A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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| Product | Description | |
|---|---|---|
| Ne-Boc-L-lysine-2-chlorotrityl resin | Ne-Boc-L-lysine-2-chlorotrityl resin. Group: Biochemicals. Alternative Names: L-Lys(Boc)-2-chlorotrityl resin. Grades: Highly Purified. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences. |  Worldwide |
| Ne-Boc-L-lysine-2-chlorotrityl resin, 0.3-0.8 meq/g | Ne-Boc-L-lysine-2-chlorotrityl resin, 0.3-0.8 meq/g. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine 4-nitroanilide | Ne-Boc-L-lysine 4-nitroanilide. Group: Biochemicals. Alternative Names: L-Lys(Boc)-pNA. Grades: Highly Purified. CAS No. 172422-76-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine 4-nitroanilide 99+% (HPLC) | Ne-Boc-L-lysine 4-nitroanilide 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-Lysine 99+% | Ne-Boc-L-Lysine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine allyl ester hydrochloride 99+% (HPLC) | Ne-Boc-L-lysine allyl ester hydrochloride 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine amide hydrochloride | Ne-Boc-L-lysine amide hydrochloride. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine methyl ester hydrochloride | Ne-Boc-L-lysine methyl ester hydrochloride. Group: Biochemicals. Alternative Names: L-Lys(Boc)-OMe·HCl. Grades: Highly Purified. CAS No. 2389-48-2. Pack Sizes: 2g, 5g, 10g, 25g, 50g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine methyl ester hydrochloride 98+% (HPLC) | Ne-Boc-L-lysine methyl ester hydrochloride 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences. | Worldwide |
| Ne-Boc-L-lysine tert-butyl ester hydrochloride 98+% | Ne-Boc-L-lysine tert-butyl ester hydrochloride 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Neboglamine hydrochloride | Neboglamine (CR-2249, XY-2401) hydrochloride is an orally active NMDA receptor glycine site positive modulator that can be used in schizophrenia research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CR-2249 hydrochloride; XY-2401 hydrochloride. CAS No. 2759182-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114753A. |  |
| Nebokitug | HY-P991010 is an CCL24-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CM101. CAS No. 2922315-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991010. | |
| nebramycin 5' synthase | Requires Fe(III). The enzyme from the bacterium Streptoalloteichus tenebrarius catalyses the activation of carbamoyl phosphate to O-carbamoyladenylate and the subsequent carbamoylation of kanamycin and tobramycin. Group: Enzymes. Synonyms: tobramycin carbamoyltransferase; TobZ. Enzyme Commission Number: EC 6.1.2.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5666; nebramycin 5' synthase; EC 6.1.2.2; tobramycin carbamoyltransferase; TobZ. Cat No: EXWM-5666. |  |
| Nebramycin IV | Nebramycin IV is an aminoglycoside antibiotic produced by Streptomyces tenebrarius. Nebramycin IV has a broad antibacterial spectrum and has a strong effect on Gram-positive and negative bacteria and mycobacteria. Synonyms: Nebramycin factor 4; 6''-O-Carbamoylkanamycin B; 6-O-(3-Amino-6-carbamoyl-3-deoxy-α-D-glucopyranosyl)-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine. CAS No. 51736-76-6. Molecular formula: C19H38N6O11. Mole weight: 526.54. |  |
| Nebratamig | Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GNC-035. CAS No. 2694723-68-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P991209. | |
| Nebularine | Nebularine is originally isolated from Agaricus nebularis. Shown to have inhibitory effects against mouse Sarcoma 180 and mycobacteria. Synonyms: 9-(beta-D-Ribofuranosyl)-9H-purine; Purine riboside; Purine-9-β-D-ribofuranoside; 9-β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; N-D-Ribosylpurine; Purinosine; NSC 65423; 6-Deaminoadenosine; 9-β-D-Ribofuranosylpurine; 9-β-D-Ribosyl-9H-purine; Desaminoadenosine; Isopurine, ribosyl-; Ribosylpurine. Grade: ≥ 95% by HPLC. CAS No. 550-33-4. Molecular formula: C10H12N4O4. Mole weight: 252.23. | |
| Nebularine | Alternate Names: Group: Biochemicals. Alternative Names: Purine-9-ß-D-ribofuranoside; 9- β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; Purinosine; NSC 65423. Grades: Highly Purified. CAS No. 550-33-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C??H??N?O? , Molecular Weight: 252.2. US Biological Life Sciences. | Worldwide |
| Nebularine (High Purity) | Nucleoside analog. Cytotoxic. DNA, RNA and protein synthesis inhibitor. Shows anticancer activity. Anti-mycobacterial. Has tuberculostatic activity. Antifungal activity. Antiviral (anti-Herpes). Adenosine deaminase inhibitor. Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA. Group: Biochemicals. Alternative Names: Purine-9-ß-D-ribofuranoside; 9- β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; Purinosine; NSC 65423. Grades: Highly Purified. CAS No. 550-33-4. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Nebularine (Purine-9-ß-D-Ribofuranoside) | Shown to have inhibitory effects against mouse Sarcoma 180 and mycobacteria. Group: Biochemicals. Alternative Names: Purine-9-ß-D-Ribofuranoside. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| NECA | NECA. Group: Biochemicals. Grades: Purified. CAS No. 35920-39-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Ne-Carboxymethyl-L-lysine (2-Amino-6-(carboxymethyl-amino)-hexanoic Acid) | Atmosphere: Inert gas. Group: Biochemicals. Alternative Names: 2-Amino-6-(carboxymethyl-amino)-hexanoic Acid. Grades: Highly Purified. CAS No. 5746-4-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ne-Carboxymethyl-L-lysine 98+% | Ne-Carboxymethyl-L-lysine 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g. US Biological Life Sciences. | Worldwide |
