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| Product | Description | |
|---|---|---|
| YD23 | YD23 is a SMARCA2 PROTAC. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. Moreover, YD23 decreases chromatin accessibility at enhancers of a number of genes including cell cycle and cell growth regulatory genes. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells mechanistically[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2951015-29-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153361. |  |
| YD2, 97% | YD2, 97%. Group: other glass and ceramic materials. CAS No. 1201915-91-4. Product ID: zinc; 4-[2-[10,20-bis(3,5-ditert-butylphenyl)-15-(4-hexyl-N-(4-hexylphenyl)anilino)porphyrin-22,24-diid-5-yl]ethynyl]benzoic acid. Molecular formula: 1230g/mol. Mole weight: C81H89N5O2Zn. CCCCCCC1=CC=C (C=C1)N (C2=CC=C (C=C2)CCCCCC)C3=C4C=CC (=N4)C (=C5C=CC (=C (C6=NC (=C (C7=CC=C3[N-]7)C8=CC (=CC (=C8)C (C) (C)C)C (C) (C)C)C=C6)C#CC9=CC=C (C=C9)C (=O)O)[N-]5)C1=CC (=CC (=C1)C (C) (C)C)C (C) (C)C. [Zn+2]. InChI=1S/C81H90N5O2. Zn/c1-15-17-19-21-23-53-27-34-63 (35-28-53) 86 (64-36-29-54 (30-37-64) 24-22-20-18-16-2) 76-72-45-43-70 (84-72) 74 (57-47-59 (78 (3, 4) 5) 51-60 (48-57) 79 (6, 7) 8) 68-41-39-66 (82-68) 65 (38-31-55-25-32-56 (33-26-55) 77 (87) 88) 67-40-42-69 (83-67) 75 (71-44-46-73 (76) 85-71) 58-49-61 (80 (9, 10) 11) 52-62 (50-58) 81 (12, 13) 14; /h25-30, 32-37, 39-52H, 15-24H2, 1-14H3, (H2-, 82, 83, 84, 85, 87, 88) ; /q-1; +2/p-1. UUCNKZFNPQUPQT-UHFFFAOYSA-M. |  |
| YE 120 | YE 120. Group: Biochemicals. Grades: Highly Purified. CAS No. 383124-82-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| YE 120 | YE 120 is a GPR35 agonist (EC50 = 32 nM in DMR assays), and also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM). Synonyms: YE 120; YE120; YE-120; 2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile. Grades: ≥98% by HPLC. CAS No. 383124-82-1. Molecular formula: C16H9Cl2N3O. Mole weight: 330.17. |  |
| YE6144 | YE6144 is a prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-150095. | |
| Yeast Beta Glucan (1,3/1,6) 70% & 85% | Yeast Beta Glucan (1,3/1,6) 70% & 85%. |  CA, FL & NJ |
| Yeast Brewers | Debittered, BioReagent, suitable for insect cell culture. Group: Fluorescence/luminescence spectroscopy. |  |
| Yeast, Brewer's, Powder, Laboratory Grade, 500 g | Brewer's Yeast, Powder, Laboratory Grade, 500 g. Grades: chem-grade laboratory. Product ID: 898900. -- SOLD FOR EDUCATIONAL USE ONLY -- |  |
| Yeast extract | 1kg Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials. Formula: N/A. CAS No. 8013-1-2. Prepack ID 35752308-1kg. See USA prepack pricing. |  |
| Yeast extract | Yeast extract is a concentrate of the soluble part of yeast, especially Saccharomyces cerevisiae. The main nutritional components of yeast extract include partly hydrolyzed protein with 35-40% of free amino acid, and it also contain B vitamins and some trace elements. Yeast extract can be used as nutrients for bacterial culture media [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 8013-1-2. Pack Sizes: 50 g; 100 g. Product ID: HY-153126. | |
| Yeast extract | 100g Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials. Formula: N/A. CAS No. 8013-1-2. Prepack ID 35752308-100g. See USA prepack pricing. | |
| Yeast extract | Yeast extract. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Yeast extract;Yeast extract, paste;Yeast extract, powder. Product Category: Heterocyclic Organic Compound. CAS No. 8013-1-2. Product ID: ACM2232731. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Yeast Extract | Yeast Extract is a food flavoring. It can be used in culture medium. Synonyms: Yeast, ext.; Yeast powder; Extract of Yeast; Yeast Extract Powder. CAS No. 8013-1-2. | |
| Yeast Extract Polar | Yeast Extract Polar. Group: Others. Stability: 3 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; natural lipids; natural; synthetic lipid; synthetic; modified lipids; headgroup modified lipids; fatty acid modified lipids; singnal transduction; cell pathways; Yeast Extract Polar; Yeast Polar Lipid Extract (S. cerevisiae). Cat No: NSMZ-048. |  |
