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| Product | Description | |
|---|---|---|
| Arvanil | Arvanil is a vanilloid TRPV1 (VR1) and cannabinoid CB1 agonist with Ki values of 0.3 and 0.5 μM respectively. It increases lung tidal volume, diaphragm activity, mean arterial blood pressure and inhibits lymphocyte proliferation. It also inhibits the anandamide transporter. It has analgesic, vasodilatory and anti-inflammatory effects in vivo. It is a structural analog of capsaicin. It induces analgesia in rat and mouse models of pain. It is resistant to hydrolysis by FAAH. It is a potent inhibitor of anandamide accumulation. It inhibits growth of astrocytoma xenograft tumors in mice. It mimics the effect of neural precursor cells and has been shown to kill TRPV1-expressing tumor cells by secreting endovanilloids. Synonyms: RT-011322; B-6699; I14-44667; RT011322; B6699; I1444667; N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide; (5Z,8Z,11Z,14Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-Eicosatetraenamide; N-Vanillylarachidonamide; (all-Z)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5,8,11,14-eicosatetraenamide. Grade: ≥98% by HPLC. CAS No. 128007-31-8. Molecular formula: C28H41NO3. Mole weight: 439.64. |  |
| ARX-1796 | ARX-1796 is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes. Synonyms: AV-006. Grade: 98%. CAS No. 2245880-46-8. Molecular formula: C14H23N3O8S. Mole weight: 393.42. | |
| arylacetonitrilase | Requires thiol compounds. Also hydrolyses other 4-substituted phenylacetonitriles, thien-2-ylacetonitrile, tolylacetonitriles, and, more slowly, benzyl cyanide. Group: Enzymes. Enzyme Commission Number: EC 3.5.5.5. CAS No. 132053-06-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4581; arylacetonitrilase; EC 3.5.5.5; 132053-06-6. Cat No: EXWM-4581. |  |
| aryl-acylamidase | Also acts on 4-substituted anilides. Group: Enzymes. Synonyms: AAA-1; AAA-2; brain acetylcholinesterase (is associated with AAA-2); pseudocholinesterase (associated with arylacylamidase). Enzyme Commission Number: EC 3.5.1.13. CAS No. 9025-18-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4402; aryl-acylamidase; EC 3.5.1.13; 9025-18-7; AAA-1; AAA-2; brain acetylcholinesterase (is associated with AAA-2); pseudocholinesterase (associated with arylacylamidase). Cat No: EXWM-4402. | |
| aryl-alcohol dehydrogenase | A group of enzymes with broad specificity towards primary alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity towards short-chain aliphatic alcohols. Group: Enzymes. Synonyms: p-hydroxybenzyl alcohol dehydrogenase; benzyl alcohol dehydrogenase; coniferyl alcohol dehydrogenase. Enzyme Commission Number: EC 1.1.1.90. CAS No. 37250-26-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0374; aryl-alcohol dehydrogenase; EC 1.1.1.90; 37250-26-3; p-hydroxybenzyl alcohol dehydrogenase; benzyl alcohol dehydrogenase; coniferyl alcohol dehydrogenase. Cat No: EXWM-0374. | |
| aryl-alcohol dehydrogenase | aryl-alcohol dehydrogenase. Product ID: ACMA00009026. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| aryl-alcohol dehydrogenase (NADP+) | Also acts on some aliphatic aldehydes, but cinnamaldehyde was the best substrate found. Group: Enzymes. Synonyms: aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate); coniferyl alcohol dehydrogenase; NADPH-linked benzaldehyde reductase; aryl-alcohol dehydrogenase (NADP). Enzyme Commission Number: EC 1.1.1.91. CAS No. 37250-27-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0375; aryl-alcohol dehydrogenase (NADP+); EC 1.1.1.91; 37250-27-4; aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate); coniferyl alcohol dehydrogenase; NADPH-linked benzaldehyde reductase; aryl-alcohol dehydrogenase (NADP). Cat No: EXWM-0375. | |
