A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata. It is a potent membrane-active agent that transforms normal erythrocytes into echinocytes. It exhibits potent antimalarial activity and might be developed into a new antimalarial drug. It had anti-tumor activity in all cell lines tested and enhanced the effect of paclitaxel and vinblastine chemotherapy. Synonyms: 4,4'-Dihydroxy-3-α,α-dimethylallyl-6-methoxychalcone; 7-Dimethoxycoumarin; 3-Dimethylallyl-4,4'-dihydroxy-6-methoxychalcone; (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one; (2E)-3-[5-(1,1-Dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one; 2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)-; 2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (E)-. Grade: >98%. CAS No. 58749-22-7. Molecular formula: C21H22O4. Mole weight: 338.40.
Licochalcone A
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs)[1]. Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) [2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 58749-22-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0372.
Licochalcone A
Licochalcone A. Group: Biochemicals. Grades: Plant Grade. CAS No. 58749-22-7. Pack Sizes: 20mg. Molecular Formula: C21H22O4, Molecular Weight: 338.4. US Biological Life Sciences.
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Licochalcone B
Licochalcone B. Group: Biochemicals. CAS No. 58749-23-8. Pack Sizes: 5mg. US Biological Life Sciences.
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Licochalcone B
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7?NLRP3 interaction[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 58749-23-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0373.
Licochalcone B
Licochalcone B is extracted from the roots of Glycyrrhiza glabra L. It inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. It could significantly reduce the LPS-induced production of NO, TNFalpha and MCP-1. Synonyms: (2E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one; 2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (E)-; (E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one; 3,4,4'-Trihydroxy-2-methoxy-trans-chalcone; 3,4,4'-Trihydroxy-2-Methoxychalcone. Grade: >98%. CAS No. 58749-23-8. Molecular formula: C16H14O5. Mole weight: 286.28.
Licochalcone C
Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 144506-14-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0374.
Licochalcone D
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144506-15-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N4187.
Licochalcone E
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 864232-34-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4182.
licodione 2'-O-methyltransferase
As well as licodione [1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione], the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, but more slowly. Group: Enzymes. Enzyme Commission Number: EC 2.1.1.65. CAS No. 77000-07-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1967; licodione 2'-O-methyltransferase; EC 2.1.1.65; 77000-07-8. Cat No: EXWM-1967.
licodione synthase
A heme-thiolate protein (P-450). It probably forms 2-hydroxyliquiritigenin which spontaneously forms licodione. NADH can act instead of NADPH, but more slowly. Group: Enzymes. Enzyme Commission Number: EC 1.14.13.87. CAS No. 157972-05-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0895; licodione synthase; EC 1.14.13.87; 157972-05-9. Cat No: EXWM-0895.
Licofelone
Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Anti-inflammatory. Group: Biochemicals. Alternative Names: 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid; ML-3000. Grades: Highly Purified. CAS No. 156897-06-2. Pack Sizes: 50mg, 100mg, 250mg, 500mg. Molecular Formula: C??H??ClNO?, Molecular Weight: 379.88. US Biological Life Sciences.
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Licofelone
Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML-3000. CAS No. 156897-06-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1452.
Licoisoflavone A
Licoisoflavone A, a potential MRP inhibitor, is a natural flavonoid derived from the roots of Glycyrrhiza uralensis Fisch. It inhibits lipid peroxidation with an IC50 of 7.2 μM. Licoisoflavone A and Licoisoflavone B inhibit copper-induced protein oxidative modification of mice brain homogenate in vitro. Synonyms: 2',4',5,7-Tetrahydroxy-3'-(3,3-dimethylallyl)isoflavone; 3-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one; Phaseoluteone; 4H-1-Benzopyran-4-one, 3-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-; 2',4',5,7-Tetrahydroxy-3'-(3,3-dimethylallyl)isoflavone; 3'-Isopentenyl-2',4',5,7-tetrahydroxyisoflavone. Grade: >95%. CAS No. 66056-19-7. Molecular formula: C20H18O6. Mole weight: 354.35.
Licoisoflavone A
Licoisoflavone A. Group: Biochemicals. CAS No. 66056-19-7. Pack Sizes: 5mg. US Biological Life Sciences.