| Necitumumab | Necitumumab (11F8; IMC-11F8; LY3012211) is a human IgG monoclonal antibody directed against EGFR. Necitumumab binds to the EGF binding site of EGFR, blocks ligand binding, neutralizes ligand-induced EGFR phosphorylation and downstream signaling, induces EGFR internalization and degradation, and mediates antibody-dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells. Necitumumab enhances antitumour activity in combination with Gemcitabine (HY-17026) and Cisplatin (HY-17394) in murine non-small-cell lung cancer xenograft models. Necitumumab can be used in research on cancers such as non-small cell lung cancer and colorectal cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 11F8; IMC-11F8; LY3012211. CAS No. 906805-06-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9964. | |
| Necrocide 1 | Necrocide 1, a necrosis by sodium overload (NECSO) inducer, is a selective transient receptor potential melastatin 4 (TRPM4) agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin (CALR) exposure, ATP secretion and high mobility group box 1 (HMGB1) release. Necrocide 1 can be used for the study of breast and prostate cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1247028-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14307. | |
| Necrosis inhibitor 2 | Necrosis inhibitor 2 (Compound B19) is a cell necrosis inhibitor. Necrosis inhibitor 2 can be used to study diseases related to the necrosis pathway, including inflammation, tumors, metabolic diseases and neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2258671-03-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160169. | |
| Necrosis Inhibitor, Necrox-2 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-2 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Necrosis Inhibitor, Necrox-5 ([5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine, Dihydrochloride) | A cell-permeable necrosis inhibitor that displays antioxidant property. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1uM NecroX-5 prevented ~50% cell death in H9C2 cells exposed to 400uM t-BuOOH for 2 hours). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 | Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Nec-1. CAS No. 4311-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15760. | |
| Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1) | Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC50 = 180nM). Group: Biochemicals. Alternative Names: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 (Nec-1) | Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis. Group: Inhibitors. Alternative Names: Nec-1. CAS No. 4311-88-0. Pack Sizes: 10mg. Product ID: S8037. Formula: C13H13N3OS. Smiles: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Necrostatin 2 | Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 852391-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14622. | |
| Necrostatin 2 racemate | Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1. CAS No. 852391-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14622A. | |
| Necrostatin 2 racemate (Nec-1s) | Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases. Group: Inhibitors. Alternative Names: 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S. CAS No. 852391-15-2. Pack Sizes: 5mg. Product ID: S8641. Formula: C13H12ClN3O2. Smiles: CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Necrostatin 2 (S enantiomer) | Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 (HY-14622). Necrostatin 2 S enantiomer inhibits TNF-α-induced necroptosis in Jurkat T cells. Necrostatin 2 S enantiomer can be used for the research of ischemic brain injury (stroke)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852391-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14622B. | |
