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| Product | Description | |
|---|---|---|
| Brexpiprazole Impurity 61 | Brexpiprazole Impurity 61. Uses: For analytical and research use. Alternative Names: 7-(4-((7-(4-chlorobutoxy)-3,4-dihydroquinolin-2-yl)oxy)butoxy)-3,4-dihydroquinolin-2(1H)-one. Molecular formula: C26H31ClN2O4. Mole weight: 470.99. Catalog: APB03451. |  |
| Brexpiprazole Impurity 62 | Brexpiprazole Impurity 62. Uses: For analytical and research use. Alternative Names: 7-(4-hydroxybutoxy)quinolin-2(1H)-one. CAS No. 1886188-97-1. Molecular formula: C13H15NO3. Mole weight: 233.26. Catalog: APB1886188971. | |
| Brexpiprazole Impurity 62 | Brexpiprazole Impurity 62. Uses: For analytical and research use. Molecular formula: C17H23Cl2NO2. Mole weight: 344.28. Catalog: APB06902. | |
| Brexpiprazole Impurity 63 | Brexpiprazole Impurity 63. Uses: For analytical and research use. Alternative Names: 7-(4-((2-(4-chlorobutoxy)quinolin-7-yl)oxy)butoxy)quinolin-2(1H)-one. CAS No. 2247155-47-9. Molecular formula: C26H27ClN2O4. Mole weight: 466.96. Catalog: APB2247155479. | |
| Brexpiprazole Impurity 64 | Brexpiprazole Impurity 64. Uses: For analytical and research use. Alternative Names: 3-bromo-7-(4-chlorobutoxy)quinolin-2(1H)-one. Molecular formula: C13H13BrClNO2. Mole weight: 330.60. Catalog: APB03450. | |
| Brexpiprazole Impurity 65 | Brexpiprazole Impurity 65. Uses: For analytical and research use. Alternative Names: 5-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one. CAS No. 2116542-20-0. Molecular formula: C25H27N3O2S. Mole weight: 433.57. Catalog: APB2116542200. | |
| Brexpiprazole Impurity 66 | Brexpiprazole Impurity 66. Uses: For analytical and research use. Alternative Names: 7-(4-((2-(4-(4-(benzo[b]thiophen-7-yl)piperazin-1-yl)butoxy)quinolin-7-yl)oxy)butoxy)quinolin-2(1H)-one. Molecular formula: C38H40N4O4S. Mole weight: 648.81. Catalog: APB03449. | |
| Brexpiprazole Impurity 67 | Brexpiprazole Impurity 67. Uses: For analytical and research use. Alternative Names: 7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-3-bromoquinolin-2(1H)-one. Molecular formula: C25H26BrN3O2S. Mole weight: 512.46. Catalog: APB03447. | |
| Brexpiprazole Impurity 68 | Brexpiprazole Impurity 68. Uses: For analytical and research use. Alternative Names: 4-(4-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)piperazin-1-yl)benzo[b]thiophene-2-carboxylic acid. Molecular formula: C26H27N3O4S. Mole weight: 477.58. Catalog: APB03446. | |
| Brexpiprazole Impurity 69 | Brexpiprazole Impurity 69. Uses: For analytical and research use. Alternative Names: 1-(benzo[b]thiophen-4-yl)-4-(3-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)propyl)piperazine 1,4-dioxide. Molecular formula: C24H25N3O4S. Mole weight: 451.54. Catalog: APB03448. | |
| Brexpiprazole Impurity 70 | Brexpiprazole Impurity 70. Uses: For analytical and research use. Alternative Names: 7-(4-(4-(1,1-dioxidobenzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one. CAS No. 1191900-59-0. Molecular formula: C25H27N3O4S. Mole weight: 465.56. Catalog: APB1191900590. | |
| Brexpiprazole Impurity 71 | Brexpiprazole Impurity 71. Uses: For analytical and research use. Alternative Names: 3-hydroxypropanoyl chloride. CAS No. 109608-73-3. Molecular formula: C3H5ClO2. Mole weight: 108.00. Catalog: APB109608733. | |
| Brexpiprazole Impurity 72 | Brexpiprazole Impurity 72. Uses: For analytical and research use. Alternative Names: 4-(1-oxidobenzo[b]thiophen-4-yl)-1-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)piperazine 1-oxide. Molecular formula: C25H27N3O4S. Mole weight: 465.17. Catalog: APB01290. | |
