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| Product | Description | |
|---|---|---|
| Astressin 2B TFA | Astressin 2B TFA is a selective and potent corticotropin-releasing factor receptor 2 (CRF2) antagonist with IC50 values of > 500 nM and 1.3 for CRF1 and CRF2 respectively. It antagonizes CRF2-mediated inhibition of gastric emptying. Grade: 98%. Molecular formula: C183H307N49O53.xC2HF3O2. Mole weight: 4041.69 (free base). |  |
| Astringin | Astringin (trans-Astringin) is an orally active natural phenolic stilbene glucoside. Astringin can inhibit the production of oxidative stress, inflammatory factors, etc. Astringin has multiple activities such as anti-oxidation, anti-inflammation, and anti-apoptosis. Astringin is also an inhibitor of ferroptosis. Astringin can be used in the research of diseases such as acute lung injury[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: trans-Astringin. CAS No. 29884-49-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4093. |  |
| Astringin(Piceatannol-3'-O- β-D-glucopyranoside) | Astringin(Piceatannol-3'-O- β-D-glucopyranoside). Group: Biochemicals. Alternative Names: Piceatannol-3'-O-beta-D-glucopyranoside; Piceatannol-3'-glucoside; Piceatannol glucoside. Grades: Plant Grade. CAS No. 29884-49-9. Pack Sizes: 20mg. Molecular Formula: C20H22O9, Molecular Weight: 406.382999999999. US Biological Life Sciences. |  Worldwide |
| Astrocyte Transfection Reagent | Transfection Reagent for Astrocyte Cell Lines and Primary Astrocytes. Optimized transfection protocol provided for transfection of siRNA, DNA, mRNA, and microRNA. Transfection Reagents. Transfection Enhancer. Complex Condenser. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 1712. |  Nevada, Texas, USA |
| Astrophloxine | A fluorescent dye. Group: Biochemicals. Alternative Names: 1, 1'-Diethyl-3, 3, 3', 3'-tetra methyl indocarbocyanine Iodide; 1-Ethyl-2-[3-(1-ethyl-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene)-1-propen-1-yl]-3,3-dimethyl-3H-indoliumIodide; Astrophloxin; SNC 2. Grades: Highly Purified. CAS No. 14696-39-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| ASTX029 | ASTX029 (Example 1) is a potent dual ERK1/2 inhibitor (IC50: 2.7 nM). ASTX029 has anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095719-92-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126288. | |
| ASTX-029 | ASTX029 is a highly potent and selective dual-mechanism ERK inhibitor. ASTX029 inhibits both ERK catalytic activity and the phosphorylation of ERK itself by MEK, despite not directly inhibiting MEK activity. Synonyms: ASTX 029; ASTX029; ERK1/2 inhibitor 2. CAS No. 2095719-92-7. Molecular formula: C29H31ClFN5O5. Mole weight: 584.04. | |
| ASTX295 | ASTX295 is an orally active and selective MDM2 antagonist with an IC50 of <1 nM. ASTX295 inhibits the MDM2-p53 interaction, activates wild-type TP53, and thereby induces the expression of relevant transcriptional targets, leading to cell death. ASTX295 drives the transition of pancreatic cancer cells from senescence to apoptosis and regulates p53 and DNA damage biomarkers. ASTX295 can be used for the research of hematologic malignancies and pancreatic cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2093449-12-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-176083. | |
| ASTX-660 2HCl | The dihydrochloride salt form of ASTX-660 which is found to be an IAP as well as XIAP inhitor that could be significant in the studies of lymphoma and solid tumours. It is still under Phase I/II trial. Synonyms: ASTX660 2HCl; ASTX-660 2HCl; ASTX 660 2HCl; 1-(6-(4-fluorobenzyl)-3,3-dimethylindolin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one dihydrochloride. Grade: 98%. CAS No. 1605316-16-2. Molecular formula: C30H43Cl2FN4O2. Mole weight: 581.59. | |
| ASTX-660 Freebase | ASTX-660 is found to be an IAP as well as XIAP inhitor that could be significant in the studies of lymphoma and solid tumours. It is still under Phase I/II trial. Synonyms: ASTX660; ASTX-660; ASTX 660; 1-(6-(4-fluorobenzyl)-3,3-dimethylindolin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one. Grade: 98%. CAS No. 1605584-14-2. Molecular formula: C30H41FN4O2. Mole weight: 508.59. | |