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Licoisoflavone A
Licoisoflavone A. Alternative Names: Phaseoluteone. CAS No. 66056-19-7. Product ID: FFC-AR-66056197. Molecular formula: C20H18O6. Mole weight: 354.35. IUPAC Name: 3-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-5,7-dihydroxychromen-4-one. Alfa Chemistry - ISO 9001:32057 Certified.
Licorice Extract
Licorice Extract. Applications: As a sweetener, licorice extract is used in food industry;as as raw materials of drugs for clearing heat and detoxicating, licorice extract is used in medicine field;as product for benefiting stomach, licorice extract is widely used in health industry;licorice extract applied in cosmetic field, licorice extract is able to nourish and cure the skin. Group: Others. Purity: 10%-98% Min. Appearance: Brown fine powder. Source: Liquorice, or licorice is the root of Glycyrrhiza glabra from which a sweet flavour can be extracted. The liquorice plant is a herbaceous perennial legume native to southern Europe, India, and parts of Asia. It is not botanically related to anise, star anise, or fennel, which are sources of similar flavouring compounds. Licorice Extract; Radix Glycyrrhizae. Cat No: EXTC-191.
Licoricesaponin G2 is an orally active component found in Licorice. Licoricesaponin G2 significantly ameliorates Bleomycin (HY-108345)-induced pulmonary fibrosis by inhibiting the TNF-α signaling pathway, reducing epithelial-mesenchymal transition, and decreasing extracellular matrix deposition. Licoricesaponin G2 inhibits cancer cells proliferation, migration, inhibits PI3K/AKT/mTOR signaling pathway and increases ROS production. Licoricesaponin G2 can be used for the research of lung cancer and pulmonary fibrosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 118441-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N6983.
Licorice-saponin H2
Liquorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a type of triterpenoid oligosaccharide glycoside found in the Glycyrrhiza genus. Liquorice-saponin H2 accumulates more in the roots of licorice plants under salt stress conditions, suggesting that it may play a role in plant stress resistance[1]. Uses: Scientific research. Category: Natural products. Alternative Names: (18β,20α)-Glycyrrhizic acid. CAS No. 118441-85-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6911.
L-iditol 2-dehydrogenase
This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. Enzymes from different organisms or tissues display different substrate specificity. The enzyme is specific to NAD+ and can not use NADP+. Group: Enzymes. Synonyms: polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD+ 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase. Enzyme Commission Number: EC 1.1.1.14. CAS No. 9028-21-1. SDH. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0043; L-iditol 2-dehydrogenase; EC 1.1.1.14; 9028-21-1; polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD+ 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD+ oxidoreductase; NAD+-dependent sorbitol dehydrogenase; NAD+-sorbitol dehydrogenase. Cat No: EXWM-0043.
Lidocaine
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lignocaine. CAS No. 137-58-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-B0185.
Lidocaine
Lidocaine. Group: Biochemicals. Alternative Names: Xylocaine; Lignocaine. Grades: Highly Purified. CAS No. 137-58-6. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C14H22N2O. US Biological Life Sciences.
Worldwide
Lidocaine Base USP
Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. Uses: topically to relieve itching, burning, and pain from inflammatory skin conditions, injected as a dental anesthetic. Group: OTC (Over-the-Counter) Active Ingredients. INCI Name: Lidocaine Base USP. CAS Number: 137-58-6.
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Lidocaine-d10
Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 851528-09-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0185S1.
Lidocaine-d10 N-Oxide
A novel labeled metabolite of Lidocaine. Group: Biochemicals. Alternative Names: 2-[Di (ethyl-d5) oxidoamino]-N- (2, 6-dimethylphenyl) acetamide; 2-[Di(ethyl-d5)amino]-2',6'-acetoxylidide N-Oxide; 2-[Di (ethyl-d5) amino]-N- (2, 6-dimethylphenyl) acetamide N2-Oxide. Grades: Highly Purified. CAS No. 851528-10-4. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Lidocaine-d6 Hydrochloride
Lidocaine-d6 Hydrochloride is the labeled analogue of Lidocaine Hydrochloride, a local anesthetic; antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C14H17D6ClN2O. US Biological Life Sciences.
