeting ligands demonstrates significant potential for advancing therapeutic interventions in oncology and related medical conditions. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000, NHS ester] (sodium salt). Grades: 95%. CAS No. 2410279-87-5. Molecular formula: C135H260N2NaO57P. Mole weight: 2877.49.
DSPE-PEG2000-FITC is a PEG lipid conjugated with fluorescein. FITC is a green dye with a peak absorption at 494 nm and a maximum emission at 520 nm, which is used for staining biological samples or nanoparticles. DSPE-PEG2000-FITC spontaneously forms lipid bilayers or micelles in water and can be used to prepare liposomes for delivering substances such as mRNA vaccines[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1000788-53-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-W440915.
DSPE-PEG2000-Mal ammonium
DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSPE-PEG2000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium. CAS No. 474922-22-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144004.
DSPE-PEG 2000 Maleimide
DMG-PEG-MAL, a multifunctional reactive polymer, plays a critical role in drug delivery and bioconjugation within the realm of biomedicine. Its utility extends to precise targeting of particular cells or tissues in the context of treating diverse ailments, including but not limited to cancer and inflammatory disorders. Alternative Names: DSPE-PEG (2000) Maleimide; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol-2000)]. Grades: ≥95%.
DSPE-PEG2000-Mannose
DSPE-PEG 2000-Mannose is a mannose-containing lipid. DSPE-PEG 2000-Mannose is used to prepare mannose-conjugated Liposome (Man-lipo) for siRNA delivery. Mannose-modified liposomes encapsulating IDO siRNA (Man-lipo-siIDO) preferentially knock down IDO expression in the draining lymph nodes and spleens of melanoma-bearing mice. Man-lipo-siIDO delays the onset time of melanoma and reduces tumor volume[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1829524-73-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168374.
DSPE PEG(2000)-N-Cy5
The molecular weight and exact mass are averages based on the polydispersity of PEG. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]-N-(Cyanine 5). Grades: >99%. CAS No. 2315262-02-1. Molecular formula: C164H299N4O55P (average MW due to polydispersity of PEG). Mole weight: 3238.14.
DSPE PEG(2000)-N-Cy7
The molecular weight and exact mass are averages based on the polydispersity of PEG. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]-N-(Cyanine 7). Grades: >99%. CAS No. 2315262-01-0. Molecular formula: C169H305N4O55P (average MW due to polydispersity of PEG). Mole weight: 3304.25.
DSPE-PEG2000-Tri-b-GalNAc is a multifunctional lipid material designed for targeted drug delivery. It combines DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) with a PEG2000 spacer and three N-acetylgalactosamine (GalNAc) moieties. This structure allows it to selectively bind to the asialoglycoprotein receptor (ASGPR) on hepatocytes, enabling efficient delivery of therapeutic agents to the liver. It is commonly used to construct liposomes or lipid nanoparticles for applications in RNA-based therapies, small molecule drug delivery, and gene delivery, enhancing the therapeutic efficacy while minimizing off-target effects. Alternative Names: Tris-β-GalNAc-GABA-PEG-Phospholipid; Triantennary β-D-GalNAc-GABA-PEG-phospholipid; Tri-GalNAc-PEG2000-DSPE; (β-D-GalNAc-sp)3-NHC(O)-GABA-PEG2k-phospholipid; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[tris-GalNAc-GABA-(polyethylene glycol)-2000. Molecular formula: (C2H4O)nC115H210N13O40P.
DSPE-PEG2000-triGalNAc ammonium salt
DSPE-PEG2000-triGalNAc ammonium salt is a polar lipid designed for targeted drug delivery to hepatocytes. It combines DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) with a PEG2000 spacer and three N-acetylgalactosamine (triGalNAc) moieties, which enable specific binding to the asialoglycoprotein receptor (ASGPR) on liver cells. This material is widely used in the construction of liposomes or lipid nanoparticles for applications in RNA interference, gene therapy, and small molecule drug delivery. Alternative Names: DSPE-PEG2000-triGalNAc ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]-N-tri(N-acetylgalactosamine), ammonium salt. CAS No. 2936651-86-2. Molecular formula: (C2H4O)nC97H180N9O38P.H3N.