| Brexpiprazole Impurity 73 | Brexpiprazole Impurity 73. Uses: For analytical and research use. Alternative Names: 2-(4-chlorobutoxy)quinolin-7-ol. Molecular formula: C13H14ClNO2. Mole weight: 251.07. Catalog: APB03445. | |
| Brexpiprazole Impurity 75 | Brexpiprazole Impurity 75. Uses: For analytical and research use. Alternative Names: 4-(benzo[b]thiophen-4-yl)piperazine-1-carbaldehyde. CAS No. 1677681-04-7. Molecular formula: C13H14N2OS. Mole weight: 246.33. Catalog: APB1677681047. | |
| Brexpiprazole Impurity 76 | Brexpiprazole Impurity 76. Uses: For analytical and research use. Alternative Names: 1-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethanone. CAS No. 1700655-62-4. Molecular formula: C14H16N2OS. Mole weight: 260.35. Catalog: APB1700655624. | |
| Brexpiprazole Impurity 77 | Brexpiprazole Impurity 77. Uses: For analytical and research use. Alternative Names: 3,10-bis(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-6b,8,12b,12c-tetrahydrocyclobuta[1,2-c:4,3-c']diquinoline-6,7(5H,6aH)-dione. Molecular formula: C50H54N6O4S2. Mole weight: 867.13. Catalog: APB03444. | |
| Brexpiprazole Impurity 78 | Brexpiprazole Impurity 78. Uses: For analytical and research use. Alternative Names: 3-chloro-N-(3-hydroxyphenyl)propanamide. CAS No. 50297-40-0. Molecular formula: C9H10ClNO2. Mole weight: 199.63. Catalog: APB50297400. | |
| Brexpiprazole Impurity 79 | Brexpiprazole Impurity 79. Uses: For analytical and research use. Alternative Names: tert-butyl 4-(benzo[b]thiophen-4-yl)piperazine-1-carboxylate. CAS No. 1191901-07-1. Molecular formula: C17H22N2O2S. Mole weight: 318.43. Catalog: APB1191901071. | |
| Brexpiprazole Impurity 8 | Brexpiprazole Impurity 8. Uses: For analytical and research use. Alternative Names: 846038-18-4(free base); 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride. CAS No. 913614-18-3. Molecular formula: C12H15ClN2S. Mole weight: 254.78. Catalog: APB913614183. | |
| Brexpiprazole Impurity 8 | Brexpiprazole Impurity 8. Uses: For analytical and research use. Molecular formula: C33H31N3O2S2. Mole weight: 565.75. Catalog: APB06889. | |
| Brexpiprazole Impurity 80 | Brexpiprazole Impurity 80. Uses: For analytical and research use. Alternative Names: 7-(4-bromobutoxy)-1-(4-chlorobutyl)-3,4-dihydroquinolin-2(1H)-one. Molecular formula: C17H23BrClNO2. Mole weight: 388.73. Catalog: APB03443. | |
| Brexpiprazole Impurity 81 | Brexpiprazole Impurity 81. Uses: For analytical and research use. Alternative Names: 7-(4-bromobutoxy)-2-(4-chlorobutoxy)-1,2,3,4-tetrahydroquinoline. Molecular formula: C17H25BrClNO2. Mole weight: 390.74. Catalog: APB03442. | |
| Brexpiprazole Impurity 82 | Brexpiprazole Impurity 82. Uses: For analytical and research use. Alternative Names: 2-(4-bromobutoxy)-7-(4-chlorobutoxy)-1,2,3,4-tetrahydroquinoline. Molecular formula: C17H25BrClNO2. Mole weight: 390.74. Catalog: APB03439. | |
| Brexpiprazole Impurity 83 | Brexpiprazole Impurity 83. Uses: For analytical and research use. Alternative Names: 1-(4-bromobutyl)-7-(4-chlorobutoxy)-3,4-dihydroquinolin-2(1H)-one. Molecular formula: C17H23BrClNO2. Mole weight: 388.73. Catalog: APB03440. | |
| Brexpiprazole Impurity 84 | Brexpiprazole Impurity 84. Uses: For analytical and research use. Alternative Names: 1-(4-chlorobutyl)-7-(4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy)butoxy)-3,4-dihydroquinolin-2(1H)-one. Molecular formula: C26H31ClN2O4. Mole weight: 470.99. Catalog: APB03441. | |