Worldwide
Lidocaine EP Impurity D-d6
Lidocaine EP Impurity D-d6. Uses: For analytical and research use. CAS No. 1216698-89-3. Molecular formula: C12H12D6N2O. Mole weight: 212.33. Catalog: APB1216698893.
Lidocaine EP Impurity E HCl
Lidocaine EP Impurity E HCl. Uses: For analytical and research use. CAS No. 1135231-62-7. Molecular formula: C20H26ClN3O2. Mole weight: 375.9. Catalog: APB1135231627.
Lidocaine EP Impurity F
Lidocaine EP Impurity F. Uses: For analytical and research use. CAS No. 142713-08-4. Molecular formula: C14H22N2O. Mole weight: 234.34. Catalog: APB142713084.
Lidocaine EP Impurity G
Lidocaine EP Impurity G. Uses: For analytical and research use. CAS No. 42459-30-3. Molecular formula: C13H20N2O. Mole weight: 220.32. Catalog: APB42459303.
Lidocaine EP Impurity I
Lidocaine EP Impurity I. Uses: For analytical and research use. CAS No. 17289-53-1. Molecular formula: C14H22N2O. Mole weight: 234.34. Catalog: APB17289531.
Lidocaine EP Impurity J
Lidocaine EP Impurity J. Uses: For analytical and research use. CAS No. 857570-37-7. Molecular formula: C14H22N2O. Mole weight: 234.34. Catalog: APB857570377.
Lidocaine EP impurity K (free acid)
Lidocaine EP impurity K (free acid). Uses: For analytical and research use. CAS No. 74634-66-5. Molecular formula: C13H20N2O. Mole weight: 220.32. Catalog: APB74634665.
Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. Water soluble form of lidocaine. Uses: used topically to relieve itching, burning, and pain from inflammatory skin conditions, injected as a dental anesthetic. Group: OTC (Over-the-Counter) Active Ingredients. INCI Name: Lidocaine HCL. CAS Number: 6108-05-0.
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Lidocaine hydrochloride
Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lignocaine hydrochloride. CAS No. 73-78-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-B0185A.
Lidocaine Hydrochloride
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE. Category: Antiarrhythmic apis. Synonyms: Lidocaine hydrochloride monohydrate. Zingo. Linocaine hydrochloride. Lignocaine hydrochloride. CAS No. 6108-05-0. Product ID: API6108050. Molecular formula: C14H25ClN2O2. Mole weight: 288.81. EINECS: 612-079-4. SMILES: CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.O.Cl.
Lidocaine Hydrochloride Monohydrate
Lidocaine hydrochloride monohydrate is a commonly used as local anesthetic in topical applications and oral mucosal biopsies. It has a short anesthetic half-life; Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration. Group: Biochemicals. Alternative Names: 2-(Diethylamino)-2',6'-acetoxylidide Hydrochloride; 2-(Diethylamino)-2',6'-dimethylacetanilide Hydrochloride; Alphacaine; DioCaine; Irtopan; Jetmonal; Lidesthesin; Lidocain Hydrochloride; Lidocaine Monohydrochloride; Lidothesin; Lignavet; Lignocaine Hydrochloride; Luan; Metaclopromide Hydrochloride; Odontalg; Proliferol; Rapidocaine; Sedagul; Versicane; Xilina Hydrochloride; Xycaine Hydrochloride; Xylanaest Purum; Xylocaine Astra; Xylocaine Hydrochloride; Xylocard; Xyloneural; Xylotox. Grades: Highly Purified. CAS No. 6108-05-0. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C14H23ClN2O, Molecular Weight: 288.81. US Biological Life Sciences.
Worldwide
Lidocaine Impurity 11
Lidocaine Impurity 11. Uses: For analytical and research use. Molecular formula: C14H19N3. Mole weight: 229.33. Catalog: APB10769.
Lidocaine impurity 12
Lidocaine impurity 12 is an impurity of Lidocaine (HY-B0185). Uses: Scientific research. Category: Signaling pathways. CAS No. 857170-72-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Z6535.
Lidocaine Impurity 12
Lidocaine Impurity 12. Uses: For analytical and research use. Molecular formula: C15H22N2O. Mole weight: 246.35. Catalog: APB10770.