DSPE-PEG4-DBCO
DSPE-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DSPE-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2112738-14-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-140955.
DSPE-PEG 5000-OH is DSPE-PEG 5000 with a hydroxy group. It can be used for PEG-biochemical conjugation, and be utilized in micelles, liposomes, and other lipid-based drug carriers. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[hydroxyl(polyethylene glycol)-5000,OH]; DSPE-PEG(5000)-OH. Molecular formula: C264H526O123NP. Mole weight: 5713.89.
DSPE-PEG8-Mal
DSPE-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2112737-94-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-140956.
DSPE-PEG-Amine, MW 2000 ammonium
DSPE-PEG-Amine, MW 2000 (ammonium), an amine derivative of phospholipid poly ethylene glycol, is used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DSPE-PEG-NH2, MW 2000 ammonium; DSPE-PEG(2000) Amine ammonium. CAS No. 474922-26-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125924.
DSPE-PEG Azide (ammonium salt)
DSPE-PEG azide is a functionalized polyethylene glycol (PEG) lipid, used to prepare conjugated polymer nanoparticles. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carbonyl-azido(polyethylene glycol)-5000] (ammonium salt). Grades: 95%. CAS No. 1938081-40-3. Molecular formula: C268H536N5O122P (average MW due to polydispersity of PEG). Mole weight: 5812.12.
DSPE-PEG-COOH is DSPE-PEG with a carboxylic acid. It can be used for PEG-biochemical conjugation, and be utilized in micelles, liposomes, and other lipid-based drug carriers. Alternative Names: Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-(carboxymethoxy)-, ammonium salt (1:1). Grades: >95%. CAS No. 474922-20-8. Molecular formula: (C2H4O)nC44H84NO12P.H3N.
DSPE-PEG-COOH sodium salt
DSPE-PEG-COOH is DSPE-PEG with a carboxylic acid. It can be used for PEG-biochemical conjugation, and be utilized in micelles, liposomes, and other lipid-based drug carriers. Alternative Names: Poly(oxy-1,2-ethanediyl), α-(carboxymethyl)-ω-[[(10R)-7-hydroxy-7-oxido-2,13-dioxo-10-[(1-oxooctadecyl)oxy]-6,8,12-trioxa-3-aza-7-phosphatriacont-1-yl]oxy]-, sodium salt (1:1). Grades: 95%. CAS No. 1403744-37-5. Molecular formula: (C2H4O)nC45H86NO12P.Na. Mole weight: 2780.38.
DSPE-PEG-Cy5
DSPE-PEG-Cy5 is an amphiphilic polymer. Pegylated phospholipids are excellent liposome formation materials that can be used for drug delivery, gene transfection and vaccine delivery as well. Pegylation of phospholipids significantly improves the blood circulation time and stability for encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands such as antibodies and peptides. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[(polyethylene glycol)]-Cyanine 5.
DSPE-PEG-DBCO
DSPE-PEG-DBCO is a linear heterobifunctional PEG reagent composed of a DSPE phospholipid and a dibenzocyclooctyne (DBCO) group. DSPE derivatives also provide stability and structural integrity to liposomal formulations, making DSPE-PEG-DBCO particularly suitable for drug delivery systems and nanoparticle functionalization. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethylene glycol)]. CAS No. 2052955-83-4.
DSPE-PEG-FITC
CD Bioparticles provides DSPE-PEG-FITC, Fluorescent Lipid PEGs with molecular weight of 1,000 Da for drug delivery. Group: Fluorescent lipid pegs.
DSPE-PEG Folate
DSPE-PEG-Folate is a conjugate of folic acid and amino-PEG-DSPE, used for folate-targeted PEGylated liposome preparation. Uses: Dspe-peg-folate incorporated into liposomes serves as a targeting ligand. folate targeted drug delivery is useful in diagnosing and treating cancer and inflammatory diseases. Alternative Names: Folic acid PEG DSPE; 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000/5000]. Grades: 98% by SEC-HPLC. CAS No. 1236288-25-7. Molecular formula: (C2H4O)nC63H104N9O15P.
