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| Product | Description | |
|---|---|---|
| TG 100801 Hydrochloride | TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fy. Synonyms: TG 100801 Hydrochloride; TG100801 Hydrochloride; TG-100801 Hydrochloride. Grades: >98%. CAS No. 1018069-81-2. Molecular formula: C33H31Cl2N5O3. Mole weight: 616.54. |  |
| Tg100948 | Heterocyclic Organic Compound. Alternative Names: SureCN265393, AGN-PC-00D4IH, TG100948, 1001341-27-0, 2-chloro-N-[2-[4- (2-pyrrolidin-1-ylethoxy) anilino]pyrimidin-5-yl]-5-[[3- (trifluoromethyl) benzoyl]amino]benzamide. CAS No. 1001341-27-0. Molecular formula: C31H28ClF3N6O3. Mole weight: 625.040630 [g/mol]. Purity: 0.96. IUPACName: 2-chloro-N-[2-[4- (2-pyrrolidin-1-ylethoxy) anilino]pyrimidin-5-yl]-5-[[3- (trifluoromethyl) benzoyl]amino]benzamide. Canonical SMILES: C1CCN (C1)CCOC2=CC=C (C=C2)NC3=NC=C (C=N3)NC (=O)C4=C (C=CC (=C4)NC (=O)C5=CC (=CC=C5)C (F) (F)F)Cl. Catalog: ACM1001341270. |  |
| TG101209 | TG101209 is a selective JAK2 inhibitor with IC 50 of 6 nM, less potent to Flt3 and RET with IC 50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. Uses: Scientific research. Group: Signaling pathways. CAS No. 936091-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10410. |  |
| TG101209 | TG101209 is a novel and potent JAK2 inhibitor. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209, when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells. Synonyms: TG101209; TG-101209; TG 101209. Grades: 0.98. CAS No. 936091-14-4. Molecular formula: C26H35N7O2S. Mole weight: 509.67. | |
| TG101209 | TG101209. Group: Biochemicals. Alternative Names: N- (1, 1-Dimethylethyl) -3- [ [5-methyl-2- [ [4- (4-methyl-1-piperazinyl) phenyl] amino] -4-pyrimidinyl] amino] benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-14-4. Pack Sizes: 2.5mg. Molecular Formula: C26H35N7O2S, Molecular Weight: 509.67. US Biological Life Sciences. |  Worldwide |
| TG101348 | Fedratinib is a potent and selective JAK2 inhibitor with IC50 value of 6 nM. It also exhibits inhibitory effects against FLT3 (IC50 = 25 nM), RET (IC50 = 17 nM) and JAK3 (IC50 = 169 nM). Synonyms: TG101348; TG 101348; TG-101348; SAR302503; SAR-302503; SAR 302503; Fedratinib; N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide. Grades: >98%. CAS No. 936091-26-8. Molecular formula: C27H36N6O3S. Mole weight: 524.68. | |
| TG101348 (SAR302503) | TG101348 is a potent, and selective inhibitor of JAK2 (IC50 = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively. Group: Biochemicals. Alternative Names: N-tert-butyl-3- (5-methyl-2- (4- (2- (pyrrolidin-1-yl) ethoxy) phenylamino) pyrimidin-4-ylamino) benzenesulfonamide. Grades: Highly Purified. CAS No. 936091-26-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Tg101831 | Heterocyclic Organic Compound. Alternative Names: 1142946-01-7, 4-(4-Methylthiophen-2-yl)-N-(4-(morpholinomethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine, SureCN4073485, AKOS016012661, AK126778, TG101831, KB-238479. CAS No. 1142946-01-7. Molecular formula: C22H23N5OS. Mole weight: 405.515920 [g/mol]. Purity: 0.96. IUPACName: 4-(4-methylthiophen-2-yl)-N-[4-(morpholin-4-ylmethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine. Canonical SMILES: CC1=CSC (=C1)C2=C3C=CNC3=NC (=N2)NC4=CC=C (C=C4)CN5CCOCC5. Catalog: ACM1142946017. | |
| Tg101975 | Heterocyclic Organic Compound. Alternative Names: 1138474-57-3, 4-(5-(3,5-Dimethylisoxazol-4-yl)benzo[b]thiophen-2-yl)-5-methyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrimidin-2-amine, SureCN3972528, AKOS016012590, AK126774, TG101975, KB-238543. CAS No. 1138474-57-3. Molecular formula: C30H31N5O2S. Mole weight: 525.664440 [g/mol]. Purity: 0.96. IUPACName: 4-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-benzothiophen-2-yl]-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrimidin-2-amine. Canonical SMILES: CC1=CN=C (N=C1C2=CC3=C (S2)C=CC (=C3)C4=C (ON=C4C)C)NC5=CC=C (C=C5)OCCN6CCCC6. Catalog: ACM1138474573. | |