Lidocaine Impurity 13
Lidocaine Impurity 13. Uses: For analytical and research use. CAS No. 5177-35-5. Molecular formula: C10H12ClNO. Mole weight: 197.66. Catalog: APB5177355.
Lidocaine Impurity 17
Lidocaine Impurity 17. Uses: For analytical and research use. Alternative Names: 2-chloro-N-(2,6-dimethylphenyl)acetamide. CAS No. 1131-01-7. Molecular formula: C10H12ClNO. Mole weight: 197.66. Catalog: APB1131017.
Lidocaine Impurity 2
Lidocaine Impurity 2. Uses: For analytical and research use. CAS No. 1596965-85-3. Molecular formula: C11H23N3O2. Mole weight: 229.32. Catalog: APB1596965853.
Lidocaine Impurity 4
Lidocaine Impurity 4. Uses: For analytical and research use. CAS No. 219500-63-7. Molecular formula: C10H13NS2. Mole weight: 211.34. Catalog: APB219500637.
Lidocaine Impurity 5
Lidocaine Impurity 5. Uses: For analytical and research use. CAS No. 2903-48-2. Molecular formula: C10H11NO3. Mole weight: 193.2. Catalog: APB2903482.
Lidocaine Impurity 6 HCl
Lidocaine Impurity 6 HCl. Uses: For analytical and research use. CAS No. 857170-05-9. Molecular formula: C14H23ClN2O. Mole weight: 270.8. Catalog: APB857170059.
Lidocaine Impurity 7 HCl
Lidocaine Impurity 7 HCl. Uses: For analytical and research use. CAS No. 77966-82-6. Molecular formula: C14H23ClN2O. Mole weight: 270.8. Catalog: APB77966826.
Lidocaine Impurity 8
Lidocaine Impurity 8. Uses: For analytical and research use. CAS No. 2315-36-8. Molecular formula: C6H12ClNO. Mole weight: 149.62. Catalog: APB2315368.
Lidocaine Impurity 9
Lidocaine Impurity 9. Uses: For analytical and research use. CAS No. 1606-01-5. Molecular formula: C6H13NO2. Mole weight: 131.18. Catalog: APB1606015.
Lidocaine N-Oxide
A novel metabolite of Lidocaine. Group: Biochemicals. Alternative Names: 2- (Diethyloxidoamino) -N- (2, 6-dimethylphenyl) acetamide; 2-(Diethylamino)-2',6'-acetoxylidide N-Oxide; 2- (Diethylamino) -N- (2, 6-dimethylphenyl) acetamide N2-Oxide. Grades: Highly Purified. CAS No. 2903-45-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Lidocaine Related Compound H
Lidocaine Related Compound H. Uses: For analytical and research use. CAS No. 1131-01-7. Mole weight: 197.66. EC Number: 214-460-7. Catalog: AP1131017-A.
Lidoflazine
Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia. Category: Active pharmaceutical ingredients. CAS No. 3416-26-0. Product ID: API3416260. Molecular formula: C30H35F2N3O. Mole weight: 491.62.
Lidoflazine
Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3416-26-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-112075.
L-idonate 5-dehydrogenase
The enzyme from the bacterium Escherichia coli is specific for 5-dehydro-D-gluconate. cf. EC 1.1.1.366, L-idonate 5-dehydrogenase (NAD+). Group: Enzymes. Enzyme Commission Number: EC 1.1.1.264. CAS No. 211737-68-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0170; L-idonate 5-dehydrogenase; EC 1.1.1.264; 211737-68-7. Cat No: EXWM-0170.
L-idonate 5-dehydrogenase (NAD+)
Involved in the catabolism of ascorbate (vitamin C) to tartrate. No activity is observed with NADP+ (cf. EC 1.1.1.264, L-idonate 5-dehydrogenase). Group: Enzymes. Enzyme Commission Number: EC 1.1.1.366. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0283; L-idonate 5-dehydrogenase (NAD+); EC 1.1.1.366. Cat No: EXWM-0283.
L-idose-[1-13C]
A stable labelled analogue of L-idose. L-idose is the L-Isomer of D-idose. Synonyms: L-[1-13C]idose; L-idose-1-13C. Molecular formula: C5[13C]H12O6. Mole weight: 181.15.