| aryl-alcohol oxidase | Oxidizes many primary alcohols containing an aromatic ring; best substrates are (2-naphthyl)methanol and 3-methoxybenzyl alcohol. Group: Enzymes. Synonyms: aryl alcohol oxidase; veratryl alcohol oxidase; arom. alcohol oxidase. Enzyme Commission Number: EC 1.1.3.7. CAS No. 9028-77-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0425; aryl-alcohol oxidase; EC 1.1.3.7; 9028-77-7; aryl alcohol oxidase; veratryl alcohol oxidase; arom. alcohol oxidase. Cat No: EXWM-0425. | |
| aryl-aldehyde dehydrogenase | Oxidizes a number of aromatic aldehydes, but not aliphatic aldehydes. Group: Enzymes. Enzyme Commission Number: EC 1.2.1.29. CAS No. 37250-94-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1135; aryl-aldehyde dehydrogenase; EC 1.2.1.29; 37250-94-5. Cat No: EXWM-1135. | |
| aryl-aldehyde dehydrogenase (NADP+) | This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-aldehyde:NADP+ oxidoreductase (ATP-forming). Other names in common use include aromatic acid reductase, and aryl-aldehyde dehydrogenase (NADP+). Group: Enzymes. Synonyms: aromatic acid reductase; aryl-aldehyde dehydrogenase (NADP). Enzyme Commission Number: EC 1.2.1.30. CAS No. 9074-94-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1137; aryl-aldehyde dehydrogenase (NADP+); EC 1.2.1.30; 9074-94-6; aromatic acid reductase; aryl-aldehyde dehydrogenase (NADP). Cat No: EXWM-1137. | |
| aryl-aldehyde oxidase | Acts on benzaldehyde, vanillin and a number of other aromatic aldehydes, but not on aliphatic aldehydes or sugars. Group: Enzymes. Enzyme Commission Number: EC 1.2.3.9. CAS No. 82657-93-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1216; aryl-aldehyde oxidase; EC 1.2.3.9; 82657-93-0. Cat No: EXWM-1216. | |
| arylalkyl acylamidase | Identified in Pseudomonas putida. Strict specificity for N-acetyl arylalkylamines, including N-acetyl-2-phenylethylamine, N-acetyl-3-phenylpropylamine, N-acetyldopamine, N-acetyl-serotonin and melatonin. It also accepts arylalkyl acetates but not acetanilide derivatives, which are common substrates of EC 3.5.1.13, aryl acylamidase. Group: Enzymes. Synonyms: aralkyl acylamidase. Enzyme Commission Number: EC 3.5.1.76. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4467; arylalkyl acylamidase; EC 3.5.1.76; aralkyl acylamidase. Cat No: EXWM-4467. | |
| arylamine glucosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Synonyms: UDP glucose-arylamine glucosyltransferase; uridine diphosphoglucose-arylamine glucosyltransferase. Enzyme Commission Number: EC 2.4.1.71. CAS No. 37277-72-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2615; arylamine glucosyltransferase; EC 2.4.1.71; 37277-72-8; UDP glucose-arylamine glucosyltransferase; uridine diphosphoglucose-arylamine glucosyltransferase. Cat No: EXWM-2615. | |
| arylamine N-acetyltransferase | Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA. Group: Enzymes. Synonyms: arylamine acetylase; β-naphthylamine N-acetyltransferase; 4-aminobiphenyl N-acetyltransferase; acetyl CoA-arylamine N-acetyltransferase; 2-naphthylamine N-acetyltransferase; arylamine acetyltransferase; indoleamine N-acetyltransferase; N-acetyltransferase (ambiguous); p-aminosalicylate N-acetyltransferase; serotonin acetyltransferase; serotonin N-acetyltransferase. Enzyme Commission Number: EC 2.3.1.5. CAS No. 9027-33-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2229; arylamine N-acetyltransferase; EC 2.3.1.5; 9027-33-2; arylamine acetylase; β-naphthylamine N-acetyltransferase; 4-aminobiphenyl N-acetyltransferase; acetyl CoA-arylamine N-acetyltransferase; 2-naphthylamine N-acetyltransferase; arylamine acetyltransferase; indoleamine N-acetyltransferase; N-acetyltransferase (ambiguous); p-aminosalicylate N-acetyltransferase; serotonin acetyltransferase; serotonin N-acetyltransferase. Cat No: EXWM-2229. | |