| Tg101976 | Heterocyclic Organic Compound. Alternative Names: 1138474-61-9, 2-(5-Methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)benzo[b]thiophene-5-carbonitrile, SureCN3967636, AKOS016012419, AK127392, TG101976, KB-223409, 2-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-yl)benzo[b]thiophene-5-carbonitrile. CAS No. 1138474-61-9. Molecular formula: C26H25N5OS. Mole weight: 455.574600 [g/mol]. Purity: 0.96. IUPACName: 2-[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]-1-benzothiophene-5-carbonitrile. Canonical SMILES: CC1=CN=C (N=C1C2=CC3=C (S2)C=CC (=C3)C#N)NC4=CC=C (C=C4)OCCN5CCCC5. Catalog: ACM1138474619. | |
| TG 4-155 | TG 4-155. Group: Biochemicals. Grades: Purified. CAS No. 1164462-05-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TG 4-155 | TG 4-155 is a high affinity and selective EP2 receptor antagonist (KB = 2.4 and 34.5 nM for EP2 and DP1 receptors, respectively) displaying >500-fold selectivity over other prostanoid receptors. TG 4-155 inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro. Synonyms: TG4-155; TG-4-155; TG 4-155; TG4155; TG-4155; TG 4155; (2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide. Grades: ≥98% by HPLC. CAS No. 1164462-05-8. Molecular formula: C23H26N2O4. Mole weight: 394.46. | |
| TG4-155 | TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a K i of 9.9 nM [1] [2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 [1]. TG4-155 has an EP2 Schild K B of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1164462-05-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18971. | |
| TG53 | TG53 is a novel inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 946369-04-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H22ClN5O2, Molecular Weight: 411.88. US Biological Life Sciences. | Worldwide |
| TG6-10-1 | TG6-10-1, a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2, has been shown antagonist activity at human EP2 receptor expressed in rat C6 cells. It shows low-nanomolar antagonist activity against EP2 (>300-fold selectivity ov. Synonyms: (E)-N-[2-[2-(trifluoromethyl)indol-1-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamideTG6-10-1; TG 6-10-1; TG-6-10-1; TP6101; TP-6101; TP 6101. CHEMBL32642041415716-58-3C23H23F3N2O4BDBM50016950AKOS0274399 55CS-4637; AK-499428; HY-16978; CS 4637; AK 499428; HY 16978; CS4637; AK499428; HY16978(E)-N-(2-(2-(Trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trime. CAS No. 1415716-58-3. Molecular formula: C23H23F3N2O4. Mole weight: 448.43. | |
| TG6-129 | TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with IC50 value of 1.6 μM. It reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages. Synonyms: SID 17503974; (E)-N-[[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]carbamothioyl]-3-(4-fluorophenyl)prop-2-enamide. Grades: ≥98%. CAS No. 1164464-14-5. Molecular formula: C20H18FN5O3S3. Mole weight: 491.6. | |
| TGF α (1-50) (rat) | TGF α (1-50) (rat) was originally identified as an agent that can reversibly confer a transformed phenotype on normal non-tumor cells, such as normal rat renal fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which enhances the effects of TGF-α through a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and a variety of tissues and tumors. (approx. ED50 = 0.2 ng/mL). Synonyms: H-Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala-OH (Disulfide bridge: Cys8-Cys21, Cys16-Cys32, Cys34-Cys43); Transforming Growth Factor-α (1-50) from rat. CAS No. 89899-53-6. Molecular formula: C244H361N71O71S6. Mole weight: 5617.38. | |
| TGFβ-IN-2 | TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC 50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387678-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146434. | |
| TGFβ-IN-5 | TGFβ-IN-5(Compd 12) is a TGFβ inhibitor useful for the study of fibroproliferative diseases associated with TGF-β signaling [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 259870-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128437. | |