| Yeast Extract Total | Yeast Extract Total. Group: Others. Stability: 3 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; natural lipids; natural; synthetic lipid; synthetic; modified lipids; headgroup modified lipids; fatty acid modified lipids; singnal transduction; cell pathways; Yeast Extract Total; Yeast Total Lipid Extract (S. cerevisiae). Cat No: NSMZ-047. | |
| Yeast Nitrogen Base With Amino Acids | Non-selective yeast growth medium. Group: Fluorescence/luminescence spectroscopy. | |
| Yeast Nitrogen Base Without Amino Acids | Yeast classification medium. Group: Fluorescence/luminescence spectroscopy. | |
| Yeast Nitrogen Base Without Amino Acids and Ammonium Sulfate | for microbiology. Group: Fluorescence/luminescence spectroscopy. | |
| Yeast, Powder, Activated, Laboratory Grade, 100 g | Storage Code: Green; general chemical storage. Grades: chem-grade laboratory. Product ID: 898890. -- SOLD FOR EDUCATIONAL USE ONLY -- | |
| Yeast Protein Extract | Yeast Protein Extract. Uses: For analytical and research use. Group: Building blocks. Alternative Names: TP. Catalog: APS013955. Shipping: Room Temperature. | |
| yeast ribonuclease | Similar enzyme: RNase U4. Group: Enzymes. Enzyme Commission Number: EC 3.1.14.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3541; yeast ribonuclease; EC 3.1.14.1. Cat No: EXWM-3541. | |
| Yeast S | A dried Aspergillus oryzae fermentation extract that is an ideal nutrient support system for yeast during the fermentation process. It contains protein, free-form amino acids, minerals, enzymes, vitamins, fiber and other nutrients. Group: Enzymes. Synonyms: Yeast S; Yeast; BRE-1622. Yeast S. Appearance: powder or liquid. Yeast S; Yeast; BRE-1622. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form) or subject to client requirement. Cat No: BRE-1622. | |
| Yeasts. Riched selenium | Yeasts. Riched selenium. Product ID: CDF4-0217. Molecular formula: NA. Category: Nutrient supplements. Product Keywords: Food Ingredients; Nutrients; CDF4-0217; Yeasts. Riched selenium; Nutrient supplements. Applications: Used as selenium enhancer in dairy products, rice products, biscuits and beverages. |  |
| Yellow 2G | analytical standard. Group: Colorant standards. | |
| Yellow Dextrin Nanopowder | Yellow Dextrin Nanopowder. Group: Metal nano dispersion. CAS No. 9004-53-9. 99.9%. | |
| Yellow iron oxide | Yellow iron oxide is commonly used in painting, concrete and scagliola. Synonyms: C.I. Pigment Yellow 42; Ariabel Yellow 300407; C.I. 77492; Cameleon Yellow; Disperse HG 457; Ecosperse Oxide Yellow RA 100CN; Ferric oxide, yellow; Goethite yellow; Iron hydroxide oxide yellow; Iron Oxide Orange Transparent 188VN; Iron oxide yellow; Iron Yellow; NX 512 Yellow; Pigment Yellow 42; Sicopharm Yellow; Synthetic yellow iron oxide pigment; Tarox Yellow Lemon; Xeracolor Yellow Oxide; Xeracolour Yellow Oxide; Zh 1 (pigment). CAS No. 51274-00-1. | |
| Yellow iron oxide | Pigment yellow 42. CAS No. 51274-00-1. Product ID: 8-04377. Molecular formula: Fe203 H20. Mole weight: 170.71. |  |
| Yellow Iron Oxide USP | Yellow Iron Oxide USP. CAS No. 51274-00-1. |  |
| YES1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| YF-0200R-A | YF-0200R-A is a pepstatin A-sensitive Candida albicans aspartyl protease inhibitor produced by Streptomyces sp. YF-0200R. It inhibits aspartyl protease from Candida albicans with IC50 value of 6.5 x 10(-4) M. Synonyms: YF 0200R-A; YF 0200R A; 8,12-Dihydroxy-2,4-dodecadienoic acid. CAS No. 156368-99-9. Molecular formula: C12H20O4. Mole weight: 228.28. | |
| YF-0200R-B | YF-0200R-B is a pepstatin A-sensitive Candida albicans aspartyl protease inhibitor produced by Streptomyces sp. YF-0200R. It inhibits aspartyl protease from Candida albicans with IC50 value of 6.2 x 10(-4) M. Synonyms: YF 0200R-B; YF 0200R B; 8,10,12-trihydroxydodeca-2,4-dienoic acid. CAS No. 156369-00-5. Molecular formula: C12H20O5. Mole weight: 244.28. | |
| YF-044P-D | YF-044P-D is a Candida albicans aspartyl protease inhibitor produced by Streptomyces sp. SF-044P. It inhibits Candida albicans aspartyl protease with IC50 of 6.4 X 10(-7) mol/L. Synonyms: YF 044P-D; YF-044-P-D. CAS No. 158335-52-5. Molecular formula: C43H57N5O9. Mole weight: 787.9. | |