| Asu11-Bivalirudin | Asu11-Bivalirudin is a modified form of the anticoagulant Bivalirudin, where the amino acid at the 11th position is replaced with a specific residue. Bivalirudin is a direct thrombin inhibitor used as an anticoagulant to prevent blood clots in patients undergoing certain medical procedures or with specific conditions. Synonyms: DPhe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asu-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu; D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-(αS,3S)-3-amino-2,5-dioxo-α-(phenylmethyl)-1-pyrrolidineacetyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine; H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asu-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH; DPhe-PRPGGGGNG-Asu-FEEIPEEYL; Bivalirudin Impurity 3; [11-12]-Cycloimido-bivalirudin; Asu 12 Bivalirudin; Bivalirudin Impurity 12; [Asu11]-Bivalirudin. Grade: ≥95%. CAS No. 1224964-32-2. Molecular formula: C98H136N24O32. Mole weight: 2162.27. | |
| Asu26-Calcitonin salmon | An impurity of Calcitonin (salmon). Calcitonin (salmon) is a synthetic form of the hormone calcitonin, derived from salmon. It is a potent 32-amino acid peptide used primarily to manage bone health and calcium regulation. Calcitonin (salmon) is used to treat conditions such as postmenopausal osteoporosis, Paget's disease, and hypercalcemia. Synonyms: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asu-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Cys1&Cys7 bridge); CSNLSTCVLGKLSQELHKLQTYPRT-Asu-TGSGTP-NH2(Cys1&Cys7 bridge); Asu26-Calcitonin; Asu26-Calcitonin (salmon); [Asu26]-Calcitonin (salmon); Asu(26)-Calcitonin (salmon). Grade: ≥95%. Molecular formula: C145H237N43O48S2. Mole weight: 3414.86. | |
| Asu30-Teriparatide | Asu30-Teriparatide is an impurity of Teriparatide, which is an anabolic osteoporosis drug used to treat osteoporosis. Synonyms: Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asu-Val-His-Asn-Phe; Teriparatide succinimide 30; [Asu30]-Teriparatide; Asu(30)-Teriparatide. Grade: ≥95%. Molecular formula: C181H289N55O50S2. Mole weight: 4099.76. | |
| Asu3-Calcitonin salmon | An impurity of Calcitonin (salmon). Calcitonin (salmon) is a synthetic form of the hormone calcitonin, derived from salmon. It is a potent 32-amino acid peptide used primarily to manage bone health and calcium regulation. Calcitonin (salmon) is used to treat conditions such as postmenopausal osteoporosis, Paget's disease, and hypercalcemia. Synonyms: Cys-Ser-Asu-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Cys1&Cys7 bridge); CS-Asu-LSTCVLGKLSQELHKLQTYPRTNTGSGTP-NH2(Cys1&Cys7 bridge); Asu3-Calcitonin; Asu3-Calcitonin (salmon); [Asu3]-Calcitonin (salmon); Asu(3)-Calcitonin (salmon). Grade: ≥95%. Molecular formula: C145H237N43O48S2. Mole weight: 3414.86. | |
| Asu9-Bivalirudin | Asu9-Bivalirudin is a modified form of the anticoagulant Bivalirudin, where the amino acid at the 9th position is replaced with a specific residue. Bivalirudin is a direct thrombin inhibitor used as an anticoagulant to prevent blood clots in patients undergoing certain medical procedures or with specific conditions. Synonyms: DPhe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asu-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu; DPhe-PRPGGGG-Asu-GDFEEIPEEYL; D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-(3S)-3-amino-2,5-dioxo-1-pyrrolidineacetyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine; H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asu-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH; [9-10]-Cycloimido-bivalirudin; [Asu9]-Bivalirudin. Grade: ≥95%. CAS No. 1224964-31-1. Molecular formula: C98H135N23O33. Mole weight: 2163.29. | |
| AsuC2 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion less than 10% of the dna fragments can be ligated. Group: Restriction Enzymes. Purity: 2000U; 10000U. CC↑SGG GGS↓CC. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: Actinobacillus suis CA. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 50% glycerol. Cat No: RE-1027EN. |  |