| Brexpiprazole Impurity 85 | Brexpiprazole Impurity 85. Uses: For analytical and research use. Alternative Names: 7-(4-((2-(4-chlorobutoxy)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)butoxy)-3,4-dihydroquinolin-2(1H)-one. Molecular formula: C26H33ClN2O4. Mole weight: 473. Catalog: APB03437. | |
| Brexpiprazole Impurity 86 | Brexpiprazole Impurity 86. Uses: For analytical and research use. Alternative Names: 7-(4-((7-(4-chlorobutoxy)-1,2,3,4-tetrahydroquinolin-2-yl)oxy)butoxy)-3,4-dihydroquinolin-2(1H)-one. Molecular formula: C26H33ClN2O4. Mole weight: 473. Catalog: APB03438. | |
| Brexpiprazole Impurity 87 | Brexpiprazole Impurity 87. Uses: For analytical and research use. Alternative Names: 7-(4-chlorobutoxy)-1-(4-((2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy)butyl)-3,4-dihydroquinolin-2(1H)-one. Molecular formula: C26H31ClN2O4. Mole weight: 470.99. Catalog: APB03436. | |
| Brexpiprazole Impurity 88 | Brexpiprazole Impurity 88. Uses: For analytical and research use. Alternative Names: 7-(4-bromobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one. Molecular formula: C17H21BrClNO2. Mole weight: 386.71. Catalog: APB03435. | |
| Brexpiprazole Impurity 89 | Brexpiprazole Impurity 89. Uses: For analytical and research use. Alternative Names: 7-(4-bromobutoxy)-2-(4-chlorobutoxy)-1,2-dihydroquinoline. Molecular formula: C17H23BrClNO2. Mole weight: 388.73. Catalog: APB03432. | |
| Brexpiprazole Impurity 9 | Brexpiprazole Impurity 9 is an impurity of brexpiprazole and related pharmaceutical formulations. Brexpiprazole is a medication utilized to treat schizophrenia and major depressive disorder. Synonyms: 5-Hydroxyquinolin-2(1H)-one; 5-Hydroxy-2(1H)-quinolone; 5-Hydroxycarbostyril; NSC 134652. Grade: > 95%. CAS No. 31570-97-5. Molecular formula: C9H7NO2. Mole weight: 161.16. |  |
| Brexpiprazole Impurity 9 | Brexpiprazole Impurity 9. Uses: For analytical and research use. Alternative Names: 7-hydroxy-3,4-dihydroquinolin-2(1H)-one. CAS No. 22246-18-0. Molecular formula: C9H9NO2. Mole weight: 163.17. Catalog: APB22246180. | |
| Brexpiprazole Impurity 90 | Brexpiprazole Impurity 90. Uses: For analytical and research use. Alternative Names: 2-(4-bromobutoxy)-7-(4-chlorobutoxy)-1,2-dihydroquinoline. Molecular formula: C17H23BrClNO2. Mole weight: 388.73. Catalog: APB03434. | |
| Brexpiprazole Impurity 91 | Brexpiprazole Impurity 91. Uses: For analytical and research use. Alternative Names: 1-(4-bromobutyl)-7-(4-chlorobutoxy)quinolin-2(1H)-one. Molecular formula: C17H21BrClNO2. Mole weight: 386.71. Catalog: APB03433. | |
| Brexpiprazole Impurity 92 | Brexpiprazole Impurity 92. Uses: For analytical and research use. Alternative Names: 7-(4-((2-(4-chlorobutoxy)-1,2-dihydroquinolin-7-yl)oxy)butoxy)quinolin-2(1H)-one. Molecular formula: C26H29ClN2O4. Mole weight: 468.97. Catalog: APB03431. | |
| Brexpiprazole Impurity 93 | Brexpiprazole Impurity 93. Uses: For analytical and research use. Alternative Names: 7-(4-((7-(4-chlorobutoxy)-1,2-dihydroquinolin-2-yl)oxy)butoxy)quinolin-2(1H)-one. Molecular formula: C26H29ClN2O4. Mole weight: 468.97. Catalog: APB03430. | |
| Brexpiprazole Impurity 94 | Brexpiprazole Impurity 94. Uses: For analytical and research use. Alternative Names: 2,7-bis(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-1,2-dihydroquinoline. Molecular formula: C41H49N5O2S2. Mole weight: 707.99. Catalog: APB03429. | |
