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| Product | Description | |
|---|---|---|
| Tomivosertib | Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC 50 s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC 50 =2-16 nM) in tumor cell lines [1]. Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: eFT508. CAS No. 1849590-01-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100022. |  |
| Tonabersat | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Tonabersat | Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-220453. CAS No. 175013-84-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15204. | |
| Tonabersat. | Tonabersat. Group: Biochemicals. Alternative Names: N-[(3S,4S)-6-Acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-3-chloro-4-fluoro-benzamide; (3S-cis)-N-(6-acetyl-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-3-chloro-4-fluorobenzamide; SB 220453. Grades: Highly Purified. CAS No. 175013-84-0. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Tonabersat-d6 | Tonabersat-d6. Group: Biochemicals. Alternative Names: N-[(3S,4S)-6-Acetyl-3,4-dihydro-3-hydroxy-2,2-(dimethyl-d6)-2H-1-benzopyran-4-yl]-3-chloro-4-fluorobenzamide; (3S-cis)-N-(6-acetyl-3,4-dihydro-3-hydroxy-2,2-(dimethyl-d6)-2H-1-benzopyran-4-yl)-3-chloro-4-fluorobenzamide; SB 220453-d6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Tonalide | Used for non-alcoholic perfumes. Group: Biochemicals. Alternative Names: 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-ethanone;5',6',7',8'-Tetrahydro-3',5',5',6',8',8'-hexamethyl-2'-acetonaphthone; AHMT (perfume); Extralide; Fixolide; NSC 19550. Grades: Highly Purified. CAS No. 21145-77-7. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Tonapofylline | Tonapofylline, a selective adenosine-1 receptor antagonist, has natriuretic effects and is able to maintain renal function, which can be beneficial to patients with congestive heart failure. Uses: Adenosine a1 receptor antagonists; adenosine a2b receptor antagonists. Synonyms: BG9928; BG-9928; BG 9928; Tonapofylline.3-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl)propanoic acid. Grades: ≥98%. CAS No. 340021-17-2. Molecular formula: C22H32N4O4. Mole weight: 416.24. |  |
| Tongkat Ali Extract | Tongkat Ali Extract. Applications: Tongkat ali extract can be used in functional food, drinks, health care products and pharmaceuticals. Group: Others. Purity: 10:1, 100:1, 200:1 as required. Appearance: Brown powder. Tongkat Ali Extract. Cat No: EXTC-204. |  |
| Tonsil Microvascular Endothelial Cells, Human (Frozen) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Tonsil Microvascular Endothelial Cells, Human (T-25 flask) | Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| TOOS (3-(N-Ethyl-3-methylanilino)-2-hydroxypropanesulfonic acid sodiumsalt) | 1g Pack Size. Group: Analytical Reagents, Biochemicals, Stains & Indicators. Formula: C12H18NNaO4S. CAS No. 82692-93-1. Prepack ID 60478758-1g. Molecular Weight 295.33. See USA prepack pricing. |  |
| Toosendanin | Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 58812-37-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0263. | |
| Toosendanin | Toosendanin is a triterpenoid derivative, acts as a novel agonist of L-type Ca2+ channels in neonatal rat ventricular cells. Group: Biochemicals. Alternative Names: [C(R), 1α, 3α, 4 β, 5α, 7α, 12α, 13α, 14 β,15 β,17α]-3,12-Bis(acetyloxy)-14,15:21,23-diepoxy-1,7,19-trihydroxy-4,8-dimethyl-11-oxo-24-Norchola-20,22-diene-4-carboxaldehyde Cyclic 4,19-Hemiacetal; 14, 15-Epoxy-4, 10- (methanoxymethano) -1H-cyclopenta [a]phenanthrene, 24-Norchola-20,22-diene-4-carboxaldehyde Deriv.; 28-Deacetylsendanin; Chuanliansu. Grades: Highly Purified. CAS No. 58812-37-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Toosendanin (Chuanliansu, 12-Acetoxyamoorastatin) | Toosendanin (Chuanliansu, 12-Acetoxyamoorastatin). Group: Biochemicals. Alternative Names: Chuanliansu; 12-Acetoxyamoorastatin. Grades: Plant Grade. CAS No. 58812-37-6. Pack Sizes: 20mg. Molecular Formula: C30H38O11, Molecular Weight: 574.615999999999. US Biological Life Sciences. | Worldwide |
