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| Product | Description | |
|---|---|---|
| LX7101 | LX7101 is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1192189-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12659. |  |
| LXG6403 | LXG6403 is an orally active and irreversible LOX inhibitor (IC50 = 1.3 μM). LXG6403 is ~3.5-fold more specific for LOX than LOXL2 and does not inhibit LOXL1. LXG6403 inhibits FAK signaling and induces ROS generation and DNA damage, leading to G1 arrest and apoptosis in chemoresistant triple-negative breast cancer (TNBC) cell lines. LXG6403 alters the extracellular matrix (ECM) and collagen structure, reducing collagen cross-linking and deposition, thereby increasing drug penetration and reducing tumor stiffness. LXG6403 overcomes Doxorubicin (HY-15142) resistance in chemoresistant TNBC PDX in vivo and can be used to study high-stiffness resistant tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315705-04-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-171955. | |
| LXH254 | LXH254 is a pan-Raf inhibitor developed for the treatment of solid tumors. Uses: Antineoplastic agents. Alternative Names: LXH-254; LXH 254; N-[3-[2-(2-Hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide. Grades: ≥98%. CAS No. 1800398-38-2. Molecular formula: C25H25F3N4O4. Mole weight: 502.49. |  |
| LXR-623 | LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC50s of 24 nM and 179 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WAY 252623. CAS No. 875787-07-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10629. | |
| LXRβ ligand 1 | LXRβ ligand 1 is a LXR β ligand-binding domain agonist, with an EC50 of 57 μM and a Ki of 28 μM against human LXR β. LXRβ ligand 1 forms hydrogen bonds with His435, stabilizes the His-Trp activation switch, and locks the ligand-binding domain in an agonist conformation; its tert-butyl moiety occupies a hydrophobic subpocket, while its phenyl moiety forms a π-π stacking interaction with Phe329. LXRβ ligand 1 serves as a structural unit for the development of LXRβ modulators[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 171049-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-33821. | |
| LXW7 | LXW7 is a αvβ3 integrin ligand. Alternative Names: LXW7; 1313004-77-1; SCHEMBL15082201; H-D-Cys(1)-Gly-Arg-Gly-Asp-D-Asp-D-Val-D-Cys(1)-NH2; HY-P0178; CS-0021086. Grades: >98%. CAS No. 1313004-77-1. Molecular formula: C29H48N12O12S2. Mole weight: 820.89. | |
| L-Xylonic acid-1,4-lactone | L-Xylonic acid-1,4-lactone is an extraordinary biomedical compound, emerging as a promising solution for studying diverse recalcitrant malignancies and neurodegenerative maladies. Derived proficiently from xylose, it showcases remarkable antioxidant attributes and assumes a pivotal stance in intracellular metabolism. Molecular formula: C5H8O5. Mole weight: 148.11. | |
| L-Xylosamine | L-Xylosamine is a bioactive molecule extensively employed in the biomedical realm assuming a fundamental role when studying a plethora of ailments intertwined with glycosaminoglycan metabolism. Its pivotal function as a precursor augments the biosynthesis of heparan sulfate, a vital constituent within the extracellular matrix. Molecular formula: C5H11NO4. Mole weight: 149.15. | |
| L-Xylose | L-Xylose is used as a selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. Alternative Names: Xylose, L-; NSC 26213. CAS No. 609-06-3. Molecular formula: C5H10O5. Mole weight: 150.13. | |
| L-xylose 1-dehydrogenase | Also oxidizes D-arabinose and D-lyxose. Group: Enzymes. Synonyms: L-xylose dehydrogenase; NADPH-xylose reductase. Enzyme Commission Number: EC 1.1.1.113. CAS No. 37250-44-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0016; L-xylose 1-dehydrogenase; EC 1.1.1.113; 37250-44-5; L-xylose dehydrogenase; NADPH-xylose reductase. Cat No: EXWM-0016. |  |
| L-Xylose-BSA | L-Xylose-BSA. | |
| L-xylulokinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-xylulose 5-phosphotransferase. This enzyme is also called L-xylulokinase (phosphorylating). This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism. Group: Enzymes. Synonyms: L-xylulokinase (phosphorylating). Enzyme Commission Number: EC 2.7.1.53. CAS No. 37278-01-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3084; L-xylulokinase; EC 2.7.1.53; 37278-01-6; L-xylulokinase (phosphorylating). Cat No: EXWM-3084. | |
| L-Xylulose | L-Xylulose, an organic sugar alcohol, finds significant utility within the dynamic biomedicine sector as a crucial carbohydrate source and an intermediary compound in the synthesis of pharmaceuticals and biochemicals. Alternative Names: L-threo-Pentulose; L-threo-2-Pentulose; L-threo-pent-2-ulose. CAS No. 527-50-4. Molecular formula: C5H10O5. Mole weight: 150.13. | |
| L-xylulose reductase | Dicarbonyl/L-xylulose reductase, also known as carbonyl reductase II, is an enzyme that in human is encoded by the DCXR gene located on chromosome 17. DCSR catalyzes the reduction of several L-xylylose as well as a number of pentoses, tetroses, trioses, alpha-dicarbonyl compounds. The enzyme is involved in carbohydrate metabolism, glucose metabolism, the uronate cycle and may play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol. Group: Enzymes. Synonyms: xylitol dehydrogenase (ambiguous). Enzyme Commission Number: EC 1.1.1.10. CAS No. 9028-17-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0002; L-xylulose reductase; EC 1.1.1.10; 9028-17-5; xylitol dehydrogenase (ambiguous). Cat No: EXWM-0002. | |