| TGF-beta receptor type-2 (131-139) | TGF-beta receptor type-2 (131-139) is a truncated fragment of TGF-beta receptor type-2. TGF-beta receptor type-2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. Synonyms: Transforming Growth Factor Beta Receptor 2 (131-139); TGF-Beta Type II Receptor (131-139). | |
| TGF-beta/Smad Compound Library | A unique collection of 180 TGF-beta/Smad signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4100. Categories: TGF-beta/Smad Compounds Libraries. |  |
| TGFBR1-IN-2 | TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 733806-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164793. | |
| TGN 020 | TGN 020. Group: Biochemicals. Grades: Purified. CAS No. 51987-99-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TGN 020 | TGN 020 is a derivative of thiadiazole and an aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). TGN 020 increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice. Synonyms: TGN-020; TGN 020; TGN020; N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide; 2-(Nicotinamido)-1,3,4-thiadiazole. Grades: ≥99% by HPLC. CAS No. 51987-99-6. Molecular formula: C8H6N4OS. Mole weight: 206.22. | |
| TGR-1202 hydrochloride | TGR-1202 hydrochloride is the hydrochloride salt of TGR-1202.TGR-1202, also known as RP5264, is a highly specific, orally available, PI3Kdelta inhibitor which is approximately 1000 -fold selective over alpha isoform, >30-50 fold over beta isoform and >15-. Synonyms: RP5264 hydrochloride; TGR1202 hydrochloride; RP 5264 hydrochloride; TGR 1202 hydrochloride; RP-5264 hydrochloride; TGR-1202 hydrochloride. CAS No. 1532533-78-0. Molecular formula: C31H25ClF3N5O3. Mole weight: 608.01. | |
| TGR5 | A potent TGR5(GPCR19) agonist that showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). Synonyms: TGR5; TGR 5; TGR-5; TGR5 Receptor Agonist; MDK00245; MDK-00245; MDK 00245. CAS No. 1197300-24-5. Molecular formula: C18H14Cl2N2O2. Mole weight: 361.222. | |
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC 50 s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca 2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14229. | |
| TGR5 Receptor Agonist (3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide) | Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells. Group: Biochemicals. Alternative Names: 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TGR5 Receptor Agonist, Cpd23g ( (4-cyclopropyl-3, 4-dihydroquinoxalin-1 (2H) -yl) (4- (2, 5-dimethylphenoxy) pyridin-3-yl) methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Agonist) | A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TGX-115, PI3K Inhibitor (8-(2-Methylphenoxy)-2-(4-morphonilyl)-4(1H)-quinolinone) | Cell-permeable. A potent and selective inhibitor of PI 3-K isoforms p110b/p110e (IC?? p110b=0.13uM, p110e=0.63uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 351071-62-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit. Recent studies showed that TGX-221 has antiproliferative activity against PTEN-deficient tumor cell lines including prostate cancers. Synonyms: TGX221; TGX 221; 7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one. Grades: 98%. CAS No. 663619-89-4. Molecular formula: C21H24N4O2. Mole weight: 364.449. | |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 663619-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10114. | |
| TGX-221, PI3K Inhibitor (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one) | Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase b (IC?? = 5nM for p110b). Inhibits other PI3K isoforms at higher concentrations (IC?? = 0.1uM for p110e, 5uM for p110a, and 3.5uM for p110g). Group: Biochemicals. Grades: Highly Purified. CAS No. 663619-89-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| TH 1020 | TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). TH 1020 competes with flagellin for TLR5 binding to inhibit the downstream TNF-α signaling pathways. Synonyms: TH1020; TH-1020; TH 1020; 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine. Grades: ≥98% by HPLC. CAS No. 1841460-82-9. Molecular formula: C23H15N7S2. Mole weight: 453.54. | |