| aryldialkylphosphatase | Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase. Group: Enzymes. Synonyms: organophosphate hydrolase; paraoxonase; A-esterase; aryltriphosphatase; organophosphate esterase; esterase B1; esterase E4; paraoxon esterase; pirimiphos-methyloxon esterase; OPA anhydrase; organophosphorus hydrolase; phosphotriesterase; paraoxon hydrolase; OPH; organophosphorus acid anhydrase. Enzyme Commission Number: EC 3.1.8.1. CAS No. 117698-12-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3770; aryldialkylphosphatase; EC 3.1.8.1; 117698-12-1; organophosphate hydrolase; paraoxonase; A-esterase; aryltriphosphatase; organophosphate esterase; esterase B1; esterase E4; paraoxon esterase; pirimiphos-methyloxon esterase; OPA anhydrase; organophosphorus hydrolase; phosphotriesterase; paraoxon hydrolase; OPH; organophosphorus acid anhydrase. Cat No: EXWM-3770. | |
| arylesterase | Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases. The natural substrates of the paraoxonases are lactones, with (±)-5-hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate. Group: Enzymes. Synonyms: A-esterase; paraoxonase; aromatic esterase. Enzyme Commission Number: EC 3.1.1.2. CAS No. 9032-73-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3445; arylesterase; EC 3.1.1.2; 9032-73-9; A-esterase; paraoxonase; aromatic esterase. Cat No: EXWM-3445. | |
| arylformamidase | Also acts on other aromatic formylamines. Group: Enzymes. Synonyms: kynurenine formamidase; formylase; formylkynureninase; formylkynurenine formamidase; formamidase I; formamidase II. Enzyme Commission Number: EC 3.5.1.9. CAS No. 156229-75-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4481; arylformamidase; EC 3.5.1.9; 156229-75-3; kynurenine formamidase; formylase; formylkynureninase; formylkynurenine formamidase; formamidase I; formamidase II. Cat No: EXWM-4481. | |
| arylmalonate decarboxylase | This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. Group: Enzymes. Synonyms: AMDASE; 2-aryl-2-methylmalonate carboxy-lyase; 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropionate-forming). Enzyme Commission Number: EC 4.1.1.76. CAS No. 144713-36-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4824; arylmalonate decarboxylase; EC 4.1.1.76; 144713-36-0; AMDASE; 2-aryl-2-methylmalonate carboxy-lyase; 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropionate-forming). Cat No: EXWM-4824. | |
| Arylomycin A2 | Arylomycin A2, an antibiotic (Antibiotic), is a lipopeptide type I signal peptidase (SPase I) inhibitor. Arylomycin A2 has antibacterial effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 459844-20-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P3884. |  |
| Arylomycin A2 | Arylomycin A is a lipopeptide compound with double aryl bridge produced by Streptomyces sp. Tu 6076. It has anti-Gram-positive bacteria activity. The most sensitive bacteria is Rhodococcus Ehmpolis. Molecular formula: C42H60N6O11. Mole weight: 824.97. | |
| Arylomycin B1 | Arylomycin B is a lipopeptide compound with double aryl bridge produced by Streptomyces sp. Tu 6075. It has anti-Gram-positive bacteria activity. The most sensitive bacteria is Rhodococcus Ehmpolis. The B series compounds are more active than the corresponding A series compounds. Molecular formula: C42H59N7O13. Mole weight: 869.97. | |
| arylsulfatase | A group of enzymes with rather similar specificities. Group: Enzymes. Synonyms: sulfatase; nitrocatechol sulfatase; phenolsulfatase; phenylsulfatase; p-nitrophenyl sulfatase; arylsulfohydrolase; 4-methylumbelliferyl sulfatase; estrogen sulfatase. Enzyme Commission Number: EC 3.1.6.1. CAS No. 9016-17-5. Sulfatases. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3742; arylsulfatase; EC 3.1.6.1; 9016-17-5; sulfatase; nitrocatechol sulfatase; phenolsulfatase; phenylsulfatase; p-nitrophenyl sulfatase; arylsulfohydrolase; 4-methylumbelliferyl sulfatase; estrogen sulfatase. Cat No: EXWM-3742. | |