| YF-18 | YF-18 is a matrine derivative that has an inhibitory effect on lung cancer cells. Studies indicated that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. In addition, it suppressed cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Uses: Anti-lung cancer. Synonyms: YF 18; YF18. | |
| YF-2 | YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC 50 s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1311423-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16531. | |
| YF-2 hydrochloride | YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC 50 s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1312005-62-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-16531A. | |
| YFGAP | YFGAP is an antibacterial peptide isolated from Yellowfin tuna (Thunnus albacares). It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: YFGAP-OH; Val-Lys-Val-Gly-Ile-Asn-Gly-Phe-Gly-Arg-Ile-Gly-Arg-Leu-Val-Thr-Arg-Ala-Ala-Phe-His-Gly-Lys-Lys-Val-Glu-Val-Val-Ala-Ile-Asn-Asp. Molecular formula: C154H258N48O40. Mole weight: 3422.04. | |
| YG1702 | YG1702 is a potent ALDH18A1-specific inhibitor. YG1702 attenuates the growth of MYCN-amplified NB and down-regulates MYCN. YG1702 physically interacts with ALDH18A1 with a high affinity and might potentially affect its enzymatic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 724737-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156443. | |
| YH239-EE | YH239-EE is an ethyl ester of YH239, which acts as a MDM2-p53 inhibitor. YH239-EE induces apoptosis in four AML cells. It promotes survival of aged muscle stem cells (muSCs). Synonyms: Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate. Grades: >98%. CAS No. 1364488-67-4. Molecular formula: C25H27Cl2N3O4. Mole weight: 504.41. | |
| YH-306 | YH-306 is a candidate drug in preventing growth and metastasis of CRC by modulating FAK signalling pathway. Synonyms: YH 306; YH306. CAS No. 1373764-75-0. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
| YH439 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Yhhu-3792 | Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2097826-24-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120782. | |
| YHO-13177 | YHO-13177 is a potent and specific inhibitor of BCRP. It potentiated the cytotoxicity of SN-38 in cancer cells and had no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells. Synonyms: YHO-13177; YHO 13177; YHO13177. Grades: >98%. CAS No. 912287-56-0. Molecular formula: C20H22N2O3S. Mole weight: 370.47. | |
| YHO-13351 | YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP. Synonyms: YHO-13351; YHO 13351; YHO13351. Grades: >98%. CAS No. 1346753-00-1. Molecular formula: C27H37N3O7S2. Mole weight: 579.73. | |
| YHO-13351 free base | YHO-13351 free base is a potent and specific inhibitor of BCRP, which is the water-soluble prodrug of YHO-13177. It potentiates the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 cells and SN-38-resistant human lung cancer A549 cells, but had little effect in the parental cells in vitro. It also potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H23 and NCI-H460, myeloma RPMI-8226 and pancreatic cancer AsPC-1 cell. It increases the intracellular accumulation of Hoechst 33342. It is rapidly converted into YHO-13177 after its oral or intravenous administration in mice. Uses: Yho-13351 free base could potentiate the cytotoxicity of sn-38, mitoxantrone and topotecan. Synonyms: YHO13351 free base; YHO 13351 free base; YHO-13351 free base. Grades: >98%. CAS No. 912288-64-3. Molecular formula: C26H33N3O4S. Mole weight: 483.62. | |
| YIGSR | YIGSR is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells [1]. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Laminin Fragment 929-933. CAS No. 110590-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0132. | |
| YIL781 | YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC 50 values of 7.90 and 8.27, respectively [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 875258-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13964. | |