| TH 1217 | TH 1217 is a potent dCTPase pyrophosphatase 1 inhibitor with IC50 value of 47 nM. Synonyms: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione. Grades: ≥98% by HPLC. CAS No. 1862212-48-3. Molecular formula: C20H17BCl2N4O6. Mole weight: 491.09. | |
| TH 1834 | TH 1834 is a Tip60 histone acetyltransferase inhibitor. TH 1834 causes apoptosis and increases unrepaired DNA damage (following ionizing radiation treatment) in breast cancer cells, yet not control cell lines or affect the activity of related HAT MOF. Synonyms: TH 1834; TH1834; TH-1834; 2-[5- (4-{[ (2-phenylethyl) ({4-[4- (pyrrolidin-1-ylmethyl) phenoxy]butyl}) amino]methyl}phenyl) -2H-1, 2, 3, 4-tetrazol-2-yl]acetic acid. Grades: 99%. Molecular formula: C33H40N6O3.2HCl. Mole weight: 641.63. | |
| TH-237A | TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. Synonyms: TH237A; TH 237A; TH237A. mesoGS 164. Grades: 0.98. CAS No. 935467-97-3. Molecular formula: C18H17F2NO3. Mole weight: 333.33. | |
| TH257 | TH257 is a Potent and selective allosteric LIMK 1/2 inhibitor. Group: Inhibitors. Alternative Names: TH257; TH-257; TH 257. CAS No. 2244678-29-1. Molecular formula: C24H26N2O3S. Mole weight: 422.54. Appearance: Solid powder. Purity: >98%. IUPACName: N-Butyl-4-[ (phenylamino)sulfonyl]-N- (phenylmethyl)benzamide. Canonical SMILES: O=C (N (CCCC)CC1=CC=CC=C1)C2=CC=C (S (=O) (NC3=CC=CC=C3)=O)C=C2. Catalog: ACM2244678291. | |
| TH-257 | TH-257 is an effective inhibitor of LIMK1 and LIMK2. The IC50 values of LIMK1 and LIMK2 are 84 nM and 39 nM, respectively, and can be used as a chemical probe for LIMK1 and LIMK2. Synonyms: TH 257; TH257; N-Butyl-4-[(Phenylamino)Sulfonyl]-N-(Phenylmethyl)Benzamide; BCP31775; EX-A4475. Grades: 98%. CAS No. 2244678-29-1. Molecular formula: C24H26N2O3S. Mole weight: 422.5. | |
| TH-263 | TH-263 is a diarylsulfonamide derivative and can be used as a control for inactive analogs of TH-257, TH-255 and TH-251. Synonyms: TH263; Oprea1_207287; BCP32731; TH 263. Grades: 98%. CAS No. 313520-94-4. Molecular formula: C21H20N2O3S. Mole weight: 380.5. | |
| TH287 | TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM. Synonyms: TH 287; TH-287. Grades: 98%. CAS No. 1609960-30-6. Molecular formula: C11H10Cl2N4. Mole weight: 269.13. | |
| TH287 hydrochloride | TH287 hydrochloride, with potent anti-cancer property, is a novel inhibitor of the MTH1 protein which is required for cancer cell survival and is overexpressed in cancer cells. IC50: MTH1 (NUDT1)= 0.8 nM. Synonyms: 6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine;hydrochloride; TH287 (hydrochloride); TH 287 hydrochloride; TH-287 hydrochloride. CAS No. 1638211-05-8. Molecular formula: C11H11Cl3N4. Mole weight: 305.59. | |
| TH34 | TH34 is a HDAC inhibitor with selectivity for HDAC6, 8 and 10. It has been shown to induce DNA damage and G2/M phase cell cycle arrest in neuroblastoma cell lines as well as primary neuroblastoma cells, suggesting that it is identified as a potential antineoplastic agent. Synonyms: 3-(benzylamino)-N-hydroxy-4-methylbenzamide. CAS No. 2196203-96-8. Molecular formula: C15H16N2O2. Mole weight: 256.30. | |
| TH5427 | TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2253744-56-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125209. | |
| TH 5427 hydrochloride | TH 5427 is a potent nudix hydrolase 5 (NUDT5) inhibitor with IC50 value of 29 nM, displaying >650-fold selectivity for NUDT5 over NUDT1/MTH1. Synonyms: 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C20H20Cl2N8O3·HCl. Mole weight: 527.79. | |
| TH 5487 | TH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with IC50 value of 342 nM. It inhibits OGG1 binding to 8-oxoG in DNA, suppressing proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro, and also inhibiting proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo. Synonyms: 4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 2304947-71-3. Molecular formula: C19H18BrIN4O2. Mole weight: 541.18. | |
| TH588 | TH588 selectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells. Synonyms: TH588; TH 588; TH-588. Grades: >98%. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. | |
