A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Nurr1 agonist 7 (compound 110) is a Nurr1 agonist with an EC 50 value of 0.12 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 228707-95-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-157026.
Nurr1 inverse agonist-1
Nurr1 inverse agonist-1 is an inverse agonist tool for the neuroprotective transcription factor Nurr1. Uses: Scientific research. Group: Signaling pathways. CAS No. 2758673-07-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-132909.
Nurulimab
Nurulimab (BCD-145) is an anti- cytotoxic T lymphocyte antigen-4 (anti-CTLA-4) human monoclonal antibody. Nurulimab can be can be used in research of melanoma [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BCD-145. CAS No. 2168561-20-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99760.
nusinersen
Nusinersen is a drug used for the treatment of spinal muscular atrophy (SMA), which is related to the mutation in the SMN1 gene. It was approved by FDA in Dec. 2016 for the treatment of SMA in adults and children. Uses: The treatment of sma. Synonyms: RNA [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G); Spinraza; ISIS 396443; 1: PN: WO2010148249 SEQID: 1 claimed DNA. Grades: ≥95%. CAS No. 1258984-36-9. Molecular formula: C234H340N61O128P17S17. Mole weight: 7127.18.
Nutlin-3
Nutlin-3 is a commercial available p53-MDM2 inhibitor, with K i of 90 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 548472-68-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50696.
Nutlin-3
Nutlin-3 is an MDM2 antagonist, inhibiting p53-Mdm2 interaction (IC50=0.09 μM) via affecting p53 binding pocket of MDM2. It has been studied in anticancer reseaches. Synonyms: (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one; 4-[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one. Grades: >98%. CAS No. 548472-68-0. Molecular formula: C30H30Cl2N4O4. Mole weight: 581.49.
Cell-permeable. Nutlin-3 is a Mdm2 (mouse double minute 2) antagonist (IC50=90nM for Nutlin-3a and 13.6uM for Nutlin-3b), p53 pathway activator, and apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 548472-68-0. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Worldwide
Nutlin-3a
Nutlin-3a is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin-3a activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. Synonyms: rebemadlin; (-)-Nutlin-3; Nutlin-3a chiral. Grades: >98%. CAS No. 675576-98-4. Molecular formula: C30H30Cl2N4O4. Mole weight: 581.5.
Nutlin-3a
Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor ( IC 50 =90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Rebemadlin. CAS No. 675576-98-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10029.
Nutlin-3b
Nutlin-3b, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM. Synonyms: Nutlin-3; nutlin 3; Nutlin 3b; FJA1772CVW; (+)-Nutlin-3; CHEMBL2152332; CHEBI:46742; 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one; 2-Piperazinone, 4-(((4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1H-imidazol-1-yl)carbonyl)-; 4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one; 4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one; 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone; cis-4-{[4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl}piperazin-2-one. Grades: >98%. CAS No. 675576-97-3. Molecular formula: C30H30Cl2N4O4. Mole weight: 581.49.
Nutmeg Neolignan
Nutmeg Neolignan is a stereomixture of erythro-Δ8'-7-Ethoxy-4-hydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan and threo-Δ8'-7-Ethoxy-4-hydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan. The mixture is novel TRPM8 agonist from nutmeg as promising cooling compound. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C46H60O12, Molecular Weight: 804.96. US Biological Life Sciences.
"""Indonesia is currently the largest producer of Nutmeg Oil in the world, providing 75% to 80% of the global supply. It is also one the top three largest producers of Mace Oil. The three areas where Nutmeg is mainly grown in Indonesia are Java, Aceh in North Sumatra and the spice island in around Sulawesi. 80 - 90% of the Nutmeg Oil processed is used for flavouring in beverages""". Uses: Oral care and pharmaceutical, Aromatherapy, Personal Care, Perfumery. Group: Plant Extracts. INCI Names: Myristica Fragrans (Nutmeg) Kernel Oil. Grades: FOOD GRADE. CAS No. 84082-68-8 ; 8008-45-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: NM-005. Olfactive Profile: Spicy, terpenic, sweet, warm, woody. EC No: 282-013-3. FEMA No: 2793. Origin: Indonesia.