| LY 165163 | LY 165163 is a potent 5-HT presynaptic receptor agonist. LY 165163 significantly decreases 5-HTP accumulation and increases DOPA accumulation in the cortex and striatum[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: p-NH2-PE-TFMPP. CAS No. 1814-64-8. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124501. | |
| LY 188011 | LY 188011 Inhibitor. Uses: Scientific use. Product Category: T6069. CAS No. 122111-03-9. |  |
| LY 2087101 | LY 2087101. Group: Biochemicals. Grades: Purified. CAS No. 913186-74-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| LY-2087101 | LY-2087101 is an allosteric potentiator of α7 nAChRs. LY-2087101 causes potentiation of agonist-evoked α7 responses by binding within the nAChR transmembrane region[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 913186-74-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-107683. | |
| LY2090314 | LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases. Group: Inhibitors. CAS No. 603288-22-8. Pack Sizes: 5mg. Product ID: S7063. Formula: C28H25FN6O3. Smiles: C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| LY2090314 | LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 603288-22-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16294. | |
| LY2090314 | LY2090314 is a potent GSK3 inhibitor with antiproliferative activity. It was shown to promote differentiation of intestinal progenitor cells from human iPSCs. Alternative Names: LY-2090314; 3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione. Grades: >98%. CAS No. 603288-22-8. Molecular formula: C28H25FN6O3. Mole weight: 512.545. | |
| LY2109761 | LY2109761 is a novel inhibitor of TGF-β receptor type I / type II kinases (IC50 = 69 nM), displaying antitumor activity. In vivo study demonstrated that LY2109761, in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases. Alternative Names: LY-2109761; 4-(2-((4-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethyl)morpholine. Grades: >98%. CAS No. 700874-71-1. Molecular formula: C26H27N5O2. Mole weight: 441.52. | |
| LY2109761 | LY2109761 is an orally active, selective TGF-β receptor type I/II inhibitor with Kis of 38 nM and 300 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 700874-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12075. | |
| LY2109761 | LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay, respectively; shown to negatively affect the phosphorylation of Smad2. LY2109761 blocks autophagy and induces apoptosis. Group: Inhibitors. CAS No. 700874-71-1. Pack Sizes: 5mg. Product ID: S2704. Formula: C26H27N5O2. Smiles: C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LY2119620 | LY2119620 is a high-affinity muscarinic M2/M4 receptor agonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 886047-22-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15885. | |
| LY 215840 | LY 215840. Group: Biochemicals. Grades: Purified. CAS No. 137328-52-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY2228820 | LY2228820. Group: Biochemicals. Alternative Names: 5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate. Grades: Highly Purified. CAS No. 862507-23-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H37FN6O6S2. US Biological Life Sciences. | Worldwide |
| LY2228820 dimesylate | LY2228820 dimesylate is the salt form of LY2228820, a tri-substituted imidazole derivative and p38α and β MAPK inhibitor. LY2228820 inhibits tumor growth in various cancer models. Alternative Names: Ralimetinib Mesylate; Ralimetinib dimesylate; 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine mesylate. Grades: >98%. CAS No. 862507-23-1. Molecular formula: C26H37FN6O6S2. Mole weight: 612.74. | |
| LY 231617 | LY 231617. Group: Biochemicals. Grades: Purified. CAS No. 141545-89-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY2334737 | LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity. Category: Active pharmaceutical ingredients. CAS No. 892128-60-8. Product ID: API892128608. Molecular formula: C17H25F2N3O5. Mole weight: 389.39. |  |
| LY 233536 | LY 233536 is a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, but few detailed information has been published yet. Alternative Names: LY 233536; LY-233536; LY233536; (3R-(3alpha,4aalpha,6beta,8aalpha))-decahydro-6-(1H-tetrazol-5-ylmethyl)- 3-Isoquinolinecarboxylic acid. Grades: 98%. CAS No. 136845-59-5. Molecular formula: C12H19N5O2. Mole weight: 265.32. | |
| LY 2365109 hydrochloride | LY 2365109 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 868265-28-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY237 | LY237 is a highly efficient complete agonist of GPR84 (pEC50 = 10.15). LY237 can be used for research on inflammation and fibrosis conditions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1892576-07-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-178234. | |