| TH588 | TH588 is a potent inhibitor of human 7,8-Dihydro-8-oxoguaninetriphosphatase MTH1 (NUDT1) with an IC50 value of 5 nM and good metabolic stability. Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. TH588 a first-in-class nudix hydrolase family inhibitor that potently and selectively engages and inhibits the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitor binds in the active site of MTH1. Group: Inhibitors. Alternative Names: TH588; TH-588; TH 588. CAS No. 1609960-31-7. Molecular formula: C13H12Cl2N4. Mole weight: 295.17. Appearance: Solid powder. Purity: >98%. IUPACName: N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine. Canonical SMILES: NC1=NC (C2=CC=CC (Cl)=C2Cl)=CC (NC3CC3)=N1. Catalog: ACM1609960317. | |
| TH588 hydrochloride | TH588 hydrochloride, with potent anti-cancer property, is a novel inhibitor that highly selectively targets MTH1 protein (IC50= 5 nM) which is required for cancer cell survival and is overexpressed in cancer cells. Synonyms: 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine;hydrochloride; TH588 (hydrochloride); TH-588 hydrochloride; TH 588 hydrochloride; N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride; 1640282-30-9. CAS No. 1640282-30-9. Molecular formula: C13H13Cl3N4. Mole weight: 331.63. | |
| TH-6 | TH-6 is a potent HDAC inhibitor with IC 50 s of 0.115, 0.135, 0.242, 0.138, 2.120 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3031349-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149029. | |
| TH9402 | TH9402, a 4,5-dibromorhodamine derivative, is a novel photo-sensitizer. PDT using TH9402 triggers a caspase-dependent intrinsic apoptotic pathway. TH9402 offers an excellent potential as an ex vivo photodynamic purging agent for autologous transplantation in MM and BC treatment. Synonyms: TH9402; TH-9402; TH 9402; Xanthylium, 3,6-diamino-4,5-dibromo-9-[2-(methoxycarbonyl)phenyl]-, chloride (1:1). CAS No. 174230-05-8. Molecular formula: C21H15Br2ClN2O3. Mole weight: 538.62. | |
| Thailanstatin A | Thailanstatin A is a splicesosome inhibitor that acts via suppressing RNA-polymerase II. It is effective against cancers, and can be used as a payload for ADCs. Synonyms: 1,6-Dioxaspiro[2.5]octane-5-acetic acid, 7-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-yl]amino]tetrahydro-3,6-dimethyl-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl]-8-hydroxy-, (3R,5S,7R,8R)-. Grades: 95%. CAS No. 1426953-21-0. Molecular formula: C28H41NO9. Mole weight: 535.63. | |
| Thailanstatin B | Thailanstatin B is a pre-mRNA splicing inhibitor. Thailanstatin B is used as a cytotoxin for ADCs. Synonyms: EX-A5053. CAS No. 1426953-23-2. Molecular formula: C28H42ClNO9. Mole weight: 572.1. | |
| Thailanstatin C | Thailanstatin C is an antiproliferative agent and pre-mRNA splicing inhibitor (IC50 = 6.84 μM) from Burkholderia thailandensis MSMB43. Synonyms: (1S,5R)-1,5-Anhydro-1-(carboxymethyl)-3-C-(chloromethyl)-2-deoxy-5-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(isobutyryloxy)-2-pentenoyl]amino}-3,6-dimethyltetrahydro-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl}-D-erythro-pentitol; D-arabino-Heptonic acid, 3,7-anhydro-5-C-(chloromethyl)-2,4-dideoxy-7-C-[(1E,3E)-3-methyl-5-[(2S,3S,5R,6R)-tetrahydro-3,6-dimethyl-5-[[(2Z,4S)-4-(2-methyl-1-oxopropoxy)-1-oxo-2-penten-1-yl]amino]-2H-pyran-2-yl]-1,3-pentadien-1-yl]-, (7R)-. Grades: ≥95%. CAS No. 1426953-24-3. Molecular formula: C30H46ClNO9. Mole weight: 600.14. | |
| Thailanstatin D | Thailanstatin D inhibits AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis. Synonyms: Spliceostatin C. CAS No. 1609105-89-6. Molecular formula: C28H41NO8. Mole weight: 519.63. | |
| Thaimycin B (9CI) | Heterocyclic Organic Compound. CAS No. 102418-16-6. Catalog: ACM102418166. | |
| thalianol synthase | This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. Group: Enzymes. Synonyms: (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Enzyme Commission Number: EC 5.4.99.31. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5572; thalianol synthase; EC 5.4.99.31; (S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming). Cat No: EXWM-5572. |  |