New Jersey
Nutmeg Oil (Java | Bogor 9% Myristicin)
Indonesia is currently the largest producer of Nutmeg Oil in the world, providing 75% to 80% of the global supply. It is also one the top three largest producers of Mace Oil. The three areas where Nutmeg is mainly grown in Indonesia are Java, Aceh in North Sumatra and the spice island in around Sulawesi. 80 - 90% of the Nutmeg Oil processed is used for flavouring in beverages. Uses: Flavor, Oral Care, Fragrance Products, Personal Care. Group: Plant Extracts. INCI Names: Myristica Fragrans (Nutmeg) Kernel Oil. Grades: FOOD GRADE. CAS No. 84082-68-8 ; 8008-45-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: NM-001. Olfactive Profile: Spicy, terpenic, sweet, warm, woody. EC No: 282-013-3. FEMA No: 2793. Origin: Indonesia.
New Jersey
Nutmeg Oil Safrole Free
"Indonesia is currently the largest producer of Nutmeg Oil in the world, providing 75% to 80% of the global supply. It is also one the top three largest producers of Mace Oil. The three areas where Nutmeg is mainly grown in Indonesia are Java, Aceh in North Sumatra and the spice island in around Sulawesi. 80 - 90% of the Nutmeg Oil processed is used for flavouring in beverages". Uses: Fragrance, Personal Care. Group: Plant Extracts. INCI Names: Myristica Fragrans (Nutmeg) Kernel Oil. Grades: FOOD GRADE. CAS No. 84082-68-8 ; 8008-45-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: NM-004. Olfactive Profile: Spicy, terpenic, sweet, warm, woody. EC No: 282-013-3. FEMA No: 2793. Origin: Indonesia.
Nuvenzepine, a new pirenzepine-analog, is an mAChR antagonist, administered intraduodenally, displayed a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. Synonyms: 11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one; 11-(N-methylisonipecotyl)-6,11-dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one; DF 545; DF-545; nuvenzepine. CAS No. 96487-37-5. Molecular formula: C19H20N4O2. Mole weight: 336.39.
Nuzhenide
Cas No. 39011-92-2.
Nuzhenide Impurity 1
An impurity of Nuezhenide. Synonyms: methyl (5E,6S)-5-ethylidene-4-[2-[[(2R,3S,4S,5R,6R)-5-[2-[(2S,3E)-3-ethylidene-5-methoxycarbonyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-4-yl]acetyl]oxy-3,4-dihydroxy-6-[2-(4-hydroxyphenyl)ethoxy]oxan-2-yl]methoxy]-2-oxoethyl]-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate. Grades: > 95%. Molecular formula: C48H64O27. Mole weight: 1073.03.
NV03
NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a K d of 2.4 μM. NV03 has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2448341-58-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125292.
NV-128
NV-128 is a novel isoflavone derivative, which has been shown in pre-clinical studies to promote cancer cell death in multi drug resistant cancer cells by inducing caspase-independent DNA degradation and cancer cell death via the AKT-mTOR pathway. In contrast to phenoxodiol and triphendiol, NV-128 has been shown to induce caspase-independent DNA degradation and cancer cell death. It appears that in conjunction with autophagy induction, NV-128 induces caspase independent cell death via the AKT-mTOR pathway resulting in beclin sequestration of Bcl-2, Bax up-regulation and mitochondrial depolarization. As a consequence, endonuclease G translocates to the nucleus where it initiates DNA degradation and cell death. This offers an opportunity for use as a monotherapy in chemoresistant cancers and enhanced efficacy against cancer targets less susceptible to phenoxodiol. The option for co-administration of combinations of these drugs is also under investigation to extend the potential therapeutic range of this unique class of oncology compounds. Synonyms: NV-128; NV 128; NV128. CAS No. 1210335-22-0.