| LY 2389575 hydrochloride | LY 2389575 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 885104-09-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY2452473 | LY2452473 is an orally bioavailable, selective androgen receptor modulator (SARM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1029692-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114530. | |
| LY-2456302 | LY-2456302, also called as CERC-501, is a potent, highly selective and centrally-penetrant kappa opioid receptor antagonist (Ki = 0.807 nM) with favorable pharmacokinetic and pharmacodynamic properties to evaluate the role of KOR in preclinical models of alcoholism. Alternative Names: 4-[4-[[(2S)-2-(3,5-dimethylphenyl)pyrrolidin-1-yl]methyl]phenoxy]-3-fluorobenzamide; 3-fluoro4-(4-((2-(3,5-dimethylphenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide; LY2456302; CERC-501; LY 2456302; CERC 501; LY-2456302; CERC501. CAS No. 1174130-61-0. Molecular formula: C26H27FN2O2. Mole weight: 418.5. | |
| LY2510924 | LY2510924 is a potent and selective CXCR4 antagonist that blocks SDF-1 binding to CXCR4 with an IC50 of 0.079 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1088715-84-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12488. | |
| LY-2510924 | LY-2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4). It has potential antineoplastic activity. It binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation upon subcutaneous administration, which may result in decreased tumor cell proliferation and migration. It plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. Uses: Ly-2510924 has potential antineoplastic activity. it plays an important role in chemotaxis and angiogenesis. Alternative Names: LY2510924; LY 2510924; Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2; Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2; L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7→1)-lactam; N(1)Phe-Tyr-Lys(iPr)-D-Arg-2Nal-Gly-D-Glu(1)-Lys(iPr)-NH2. Grades: 98%. CAS No. 1088715-84-7. Molecular formula: C62H88N14O10. Mole weight: 1189.47. | |
| LY2510924 acetate | Ly2510924 acetate is a potent and selective CXCR4 antagonist that prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM. It has potential antineoplastic activity. Alternative Names: L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7→1)-lactam, acetate (1:1); LY 2510924 acetate; LY-2510924 acetate; N(1)Phe-Tyr-Lys(iPr)-D-Arg-2Nal-Gly-D-Glu(1)-Lys(iPr)-NH2 acetate. Grades: ≥95%. Molecular formula: C62H88N14O10.C2H4O2. Mole weight: 1249.53. | |
| LY 255283 | LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils. LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years.1,2 The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100nM.3 LY255283 exhibits IC50 values of ~950nM and >10uM at human recombinant BLT2 and BLT1 receptors, respectively.4 LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10uM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260nM.1. Group: Biochemicals. Alternative Names: 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone. Grades: Highly Purified. CAS No. 117690-79-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C19H28N4O3, Molecular Weight: 360.5. US BiolÂ… | Worldwide |
| LY-2562175 | LY2562175 is a potent and selective FXR agonist in vitro. It has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. It was developed by Eli Lilly and Company and in clinic phase 1 trials with no progress. Uses: Ly2562175 has robust lipid modulating properties, lowering ldl and triglycerides while raising hdl in preclinical species. Alternative Names: LY2562175; LY 2562175; LY-2562175;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid. Grades: >98%. CAS No. 1103500-20-4. Molecular formula: C28H27Cl2N3O4. Mole weight: 540.44. | |
| LY-2584702 tosylate salt | LY-2584702 tosylate salt is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1082949-68-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-12493A. | |
| LY2606368 | LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. Alternative Names: LY-2606368; LY 2606368. Grades: >98%. CAS No. 1234015-52-1. Molecular formula: C18H19N7O2. Mole weight: 365.397. | |
| LY2606368 dihydrochloride | The dihydrochloride salt form of LY2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. It is still under Phase II clinical trial against breast cancer and some other sorts of cancers. Uses: The dihydrochloride salt form of ly2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. Alternative Names: UNII-9RFT476U2L; 9RFT476U2L; LY2606368 (dihydrochloride); 1234015-54-3; HY-18174A; CS-3507; CS 3507; CS3507; LY2606368; LY 2606368; LY-2606368. Grades: 98%. CAS No. 1234015-54-3. Molecular formula: C18H21Cl2N7O2. Mole weight: 438.31. | |
| LY 266097 hydrochloride | LY 266097 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 172895-39-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY266097 hydrochloride | LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172895-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103094. | |
| LY-266500 | LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC50 =0.6 μM) and Leishmania donovani (IC50 =2.86 μM). LY-266500 can be used for research on parasitic infections[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 147104-27-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-W973644. | |