DSPE-PEG-folate diammonium salt
DSPE-PEG-folate diammonium salt. CAS No. 1236288-25-7.
DSPE-PEG-Folate, MW 3350
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1236288-25-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144009.
DSPE-PEG-Galactose
DSPE-PEG-Galactose is a PEG lipid that can be used for protein-PEG conjugation.
DSPE-PEG maleimide
DSPE-PEG Maleimide is a functionalized PEG Lipid conjugate. Uses: Used in the preparation of neutral liposomes, immunoliposomes, and used to conjugate with p5 peptide to improve peptide incorporation into liposomes. Alternative Names: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)] ammonium salt; Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]-, ammonium salt. Grades: ≥95%. CAS No. 474922-22-0. Molecular formula: (C2H4O)nC51H92N3O13P.H3N.
DSPE-PEG-maleimide ammonium salt
DSPE-PEG-maleimide ammonium salt. CAS No. 474922-22-0.
DSPE-PEG-Maleimide (MW 2000) sodium
DMG-PEG-MAL, a multifunctional reactive polymer, plays a critical role in drug delivery and bioconjugation within the realm of biomedicine. Its utility extends to precise targeting of particular cells or tissues in the context of treating diverse ailments, including but not limited to cancer and inflammatory disorders. Alternative Names: DSPE-PEG 2000 Maleimide sodium. Grades: 95%.
DSPE-PEG-Mannose
DSPE-PEG-Mannose is an active target material, It can be used as an antitumor drug carrier and active targeted delivery. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-Mannose (sodium salt). Grades: >90%.
DSPE-PEG-NH2
DSPE-PEG-NH2,1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol) -amine (sodium salt) is a active targeting drug delivery material,it can be conjugated with peptides, antibodies, or proteins which contain NHS esters, carboxy groups on the surface. Synonyms: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol) -amine (sodium salt). Product ID: MSMN-055. Category: Raw Materials.
DSPE-PEG-NHS
1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated polyethylene glycol with active succinimidyl ester (DSPE-PEG-NHS) is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an active ester group. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the acid group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide. Alternative Names: Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[3-[[5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,5-dioxopentyl]amino]propoxy]-; 3-(N-succinimidyloxyglutaryl)aminopropyl, polyethyleneglycol-carbamyl distearoylphosphatidyl-ethanolamine. CAS No. 1244955-19-8. Molecular formula: (C2H4O)nC54H98N3O15P.
DSPE-PEG-OH
DSPE-PEG(2000) Amine is a functionalized polyethylene glycol (PEG) conjugated lipid that has both hydrophilicity and hydrophobicity. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol) -hydroxyl (sodium salt). Grades: ≥95% (NMR).
DSPE-PEG-SCM
DSPE-PEG-SCM, a conjugatable PEGylated phospholipid utilized in drug delivery systems, specifically designed for the targeted treatment of cancer cells. This innovative compound possesses the ability to enhance drug solubility and prolong circulation time within the body, showcasing its potential as a valuable asset in cancer therapy. Alternative Names: DSPE-PEG-succinimidyl carboxyl methyl ester. Grades: ≥95%.
DSPE-PEG-SH
DSPE-PEG-SH is a heterobifunctional PEGylation reagent with a DSPE phospholipid and a thiol group. It can be used in targeted drug delivery with the lipid bilayer. Alternative Names: DSPE-PEG 2000-SH; DSPE-PEG-Thiol; 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-thiol. Mole weight: DSPE-PEG-SH, MW 2000.
DSPE-PEG-TCO, MW 2K
DSPE-PEG-TCO, MW 2K. Grades: 0.9.
DSPE-polysarcosine66
DSPE-polysarcosine66 is a phospholipid polyPEG which can self-assemble to form lipid bilayer in aqueous solution. Polysarcosine is poly (n-methylated glycine) that is is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. Please contact us for GMP-grade inquiries. Alternative Names: DSPE-polysarcosine66; BP-28276. Molecular formula: C46H92N3O9P. Mole weight: 862.2.