| Arylsulfatase E isoform 3 (503-517) | Arylsulfatase E isoform 3 (503-517) is a peptide derived from Arylsulfatase E isoform 3. Arylsulfatase E is a member of the arylsulfatase subfamily of sulfatase enzymes that catalyze the hydrolysis of sulfate esters. Synonyms: ARSE isoform 3 (503-517). | |
| aryl-sulfate sulfotransferase | The enzyme, characterized from bacteria that colonize the human and mouse intestine, catalyses the transfer of a sulfate group from a phenol sulfate ester to other phenolic compounds. Activity is enhanced by Mg2+ and Mn2+. Unlike EC 2.8.2.9, tyrosine-ester sulfotransferase and EC 2.8.2.1, aryl sulfotransferase, the enzyme does not act on 3'-phosphoadenylyl sulfate or adenosine 3',5'-bisphosphate.The level of sulfation of polyphenols depends on the positions of the hydroxyl groups. Hydroxy groups of tyrosine residues in peptides such as angiotensin can also act as acceptors. The reaction proceeds according to a ping pong bi bi mechanism. Group: Enzymes. Synonyms: arylsulfate-phenol sulfotransferase; arylsulfotransferase; ASST; arylsulfate sulfotransferase; arylsulfate:phenol sulfotransferase; astA (gene name). Enzyme Commission Number: EC 2.8.2.22. CAS No. 158254-86-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3381; aryl-sulfate sulfotransferase; EC 2.8.2.22; 158254-86-5; arylsulfate-phenol sulfotransferase; arylsulfotransferase; ASST; arylsulfate sulfotransferase; arylsulfate:phenol sulfotransferase; astA (gene name). Cat No: EXWM-3381. | |
| aryl sulfotransferase | A number of aromatic compounds can act as acceptors. Organic hydroxylamines are not substrates (cf. EC 2.8.2.9 tyrosine-ester sulfotransferase). Group: Enzymes. Synonyms: phenol sulfotransferase; sulfokinase; 1-naphthol phenol sulfotransferase; 2-naphtholsulfotransferase; 4-nitrocatechol sulfokinase; arylsulfotransferase; dopamine sulfotransferase; p-nitrophenol sulfotransferase; phenol sulfokinase; ritodrine sulfotransferase; PST. Enzyme Commission Number: EC 2.8.2.1. CAS No. 9026-9-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3368; aryl sulfotransferase; EC 2.8.2.1; 9026-09-9; phenol sulfotransferase; sulfokinase; 1-naphthol phenol sulfotransferase; 2-naphtholsulfotransferase; 4-nitrocatechol sulfokinase; arylsulfotransferase; dopamine sulfotransferase; p-nitrophenol sulfotransferase; phenol sulfokinase; ritodrine sulfotransferase; PST. Cat No: EXWM-3368. | |
| Arzoxifene | Arzoxifene, also known as LY353381, a synthetic aromatic derivative with anti-estrogenic properties, displays greater bioavailability and higher anti-estrogenic potency in the breast than another selective estrogen receptor modulators (SERMs),raloxifene. Synonyms: 2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol; 4'F-DMA; 182133-27-3 (hydrochloride salt); arzoxifene; LY 353381; LY-353381; LY353381. Grade: >98%. CAS No. 182133-25-1. Molecular formula: C28H29NO4S. Mole weight: 475.60. | |
| Arzoxifene hydrochloride | Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY353381 hydrochloride; SERM III hydrochloride. CAS No. 182133-27-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-13556A. | |
| AS-041164 | The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a highly potent and selective PI3Kγ inhibitor that inhibits PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ with IC50 values of 240 nM, 1.45 μM, 70 nM and 1.70 μM, respectively. It also blocks RANTES-induced neutrophil migration and displays anti-inflammatory activity in various in vivo rodent models. Synonyms: 5-Benzo[1,3]dioxol-5-ylmethylene-thiazolidine-2,4-dione. Grade: ≥98%. CAS No. 6318-41-8. Molecular formula: C11H7NO4S. Mole weight: 249.2. | |
| AS101 | AS101 is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia. Synonyms: AS-101; IVX-Q-101; PRX-0001; PRX-0002; PRX-001; WAX-120337; IVXQ-101; AS101; IVXQ101; PRX0001; PRX0002; PRX001; WAX120337; AS 101; IVX Q 101; PRX 0001; PRX 0002; PRX 001; WAX 120337; IVXQ 101; US brand name: Ossirene; IVX-Q-101. Ammonium trichloro(dioxoethylene-O,O') tellurate. CAS No. 106566-58-9. Molecular formula: C2H4Cl3O2Te.H4N. Mole weight: 312.049. | |