| AsuHP I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (dam-) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 2-fold overdigestion with enzyme about 30% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 200U; 1000U. GGTGA(N)8↑ CCACT(N)7&darr. Activity: 2000-5000u.a./ml. Appearance: 10 X SE-buffer O. Storage: -20°C. Form: Liquid. Source: Actinobacillus suis HP. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: RE-1028EN. | |
| Asukamycin | Asukamycin, a manumycin-type metabolite, is isolated from Streptomyces nodosus subsp. asukaensis. It exhibits antibiotic properties and inhibits the growth of various tumor cell lines. Synonyms: asukamycin A1; Manumycin F; 2,4,6-Heptatrienamide, 7-cyclohexyl-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-, (2E,4E,6E)-. Grade: >98%. CAS No. 61116-33-4. Molecular formula: C31H34N2O7. Mole weight: 546.61. | |
| Asulam | Carbamate herbicide; folic acid biosynthesis inhibitor. Group: Biochemicals. Alternative Names: N-[ (4-Aminophenyl) sulfonyl]carbamic Acid Methyl Ester; Sulfanilylcarbamic Acid Methyl Ester; Asulox F; MB 9057; Methyl (4-Aminophenylsulfonyl) carbamate; Methyl 4-Amino Benzene sulfonylcarbamate; Methyl p-Amino Benzene sulfonylcarbamate; N1-Methoxycarbonyl sulfanilamide ; Plakin. Grades: Highly Purified. CAS No. 3337-71-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Asunaprevir | Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC50 of 0.2 nM-3.5 nM[1]. Asunaprevir inhibits SARS-CoV-2 3CLpro activity[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-650032. CAS No. 630420-16-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14434. | |
| Asunaprevir | Asunaprevir is a potent hepatitis C virus (HCV) non-structural protein protease inhibitor currently in Phase III clinical trials for the treatment of HCV infection. Uses: Protease inhibitors. Synonyms: BMS-650032; BMS 650032; BMS650032; Asunaprevir. brand name: Sunvepra. Grade: >98%. CAS No. 630420-16-5. Molecular formula: C35H46ClN5O9S. Mole weight: 748.29. | |
| Asundexian | Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-2433334. CAS No. 2064121-65-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137431. | |
| Asunercept | Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein (hIgG1) targeting CD95L. Asunercept disrupts CD95/CD95L signaling by selectively binding to CD95L. Asunercept can be used in the research of glioblastoma multiforme (GBM), myelodysplastic syndrome (MDS), and graft-versus-host disease (GvHD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APG101; CAN008. CAS No. 1450882-18-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99445. | |
| AsuNH I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (HindIII-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. G↑CTAGC CGATC↓G. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y, BSA. Storage: -20°C. Form: Liquid. Source: Actinobacillus suis NH. Pack: 10 mM Tris-HCl (pH 7.5); 250 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 100 μg/ml BSA; 50% glycerol. Cat No: RE-1029EN. | |
| Asvasiran sodium | Asvasiran sodium is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-RSV01 sodium. CAS No. 1386946-83-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158824A. | |
| ASX-173 | ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC50 = 0.113 μM, Ki = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2748800-08-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-175282. | |
| Asymmetric dimethylarginine | Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NG,NG-Dimethylarginine. CAS No. 30315-93-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113216. | |
| Asymmetric-dimethylarginine-d6 dihydrochloride | Asymmetric-dimethylarginine-d6 (dihydrochloride) is the deuterium labeled Asymmetric-dimethylarginine dihydrochloride[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NG,NG-Dimethylarginine-d6 dihydrochloride. CAS No. 1313730-20-9. Pack Sizes: 1 mg. Product ID: HY-113216BS. | |