DSPE-psar2000
Polysarcosine (pSar) is a polypeptoid based on the amino acid sarcosine. pSar lipids could change the physical nature of the LNP. pSar LNPs have also proven to be an excellent mRNA transfection agent. When compared to similar LNPs formulated with PEGylated lipids, LNPs formulated with pSar lipids exhibited a more robust mRNA transfection potency while also showing an improved safety profile.
DSPE-RGD Lipid
DSPE-RGD Lipid. Alternative Names: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-(cysarginylglycylaspartate-maleimidomethyl)cyclohexane-carboxamide] (sodium salt). CAS No. 2260795-79-5. Purity: >99%. Product ID: ALCFA2260795795. Molecular formula: C68H120N9Na2O18PS. Mole weight: 1460.75. Alfa Chemistry - ISO 9001:32057 Certified.
DSPE-Thiol
DSPE-Thiol is a phophalipid capped with thiol group. The thiol capped head can selectively react with maleimide. DSPE-Thiol can also be used for the preparation of phospholipid dimers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144735-82-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W441004.
DSPE-Thiol
DSPE-Thiol is a maleimide reactive phospholipid. In water, the phospholipid molecule can orient itself into lipid bilayer and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. Please contact us for GMP-grade inquiries. Alternative Names: DSPE-Thiol; 144735-82-0; HY-W441004; BP-26165; CS-0435870; G76896; (2R)-3-((Hydroxy(2-(3-mercaptopropanamido)ethoxy)phosphoryl)oxy)propane-1,2-diyl distearate. Grades: 0.95. CAS No. 144735-82-0. Molecular formula: C44H86NO9PS. Mole weight: 836.2.
DSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC50 of 43.9 nM, and the IC50 values for human PDE1A and 1C are 97.6 and 431.8 nM, respectively. DSR-141562 can be used for the study of positive symptoms, negative symptoms and cognitive impairments associated with schizophrenia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2007975-22-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136569.
DSR 6434
DSR 6434. Group: Biochemicals. Grades: Purified. CAS No. 1059070-10-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
DSR-6434
DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1059070-10-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110120.
DSRM-3716
DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Iodoisoquinoline. CAS No. 58142-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-W021879.
DSS
DSS. CAS No. 23024-29-5. Pack Sizes: Gram Quantities: 1 gm. Order Number: CL100.
www.prochemonline.com
DSS Crosslinker
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Alternative Names: Disuccinimidyl suberate; Suberic acid bis(N-hydroxysuccinimide ester); Di(N-succinimidyl) Suberate; Octanedioic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester; 1,1'-[(1,8-Dioxooctane-1,8-diyl)bis(oxy)]di(pyrrolidine-2,5-dione). Grades: 98%. CAS No. 68528-80-3. Molecular formula: C16H20N2O8. Mole weight: 368.34.
DST
DST. Pack Sizes: Gram Quantities: 1 gm. Order Number: CL108.
www.prochemonline.com
D-stereospecific aminopeptidase
Known from the bacterium Ochrobactrum anthropi. In peptidase family S12 (D-Ala-D-Ala carboxypeptidase family). Group: Enzymes. Synonyms: D-aminopeptidase. Enzyme Commission Number: EC 3.4.11.19. CAS No. 57534-78-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4015; D-stereospecific aminopeptidase; EC 3.4.11.19; 57534-78-8; D-aminopeptidase. Cat No: EXWM-4015.
Ds-threo-Isocitric acid monopotassium salt
Ds-threo-Isocitric acid monopotassium salt. CAS No. 20226-99-7. Cenik is your partner of choice for specialised chemicals. We don't just provide products - we supply solutions to your technical and regulatory specifications.
Ds(+)-threo-Isocitric acid trisodium salt
Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation. Group: Biochemicals. Alternative Names: (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid trisodium salt. Grades: Highly Purified. CAS No. 903507-52-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C6H5O7 3Na, Molecular Weight: 258.1. US Biological Life Sciences.