| LY-272015 hydrochloride | LY-272015 hydrochloride is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172895-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100851A. | |
| LY2784544 | LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells. Alternative Names: Gandotinib; LY-2784544; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine. Grades: >98%. CAS No. 1229236-86-5. Molecular formula: C23H25ClFN7O. Mole weight: 469.949. | |
| LY2794193 | LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM, EC50=0.47 nM; hmGlu2 Ki=412 nM, EC50=47.5 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2173037-97-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-119243. | |
| LY2795050 | LY2795050, a κ-opioid Receptor antagonist, has been found to be effective in imaging KOR behaving as a PET tracer. IC50: 0.72 nM and 25.8 nM for κ-opioid Receptor and κ-opioid. Uses: Ly2795050 is a κ-opioid receptor antagonist that has been found to be effective in imaging kor behaving as a pet tracer. Alternative Names: LY2795050; LY 2795050; LY-2795050; (S)-LY2795050; UNII-71PAL357HO; CHEMBL1921842; 71PAL357HO; BDBM50358166. Grades: 98%. CAS No. 1346133-08-1. Molecular formula: C23H22ClN3O2. Mole weight: 407.89. | |
| LY2811376 | LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Uses: Scientific research. Category: Signaling pathways. CAS No. 1194044-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10472. | |
| LY2835219 (Abemaciclib) Mesylate | Abemaciclib mesylate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3. Group: Inhibitors. Alternative Names: LY2835219 mesylate. CAS No. 1231930-82-7. Pack Sizes: 5mg. Product ID: S7158. Formula: C27H32F2N8.CH4O3S. Smiles: CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LY2874455 | LY2874455 is a pan-FGFR inhibitor with IC50s of 2.8, 2.6, 6.4, 6 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254473-64-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-13304. | |
| LY2880070 | LY2880070 is an orally active CHK1 inhibitor, IC50 ? 1 nM. LY2880070 can be used as an anticancer agent for combination with DNA damaging agents[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375637-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148962. | |
| LY2886721 | LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262036-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13240. | |
| LY2922470 | LY2922470 Inhibitor. Uses: Scientific use. Product Category: T15810. CAS No. 1423018-12-5. | |
| LY294002 | LY294002 is a potent inhibitor of phosphoinositide PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively. Alternative Names: LY294002; LY-294002; LY 294002; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholino-8-phenyl-4H-chromen-4-one. Grades: >98%. CAS No. 154447-36-6. Molecular formula: C19H17NO3. Mole weight: 307.349. | |
| LY294002 | LY294002 Inhibitor. Uses: Scientific use. Product Category: T2008. CAS No. 154447-36-6. | |
| LY294002 | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. | Worldwide |
| LY294002 | LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively[1]. LY294002 also inhibits CK2 with an IC50 of 98 nM[2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is an apoptosis activator[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 154447-36-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10108. | |
| LY294002 | LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis. Group: Inhibitors. Alternative Names: SF 1101, NSC 697286. CAS No. 154447-36-6. Pack Sizes: 10mg. Product ID: S1105. Formula: C19H17NO3. Smiles: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| LY 294002 hydrochloride | LY 294002 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 934389-88-5. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| LY294002 hydrochloride | LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC50 values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 934389-88-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10108A. | |
| LY2940094 | LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BTRX-246040. CAS No. 1307245-86-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-114452. | |
| LY2955303 | LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1433497-19-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107765. | |
| LY 3000328 | LY 3000328 (Z-FL-COCHO) is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-FL-COCHO. CAS No. 1373215-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15533. | |
| LY3009120 | LY3009120 (DP-4978) is a pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT with IC50s of 5.8, 9.1 and 15 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DP-4978. CAS No. 1454682-72-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12558. | |
| LY3009120 | LY03009120 is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1. Alternative Names: LY3009120; LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978. Grades: 98%. CAS No. 1454682-72-4. Molecular formula: C23H29FN6O. Mole weight: 424.51. | |
| LY 303511 | LY 303511. Group: Biochemicals. Grades: Purified. CAS No. 154447-38-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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