A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SBP-101. CAS No. 748119-79-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132822.
Ivuxolimab
Ivuxolimab is a humanized agonistic IgG2 monoclonal antibody. Ivuxolimab selectively binds to OX40, resulting in proliferation of memory and effector T lymphocytes. Synonyms: PF-04518600; PF 04518600; PF04518600. CAS No. 2128729-41-7.
Ivy extract is prepared from leaf and stem of araliaceae family plant Hedera nepalensis var. sinensis (tobl.) rehd. Ivy extract is a product that widely used in medicine and cosmetics. Ivy extract has the function of moisturizing skin, and reducing wrinkles on face. Group: Others. Mole weight: 472.7. Ivy Extract; Hedera Nepalensis Var. Sinensis (Tobl.) Rehd. Cat No: EXTC-059.
Ivy Extract
Extract obtained from Hedera Helix (Ivy) leaves and stems. Contains 20% extract dissolved in water and glycerin. Has good soothing, anti-irritant and skin-softening properties. Uses: Creams, lotions, bath care products and after sun lotions. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84082-54-2 / 122-99-6. Appearance: Light to medium amber liquid, characteristic odor. Catalog: CI-SC-0818.
Ivy P.E. 4:1 (Hedera helix)
Ivy P.E. 4:1 (Hedera helix).
CA, FL & NJ
IWP-051
IWP-051 is a soluble guanylate cyclase (sGC) stimulator with EC50 of 290nM. IWP-051 shows >99% plasma protein binding, high permeability, high metabolic stability, and no efflux in a Caco-2 model of intestinal absorption. Synonyms: IWP-051; IWP051; IWP 051; 5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4(3H)-one. Grades: 98%. CAS No. 1354041-91-0. Molecular formula: C17H11F2N5O2. Mole weight: 355.30.
IWP 12
IWP 12 is a Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn). It blocks post resection juvenile zebrafish tailfin regeneration and is suitable for in vivo assays. It is a membrane-bound O-acyltransferase (MBOAT) and activates Wnt proteins with IC50 value of 15 nM. It inhibits Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. Synonyms: IWP12; IWP 12; IWP-12; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]acetamide. Grades: ≥98% by HPLC. CAS No. 688353-45-9. Molecular formula: C18H18N4O2S3. Mole weight: 418.56.
IWP 12
IWP 12. Group: Biochemicals. Grades: Purified. CAS No. 688353-45-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
IWP 2
IWP 2. Group: Biochemicals. Grades: Purified. CAS No. 686770-61-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
IWP-2
IWP-2. Group: Biochemicals. Alternative Names: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide. Grades: Highly Purified. CAS No. 686770-61-6. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C22H18N4O2S3. US Biological Life Sciences.
Worldwide
IWP-2
IWP-2 is an inhibitor of Wnt processing and secretion with an IC 50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC 50 of 40 nM for the gatekeeper mutant M82F CK1δ [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 686770-61-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13912.
Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC50 = 27nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the membrane-bound O-acyltransferase (MBOAT) family, which adds a palmitoyl group to Wnt proteins that is essential to their signaling ability and is required for Wnt secretion. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
IWP-2-V2
IWP-2 is an inhibitor of Wnt production (IC50 = 27 nM) that inhibits porcupine, a membrane-bound acyltransferase that is essential to the pamitoylation of Wnt ligands. IWP-2-V2 is an IWP-2 derivative with less potency. Synonyms: 2-((3-benzyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98%. CAS No. 877618-79-6. Molecular formula: C23H20N4O2S3. Mole weight: 480.6.
IWP-3 (Inhibitor of Wnt Production-3)
IWP-3 (Inhibitor of Wnt Production-3). Group: Biochemicals. Alternative Names: 2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N- (6-methyl-2-benzothiazolyl)-acetamide. Grades: Highly Purified. CAS No. 687561-60-0. Pack Sizes: 10mg. Molecular Formula: C22 H17 FN 4O2S3 , Molecular Weight: 484.6. US Biological Life Sciences.
Worldwide
IWP 4
IWP 4 is a novel and potent inhibitor of Wnt/β-catenin signaling with IC50 value of 25 nM. It blocks palmitylation, subsquent secretion and activity of Wnt. It induces the differentiation of human pluripotent stem cells into cardiomyocytes. It has minimal effect on Notch and Hedgehog signaling pathways. Synonyms: IWP4; IWP 4; IWP-4; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide; 2-(3,4,6,7-Tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98% by HPLC. CAS No. 686772-17-8. Molecular formula: C23H20N4O3S3. Mole weight: 496.62.
IWP 4
IWP 4. Group: Biochemicals. Grades: Purified. CAS No. 686772-17-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
IWP-4
IWP-4 is a small molecule Wnt inhibitor with an IC 50 of 25 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 686772-17-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12879.
IWP L6
IWP L6 (Porcn Inhibitor III) is a Porcn inhibitor with an EC 50 of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Porcn Inhibitor III. CAS No. 1427782-89-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-15825.
IWP L6
IWP L6. Group: Biochemicals. Grades: Purified. CAS No. 1427782-89-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
IWP-L6
IWP-L6 is a potent Porcupine inhibitor with EC50 value of 0.5 nM. It also inhibits Wnt/β-catenin pathway. Synonyms: IWP L6; Porcn Inhibitor III; 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide. Grades: >98%. CAS No. 1427782-89-5. Molecular formula: C25H20N4O2S2. Mole weight: 472.58.
IWR-1
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. Uses: Scientific research. Group: Signaling pathways. Alternative Names: endo-IWR 1; IWR-1-endo. CAS No. 1127442-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12238.