NV-5138
NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2095886-80-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114384.
NV-5138
NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 possesses rapid antidepressant effects. Synonyms: 4-(difluoromethyl)-L-leucine; ((S)-2-Amino-5,5-difluoro-4,4-dimethylpentanoic acid. Grades: ≥98%. CAS No. 2095886-80-7. Molecular formula: C7H13F2NO2. Mole weight: 181.18.
NV-5138 hydrochloride
NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2639392-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-114384B.
N-Valeryl-D-glucosamine
N-Valeryl-D-glucosamine, an imperative compound widely employed in the biomedical sector, is esteemed for its tremendous prospects in the pharmaceutical arena. Its significance lies in the development of therapeutic agents targeting diverse ailments encompassing inflammation and autoimmune disorders. Synonyms: N-Valeryl-D-glucosamine; 63223-57-4; N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]pentanamide; SCHEMBL5157878; N-N-VALERYL-D-GLUCOSAMILE; MFCD00059805; 2-Deoxy-2-valeramido-D-glucopyranose; 2-Deoxy-2-pentanamido-D-glucopyranose; V0011; T72746; W-203351; N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)pentanamide. CAS No. 63223-57-4. Molecular formula: C11H21NO6. Mole weight: 263.29.
N-valeryl-D,L-penicillamine
N-valeryl-D,L-penicillamine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
N-Valinyl-1-deoxy-D-glucitol
N-Valinyl-1-deoxy-D-glucitol is an exceptional biomedical compound, demonstrating remarkable potential in the research for diabetes. It serves as a potent α-glucosidase inhibitor. Synonyms: N-Glucosyl-L-valine. Molecular formula: C11H23NO7. Mole weight: 281.30.
N-Vanillyldecanamide
N-Vanillyldecanamide is found in the fruits of Capsicum annuum L. var. annuum. Synonyms: Decylic acid vanillylamide. Grades: > 95%. CAS No. 31078-36-1. Molecular formula: C18H29NO3. Mole weight: 307.43.
N-Vanillyldecanamide
N-Vanillyldecanamide, a capsaicinoid isolated from the fruits of Capsicum annuum , significantly reduced the radical length of Lactuca sativa seedling in a dose-dependent manner [1]. Uses: Scientific research. Group: Natural products. CAS No. 31078-36-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5099.
N-Vanillylnonanamide
1g Pack Size. Group: Biochemicals, Organics, Research Organics & Inorganics. Formula: C17H27NO3. CAS No. 2444-46-4. Prepack ID 28253688-1g. Molecular Weight 293.4. See USA prepack pricing.
N-Vinyl-2-pyrrolidone
N-Vinyl-2-pyrrolidone. Group: Biochemicals. Alternative Names: 1-Vinyl-2-pyrrolidinone; 1-Vinylpyrrolidin-2-one. Grades: Highly Purified. CAS No. 88-12-0. Pack Sizes: 1kg, 2kg, 5kg. US Biological Life Sciences.
Worldwide
N-Vinyl-2-pyrrolidone 99+% (GC)
N-Vinyl-2-pyrrolidone 99+% (GC). Group: Biochemicals. Grades: GC. CAS No. 88-12-0. Pack Sizes: 100g, 250g, 1Kg, 4Kg, 5Kg. US Biological Life Sciences.
100g Pack Size. Group: Antibiotics, Bioactive Small Molecules, Research Organics & Inorganics. Formula: C8H13NO. CAS No. 2235-00-9. Prepack ID 90026843-100g. Molecular Weight 139.19. See USA prepack pricing.