| Asymmetric dimethylarginine (Standard) | Hesperetin (Standard) is the analytical standard of Hesperetin. This product is intended for research and analytical applications. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NG,NG-Dimethylarginine (Standard). CAS No. 30315-93-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113216R. | |
| Asymmetric Doubler (Lev) Phosphoramidite | Asymmetric Doubler (Lev) Phosphoramidite is a critical reagent used in the synthesis of nucleic acids with high efficiency and precision. It serves as a catalyst for the asymmetric doubling of chiral phosphoramidites, making it an essential tool for the production of oligonucleotides used in diagnostics and therapeutics for various diseases including cancer, viral infections and genetic disorders. Synonyms: 1-[5-(4,4'-dimethoxytrityloxy)pentylamido]-3-[5-levulinyloxypentylamido]-propyl-2-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C48H67N4O10P. Mole weight: 891.04. | |
| Asymmetric Methylene Conjugated Emtricitabine Dimer | Asymmetric Methylene Conjugated Emtricitabine Dimer is an impurity of Emtricitabine, which is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: Emtricitabine Tenofovir FT3 IMP; Emtricitabine Asymmetric Dimer; 4-Amino-5-fluoro-1-[(2R,5S)-2-[[[[5-fluoro-1,2-dihydro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-oxo-4-pyrimidinyl]amino]methoxy]methyl]-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone; 2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[(2R,5S)-2-[[[[5-fluoro-1,2-dihydro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-oxo-4-pyrimidinyl]amino]methoxy]methyl]-1,3-oxathiolan-5-yl]-; Emtricitabine FT3. Grade: ≥95%. CAS No. 1962114-96-0. Molecular formula: C17H20F2N6O6S2. Mole weight: 506.50. | |
| Aszonalenin | Aszonalenin is a nitrogen-containing heterocyclic antibiotic produced by Aspergillus zonatus. It can cause abnormal second division of sea urchin embryo. CAS No. 81797-27-5. Molecular formula: C23H23N3O2. Mole weight: 373.45. | |
| Aszonapyrone A | Aszonapyrone A is a lactone antibiotic produced by Aspergillus zonatus, which has anti-Staphylococcus aureus activity. CAS No. 83103-08-6. Molecular formula: C28H40O5. Mole weight: 456.61. | |
| AT 1001 | AT 1001 is an orally effective α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) antagonist with a Ki value of 2.64 nM. AT 1001 reversibly blocks Epibatidine (HY-101078)-induced inward currents in HEK cells transfected with α3β4 nAChR. AT 1001 dose-dependently blocks nicotine self-administration behavior in rats, alleviates gluten-induced gastrointestinal symptoms, blocks tight junction toxin-induced immune responses, and reduces the incidence of type 1 diabetes in rats. AT 1001 can be used in the research of nicotine addiction and celiac disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314801-63-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135783. | |
| AT 1001 | AT 1001 is a partial agonist and antagonist of α3β4 nAChR ligand (Ki value 2.6?nM at α3β4 nAChR). In vivo AT-1001 potently blocks nicotine self-administration in dose manner. Synonyms: AT 1001; AT1001; AT-1001. Grade: 99%. CAS No. 1314801-63-2. Molecular formula: C15H21BrN2. Mole weight: 309.24. | |
| AT101 | AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM. Synonyms: AT-101; AT 101; AT101. Grade: >98%. CAS No. 90141-22-3. Molecular formula: C30H30O8·C2H4O2. Mole weight: 578.6. | |
| AT 101 | AT 101. Group: Biochemicals. Grades: Purified. CAS No. 90141-22-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AT 1015 | AT 1015 has been found to be a 5-HT2A receptor antagonist and exhibit antithrombotic activities. Synonyms: AT-1015 anhydrous, AT 1015; AT1015; AT-1015 HCl anhydrous, AT-1015 hydrochloride anhydrous; N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]ethyl]-1-formyl-4-piperidinecarboxamide hydrochloride. Grade: ≥97% by HPLC. CAS No. 190508-50-0. Molecular formula: C29H33N3O2.HCl. Mole weight: 492.05. | |