| YIL 781 | YIL 781 is a ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM) with no significant affinity for the motilin receptor (Ki = 6 μM). YIL 781 inhibits ghrelin to reduce insulin secretion both in vivo and in vitro. YIL 781 may be beneficial for the treatment of obesity and diabetes. Uses: Potential treatment of obesity and diabetes. Synonyms: YIL 781; YIL781; YIL-781; 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone; KB-276128; KB 276128; KB276128. Grades: ≥98% by HPLC. CAS No. 875258-85-8. Molecular formula: C24H28FN3O2. Mole weight: 409.51. | |
| YIL781 hydrochloride | YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC 50 values of 7.90 and 8.27, respectively [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1640226-17-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13964A. | |
| YIL 781, Hydrochloride Salt | Ghrelin receptor antagonist (GHS-R1a) (Ki = 17nM). Displays no significant affinity for the motilin receptor (Ki = 6uM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo. Group: Biochemicals. Alternative Names: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone. Grades: Highly Purified. CAS No. 875258-85-8. Pack Sizes: 5mg. Molecular Formula: C??H??FN?O?.HCl, Molecular Weight: 445.96. US Biological Life Sciences. | Worldwide |
| YJC-10592 | YJC-10592 is a CC chemokine receptor 2 (CCR2) antagonist (IC50 value 1.12 μM). Synonyms: YJC-10592; YJC 10592; YJC10592. Grades: 98%. CAS No. 1226894-87-6. Molecular formula: C27H31ClF3N5O3. Mole weight: 566.01. | |
| YK11 | YK11 is a partial agonist of androgen receptor , with osteogenic activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1370003-76-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107480. | |
| YK-2168 | YK-2168 is a differentiated selective inhibitor of CDK9 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2571068-74-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162919. | |
| YK 3-237 | YK 3-237 is a sirtuin-1 (SIRT1) activator. YK 3-237 inhibits proliferation of breast cancer cell lines expressing mutant p53, and induces G2/M cell cycle arrest in triple negative breast cancer cells (TNBCs) in vitro. Synonyms: B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid. Grades: ≥98% by HPLC. CAS No. 1215281-19-8. Molecular formula: C19H21BO7. Mole weight: 372.18. | |
| YK-4-279 | YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. Synonyms: YK-4-279; YK4-279; YK 4-279; YK-4279; YK4279; YK 4279. Grades: >98%. CAS No. 1037184-44-3. Molecular formula: C17H13Cl2NO4. Mole weight: 366.20. | |
| YK-4-279 | YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1037184-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14507. | |
| YKL-05-099 | YKL-05-099 is a selective inhibitor of Salt-Inducible Kinase (SIK). Uses: Designed for use in research and industrial production. Additional or Alternative Names: YKL-05-099; YKL 05 099; YKL05099. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1936529-65-5. Molecular formula: C32H34ClN7O3. Mole weight: 600.12. Purity: >98%. IUPACName: 3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one. Canonical SMILES: O=C1N(C2=NC=C(OC)C=C2)C3=NC(NC4=CC=C(C5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6Cl. Product ID: ACM1936529655. Alfa Chemistry ISO 9001:2015 Certified. | |
| YKL-05-099 | YKL-05-099 has slightly less potent SIK2-inhibitory (IC50 = 40 ± 25 nM) and IL-10-enhancing activities (EC50 = 460 ± 110 nM), but is non-toxic at concentrations ≤ 10 μM and stable in mouse liver microsomes for > 2 hours. Synonyms: YKL 05 099; YKL05099. CAS No. 1936529-65-5. Molecular formula: C32H34ClN7O3. Mole weight: 600.11. | |
| YKL-05-099 | YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1936529-65-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-101147. | |
| YKL-06-061 | YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172617-15-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-120056. | |