| Necrostatin-5 (Nec-5, 3-p-Methoxyphenyl-5, 6-tetramethylenothieno [2, 3-d]pyrimidin-4-one-2-mercaptoethylcyanide) | Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5. Group: Biochemicals. Alternative Names: 3-p-Methoxyphenyl-5, 6-tetramethylenothieno [2, 3-d]pyrimidin-4-one-2-mercaptoethylcyanide) . Grades: Highly Purified. CAS No. 337349-54-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-5 (Nec-5, 3-p-Methoxyphenyl-5, 6-tetra methyl enothienopyrimidin-4-one-2-mercaptoethylcyanide) | Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Group: Biochemicals. Alternative Names: Nec-5, 3-p-Methoxyphenyl-5, 6-tetra methyl enothienopyrimidin-4-one-2-mercaptoethylcyanide. Grades: Highly Purified. CAS No. 337349-54-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-7 (Nec-7) | Necroptosis inhibitor. Does not inhibit RIP1 kinase. Group: Biochemicals. Alternative Names: Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-7 ((Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7) | A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 as Nec-7 does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in the pathway. Group: Biochemicals. Alternative Names: (Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Necrosulfonamide | Necrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL). Group: Inhibitors. CAS No. 1360614-48-7. Pack Sizes: 10mg. Product ID: S8251. Formula: C18H15N5O6S2. Smiles: COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(S3)[N+](=O)[O-]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| Necrosulfonamide | Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinsons disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1360614-48-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100573. | |
| Necrosulfonamide | Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway. Group: Biochemicals. Alternative Names: N-[4-[[ (3-Methoxypyrazinyl) amino]sulfonyl]phenyl]-3- (5-nitro-2-thienyl) -2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Necrosulfonamide-d4 | Labeled Necrosulfonamide. Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway. Group: Biochemicals. Alternative Names: N-[4-[[ (3-Methoxypyrazinyl) amino]sulfonyl] (phenyl]-d4) -3- (5-nitro-2-thienyl) -2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl](phenyl-d4)]-3-(5-nitrothiophene-2-yl)acrylamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Necrosulfonamide-d4 | Necrosulfonamide-d4 is the deuterium labeled Necrosulfonamide (HY-100573). Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinsons disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways. Uses: Scientific research. Category: Signaling pathways. CAS No. 1795144-22-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-100573S. | |
| NecroX-5 | NecroX-5 is a derivative of the NecroX, reduces intracellular calcium concentration, and possesses anti-inflammatory and anti-cancer activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1383718-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104015. | |
| NecroX-7 | NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1120332-55-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124750. | |
| Nectaryl | Nectaryl. CAS No. 95962-14-4. VIGON Item # 500924. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, peach cyclopentanone. |  America & Internationally |
| Ned 19 | Ned 19 is a selective membrane-permeant non competitive NAADP antagonist and inhibits NAADP-mediated Ca2+ signaling, with an IC50 of 65 nM[1]. Ned 19 strongly inhibits tumor growth and vascularization as well as lung metastases in mice[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 874374-25-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-103316A. | |
| Ne-Dimethyl-L-lysine hydrochloride | Ne-Dimethyl-L-lysine hydrochloride. Group: Biochemicals. Alternative Names: L-Lys(Me)2-OH·HCl. Grades: Highly Purified. CAS No. 2259-86-1. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. US Biological Life Sciences. | Worldwide |
| Ne-Dimethyl-L-lysine hydrochloride 98+% (NMR) | Ne-Dimethyl-L-lysine hydrochloride 98+% (NMR). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100mg, 250mg, 1g, 5g. US Biological Life Sciences. | Worldwide |
| Nedisertib | Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Peposertib; M3814. CAS No. 1637542-33-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101570. | |
| Nedisertib (M3814) | Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM. Group: Inhibitors. Alternative Names: Peposertib, MSC2490484A. CAS No. 1637542-33-6. Pack Sizes: 5mg. Product ID: S8586. Formula: C24H21ClFN5O3. Smiles: COC1=NN=C(C=C1)C(C2=C(C=C(C(=C2)C3=NC=NC4=C3C=CC(=C4)N5CCOCC5)F)Cl)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| Nedizantrep | GDC-6599 is an orally active TRPA1 inhibitor, with IC50 values of 5.3 nM in humans, 6.6 nM in rats, 9.3 nM in dogs, 7.2 nM in monkeys, and 15 nM in guinea pigs. GDC-6599 can be used in the research of neuropathic pain and respiratory diseases such as asthma and chronic cough[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-6599. CAS No. 2376824-99-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156684. | |
| Ned-K | Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR)-induced Ca2+ oscillations in cardiomyocytes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250019-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131041. | |
| Nedometinib | Nedometinib (NFX-179) is a specific MEK1 inhibitor with an IC50 of 135 nM. Nedometinib inhibits p-ERK, MAPK. Nedometinib exerts anticancer activity against squamous cell carcinoma. Nedometinib can be used for research in dermatosis, neurofibromatosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NFX-179. CAS No. 2252314-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-156625. | |