N-Vinylformamide (NVF) is a class of N-vinylamide that is a precursor to amide and amine functional polymer. It has attractive properties that include high reactivity in polymerization and hydrolysis. Uses: Nvf can be used in the free radical polymerization formation of poly(nvf) with a molecular weight ranging from 104 to 106. Group: Polymer/macromoleculevinyl monomers. Alternative Names: n-ethenyl-formamid. CAS No. 13162-05-5. Molecular formula: C3H5NO. Mole weight: 71.08 g/mol. Purity: 0.98. Canonical SMILES: [H]C(=O)NC=C. Density: 1.014 g/mL at 25 °C (lit.). Catalog: ACM-MO-13162055.
N-Vinylphthalimide
1g Pack Size. Group: Building Blocks, Organics. Formula: C10H7NO2. CAS No. 3485-84-5. Prepack ID 89997051-1g. Molecular Weight 173.17. See USA prepack pricing.
N-Vinylphthalimide
This product is suitable for scientific research. Group: Organic & printed electronicsvinyl monomers. Alternative Names: 2-Vinylisoindoline-1,3-dione. CAS No. 3485-84-5. Molecular formula: C10H7NO2. Mole weight: 173.17 g/mol. Appearance: White to Light Yellow to Light Orange Powder to Crystal. Purity: 98.0%(GC). IUPACName: 2-ethenylisoindole-1,3-dione. Canonical SMILES: C=CN1C(=O)c2ccccc2C1=O. ECNumber: 222-473-4. Catalog: ACM-MO-3485845.
N-Vinylphthalimide
N-Vinylphthalimide. Uses: This product is suitable for scientific research. Group: other materials monomers. Alternative Names: 2-Vinylisoindoline-1,3-dione. CAS No. 3485-84-5. Product ID: 2-ethenylisoindole-1,3-dione. Molecular formula: 173.17. Mole weight: C10H7NO2. C=CN1C(=O)c2ccccc2C1=O. 1S/C10H7NO2/c1-2-11-9 (12)7-5-3-4-6-8 (7)10 (11)13/h2-6H, 1H2. IGDLZDCWMRPMGL-UHFFFAOYSA-N. >98.0%(GC)(N).
N-Vinylpyrrolidone
Polyvinylpyrrolidone is a white powder. Compatible with a wide range of hydrophilic and hydrophobic resins. (NTP, 1992);Liquid;White or nearly white powder;YELLOW-TO-BROWN HYGROSCOPIC POWDER.;COLOURLESS-TO-YELLOW LIQUID.;White powder. Group: Polymers. Product ID: 1-ethenylpyrrolidin-2-one. Molecular formula: 111.14g/mol. Mole weight: (C6H9NO)n;C6H9NO;C6H9NO. C=CN1CCCC1=O. InChI=1S/C6H9NO/c1-2-7-5-3-4-6 (7)8/h2H, 1, 3-5H2. WHNWPMSKXPGLAX-UHFFFAOYSA-N.
n-vinylpyrrolidone/styrene copolymer
n-vinylpyrrolidone/styrene copolymer. Group: Polymers. CAS No. 25086-29-7. Pack Sizes: 1 g. Mole weight: C14H17NO.
NVP 2 is a potent, ATP-competitive CDK9 inhibitor with IC50 value of 0.5 nM, exhibiting selectivity for CDK9 over a panel of 468 kinases. Synonyms: 4- [ [ [5'-Chloro-2'- [ [trans-4- [ [ (1R) -2-methoxy-1-methylethyl]amino]cyclohexyl]amino] [2, 4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile. Grades: ≥97% by HPLC. CAS No. 1263373-43-8. Molecular formula: C27H37ClN6O2. Mole weight: 513.07.
NVP 231
NVP 231. Group: Biochemicals. Grades: Purified. CAS No. 362003-83-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NVP-231
NVP-231 is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP-231 is active in the low nanomolar range on purified as well as cellular CerK and abrogates phosphorylation of ceramide, resulting in decreased endogenous C1P levels. When combined with another ceramide metabolizing inhibitor, such as tamoxifen, NVP-231 synergistically increased ceramide levels and reduced cell growth. Therefore, NVP-231 represents a novel and promising compound for controlling ceramide metabolism that may provide insight into CerK physiological function. Synonyms: NVP-231; NVP 231; NVP231. CAS No. 362003-83-6. Molecular formula: C25H25N3O2S. Mole weight: 431.554.