| AT 1015 | AT 1015. Group: Biochemicals. Grades: Purified. CAS No. 190508-50-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AT-101 acetic acid | AT101 acetic acid is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. It is used as the treatment of non Hodgkin's lymphoma, prostate cancer, and non small cell cancer. It binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM. It induces apoptosis in vitro through activation of caspase-9. It delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo. It was developed by Ascenta and in clinical phase 2. Uses: At101 acetic acid is used as the treatment of non hodgkin's lymphoma, prostate cancer, and non small cell cancer. Synonyms: AT-101 acetic acid; AT 101 acetic acid; AT101 acetic acid; (R)-(-)-Gossypol acetic acid; (-)-Gossypol acetic acid; (R)-Gossypol acetic acid; Acetic acid 7-(8-formyl-1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)-2,3,8-trihydroxy-6-methyl-4-propan-2-ylnaphthalene-1-carbaldehyde. Grade: >98 %. CAS No. 866541-93-7. Molecular formula: C32H34O10. Mole weight: 578.61. | |
| AT-121 | T-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). AT-121 can decrease capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys in a dose-dependent manner. Synonyms: AT-121; 2099681-31-7; N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-sulfamide; 3-oxo-1'-(4-propan-2-ylcyclohexyl)-2-[2-(sulfamoylamino)ethyl]spiro[1H-isoquinoline-4,4'-piperidine]; SCHEMBL18920959; SCHEMBL20230173; SCHEMBL21179793; DTXSID801336428; GLXC-25688; EX-A8003; AKOS040755934; HY-112692; CS-0062666; Q56448036; N-{2-[1'-(cis-4-Isopropylcyclohexyl)-3-oxo-1H-spiro[isoquinoline-4,4'-piperidin]-2(3H)-yl]ethyl}sulfuric diamide. Grade: ≥95%. CAS No. 2099681-31-7. Molecular formula: C24H38N4O3S. Mole weight: 462.65. | |
| AT-121 hydrochloride | AT-121 hydrochloride is a safe and non-addictive analgesic with antinociceptive and antiallodynic effects. AT-121 hydrochloride is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. Synonyms: AT121 hydrochloride; AT 121 hydrochloride. CAS No. 2099681-71-5. Molecular formula: C24H39ClN4O3S. Mole weight: 499.11. | |
| AT-130 | AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 211364-06-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100028. | |
| AT13148 | AT13148 is an orally available multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. It can block phosphorylation of AKT, p70S6K, PKA, ROCK and SGK substrates, and induce apoptosis in cancer cells. Synonyms: AT-13148; (1S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol. Grade: >98%. CAS No. 1056901-62-2. Molecular formula: C17H16ClN3O. Mole weight: 313.78. | |
| AT 13148 dihydrochloride | AT13148 is an orally available multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. It can block phosphorylation of AKT, p70S6K, PKA, ROCK and SGK substrates, and induce apoptosis in cancer cells. Synonyms: (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol dihydrochloride. Grade: 98%. Molecular formula: C17H16ClN3O.2HCl. Mole weight: 386.70. | |
| AT-1459 | AT-1459 is a novel, direct thrombin inhibitor with antithrombotic efficacy (Ki = 4.9 nM). Uses: Thrombin inhibitor. Synonyms: AT-1459; AT 1459; AT1459; UNII-JWP323ABVS; Butanoic acid, 4-[[(3S)?-1-[2-[(2S)?-2-[2-[6-(aminoiminomethyl)?-1-ethyl-1H-indol-2-yl]?ethyl]?-1-pyrrolidinyl]?-2-oxoethyl]?hexahydro-2-oxo-1H-azepin-3-yl]?amino]?-. Grade: ≥95%. CAS No. 294658-50-7. Molecular formula: C29H42N6O4. Mole weight: 538.32. | |
| AT 1902 | AT 1902 is a bio-active compound, but no detailed information has been published yet. Synonyms: AT 1902; AT-1902; AT1902; BRN 1714871; Nitriloacetic acid trihydride; NSC 351359; Nitrazine; Nitrazine; N,N-Bis(2-hydrazino-2-oxoethyl)glycine hydrazide; Glycine, N,N-bis(2-hydrazino-2-oxoethyl)-, hydrazide (9CI). Grade: 98%. CAS No. 80155-82-4. Molecular formula: C6H15N7O3. Mole weight: 233.23. | |
| AT 2433 A1 | AT 2433 A1 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. It can prolong the survival period of transplanted leukemia P388 mice. Synonyms: AT2433-A1; 6-Methyl-11-chloro-12-[6-O-[4-(methylamino)-2,4-dideoxy-alpha-L-threo-pentopyranosyl]-4-O-methyl-beta-D-glucopyranosyl]-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. Grade: >98%. CAS No. 102644-20-2. Molecular formula: C34H35ClN4O9. Mole weight: 679.11. | |
