A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Tungstosilicic acid hydrate. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g, 250g. US Biological Life Sciences.
Worldwide
Tunicamycin
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity[1][2][3].Tunicamycin increases exosome release in cervical cancer cells[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 11089-65-9. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0098.
Tunicamycin
N-linked glycosylation is a highly regulated post-translational modification that is involved in protein folding and conformation, oligomerization, sorting, cell-cell interactions, and targeting of proteins to sub- or extra-cellular locations. It is initiated in the endoplastic reticulum with the transfer of a carbohydrate moiety to an asparagine residue within a specific amino acid consensus sequence and then further processed in the Golgi whereupon a mature glycoprotein is exported through the secretory machinery to the plasma membrane. Tunicamycin, a mixture of nucleoside antibiotics, is a specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis thereby inducing protein unfolding. At 500 nM, it can impair the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, and IGF-IR.1 Also at 500 nM, it radiosensitizes U251 glioma and BXPC3 pancreatic adenocarcinoma cells to chemotherapy.1 Tunicamycin impairs ALK phosphorylation Group: Biochemicals. Alternative Names: Streptomyces Iysosuperficus. Grades: Molecular Biology Grade. CAS No. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C39H64N4O16, Molecular Weight: 844.4. US Biological Life Sciences.
Tunicamycin, a mixture of homologous nucleoside antibiotics, has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. Tunicamycin blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. It exhibits a range of biological activities, including antimicrobial, antivirus, and antitumor effects. It is produced by certain bacteria, including Streptomyces lysosuperficus and Streptomyces chartreusis. Grades: ≥98%. CAS No. 11089-65-9.
Tunicamycin
Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis. Group: Inhibitors. CAS No. 11089-65-9. Pack Sizes: 5mg. Product ID: S7894. Formula: C37H60N4O16. Storage Conditions: 3 years -20°C powder.
United States; Europe
Tunicamycin D
Tunicamycin D is a member of the tunicamycin group of nucleoside antibiotics, which are known for their antibacterial, antiviral, and antitumor activities. These activities are primarily due to the inhibition of bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY), an enzyme crucial for the biosynthesis of peptidoglycan, which is a major component of bacterial cell walls. Tunicamycins also inhibit the human enzyme UDP-N-acetylglucosamine-dolichyl phosphate N-acetylglucosamine-phosphotransferase (GPT), which is involved in the first step of N-linked glycosylation of proteins in the endoplasmic reticulum. This inhibition can lead to the prevention of N-glycan attachment to proteins, affecting their proper folding, trafficking, and function, and ultimately inducing cellular stress and apoptosis. Alternative Names: 2,4(1H,3H)-Pyrimidinedione, 1-[(11S)-11-O-[2-(acetylamino)-2-deoxy-α-D-glucopyranosyl]-6,10-dideoxy-10-[[(2E)-15-methyl-1-oxo-2-hexadecen-1-yl]amino]-L-galacto-β-D-allo-undecodialdo-1,4-furanose-11,7-pyranos-1-yl]-; 1-[(11S)-11-O-[2-(Acetylamino)-2-deoxy-α-D-glucopyranosyl]-6,10-dideoxy-10-[[(2E)-15-methyl-1-oxo-2-hexadecen-1-yl]amino]-L-galacto-β-D-allo-undecodialdo-1,4-furanose-11,7-pyranos-1-yl. Grades: ≥95%. CAS No. 66081-38-7. Molecular formula: C40H66N4O16. Mole weight: 858.98.
Tunlametinib
Tunlametinib is a highly selective, orally active MEK1/2 inhibitor (IC50=1.9 nM, MEK1). Tunlametinib blocks the RAS-RAF-MEK-ERK signaling pathway, arrests tumor cell cycle and promotes apoptosis. Tunlametinib potently inhibits the proliferation of RAS/RAF mutant cancer cells (such as BRAF V600E, KRAS G12C mutant cells). Tunlametinib shows synergistic anti-tumor effects with BRAF/KRASG12C/SHP2 inhibitors, Docetaxel (HY-B0011). Tunlametinib can be used to study targeted therapy for RAS/RAF mutation-driven malignancies (such as melanoma, colorectal cancer, and non-small cell lung cancer)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HL-085. CAS No. 1801756-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-132844.
Tupichinol A
Tupichinol A is a natural compound isolated from the underground parts of Tupistra chinensis. Alternative Names: (2R,3R)-2-(4-hydroxyphenyl)-7-methoxy-8-methyl-3,4-dihydro-2H-chromen-3-ol. Grades: 98.5%. CAS No. 497142-88-8. Molecular formula: C17H18O4. Mole weight: 286.32.
Turanose
Turanose is an isomer of Sucrose that naturally exists in honey. Turanose has anti-inflammatory and regulates adipogenesis effect. Turanose has potential for obesity and related chronic diseases research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 547-25-1. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-113334.