| Brexpiprazole Impurity 95 | Brexpiprazole Impurity 95. Uses: For analytical and research use. Alternative Names: 7-(4-((2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-1,2-dihydroquinolin-7-yl)oxy)butoxy)quinolin-2(1H)-one. Molecular formula: C38H42N4O4S. Mole weight: 650.83. Catalog: APB03428. | |
| Brexpiprazole Impurity 96 | Brexpiprazole Impurity 96. Uses: For analytical and research use. Alternative Names: 7-(4-((7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-1,2-dihydroquinolin-2-yl)oxy)butoxy)quinolin-2(1H)-one. Molecular formula: C38H42N4O4S. Mole weight: 650.83. Catalog: APB03427. | |
| Brexpiprazole Impurity 97 | Brexpiprazole Impurity 97. Uses: For analytical and research use. Alternative Names: 1-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-7-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butoxy)quinolin-2(1H)-one. CAS No. 2518081-42-8. Molecular formula: C38H40N4O4S. Mole weight: 648.81. Catalog: APB2518081428. | |
| Brexpiprazole Impurity 99 | Brexpiprazole Impurity 99. Uses: For analytical and research use. Alternative Names: 8-(benzo[b]thiophen-4-yl)-5,8-diazaspiro[4.5]decan-5-ium hydroxide. CAS No. 2549192-46-1. Molecular formula: C16H22N2OS. Mole weight: 290.42. Catalog: APB2549192461. | |
| Brexpiprazole Impurity A | Brexpiprazole Impurity A. Uses: For analytical and research use. Alternative Names: 4,5-dichloro-3,6-dihydroxyphthalonitrile. CAS No. 4640-41-9. Molecular formula: C8H2Cl2N2O2. Mole weight: 229.02. Catalog: APB4640419. | |
| Brexpiprazole Impurity B | Brexpiprazole Impurity B. Uses: For analytical and research use. Alternative Names: 2,7-bis(4-chlorobutoxy)-3,4-dihydroquinoline. Molecular formula: C17H23Cl2NO2. Mole weight: 344.28. Catalog: APB03458. | |
| Brexpiprazole Impurity C | Brexpiprazole Impurity C. Uses: For analytical and research use. Alternative Names: 7-(4-(4-chlorobutoxy)butoxy)quinolin-2(1H)-one. Molecular formula: C17H22ClNO3. Mole weight: 323.81. Catalog: APB03459. | |
| Brexpiprazole Impurity D | Brexpiprazole Impurity D. Uses: For analytical and research use. Alternative Names: 7,7'-((oxybis(butane-4,1-diyl))bis(oxy))bis(quinolin-2(1H)-one). Molecular formula: C26H28N2O5. Mole weight: 448.51. Catalog: APB03457. | |
| Brexpiprazole Impurity E | Brexpiprazole Impurity E. Uses: For analytical and research use. Alternative Names: 7-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butoxy)-1-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)quinolin-2(1H)-one. Molecular formula: C35H33N3O6. Mole weight: 591.65. Catalog: APB03456. | |
| Brexpiprazole Impurity F | Brexpiprazole Impurity F. Uses: For analytical and research use. Alternative Names: 7-(4-chlorobutoxy)-1-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)quinolin-2(1H)-one. CAS No. 2060029-80-1. Molecular formula: C26H27ClN2O4. Mole weight: 466.96. Catalog: APB2060029801. | |
| Brexpiprazole Impurity G | Brexpiprazole Impurity G. Uses: For analytical and research use. Alternative Names: 4-(benzo[b]thiophen-4-yl)-1-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)piperazine 1-oxide. CAS No. 1191900-58-9. Molecular formula: C25H27N3O3S. Mole weight: 449.57. Catalog: APB1191900589. | |
| Brexpiprazole Impurity H | Brexpiprazole Impurity H. Uses: For analytical and research use. Alternative Names: 1-(benzo[b]thiophen-4-yl)-4-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)piperazine 1,4-dioxide. CAS No. 2247155-42-4. Molecular formula: C25H27N3O4S. Mole weight: 465.56. Catalog: APB2247155424. | |