| TopFluor(R)-PGPE | TopFluor(R)-PGPE. Group: Others. Purity: >99%. Mole weight: 900.834. Stability: 1 Years. Storage: -20°C. 1-Palmitoyl-2-glutaroyl-sn-glycero-3-phosphoethanolamine-N-[4-(dipyrrometheneboron difluoride)butanoyl] (ammonium salt); PGPE. Cat No: PHOZ-018. | |
| TopFluor(R)-POVPE (DMA) | TopFluor(R)-POVPE (DMA). Group: Others. Purity: >99%. Mole weight: 930.903. Stability: 1 Years. Storage: -20°C. 1-Palmitoyl-2-(5,5-dimethoxyvaleroyl)-sn-glycero-3-phosphoethanolamine-N-[4-(dipyrrometheneboron difluoride)butanoyl] (ammonium salt); POVPE (DMA). Cat No: PHOZ-019. | |
| Topiramate | 2,3:4,5-Di-O-isopropylidene-1-O-sulfamoyl-β-D-fructopyranose. CAS No. 97240-79-4. Product ID: 1-01733. Molecular formula: C12H21NO8S. Mole weight: 339.36. Reference: Anticonvulsant. |  |
| Topiramate | Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels , increases in potassium conductance, and inhibition of carbonic anhydrase [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: McN 4853; RWJ 17021. CAS No. 97240-79-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0122. | |
| Topiramate-D12 solution | 100 ?g/mL in methanol, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| Topiramate Desacetal Impurity (4,5-diol-Topiramate) | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: 2,3-O-(1-Methylethylidene)-b-D-fructopyranose 1-sulfamate Topiramate desacetal impurity. CAS No. 106881-41-8. Molecular formula: C9H17NO8S. Mole weight: 299.30. | |
| Topiramate D-galactopyranose | Topiramate D-galactopyranose is a scientifically formulated pharmaceutical compound, used for studying epilepsy and migraine headaches. Marrying the prowess of anticonvulsant properties and the ability to curb repetitive neuronal firing, it exhibits a mechanism of action rooted in augmenting GABA receptor activity while diminishing glutamate receptor activity. Molecular formula: C18H31NO13S. Mole weight: 501.50. | |
| Topiramate Didesacetal Impurity | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: β-D-Fructopyranose 1-Sulfamate. CAS No. 106881-42-9. Molecular formula: C6H13NO8S. Mole weight: 259.24. | |
| Topiramate Dimer Impurity | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Molecular formula: C24H39NO13S. Mole weight: 581.63. | |
| Topiramate EP Impurity C | Topiramate EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 106881-41-8. Molecular formula: C9H17NO8S. Mole weight: 299.29. Catalog: APB106881418. | |
| Topiramate Impurity 1 | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: 2,3. CAS No. 106881-35-0. Molecular formula: C12H19N3O8S. Mole weight: 365.36. | |
| Topiramate Impurity 12 | Topiramate Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 106881-42-9. Molecular formula: C6H13NO8S. Mole weight: 259.23. Catalog: APB106881429. | |
| Topiramate Impurity 16 | Topiramate Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10489-81-3. Molecular formula: C6H12O6. Mole weight: 180.16. Catalog: APB10489813. | |
| Topiramate Impurity 2 | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: 4,5-O-(1-Methylethylidene)-b-D-fructopyranose 1-sulfamate. CAS No. 851957-35-2. Molecular formula: C9H17NO8S. Mole weight: 299.30. | |
| Topiramate impurity B | Topiramate Impurity B is a pharmaceutical offering, aiding in anchoring the assessment of quality and purity within topiramate formulations, an eminent remedy for epilepsy research and migraine prophylaxis. Synonyms: Topiramate related compound B. | |
| Topiramate impurity C | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: (2,2,7,7-tetramethyl-tetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d] pyran-3a-yl)methyl sulfurochloridoate. Molecular formula: C12H19ClO8S. Mole weight: 358.79. | |
| Topiramate Impurity D | Cas No. 25018-67-1. | |
| Topiramate N-Methyl Impurity | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: N-Methyl Topiramate; 2,3:4,5-bis-O-(1-Methylethylidene)-β-D-Fructopyranose 1-(N-Methylsulfamate); 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose Methylsulfamate. CAS No. 97240-80-7. Molecular formula: C13H23NO8S. Mole weight: 353.39. | |
| Topiramate Related Compound A | One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose; 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose; USP Topiramate Related Compound A; Diacetonefructose; ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methanol. Grades: ≥98%. CAS No. 20880-92-6. Molecular formula: C12H20O6. Mole weight: 260.28. | |