| AT 2433 A2 | AT 2433 A2 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. Synonyms: AT 2433-A2; AT2433-A2. Grade: >98%. CAS No. 102644-19-9. Molecular formula: C33H33ClN4O9. Mole weight: 665.09. | |
| AT 2433 B1 | AT 2433 B1 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. It can prolong the survival period of transplanted leukemia P388 mice. Synonyms: AT2433-B1. Grade: >98%. CAS No. 102622-96-8. Molecular formula: C34H36N4O9. Mole weight: 644.67. | |
| AT 2433 B2 | AT 2433 B2 is an anti-tumor antibiotic produced by Actinomadura melliaura. It has activity against gram-positive bacteria. Synonyms: AT2433-B2; 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 12-(6-O-(4-amino-2,4-dideoxypentopyranosyl)-4-O-methylhexopyranosyl)-12,13-dihydor-6-methyl-. Grade: >98%. CAS No. 102622-95-7. Molecular formula: C33H34N4O9. Mole weight: 630.64. | |
| AT-265 | AT-265 is a nucleoside antibiotic produced by Streptomyces rishiensis. It has anti-gram-positive and negative bacteria activity. Synonyms: 5'-Sulfamoyl-2-chloroadenosine; 2-chloro-5'-o-sulfamoyladenosine; Antibiotic AT 265. Grade: >98%. CAS No. 66522-52-9. Molecular formula: C10H13ClN6O6S. Mole weight: 380.77. | |
| AT-308 | AT-308 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: AT-308; AT 308; AT308; AC1L4RQW; AC1Q642X; Ethyl 2-methyl-2-{4-[5-(pyridin-3-yl)-1,2,4-oxadiazol-3-yl]phenoxy}propanoate. Grade: ≥98%. CAS No. 40915-84-2. Molecular formula: C19H19N3O4. Mole weight: 353.38. | |
| AT-406 | AT-406 is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3 (with Ki of 66.4 nM), cIAP1-BIR3(with Ki of 1.9 nM) and cIAP2-BIR3 (with Ki of 5.1 nM), respectively. Synonyms: AT406; AT 406; SM-406; SM 406; SM406; ARRY-334543; ARRY 334543; ARRY334543. Grade: >98%. CAS No. 1071992-99-8. Molecular formula: C32H43N5O4. Mole weight: 561.71. | |
| AT-406 hydrochloride | AT-406 hydrochloride, a potent and orally bioavailable smac mimetic and an antagonist of apoptosis proteins (IAPs) inhibitor, binds to XIAP, cIAP1 and cIAP2 proteins with Kis of 66.4, 1.9 and 5.1 nM, respectively. It can effectively antagonize XIAP BIR3 protein in a cell-free functional assay, induce rapid degradation of cellular cIAP1 protein, and inhibit the growth of various human cancer cell lines. It can effectively induce the apoptosis in xenograft tumors. Synonyms: Xevinapant hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride; (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide hydrochloride; (5S,8S,10aR)-N-(Diphenylmethyl)-5-[(N-methyl-L-alanyl)amino]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide hydrochloride (1:1). Grade: ≥98%. CAS No. 1071992-57-8. Molecular formula: C32H44ClN5O4. Mole weight: 598.18. | |
| AT 4930 | AT-4930 is a bio-active molecular, but detailed information has not been published yet. Synonyms: AT 4930; AT4930; AT-4930; 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-Quinolinecarboxylic acid. Grade: 98%. CAS No. 123016-40-0. Molecular formula: C19H23FN4O. Mole weight: 374.41. | |
| AT 56 | AT 56. Group: Biochemicals. Grades: Purified. CAS No. 162640-98-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AT-56 | AT-56 is a potent, selective and orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS), with an IC50 of 95 μM and Ki of 75 μM. AT-56 could selectively suppress the drowsiness or pain reaction mediated by L-PGDS-catalyzed PGD2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 162640-98-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13988. | |
| AT-56 | Orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 muM, IC50 = 95 muM). Inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2alpha production. Synonyms: AT 56; AT56; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine. Grade: ≥98%. CAS No. 162640-98-4. Molecular formula: C25H27N5. Mole weight: 397.53. | |
| AT-56 | AT-56. Group: Biochemicals. Alternative Names: 4-(5H-Dibenzo[a, d]cyclohepten-5-ylidene)-1-[4-(1H-tetrazol-5-yl)butyl]-piperidine. Grades: Highly Purified. CAS No. 162640-98-4. Pack Sizes: 5mg. Molecular Formula: C25H27N5, Molecular Weight: 397.52. US Biological Life Sciences. | Worldwide |