IWR-1
IWR-1. CAS No: 430429-02-0
Sarchem Laboratories New Jersey NJ
IWR-1-endo
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Synonyms: IWR-1; IWR 1; IWR1; IWR-1-endo. Grades: >98%. CAS No. 1127442-82-3. Molecular formula: C25H19N3O3. Mole weight: 409.44.
Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3 β. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3 β. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay). Group: Biochemicals. Alternative Names: 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide. Grades: Highly Purified. CAS No. 1127442-82-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 409.4. US Biological Life Sciences.
Worldwide
IXA4
IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 transiently activates protective IRE1/XBP1s signaling in liver without inducing RIDD or TRAF2/JNK signaling. IXA4 treatment improves systemic glucose metabolism and liver insulin action through IRE1-dependent remodeling of the hepatic transcriptome that reduces glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Our findings indicate that systemic, transient activation of IRE1/XBP1s signaling engenders multi-tissue benefits that integrate to mitigate obesity-driven metabolic dysfunction. Group: Inhibitors. Alternative Names: IXA4; IXA-4; IXA 4. CAS No. 1185329-96-7. Molecular formula: C24H28N4O4. Mole weight: 436.51. Appearance: Solid powder. Purity: >98%. IUPACName: N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide. Canonical SMILES: CC1=CC=C (OCCN (C (CN2N=CC (NC (=O)CCOC3=CC=CC=C3)=C2)=O)C)C=C1. Catalog: ACM1185329967.
Ixabepilone
Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Group: Inhibitors. Alternative Names: IXABEPILONE;(1R,5S,6S,7R,10S,14S,16S)-6,10-dihydroxy-1,5,7,9,9-pentamethyl-14-[(E) -1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-13-azabicyclo[14. 1.0]heptadecane-8,12-dione;Aza-epothilone B;Bms 247550-1;Ixempra;Ixempra kit;Unii-K27005np0a;Azi-epothilone B. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7. Appearance: Solid. Purity: 0.9984. Canonical SMILES: O=C ([C@@H] ([C@H] ([C@H] (CCC[C@]1 (O[C@]1 (C[C@H] (N2)/C (C)=C/C3=CSC (C)=N3)[H])C)C)O)C)C (C) ([C@H] (CC2=O)O)C. Catalog: ACM219989841.
Ixabepilone
Ixabepilone (also known as azaepothilone B, or BMS-247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Ixabepilone was approved in 2007. Synonyms: Azaepothilone B; BMS247550; BMS-247550; BMS 247550; Ixempra. Grades: >98%. CAS No. 219989-84-1. Molecular formula: C27H42N2O5S. Mole weight: 506.7.
Ixabepilone
Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-247550; Aza-epothilone B. CAS No. 219989-84-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-10222.
an impurity of ixabepilone. Synonyms: (4S,7R,8S,9S,13R,14R)-14-((S,E)-2-Amino-3-methyl-4-(2-methylthiazol-4-yl)but-3-en-1-yl)-4,8,13-trihydroxy-5,5,7,9,13-pentamethyloxacyclotetradecane-2,6-dione. Grades: > 95%. CAS No. 1220999-09-6. Molecular formula: C27H44N2O6S. Mole weight: 524.73.
Ixabepilone Impurity 7
an impurity of ixabepilone. Synonyms: (3S,6R,7S,8S)-11-((2R,3S)-3-((S,E)-2-Azido-3-methyl-4-(2-methylthiazol-4-yl)but-3-en-1-yl)-2-methyloxiran-2-yl)-3,7-dihydroxy-4,4,6,8-tetramethyl-5-oxoundecanoic Acid. Grades: > 95%. Molecular formula: C27H42N4O6S. Mole weight: 550.72.
Ixaconazole chloride
Ixaconazole chloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 497235-79-7. Molecular Formula: C35H36Cl2F2N8O5S. Mole Weight: 789.68. Catalog: APB497235797.
Ixaconazole Impurity31
Ixaconazole Impurity31. Uses: For analytical and research use. Group: Impurity standards. CAS No. 40805-50-3. Molecular Formula: C9H6ClNO. Mole Weight: 179.6. Catalog: APB40805503.
Ixaconazole-Intermediate 11 (p-cyanoacetophenone)
Ixaconazole-Intermediate 11 (p-cyanoacetophenone). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1443-80-7. Molecular Formula: C9H7NO. Mole Weight: 145.16. Catalog: APB1443807.
Ixaconazole side chain intermediate 3
Ixaconazole side chain intermediate 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 20099-89-2. Molecular Formula: C9H6BrNO. Mole Weight: 224.05. Catalog: APB20099892.
Ixaconazole side chain intermediate 4
Ixaconazole side chain intermediate 4. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H19CIN2O4. Mole Weight: 314.77. Catalog: APB10584.
Ixazomib
Ixazomib is a proteasome inhibitor and the biologically active form of MLN9708. Ixazomib exhibits an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both Ixazomib and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only Ixazomib alleviated osteolytic bone disease in the DP54-Luc model. Synonyms: MLN2238; MLN-2238; MLN 2238; Ixazomib. Trade name: Ninlaro. (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid. Grades: > 95%. CAS No. 1072833-77-2. Molecular formula: C14H19BCl2N2O4. Mole weight: 361.026.
Ixazomib
Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC 50 of 3.4 nM ( K i of 0.93 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN2238. CAS No. 1072833-77-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10453.
Ixazomib citrate
Ixazomib citrate (MLN9708) is a selective, orally active, second-generation proteasome inhibitor. Ixazomib citrate can be used for the study of a broad range of human malignancies [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN9708. CAS No. 1239908-20-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10452.
Ixazomib Impurity 1
Ixazomib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (R)-2,2'-(2-(1-(2,5-dichlorobenzamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid. Molecular Formula: C18H20BCl2NO8. Mole Weight: 460.07. Catalog: APB02180.