| Nedosiran | Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Category: Active pharmaceutical ingredients. CAS No. 2266591-83-5. Product ID: API2266591835. Molecular formula: C662H808F19N231O413P57S6Na57. Mole weight: 22,238 Da. |  |
| Nedosiran sodium | Nedosiran (DCR-PHXC) sodium is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran sodium represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran sodium is a GalNAc-dsRNA conjugate[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DCR-PHXC sodium. CAS No. 2247026-22-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-132606A. | |
| Needle Mushroom Powder | Needle Mushroom Powder contains a large quantity of a protein, designated Five, which helps to regulate the immune system. Animal testing indicated possible uses for vaccines and cancer immunotherapy. Needle Mushroom Powder also contains flammutoxin, a cytolytic and cardiotoxic protein that may possibly be poorly absorbed orally. Group: Others. Needle Mushroom Powder; Flammulina Velutipes. Cat No: EXTC-074. | |
| Neem | This product contains essential fatty acids and vitamin E to work double time on hydrating and plumping the skin, for a healthy look and feel. Pack Sizes: 1 kg. Product ID: CDC10-0556. Category: Anti-Acne Ingredients. Product Keywords: Cosmetic Ingredients; Active Ingredients; Anti-Acne Ingredients; Neem; CDC10-0556. |  |
| Nefazodone | Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83366-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119209. | |
| Nefazodone hydrochloride | Nefazodone hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 82752-99-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Nefazodone hydrochloride | Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMY-13754; MJ-13754-1. CAS No. 82752-99-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B1396. | |
| Nefazodone hydrochloride | Nefazodone hydrochloride. CAS No: 82752-99-6 |  Sarchem Laboratories New Jersey NJ |
| Nefazodone Hydrochloride | Nefazodone Hydrochloride is a synthetic antidepressant compound of the phenylpiperazine class. It is classified as a serotonin receptor modulator and reuptake inhibitor (SARI), notable for its dual action on both serotonin receptors and the serotonin transporter. Applications: Indicated for the treatment of depression and anxiety disorders. nefazodone hydrochloride is a serotonin receptor modulator and reuptake inhibitor (sari) that combines 5-ht2a receptor antagonism with serotonin and norepinephrine reuptake inhibition. it is particularly notable for its favorable effects on sleep architecture and sexual function. Category: Active pharmaceutical ingredients. Synonyms: 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride. CAS No. 82752-99-6. Product ID: API82752996. Molecular formula: C25H33Cl2N5O2. Mole weight: 506.5. InChIKey: DYCKFEBIOUQECE-UHFFFAOYSA-N. Appearance: White solid. | |
| Nefazodone, Hydrochloride (2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride) | A selective serotonin 5-HT2 receptor antagonist. An antidepressant. Group: Biochemicals. Alternative Names: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Nefazodone Hydrochloride (5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone) | A potent 5-HT2A receptor antagonist (Kd = 26nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48nM) and 5-HT1A receptor (Kd = 80nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 82752-99-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Nefazodone Related Compound A | Nefazodone Related Compound A. Uses: For analytical and research use. CAS No. 52605-52-4. Mole weight: 309.66. Catalog: AP52605524-A. |  |
| Neferine | Neferine. Group: Biochemicals. Grades: Plant Grade. CAS No. 2292-16-2. Pack Sizes: 20mg. Molecular Formula: C38H44N2O6, Molecular Weight: 624.77. US Biological Life Sciences. | Worldwide |
| Neferine | Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Neferine. CAS No. 2292-16-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0441. | |
| Nef Hck Activation Inhibitor, B9 (Nef Dimerization Blocker, (E)-4-((3-Chlorophenyl)diazenyl)-5-hydroxy-3-(4-nitrophenyl)-1H-pyrazole-1-carbothioamide) | A cell-permeable diphenylpyrazolo compound that disrupts HIV accessary protein Nef dimerization (IC50 = 3uM in HEK293T cells) and prevents Nef-mediated Src family kinase Hck activation (IC50 = 2.8uM) without directly affecting the catalytic activity of c-Src, Hck, Lck, or Lyn. Shown to suppress HIV and SIV viral replication (IC50/strain/culture = 1uM/SIV deltaB670/CEM-174 and <0.3uM/HIV-1 NL4-3/CEM-T4) and infectivity, being ineffective against the replication of Nef-defective HIV-1 mutant. Molecular docking and in vitro binding studies reveal a high-affinity B9-targeting site formed at the Nef dimerization interface and a low-affinity binding site on each Nef monomer at the dimer interface periphery. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?S, Primary Target: Nef. US Biological Life Sciences. | Worldwide |
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