NVP-231
NVP-231. Group: Biochemicals. Alternative Names: N-[2-(Benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13, 7]decane-1-carboxamide; NVP 231. Grades: Highly Purified. CAS No. 362003-83-6. Pack Sizes: 10mg. Molecular Formula: C25H25N3O2S, Molecular Weight: 431.55. US Biological Life Sciences.
A potent antagonist for NMDA receptors. Modestly higher selectivity for the NR2A than for the NR2B containing NMDA receptors (IC50 = 0.015 and 0.078uM) but insufficient to discriminate between NR2A and NR2B-containing NMDA receptors. Widely used for researches in synaptic plastic, learning and memory, and epilepsy. Group: Biochemicals. Grades: Highly Purified. CAS No. 459836-30-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
NVP-ABE-171
NVP-ABE171 is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. Uses: Pde4 inhibitor. Synonyms: ABE171; ABE-171; ABE 171; NVP-ABE171; NVP-ABE-171; NVP-ABE 171. 4-[8-(2,1,3-benzoxadiazol-5-yl)-1,7-naphthyridin-6-yl]benzoic acid; 4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyridin-6-yl)benzoic acid. Grades: ≥95%. CAS No. 426268-06-6. Molecular formula: C21H12N4O3. Mole weight: 368.35.
NVP-ACC789
NVP-ACC789 is a potent, selective and orally active inhibitor of the VEGF receptor tyrosine kinases, antagonizing tumor-driven angiogenesis. Uses: A potent, selective and orally active inhibitor of the vegf receptor tyrosine kinases. Synonyms: NVP-ACC789; NVP-ACC 789; NVP-ACC-789; ACC-789; ACC 789; ACC789; ZK-202650; ZK 202650; ZK202650.AC1OCFN3;N-(3-bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine. Grades: ≥96%. CAS No. 300842-64-2. Molecular formula: C21H17BrN4. Mole weight: 405.3.
NVP ADW 742
NVP ADW 742. Group: Biochemicals. Grades: Purified. CAS No. 475488-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NVP-AEW541
NVP-AEW541 is a selective inhibitor of Insulin-like growth factor 1 receptor (IGF-1R) kinase. It abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Synonyms: AEW-541; AEW 541; AEW541; 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥98%. CAS No. 475488-34-7. Molecular formula: C27H29N5O. Mole weight: 439.6.
NVP-AUY 922
NVP-AUY 922 is a potent inhibitor of heat shock protein 90 (Hsp90) that prevents the proliferation of a range of human cancer cell lines. NVP-AUY 922 has been shown to enhance the radiation sensitivity of tumor cell lines under hypoxia. Group: Biochemicals. Alternative Names: 5-[2, 4-Dihydroxy-5- (1-methylethyl) phenyl]-N-ethyl-4-[4- (4-morpholinylmethyl) phenyl]-3-isoxazolecarboxamide; VER 52296; NVP-AUY922. Grades: Highly Purified. CAS No. 747412-49-3. Pack Sizes: 10mg. US Biological Life Sciences.
NVP-BAG956 is a potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in vivo. It inhibits cellular AKT phosphorylation at Thr308 and blocks cell proliferation, causing arrest in G1 phase of the cell cycle. It slows tumor progression in mouse xenograft models. Synonyms: BAG-956; BAG 956; BAG956; NVP-BAG956; NVP-BAG-956; NVP-BAG 956. Grades: >98%. CAS No. 853910-02-8. Molecular formula: C28H21N5. Mole weight: 427.5.