| AS 101 | AS 101. CAS No. 106566-58-9. Purity: 95%. Product ID: ACM106566589. Molecular formula: C2H4Cl3O2Te·NH4. Mole weight: 312.05. Alfa Chemistry - ISO 9001:32057 Certified. | |
| AS1134900 | AS1134900 is a highly selective uncompetitive allosteric inhibitor of NADP+-dependent malic enzyme 1 (ME1) with an IC50 of 0.73 μM. AS1134900 can be used in the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 149760-98-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150621. | |
| AS 1269574 | GPR119 has been found to be a GPR119 agonist and could stimulate the activity of proglucagon gene promoter. Synonyms: AS1269574; AS-1269574; AS 1269574; 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol. Grade: ≥98% by HPLC. CAS No. 330981-72-1. Molecular formula: C13H14BrN3O. Mole weight: 308.17. | |
| AS 1269574 | AS 1269574. Group: Biochemicals. Grades: Purified. CAS No. 330981-72-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| AS-136A | AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC50 of 2 μM for measles virus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 949898-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-134909. | |
| AS 1411 | AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGRO-100. CAS No. 301636-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147081. | |
| AS1517499 | AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 919486-40-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100614. | |
| AS1517499 | AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM. Group: Inhibitors. CAS No. 919486-40-1. Pack Sizes: 5mg. Product ID: S8685. Formula: C20H20ClN5O2. Smiles: C1=CC=C(C=C1)CNC2=NC(=NC=C2C(=O)N)NCCC3=CC(=C(C=C3)O)Cl. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| AS 1517499 | AS 1517499 is a potent and selective STAT6 inhibitor (IC50 = 21 nM). Synonyms: AS-1517499; AS1517499; AS 1517499. 4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide. Grade: 99%. CAS No. 919486-40-1. Molecular formula: C20H20ClN5O2. Mole weight: 397.86. | |
| AS-1669058 | AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist originated by Astellas Pharma. No recent reports of development were identified for preclinical development in Type-2-diabetes-mellitus in Japan. Uses: Type 2 diabetes mellitus. Synonyms: 3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide; AS 1535907; AS 1669058; AS 1907417; GPR119 agonists - Astellas Pharma; 1395553-32-8(OXLATE). Grade: 98%. CAS No. 1395553-31-7. Molecular formula: C18H15BrF2N4O. Mole weight: 421.24. | |
| AS-1669058 oxalate | AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist originated by Astellas Pharma. No recent reports of development were identified for preclinical development in Type-2-diabetes-mellitus in Japan. Uses: Type 2 diabetes mellitus. Synonyms: AS-1669058 oxalate; AS 1669058 oxalate; AS1669058 oxalate; 3-(2-((2-(4-bromo-2,5-difluorophenyl)-6-methylpyrimidin-4-yl)amino)ethyl)pyridine 1-oxide oxalate. Grade: 98%. CAS No. 1395553-32-8. Molecular formula: C18H15BrF2N4O.C2H2O4. Mole weight: 511.28. | |
| AS1810722 | AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 909561-15-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134772. | |
| AS1810722 | AS1810722 shows potent STAT6 inhibition and a good CYP3A4 inhibition profile. Synonyms: AS-1810722. Grade: 98%. CAS No. 909561-15-5. Molecular formula: C25H25F2N7O. Mole weight: 477.51. | |
| AS-183 | AS-183 is an enzyme inhibitor produced by Scedosporium sp. SPC-15549. Synonyms: 3(2H)-Furanone, 2-hydroxy-2,4-dimethyl-5-(1,3,5,7-tetramethylnonyl)-. Grade: >98%. CAS No. 147317-12-2. Molecular formula: C19H34O3. Mole weight: 310.47. | |