| Topiramate Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Topiroxostat | Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC 50 value of 5.3 nM and a K i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4 -inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FYX-051. CAS No. 577778-58-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14874. | |
| Topiroxostat | Topiroxostat is a novel and potent xanthine oxidoreductase (XOR) inhibitor. Uses: Enzyme inhibitors. Synonyms: FYX051; FYX051; FYX 051; Topiroxostat. trade names Topiloric Uriadec. Grades: >98%. CAS No. 577778-58-6. Molecular formula: C13H8N6. Mole weight: 248.24. | |
| Topiroxostat Impurity 1 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Synonyms: 4-(5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl)picolinonitrile; 4-(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)pyridine-2-carbonitrile; TOPIROXOSTAT IMPURITY 1; DTXSID001166750; 2-Pyridinecarbonitrile, 4-[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]-. Molecular formula: C7H10N6O. Mole weight: 194.2. | |
| Topiroxostat Impurity 10 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H8N4O. Mole weight: 248.25. | |
| Topiroxostat Impurity 11 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H6N6O. Mole weight: 274.24. | |
| Topiroxostat Impurity 12 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H9N7O. Mole weight: 291.27. | |
| Topiroxostat Impurity 13 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H7N7. Mole weight: 273.26. | |
| Topiroxostat Impurity 2 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C7H8N4O2. Mole weight: 180.17. | |
| Topiroxostat Impurity 3 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C6H7N3O2. Mole weight: 153.14. | |
| Topiroxostat Impurity 4 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C12H9N5O. Mole weight: 239.24. | |
| Topiroxostat Impurity 5 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Synonyms: 4-Amino-3,5-bis(4-pyridyl)-1,2,4-triazole; 4,4'-(4-Amino-4H-1,2,4-triazole-3,5-diyl)di-pyridine; 3,5-Di-4-pyridinyl-4H-1,2,4-triazol-4-amine. CAS No. 38634-05-8. Molecular formula: C13H10N6O. Mole weight: 266.26. | |
| Topiroxostat Impurity 6 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C13H9N5O2. Mole weight: 267.25. | |
| Topiroxostat Impurity 7 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C20H2N10. Mole weight: 392.39. | |
| Topiroxostat Impurity 9 | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Synonyms: Topiroxostat Impurity 9; 577778-82-6; 4-(5-(2-Cyanopyridin-4-yl)-1H-1,2,4-triazol-3-yl)pyridine 1-oxide; SCHEMBL4678077; 4-[5-(1-hydroxypyridin-4-ylidene)-1,2,4-triazol-3-yl]pyridine-2-carbonitrile. CAS No. 577778-82-6. Molecular formula: C13H8N6O. Mole weight: 264.25. | |
| Topiroxostat Impurity C | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C13H7N5O. Mole weight: 249.23. | |
| Topiroxostat Impurity F | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C12H11N5O2. Mole weight: 257.25. | |
| Topiroxostat Impurity L | One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C13H8N6O. Mole weight: 264.25. | |
| TOPK, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Topo I (197-651) (core domain) human | recombinant, expressed in insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Topo I (C651-765) (C terminal domain) human | recombinant, expressed in insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Topo I (N1-197) (NTD) human | recombinant, expressed in insect cells, ?85% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Topoisomerase I from E. coli, Recombinant | Topoisomerase I relaxes supercoiled DNA molecules. The enzyme initiates transient breakages and rejoins of phosphodiester bonds in superhelical turns of closed-circular DNA. Enzyme activity is independent of right-and left-handed superhelices. Topoisomerase i (e. coli) catalyzes the relaxation of negatively supercoiled dna. topoisomerase i has also been implicated in knotting and unknotting dna and in linking complementary rings of single-stranded dna into double-stranded rings. the intact holoenzyme is a 97 kda protein. Group: Enzymes. Synonyms: Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. TOPO I. Storage: at -20°C. Form: 50 mM KCl, 10 mM Tris-HCl (pH 7.5), 35 mM (NH4)2SO4, 0.1 mM EDTA, 1 mM DTT and 50% glycerol. Source: E. coli. Species: E. coli. Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. Cat No: NATE-1339. | |