| Brexpiprazole Impurity I | Brexpiprazole Impurity I. Uses: For analytical and research use. Alternative Names: 7-(4-(4-(1-oxidobenzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one. CAS No. 1191900-51-2. Molecular formula: C25H27N3O3S. Mole weight: 449.57. Catalog: APB1191900512. | |
| Brexpiprazole Impurity I (Trifluoroacetate) | Brexpiprazole Impurity I (Trifluoroacetate). Uses: For analytical and research use. Alternative Names: 7-(4-(4-(1-oxidobenzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one 2,2,2-trifluoroacetate. Molecular formula: C25H27N3O3S·CF3COOH. Mole weight: 563.59. Catalog: APB01292. | |
| Brexpiprazole Impurity J | Brexpiprazole Impurity J. Uses: For analytical and research use. Alternative Names: 7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)-1-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)quinolin-2(1H)-one. CAS No. 2094559-58-5. Molecular formula: C38H40N4O4S. Mole weight: 648.81. Catalog: APB2094559585. | |
| Brexpiprazole Impurity K | Brexpiprazole Impurity K. Uses: For analytical and research use. Alternative Names: 7-(4-((7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2-yl)oxy)butoxy)quinolin-2(1H)-one. CAS No. 2116542-21-1. Molecular formula: C38H40N4O4S. Mole weight: 648.81. Catalog: APB2116542211. | |
| Brexpiprazole Impurity K (Hydrochloride) | Brexpiprazole Impurity K (Hydrochloride). Uses: For analytical and research use. Alternative Names: 7-(4-((7-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2-yl)oxy)butoxy)quinolin-2(1H)-one hydrochloride. Molecular formula: C38H40N4O4S·HCl. Mole weight: 685.27. Catalog: APB01291. | |
| Brexpiprazole Impurity M | Brexpiprazole Impurity M. Uses: For analytical and research use. Alternative Names: 1-(4-chlorobutyl)-7-(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butoxy)quinolin-2(1H)-one. CAS No. 2247155-48-0. Molecular formula: C26H27ClN2O4. Mole weight: 466.96. Catalog: APB2247155480. | |
| Brexpiprazole Impurity N | Brexpiprazole Impurity N. Uses: For analytical and research use. Alternative Names: 2454317-16-7(free base); 4-(benzo[b]thiophen-4-yl)-1,1-bis(4-((2-oxo-1,2-dihydroquinolin-7-yl)oxy)butyl)piperazin-1-ium chloride. CAS No. 2454317-17-8. Molecular formula: C38H41N4O4S·Cl. Mole weight: 685.28. Catalog: APB2454317178. | |
| Brexpiprazole Nitroso Impurity 1 | Brexpiprazole Nitroso Impurity 1. Uses: For analytical and research use. Alternative Names: 1-(benzo[b]thiophen-4-yl)-4-nitrosopiperazine. CAS No. 2639426-95-0. Molecular formula: C12H13N3OS. Mole weight: 247.32. Catalog: APB2639426950. | |
| Brexpiprazole-[piperazin-d8] | Brexpiprazole-[piperazin-d8] is the labelled analogue of Brexpiprazole. Brexpiprazole is a partial agonist of dopamine D2 receptor used as an atypical antipsychotic. It was approved by FDA for the treatment of schizophrenia. Synonyms: Brexpiprazole-piperazin-D8; 7-[4-(4-(Benzo[b]thien-4-yl)-piperazin-1-yl)butoxy]-1H-quinolin-2-one-d8; Brexpiprazole-d8; 7-[4-[4-(1-Benzothiophen-4-yl)-2,2,3,3,5,5,6,6-d8-piperazin-1-yl]butoxy]-1H-quinolin-2-one. Grade: >95%. CAS No. 1427049-21-5. Molecular formula: C25H19D8N3O2S. Mole weight: 441.63. | |
| Brexpiprazole S-oxide | Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor. Synonyms: DM-3411; 7-[4-[4-(1-Oxidobenzo[b]thien-4-yl)-1-piperazinyl]butoxy]-2(1H)-quinolinone; 4-(4-{4-[(2-Oxo-1,2-dihydro-7-quinolinyl)oxy]butyl}-1-piperazinyl)-1-benzothiophenium-1-olate. Grade: ≥95%. CAS No. 1191900-51-2. Molecular formula: C25H27N3O3S. Mole weight: 449.57. | |
| Brexpiprazole S-oxide | Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DM-3411. CAS No. 1191900-51-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-133152. |  |