| AS1842856 | AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy. Group: Inhibitors. CAS No. 836620-48-5. Pack Sizes: 10mg. Product ID: S8222. Formula: C18H22FN3O3. Smiles: CCN1C=C(C(=O)C2=C1C=C(C(=C2N)F)NC3CCCCC3)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| AS1842856 | AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 836620-48-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-100596. | |
| AS 1842856 | AS 1842856 is a potent and selective inhibitor of Forkhead box protein O1 transcription factor (FoxO1; IC50 = 33 nM). AS 1842856 reduces glucose production in dose manner via the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. AS 1842856 is promisingly to be a therapy of type 2 diabetes mellitus and obesity. Uses: Potential treatment of type 2 diabetes mellitus and obesity. Synonyms: AS1842856; AS-1842856; AS 1842856. 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Grade: 98%. CAS No. 836620-48-5. Molecular formula: C18H22FN3O3. Mole weight: 347.38. | |
| AS1842856 (Standard) | AS1842856 (Standard) is the analytical standard of AS1842856 (HY-100596). This product is intended for research and analytical applications. AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy[1]. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 836620-48-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100596R. | |
| AS-186c | AS-186c is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 11.5 μmol/L. Synonyms: 1-(7-{2-[2,6-dihydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]-3-hydroxy-5-methylphenyl}-8,12-dihydroxy-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C43H46O12. Mole weight: 754.82. | |
| AS-186d | AS-186d is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Penicillum asperosporum KY1635. The IC50 for inhibiting ACAT was 12.4 μmol/L. Synonyms: 1-(8,12-dihydroxy-7-{3-hydroxy-2-[6-hydroxy-3-(1-hydroxy-3-methylbutyl)-2-methoxybenzoyl]-5-methylphenyl}-4-methoxy-10-methyl-5-oxo-7,8-dihydro-5H-dibenzo[b,h][1,5]dioxonin-3-yl)-3-methylbutyl acetate. Molecular formula: C44H50O13. Mole weight: 786.86. | |
| AS 1892802 | AS 1892802 has been found to be an ATP-competitive ROCK inhibitor and could show analgesic activities at some extent. Synonyms: AS 1892802; AS1892802; AS-1892802; N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea. Grade: ≥99% by HPLC. CAS No. 928320-12-1. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| AS 1892802 | AS 1892802. Group: Biochemicals. Grades: Purified. CAS No. 928320-12-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AS 19 | Potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced. Group: Biochemicals. Alternative Names: (2S) - (+) -5- (1, 3, 5-Trimethylpyrazol-4-yl) -2- (dimethylamino) tetralin. Grades: Highly Purified. CAS No. 1000578-26-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??N?, Molecular Weight: 283.41. US Biological Life Sciences. | Worldwide |
| AS 19 | AS 19 has been found to be a potent SR-7 agonist and could probably enhance memory consolidation. Synonyms: AS 19; AS-19; AS19; (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin. Grade: ≥98% by HPLC. CAS No. 1000578-26-6. Molecular formula: C18H25N3. Mole weight: 283.41. | |
| AS1940477 | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
| AS1949490 | AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 μM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1203680-76-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18686. | |
| AS 1949490 | AS 1949490. Group: Biochemicals. Grades: Purified. CAS No. 1203680-76-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AS 1949490 | AS1949490 has been found to be a selective SHIP2 phosphatase inhibitor and show antidiabetic activities. Synonyms: AS1949490; AS-1949490; AS 1949490; 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide. Grade: ≥99% by HPLC. CAS No. 1203680-76-5. Molecular formula: C20H18ClNO2S. Mole weight: 371.88. | |