| YKL-06-061 | YKL-06-061 is a small molecule serine/threonine-protein kinase SIK1 inhibitor (Ki = 6.56 nM) that is hopefully developed to be a dermatologic drug impacting UV protection and skin cancer risk. It causes a dose-dependent increase in microphthalmia-associated transcription factor (MITF) mRNA expression during 3-hour function in normal human melanocytes, UACC62 human melanoma cells, and UACC257 human melanoma cells. Uses: A potential dermatologic drug. Synonyms: YKL06-061; YKL 06-061; YKL-06061. CAS No. 2172617-15-9. Molecular formula: C30H37N7O2. Mole weight: 527.67. | |
| YKL-06-062 | YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172617-16-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-129141. | |
| YKL-06-062 | YKL-06-062 is a small molecule serine/threonine-protein kinase SIK1 inhibitor (Ki = 2.12 nM) that is hopefully developed to be a dermatologic drug impacting UV protection and skin cancer risk. It causes a dose-dependent increase in microphthalmia-associated transcription factor (MITF) mRNA expression during 3-hour function in normal human melanocytes, UACC62 human melanoma cells, and UACC257 human melanoma cells. Uses: A potential dermatologic drug. Synonyms: YKL 06 062. CAS No. 2172617-16-0. Molecular formula: C31H39N7O. Mole weight: 525.69. | |
| YKL-5-124 | YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1957203-01-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101257. | |
| YL-109 | Mice treated with vehicle showed significantly enlarged tumors, whereas mice treated with YL-109 showed attenuated tumor growth using MCF-7 cells. Interestingly, YL-109 also suppressed tumor growth in mice injected with MDA-MB-231 cells. Compared with the vehicle control, YL-109 significantly reduced lung metastasis. Synonyms: YL-109; YP109; YP 109. Grades: >98%. CAS No. 36341-25-0. Molecular formula: C14H11NO2S. Mole weight: 257.31. | |
| YL-365 | YL-365 is a angonist of GPR34. YL-365 is used for pain and cancer research[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156815. | |
| YL-5092 | YL-5092 is an inhibitor for YT521-B homology (YTH) domain-containing protein 1 (YTHDC1). YL-5092 inhibits acute myeloid leukemia cell with IC50 of 0.28-2.87 ?M. YL-5092 exhibits antitumor efficacy in MOLM-13 or U937 xenograft mice[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3056857-07-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164607. | |
| YL-704A1 | YL-704A1 is a main component of YL-704, a macrolide antibiotic complex isolated from Streptomyces platensis subsp. malvinus. It is active against gram-positive bacteria. Synonyms: Yl 704A1; Yl 704 A1. CAS No. 40615-47-2. Molecular formula: C43H71NO15. Mole weight: 842. | |
| Ylangenol | Ylangenol is extracted from Laggera pterodonta. CAS No. 41610-69-9. Molecular formula: C15H24O. Mole weight: 220.356. | |
| Ylang Ylang Oil | 100g Pack Size. Group: Aroma Chemicals, Biochemicals, Flavours and Fragrance Materials. Formula: N/A. CAS No. 8006-81-3. Prepack ID 89992786-100g. See USA prepack pricing. | |
| YLF-466D | YLF466D activated recombinant human α1β1γ1, α2β1γ1 and rat liver AMPK. It also activated AMPK α-subunit truncations containing an autoinhibitory domain(AID) and exhibited additivity with AMP and A-769662. Molecular docking of YLF466D with the S pombe AMPKa (25-351) suggests it may bind in the cleft between the kinase domain and the AID antagonizing the auto-inhibition distinct from AMP and A-769662. Incubation of YLF466D in Hela cells activated cellular AMPK without detectable changes in AMP:ATP ratio, proving AMPK was allosterically activated by YLF466D. YLF466D activated cellular AMPK in both L6 myotubes and HepG2 cells with evoking intracellular AMP:ATP ratio accompanied by depolarizing mitochondria membrane potential, but has no effect on the dephosphorylation of PP2Cα on AMPK. Thus, YLF466D activated cellular AMPK through dual mechanisms. Functional studies shown YLF466D stimulated glucose uptake in L6 myotubes, decreased glucose output and lipid content in hepatocyte. Acute and chronic treatment of YLF466D on diabetic db/db mice and diet induced obese mice improved metabolic parameters. Synonyms: C24; YLF 466D; YLF466D. Grades: >98%. CAS No. 1273323-67-3. Molecular formula: C29H20ClNO3. Mole weight: 465.93. | |
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