| AT-584 | AT-584, an azoniatricyclo compound, could have potential biological activity in pharmaceutical studies. Synonyms: AT 584; AT-584; AT584; Hexamethylenetetramine salt of p-(bis(2-chloroethyl)amino)-alpha-bromoacetophenone; 1-(p-(Bis(2-chloroethyl)amino)phenacyl)-3,5,7-triaza-1-azoniaadamantane bromide; 1-(2-(4-(Bis(2-chloroethyl)amino)phenyl)-2-oxoethyl)-3,5,7-triaza-1-azonia. Grade: 98%. CAS No. 16810-17-6. Molecular formula: C18H26BrCl2N5O. Mole weight: 479.24. | |
| AT6 | AT6 is a PROTAC AT1 analogue, which is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 with highly selectivity to bromodomain (Brd4). Uses: Scientific research. Category: Signaling pathways. CAS No. 2098836-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-112375. | |
| AT-61 | AT-61 is a nonnucleoside analogue inhibitors of hepatitis B virus (HBV) replication. Uses: Inhibitors of hepatitis b virus (hbv) replication. Synonyms: AT 61; AT-61; AT61; N-(1-(Bromophenylmethylene)-2-oxo-2-piperidylethyl)benzamide; Benzamide, N-(2-chloro-2-phenyl-1-(1-piperidinylcarbonyl)ethenyl)-; N-[1-(Bromophenylmethylene)-2-oxo-2-piperidylethyl]benzamide. Grade: ≥98%. CAS No. 300669-68-5. Molecular formula: C21H21ClN2O2. Mole weight: 368.86. | |
| AT7519 | AT7519 (AT7519M) as a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT7519M. CAS No. 844442-38-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50940. | |
| AT-7519 | AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Synonyms: AT-7519, AT7519, AT 7519, AT-7519 free base. Grade: 0.98. CAS No. 844442-38-2. Molecular formula: C16H17Cl2N5O2. Mole weight: 382.24. | |
| AT7519 HCl | AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Synonyms: AT7519 HCl; AT 7519 HCl; AT-7519 HCl. CAS No. 902135-91-5. Molecular formula: C16H18Cl3N5O2. Mole weight: 418.71. | |
| AT 7519 mesylate | AT 7519 mesylate is a small-molecule inhibitor of CDK including CDK 1, 2, 4, 5, 6, and 9 in vitro and it induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition. Synonyms: AT 7519 mesylate; AT7519 mesylate; AT-7519 mesylate; AT-7519M; AT 7519M, AT7519M; 4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide methanesulfonic acid. Grade: 99%. CAS No. 902135-89-1. Molecular formula: C16H17Cl2N5O2.CH4O3S. Mole weight: 478.35. | |
| AT7519 trifluoroacetate | AT7519 is an ATP competitive CDK inhibitor with a Ki value of 38 nM for CDK1. AT7519 is inactive against all non-CDK kinases with the exception of GSK3β (IC50 = 89 nM). AT7519 shows potent antiproliferative activity in a variety of human tumor cell lines with IC50 values ranging from 40 nM for MCF-7 to 940 nM for SW620 consistent with the inhibition of CDK1 and CDK2. AT7519 induces dose-dependent cytotoxicity in multiple myeloma (MM) cell lines with IC50 values ranging from 0.5 to 2 μM at 48 hours, with the most sensitive cell lines being MM.1S (0.5 μM) and U266 (0.5 μM) and the most resistant MM.1R (>2 μM). It does not induce cytotoxicity in peripheral blood mononuclear cells (PBMNC). AT7519 partially overcomes the proliferative advantage conferred by IL6 and IGF-1 as well as the protective effect of bone marrow stromal cells (BMSCs). AT7519 induces rapid dephosphorylation of RNA pol II CTD at serine 2 and serine 5 sites, and leads to the inhibition of transcription, partially contributing to AT7519 induced cytotoxicity of MM cells. AT7519 induces activation of GSK-3β by down-regulating GSK-3β phosphorylation, which also contributes to AT7519 induced apoptosis independent of the inhibition of transcription. A twice daily dosing of AT7519 (9.1 mg/kg) causes tumor regression of both early-stage and advanced-stage s.c. tumors in the HCT116 and HT29 colon cancer xenograft models. AT7519 tre | |
| AT7867 | AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family. Synonyms: AMG-706; AMG 706; AMG706; AT7867; AT 7867; AT-7867. Grade: >98%. CAS No. 857531-00-1. Molecular formula: C20H20ClN3. Mole weight: 337.85. | |
| AT7867 | AT7867 is a potent ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 857531-00-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12059. | |
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