NVP-BBD130
NVP-BBD130 is a potent and selective dual PI3K/mTOR inhibitor. It can suppress the growth and proliferation of melanoma primary tumors and metastasis via inhibiting NVP-BEZ235 and BBD130. Uses: Antitumor agent. Synonyms: 2-methyl-2-[4-[3-methyl-2-oxo-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile. Grades: 99%. CAS No. 853910-61-9. Molecular formula: C28H21N5O. Mole weight: 443.5.
NVP-BEP800
NVP-BEP800 is a novel, fully synthetic Hsp90β inhibitor with IC50 of 58 nM, which exhibits >70-fold selectivity against Hsp90 family members Grp94 and Trap-1. Synonyms: VER82576; VER 82576; VER-82576; XL184; XL 184; XL-184; BMS-907351; BMS 907351; BMS907351; NVP BEP800; NVP-BEP 800; NVP BEP-800; BEP-800; BEP800; BEP 800. Grades: >98%. CAS No. 847559-80-2. Molecular formula: C21H23Cl2N5O2S. Mole weight: 480.41.
NVP-BEZ 235
Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Group: Biochemicals. Alternative Names: 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile; 2-Methyl-2- [4- [3-methyl-2-oxo-8- (quinolin-3-yl) -2, 3-dihydroimidazo [4, 5-c] quinolin-1-yl] phenyl] propionitrile; BEZ 235. Grades: Highly Purified. CAS No. 915019-65-7. Pack Sizes: 10mg. US Biological Life Sciences.
Potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively); it showed siginificant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3. Synonyms: Infigratinib phosphate; BGJ-398 phosphate; NVP-BGJ398 phosphate; NVPBGJ398 phosphate. Grades: >98%. CAS No. 1310746-10-1. Molecular formula: C26H34Cl2N7O7P. Mole weight: 658.47.
NVP BHG 712
NVP BHG 712. Group: Biochemicals. Grades: Purified. CAS No. 940310-85-0. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
NVP-BHG712
NVP-BHG712 / BHG-712 inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. It also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively. Group: Fluorinated apis. Alternative Names: BHG-712. CAS No. 940310-85-0. Molecular formula: C26H20F3N7O. Mole weight: 503.48. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 4-methyl-3-[ (1-methyl-6-pyridin-3-ylpyrazolo[3, 4-d]pyrimidin-4-yl)amino]-N-[3- (trifluoromethyl)phenyl]benzamide. Catalog: OFC940310850.
NVP-BHG712
NVP-BHG712 is a EphB4 kinase inhibitor and BCR-ABL inhibitor. NVP-BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. Furthermore, NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration. In vivo, NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity in vitro or in cellular assays. The data shown here suggest a close cross talk between the VEGFR and EphR signaling during vessel formation. In addition to its established function in vascular remodeling and endothelial arterio-venous differentiation, EphB4 forward signaling appears to be an important mediator of VEGF induced angiogenesis since inhibition of EphB4 forward signaling is sufficient to inhibit VEGF induced angiogenesis. Synonyms: NVP BHG712; NVP BHG-712; NVP BHG 712; BHG-712; BHG712; BHG 712. CAS No. 940310-85-0. Molecular formula: C26H20F3N7O. Mole weight: 503.489.
NVP-BKM 120
NVP-BKM 120. Group: Biochemicals. Alternative Names: BKM 120; Buparlisib; 5-(2,6-di-4-Morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine. Grades: Highly Purified. CAS No. 944396-07-0. Pack Sizes: 5mg. Molecular Formula: C18H21F3N6O2, Molecular Weight: 410.39. US Biological Life Sciences.
Worldwide
NVP-BKM120 Hydrochloride
NVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Synonyms: BKM-120 hydrochloride; BKM120 hydrochloride; BKM 120 hydrochloride. Grades: >98%. CAS No. 1312445-63-8. Molecular formula: C18H22ClF3N6O2. Mole weight: 446.85.