| Topoisomerase I from Human, Recombinant | Topoisomerase I relaxes supercoiled DNA molecules. The enzyme initiates transient breakages and rejoins of phosphodiester bonds in superhelical turns of closed-circular DNA. Enzyme activity is independent of right-and left-handed superhelices. Group: Enzymes. Synonyms: Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. TOPO I. Stability: Stable for 3 months undiluted. Storage: Store at -80°C. It is recommended that the enzyme is aliquoted to avoid repeated freeze-thaw cycles. Source: Baculovirus-infected insect cells (Spodoptera frugiperda). Species: Human. Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. Cat No: NATE-1340. | |
| Topoisomerase II-alpha-b (828-836) | Topoisomerase II-alpha-b (828-836) is a peptide derived from Topoisomerase II-alpha-b. Topoisomerase II-alpha is an enzyme that controls and alters the topologic states of DNA during transcription. Human topoisomerase II enzymes are targets for a number of widely used anticancer agents. | |
| Topoisomerase II inhibitor 14 | Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 305343-00-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W278582. | |
| Topoisomerase II Inhibitor (BNS-22) | A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50=2.8uM and 0.42uM for TOP2a and TOP2b, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of y-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10uM. It also exhibits significant anti-proliferative activities against several human cancer cell lines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Topoisomerase II Inhibitor, BNS-22 | The Topoisomerase II Inhibitor, BNS-22 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Topoisomerase II? Inhibitor, TSC24 | The Topoisomerase II? Inhibitor, TSC24 controls the biological activity of Topoisomerase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Topo I (Y723F) (mt Y723F) human | recombinant, expressed in insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Topopyrone A | It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone A selectively inhibits topoisomerase I with the IC50 of 1.22 ng/mL. It also has anti-Gram-positive bacteria activity. Molecular formula: C18H9ClO7. Mole weight: 372.71. | |
| Topopyrone B | It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone B selectively inhibits topoisomerase I with the IC50 of 0.15 ng/mL. It also has anti-Gram-positive bacteria activity and it has a strong inhibitory effect on herpes virus, especially varicella zoster virus (VZV). Molecular formula: C18H9ClO7. Mole weight: 372.71. | |
| Topopyrone C | It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone C selectively inhibits topoisomerase I with the IC50 of 4.88 ng/mL. It also has anti-Gram-positive bacteria activity. Molecular formula: C18H10O7. Mole weight: 338.27. | |
| Topopyrone D | It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone A selectively inhibits topoisomerase I with the IC50 of 19.63 ng/mL. Molecular formula: C18H10O7. Mole weight: 338.27. | |
| Topostatin | Topostatin is originally isolated from Thermomonos pora alba No. 1520. It has inhibitory effects on human tumor cells, and the IC50 of SNB-75 and SNB-78 were 0.4 μmol/L and 7 μmol/L, respectively. Molecular formula: C36H58N4O11S. Mole weight: 754.93. | |
| Topotecan | Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF 104864A; NSC 609669. CAS No. 123948-87-8. Pack Sizes: 1 mg. Product ID: HY-13768. | |
| Topotecan Bis N-Oxide | One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4S)-1-(4-Ethyl-4,9-dihydroxy-6-oxido-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4',6,7]indolizino[1,2-b]quinolin-10-yl)-N,N-dimethylmethanamine Oxide. Molecular formula: C23H23N3O7. Mole weight: 453.46. | |
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