| Thalicarpine | Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. Synonyms: Thaliblastine; Taliblastine; Taliblastin; NY-IV-34-1; NSC-68075; NSC 68075; (S)-9-(2-(((S)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-4,5-dimethoxyphenoxy)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline. CAS No. 5373-42-2. Molecular formula: C41H48N2O8. Mole weight: 696.83. | |
| Thalidomide | Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K d of ?250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate. Uses: Scientific research. Group: Signaling pathways. CAS No. 50-35-1. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-14658. | |
| Thalidomide | Recruits SALL4 to cereblon-CRL4 ubiquitin ligase. Uses: Angiogenesis inhibitors; immunosuppressive agents; leprostatic agents; teratogens. Synonyms: alphaphthalimidoglutarimide. Nphthaloylglutamimide; Nphthalylglutamic acid imide. US brand names: Synovir; Thalomid. Foreign brand names: Contergan; Distaval; Kevadon; Neurosedyn; Pantosediv; Sedoval K17; Softenon Talimol; Abbreviation: THAL. Grades: ≥99% (HPLC). CAS No. 50-35-1. Molecular formula: C13H10N2O4. Mole weight: 258.23. | |
| Thalidomide (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione) | Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Thalidomide 4'-ether-alkylC2-amine hydrochloride | Thalidomide 4'-ether-alkylC2-amine hydrochloride is a synthetic E3 ligand-linker conjugate containing a cereblon ligand based on Thalidomide and a short C2 alkyl linker with terminal amine for covalent binding, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Thalidomide - linker 6. Grades: ≥95% by HPLC. CAS No. 2341840-99-9. Molecular formula: C15H16ClN3O5. Mole weight: 353.76. | |
| Thalidomide-4-O-C4-NH2 hydrochloride | Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376990-29-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130948B. | |
| Thalidomide-5-PEG3-NH2 hydrochloride | Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2761385-81-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-138786A. | |
| Thalidomide-d4 | Heterocyclic Organic Compound. Alternative Names: THALIDOMIDE-D4;2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4. CAS No. 1219177-18-0. Molecular formula: C13H6D4N2O4. Mole weight: 262.25. Appearance: Off-White to Beige Powder. Purity: 0.96. IUPACName: 4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Canonical SMILES: C1CC (=O)NC (=O)C1N2C (=O)C3=CC=CC=C3C2=O. Catalog: ACM1219177180. | |
| Thalidomide-d4 (2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4) | Labelled Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. Group: Biochemicals. Alternative Names: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Thalidomide Impurity 1 | Thalidomide Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 26581-81-7. Molecular Formula: C13H12N2O3. Mole Weight: 244.25. Catalog: APB26581817. |  |
| Thalidomide-O-amido-C6-NH2 (TFA) | Thalidomide-O-amido-C6-Amine trifluoroacetate is a PROTAC block consist of Thalidomide linked to alkyl with Amine functional group for conjugation reactions. Synonyms: Thalidomide-O-amido-C6-NH2 (TFA); Cereblon Ligand-Linker Conjugates 11 (TFA); E3 Ligase Ligand-Linker Conjugates 25 (TFA); Thalidomide-O-amido-C6-Amine Trifluoroacetate; N-(6-aminohexyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;2,2,2-trifluoroacetic acid. CAS No. 1950635-14-9. Molecular formula: C23H27F3N4O8. Mole weight: 544.48. | |
| Thalidomide-O-amido-C8-NH2 (TFA) | Thalidomide-O-amido-C8-NH2 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. Synonyms: E3 Ligase Ligand-Linker Conjugates 17. CAS No. 1950635-16-1. Molecular formula: C25H31F3N4O8. Mole weight: 572.53. | |
| Thalidomide-O-amido-PEG2-C2-NH2 TFA | Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA. CAS No. 1957235-75-4. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-112617A. | |
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