| Brexpiprazole (Standard) | Brexpiprazole (Standard) is the analytical standard of Brexpiprazole. This product is intended for research and analytical applications. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-34712 (Standard). CAS No. 913611-97-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15780R. | |
| Briakinumab | Briakinumab is a human anti-IL-12 monoclonal antibody developed for the treatment of rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and Crohn's Disease. Synonyms: ABT-874; ABT 874; ABT874. Grade: 95%. CAS No. 339308-60-0. Molecular formula: C6376H9874N1722O1992S44. Mole weight: 143.9 kDa. | |
| Briakinumab | Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-874. CAS No. 339308-60-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99486. | |
| Brialmontin 1 | Brialmontin 1 is a highly efficacious compound employed in the research of diverse cancer forms, encompassing breast, lung and colon malignancies manifesting remarkable anticancer potential through precise engagement with distinct molecular cascades, consequently studying malignant cell proliferation. Synonyms: NSC-646005. CAS No. 128585-08-0. Molecular formula: C22H28O5. Mole weight: 372.45. | |
| Brialmontin 2 | Brialmontin 2 is an avant-garde biomedical innovation, meticulously aims at studying and remedying intricate bacterial infections. CAS No. 128585-09-1. Molecular formula: C21H26O5. Mole weight: 358.43. | |
| Briciclib | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. It is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. It may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. It inhibits the proliferation of MCL, gastric, breast and esophageal cancer cell lines at nanomolar concentrations (GI50 = 9.8 - 12.2 nM) in vitro. It binds to eIF4E, blocking cap-dependent translation of cyclin D1 and other cancer proteins and leads to tumor cell death in vitro. It is active in nonclinical tumor models when combined with several chemotherapeutics. Uses: Briciclib may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. it is active in nonclinical tumor models when combined with several chemotherapeutics. Synonyms: Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate); ON-014185; (E)-5-[[(2,4,6-Trimethoxystyryl)sulfonyl]methyl]-2-methoxyphenyl dihydrogen phosphate; [2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]phenyl] dihydrogen phosphate. Grade: >98 %. CAS No. 865783-99-9. Molecular formula: C19H23O10PS. Mole weight: 474.42. | |
| Briciclib | Briciclib (ON 014185) is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib can be used for the study of hematological system tumors and solid tumors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ON 014185. CAS No. 865783-99-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16366. | |
| Briciclib sodium | Briciclib, also known as ON 013105 or ON 014185, is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is often overexpressed in a variety of hematologic and solid tumors and is correlated with poor prognosis. Synonyms: ON-013105; ON013105; ON 013105; ON 014185; ON014185; ON-014185. Grade: >98%. CAS No. 865784-01-6. Molecular formula: C19H21Na2O10PS. Mole weight: 518.38. | |
| Brigatinib | Brigatinib is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy. Group: Inhibitors. Alternative Names: AP26113. CAS No. 1197953-54-0. Pack Sizes: 5mg. Product ID: S8229. Formula: C29H39ClN7O2P. Smiles: CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
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