| AS 2034178 | AS 2034178 has been found to be a FFA1/GPR40 agonist and could probably be used against diabetes. Synonyms: AS 2034178; AS2034178; AS-2034178; 2-Fluoro-4-[[[1,2,3,4-Tetrahydro-1-(2-phenoxyethyl)-5-quinolinyl]methyl]amino]benzenepropanoic acid. Grade: ≥98% by HPLC. CAS No. 1030846-42-4. Molecular formula: C27H29FN2O3. Mole weight: 448.53. | |
| AS 2034178 | AS 2034178. Group: Biochemicals. Grades: Purified. CAS No. 1030846-42-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AS-2444697 HCl | AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86. | |
| AS 252424 | AS 252424. Group: Biochemicals. Grades: Purified. CAS No. 900515-16-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AS-252424 | AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 900515-16-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-13532. | |
| AS-252424 | AS-252424 is a novel, potent PI3Kγ inhibitor (IC50 of 30 nM) with a 30-fold selectivity for PI3Kγ than PI3Kα, and low inhibitory activity towards PI3Kδ/β. Synonyms: AS252424; AS 252424; AS-252424. Grade: >98%. CAS No. 900515-16-4. Molecular formula: C14H8FNO4S. Mole weight: 305.28. | |
| AS 252424 bispotassium salt | AS 252424 bispotassium salt is the potassium salt form of AS 252424, which is a potent and selective PI3K p110γ inhibitor. Synonyms: AS 252424 bispotassium salt; AS252424 bispotassium salt; AS-252424 bispotassium salt; dipotassium (5Z)-5-[[5-(4-fluoro-2-oxidophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazol-2-olate. Grade: 99%. Molecular formula: C14H6FNO4S.K2. Mole weight: 381.46. | |
| AS-254s | AS-254s is the inhibitor for absent, small, or homeotic-like 1 protein (ASH1L) with an IC50 of 94 nM (FP assay). AS-254s exhibits antiproliferative activity against MLL1-rearranged leukemic cells with GI50 <1 μM. AS-254s induces the differentiation of MLL1-r leukemic cell[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3096805-79-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-170494. | |
| AS2717638 | AS2717638 is a potent, selective, orally active and brain-penetrant lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. It significantly improves allodynia induced by PGE2, PGF2α and AMPA. Synonyms: 1(2H)-Isoquinolinone, 6,7-dimethoxy-2-(5-methyl-1,2-benzisoxazol-3-yl)-4-(1-piperidinylcarbonyl)-; 6,7-Dimethoxy-2-(5-methyl-1,2-benzoxazol-3-yl)-4-(piperidin-1-ylcarbonyl)isoquinolin-1(2H)-one; 6,7-Dimethoxy-2-(5-methyl-1,2-benzoxazol-3-yl)-4-(1-piperidinylcarbonyl)-1(2H)-isoquinolinone. Grade: ≥95%. CAS No. 2148339-28-8. Molecular formula: C25H25N3O5. Mole weight: 447.48. | |
| AS2717638 | AS2717638 is a highly selective, brain-penetrant and orally active lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 38 nM. AS2717638 is highly selective and shows no significant antagonistic activity against other LPA receptors (LPA1, LPA2, and LPA3). AS2717638 can be used in the research of pain and neuroinflammation-related diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2148339-28-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114379. | |
| AS2863619 | AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2241300-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126675A. | |
| AS2863619 | AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells. Group: Inhibitors. CAS No. 2241300-51-4. Pack Sizes: 2mg. Product ID: S8903. Formula: C16H14Cl2N8O. Smiles: CC1=NC2=C(N1)C=C(C=C2)N3C4=C(C=NC=C4)N=C3C5=NON=C5N.Cl.Cl. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| AS2863619 | AS2863619 is an orally active cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.61 nM and 4.277 nM, respectively. In vitro, AS2863619 is a potent Foxp3 inducer in Tconv cells. Synonyms: 4-[1-(2-methyl-1H-benzimidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine dihydrochloride; 4-(1-(2-Methyl-1H-benzo[d]imidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine dihydrochloride. CAS No. 2241300-51-4. Molecular formula: C16H14Cl2N8O. Mole weight: 405.24. | |
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