Turkesterone
Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. Alternative Names: turkesterone group; 2,3,11,14,20,22,25-Heptahydroxycholestenone. Grades: >95%(HPLC). CAS No. 41451-87-0. Molecular formula: C27H44O8. Mole weight: 496.63.
Turkesterone
Turkesterone is a potent ecdysteroid. Turkesterone acts as an ecdysteroid receptor (EcR) agonist in some insect systems[1]. Uses: Scientific research. Category: Natural products. CAS No. 41451-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N2548.
Turmeric
This exotic root plant is spicy and vibrant and perfectly targets discoloration to smooth out scars and hyperpigmentation. Pack Sizes: 1 kg. Product ID: CDC10-0554. Category: Anti-Acne Ingredients. Product Keywords: Cosmetic Ingredients; Active Ingredients; Anti-Acne Ingredients; Turmeric; CDC10-0554.
Turmeric Extract
Turmeric extract is prepared from curcuma longa of the ginger family, which native to India, China. Turmeric extract also known as curcuma longa extract are taken from the rhizome, which has a characteristic bright yellow color, the active ingredien of turmeric extract is curcumin, which has the function of reducing blood fat, resisting tumor, anti-inflammatory and cholagogic and antioxidant effects. Group: Others. Mole weight: 368.38. Turmeric Extract; Curcuma Longa Linn. Cat No: EXTC-022.
Turmetabart (Anti-SEZ6 Antibody (SC17)) is a humanized anti-SEZ6 IgG1 monoclonal antibody. Anti-SEZ6 Antibody (SC17) can be used to synthesize antibody-drug conjugates (ADC) product, ABBV-011. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-SEZ6 Antibody (SC17); ABBV-011 antibody; ABBV-706 antibody. CAS No. 2650574-80-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P991041.
Turofexorate isopropyl
Turofexorate isopropyl (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FXR-450; XL335; WAY-362450. CAS No. 629664-81-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50911.
Turofexorate Isopropyl
Turofexorate Isopropyl is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist. Alternative Names: WAY-362450; WAY362450; WAY 362450; XL335; XL 335; XL-335; Turofexorate isopropyl. Grades: >98%. CAS No. 629664-81-9. Molecular formula: C25H24F2N2O3. Mole weight: 438.47.
Turpentine Oil
Turpentine Oil. We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner.
US and Canada
Turpentine Oil
Turpentine Oil. CAS No. 8006-64-2. FEMA No. 3089. Kosher: Y. VIGON Item # 504263. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers.
America & Internationally
TURPENTINE OIL
TURPENTINE OIL. CAS No. 8006-64-2.
Turpentine Oil BP/ EP
Turpentine Oil BP/ EP. CAS No. 8006-64-2.
Tusamitamab
Tusamitamab is an IgG1 monoclonal antibody that targets CEACAM5. Tusamitamab can be used to synthesize ADC Tusamitamab ravtansine (SAR408701) (HY-P99542)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR-408377; PF-08046050 Antibody; SAR445953 Antibody. CAS No. 2349294-95-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99054.
Tusamitamab ravtansine
Tusamitamab ravtansine (SAR-408701) is a targeted ADC against tumor cells expressing CEACAM5, composed of a humanized anti-CEACAM5 monoclonal antibody covalently linked to the potent cytotoxic agent, maytansinoid DM4 (HY-12454), via a cleavable linker. Tusamitamab ravtansine has an average drug-to-antibody ratio (DAR) of 3.8[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR-408701; HuMAb2-3-SPDB-DM4. CAS No. 2254086-60-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99542.
Tusamitamab ravtansine
Tusamitamab ravtansine is an antibody-drug conjugate consisting of an anti-carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) antibody conjugated to the potent cytotoxic antitubulin DM4. It has been used in the research of solid tumor treatment. Alternative Names: SAR-408701; SAR 408701; SAR408701. CAS No. 2254086-60-5.
Tuspetinib
Tuspetinib (HM43239) is an orally active and selective FLT3 inhibitor with IC50s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. Tuspetinib inhibits the kinase activity of FLT3 as a reversible type I inhibitor and modulates p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Tuspetinib inhibits the proliferation and induces the apoptosis of leukemic cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HM43239. CAS No. 2294874-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145015.
Tussilagone
Tussilagone. Group: Biochemicals. Alternative Names: Farfaratin. Grades: Plant Grade. CAS No. 104012-37-5. Pack Sizes: 10mg. Molecular Formula: C23H34O5, Molecular Weight: 390.512999999999. US Biological Life Sciences.
Worldwide
Tussilagone
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 104012-37-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1388.
Tuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M1774; ATR inhibitor 1. CAS No. 1613200-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111451.
Tuxobertinib
Tuxobertinib (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. Tuxobertinib shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BDTX-189. CAS No. 2414572-47-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136789.
TVB-3166
TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC50s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1533438-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120394.
TVB-3664
TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2097262-58-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120062.
TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 877877-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12020.