L-idose-[2-13C]
A stable labelled analogue of L-idose. L-idose is the L-Isomer of D-idose. Synonyms: L-[2-13C]idose; L-idose-2-13C. Molecular formula: C5[13C]H12O6. Mole weight: 181.15.
L-idose-[6-13C]
A stable labelled analogue of L-idose. L-idose is the L-Isomer of D-idose. Synonyms: L-[6-13C]idose; L-idose-6-13C. CAS No. 115973-80-3. Molecular formula: C5[13C]H12O6. Mole weight: 181.15.
L-Iduronic acid-[1,6-13C2]
L-Iduronic acid-[1,6-13C2] is a valuable biochemical utilized in the biomedical industry for its role in synthesizing drugs used to study diseases related to abnormal glycosaminoglycan metabolism. Its isotopic label, 13C2, aids in research and drug development, facilitating accurate tracing and analysis of metabolic pathways. Synonyms: L-Iduronic acid-1,6-13C2; (1,6-13C2)L-Iduronic acid; Aldehydo-L-iduronic acid-1,6-13C2. Grade: ≥97%; 99% atom 13C. Molecular formula: C4[13C]2H10O7. Mole weight: 196.13.
L-iduronidase
Iduronidase (EC 3.2.1.76, L-iduronidase, alpha-L-iduronidase, laronidase) is an enzyme with the systematic name glycosaminoglycan alpha-L-iduronohydrolase. This enzyme catalyses the hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.It is a glycoprotein enzyme found in the lysosomes of cells. It is involved in the degeneration of glycosaminoglycans such as dermatan sulfate and heparan sulfate. The enzyme acts by hydrolyzing the terminal alpha-L-induronic acid residues of these molecules, degrading them. The protein is reported as having a mass of approximately 83 kilodaltons. Group: Enzymes. Synonyms: α-L-iduronidase. Enzyme Commission Number: EC 3.2.1.76. CAS No. 9073-56-7. IDUA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3940; L-iduronidase; EC 3.2.1.76; 9073-56-7; α-L-iduronidase. Cat No: EXWM-3940.
Liensinine
Liensinine is a bisbenzylisoquinoline alkaloid. By inhibiting the PI3K/AKT and JNK/p38-MAPK signaling pathways, Liensinine suppresses autophagy and apoptosis, clears Aβ, and exerts anti-inflammatory, antioxidant and neuroprotective effects. Liensinine activates AMPK and inhibits the expression of HIF-1α and VEGF, thereby suppressing angiogenesis. Liensinine exerts anti-tumor effects through ROS-mediated inhibition of the JAK2/STAT3 signaling pathway. Liensinine can be used for the research of diseases such as Alzheimer's disease, hepatocellular carcinoma, osteosarcoma, sepsis-induced organ injury and stroke[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2586-96-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0484.
Liensinine diperchlorate
Liensinine diperchlorate. Group: Biochemicals. Grades: Plant Grade. CAS No. 5088-90-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Lifastuzumab
Lifastuzumab is a humanized anti-NaPi2b IgG1 monoclonal antibody. Lifastuzumab can be coupled with monomethyl auristatin E (MMAE) (HY-15162) through ADC Linker to form an antibody-drug conjugate (ADC) Lifastuzumab vedotin (HY-P99705) with anticancer activity. Lifastuzumab vedotin can be studied in research for non-small cell lung cancer and ovarian cancer. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1615697-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99970.
Lificiguat
Lificiguat binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YC-1. CAS No. 170632-47-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14927.
Lifirafenib
Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BGB-283. CAS No. 1446090-79-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18957.
Lifitegrast
Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR 1118; SHP-606. CAS No. 1025967-78-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-19344.
Lifitegrast Impurity 10
Lifitegrast Impurity 10. Uses: For analytical and research use. CAS No. 90484-22-3. Molecular formula: C9H6O3. Mole weight: 162.14. Catalog: APB90484223.
Lifitegrast Impurity 11
Lifitegrast Impurity 11. Uses: For analytical and research use. CAS No. 77095-51-3. Molecular formula: C9H6O3. Mole weight: 162.14. Catalog: APB77095513.