Worldwide
D-(+)-Sucrose
1kg Pack Size. Group: Carbohydrates, Sugars. Formula: C12H22O11. CAS No. 57-50-1. Prepack ID 90005036-1kg. Molecular Weight 342.3. See USA prepack pricing.
D-(+)-Sucrose ACS Reagent
1kg Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates, Diagnostic Raw Materials. Formula: C12H22O11. CAS No. 57-50-1. Prepack ID 90028177-1kg. Molecular Weight 342.3. See USA prepack pricing.
D-(+)-Sucrose, plant cell culture tested
100g Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates, Diagnostic Raw Materials. Formula: C12H22O11. CAS No. 57-50-1. Prepack ID 41080463-100g. Molecular Weight 342.3. See USA prepack pricing.
D-(+)-Sucrose, plant cell culture tested
500g Pack Size. Group: Analytical Reagents, Biochemicals, Carbohydrates, Diagnostic Raw Materials. Formula: C12H22O11. CAS No. 57-50-1. Prepack ID 41080463-500g. Molecular Weight 342.3. See USA prepack pricing.
DT-061
DT-061 is orally bioavailable activator of protein phosphatase 2A (PP2A). PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. Alternative Names: SMAP. CAS No. 1809427-19-7. Molecular formula: C25H23F3N2O5S. Mole weight: 520.52.
DT-061
DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1809427-19-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-112929.
DT2216
DT2216 is a potent and selective BCL-XL (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax-piperazine (HY-44432), a linker, and a VHL E3 ubiquitin ligase (Pink: Navitoclax-piperazine; Blue: VHL ligand; Black: linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2365172-42-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130604.
dT-3'-PS Phosphoramidite
dT-3'-PS Phosphoramidite is a thymidine-derived phosphoramidite used for the synthesis of oligonucleotides containing a 3'-phosphorothioate (PS) linkage. The phosphorothioate modification replaces a non-bridging oxygen atom in the phosphate backbone with a sulfur atom, enhancing the nuclease resistance and biological stability of the resulting oligonucleotides. The thymine base is unmodified, ensuring normal base pairing during hybridization. This phosphoramidite is particularly valuable in therapeutic applications, such as antisense oligonucleotides and siRNA, where improved stability, enhanced pharmacokinetics, and resistance to enzymatic degradation are critical for effective performance. Alternative Names: dT ThioPhosphamidite; Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[2-(benzoylthio)ethyl] P-1-pyrrolidinylphosphonothioite]; Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[S-[2-(benzoylthio)ethyl] 1-pyrrolidinylphosphonothioite]; 5'-Dimethoxytrityl-2'-deoxyThymidine, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)]-thiophosphoramidite; 5'-DMT-dT-3'-PS-Phosphoramidite. Grades: ≥90%. CAS No. 178272-24-7. Molecular formula: C44H48N3O8PS2. Mole weight: 841.97.
dTAG-13
dTAG-13(FKBP12 PROTAC dTAG-13) is an ortho-substituted, heterobifunctional selective degrader of FKBP12F36V that effectively engage FKBP12F36V and CRBN leading to rapid and selective CRBN-mediated degradation of FKBP12F36V.It can useful for target validation in the context of drug discovery. Group: Inhibitors. Alternative Names: FKBP12 PROTAC dTAG-13. CAS No. 2064175-41-1. Pack Sizes: 5mg. Product ID: S9813. Formula: C57H68N4O15.
United States; Europe
dTAG-13-NEG
dTAG-13-NEG is a negative control of dTAG-13 (HY-114421). dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2451573-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-161157.
dTAG-47
dTAG-47 is a FKBP12F36V PROTAC degrader. dTAG-47 efficiently degrades FKBP12F36V-MELK(sg3R) in MELK?/? MDA-MB-468-FKBP12F36V-MELK(sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC). (Pink: FKBP12F36V ligand (HY-114420), Blue: CRBN Ligand (HY-W087383), Black: Linker (HY-42773), E3 ligase ligand-linker conjugate (HY-175952))[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2265886-81-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147098.