A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06523435; hu24. CAS No. 1869928-62-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99828.
Cofetuzumab pelidotin
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06647020; ABBV-647; h6M24-vc0101. CAS No. 1869937-48-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99829.
Coffee Arabica Extract
Derived from the fruit portion of the Coffea arabica plant, this ingredient is a very good antioxidant when applied to skin (and consumed orally in the popular beverage coffee). Among other antioxidants, coffee is a rich source of ferulic acid. Arabica contains almost 60% more lipids and almost twice the amount of sugar. These play an important part in not only the flavor, but the aroma and body of the coffee. Arabica beans taste better because the increase in sugar gives the coffee a better taste, a cleaner mouthfeel, and a decrease in bitterness. The main constituents of coffee are caffeine, tannin, fixed oil, carbohydrates, and proteins. It contains 2-3% caffeine, 3-5% tannins, 13% proteins, and 10-15% fixed oils. In the seeds, caffeine is present as a salt of chlorogenic acid (CGA). Uses: Flavor. Group: Plant Extracts. INCI Names: Coffea Arabica (Coffee) Seed Extract. Grades: INDUSTRIAL GRADE. CAS No. 84650-00-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CF-0201. Olfactive Profile: Coffee, earthy, fruity, bitter. EC No: 283-481-2. Origin: Indonesia.
New Jersey
Coffee Arabica Oil - CO2
Known for its distinct and complex aroma, the Coffee Oil, Obtained from green or roasted Coffee beans, offers a host of benefits for the mind and body. Rich in antioxidants and flavonoids, Coffee Oil protects, moisturizes the skin while the invigorating aroma of the Coffee Oil helps to uplift the mood. Uses: Flavor and Fragrances. Group: Plant Extracts. INCI Names: Coffea Arabica (Coffee) Seed Oil. Grades: INDUSTRIAL GRADE. CAS No. 84650-00-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CF-001. Olfactive Profile: Coffee, earthy, fruity, bitter. EC No: 283-481-1. Origin: Indonesia.
New Jersey
Coffee CO2 Colombia
Coffee CO2 Colombia (Oil Soluble). CAS No. 84650-00-0. Kosher: Y. VIGON Item # 507789. Categories: Speciality Ingrdients Suppliers, Flavors, Aromatherapy, Essetial Oils.
America & Internationally
Coffee CO2 Extract Arabica
Coffee CO2 Extract Arabica (Water Soluble). CAS No. 68916-18-7. Kosher: Y. VIGON Item # 503647. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Coffee CO2 Extract Arabica
Coffee CO2 Extract Arabica (Oil Soluble). CAS No. 84650-00-0. Kosher: Y. VIGON Item # 503646. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Coffee CO2 Extract Espresso
Coffee CO2 Extract Espresso (Water Soluble). CAS No. MIXTURE. Kosher: Y. VIGON Item # 503649. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Coffee CO2 Extract Espresso
Coffee CO2 Extract Espresso (Oil Soluble). CAS No. 68916-18-7. Kosher: Y. VIGON Item # 503648. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Coffee CO2 Heavy Roasted
Coffee CO2 Heavy Roasted (Oil Soluble). CAS No. 68916-18-7. Kosher: Y. VIGON Item # 504879. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers, Aromatherapy, Essetial Oils.
America & Internationally
Coffee CO2 Heavy Roasted
Coffee CO2 Heavy Roasted (Water Soluble). CAS No. 68916-18-7. Kosher: Y. VIGON Item # 505099. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers, Aromatherapy, Essetial Oils.
America & Internationally
Coffee Extract
Coffee seed extract, 20% in water-glycerin, excellent for skin conditioning and toning. Product ID: CI-SC-0839. Alfa Chemistry - ISO 9001:32057 Certified.
Coffee Extract Italian Naturome
Coffee Extract Italian Naturome. CAS No. 68916-18-7. Kosher: Y. VIGON Item # 503569. Categories: Speciality Ingrdients Suppliers, Flavors.
Robusta originated in central and western sub-Saharan Africa. It is the second most popular coffee in the world, making up 40% of the worlds coffee production. Robusta coffee benefits are increases energy and improves mental health and well-being, contains antioxidants, which are beneficial for skin and hair. It has a diuretic effect and can help with nausea. It is a high-caffeine, creamy, somewhat bitter version of the coffee full of benefits. The main constituents of coffee are caffeine, tannin, fixed oil, carbohydrates, and proteins. It contains 2-3% caffeine, 3-5% tannins, 13% proteins, and 10-15% fixed oils. In the seeds, caffeine is present as a salt of chlorogenic acid (CGA). Uses: Flavor. Group: Plant Extracts. INCI Names: Coffea Robusta (Coffee) Seed Extract. Grades: INDUSTRIAL GRADE. CAS No. 97593-13-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CF-0202. Olfactive Profile: Peanuty, roasted, smokey, bitter. EC No: 307-315-5. Origin: Indonesia.
New Jersey
Coffee Robusta Oil - CO2
Van Aroma is one of the leading producers of Coffee Robusta Oil - CO2. Van Aroma is one of the biggest exporters in Indonesia. We produce and export Coffee Robusta Oil - CO2 from sustainable and fully traceable sources. Uses: Aromatherapy, Skin Care, Pharmaceutical. Group: Plant Extracts. INCI Names: Coffea Robusta (Coffee) Seed Oil. Grades: INDUSTRIAL GRADE. CAS No. 97593-13-0. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: CF-002. Olfactive Profile: Peanuty, roasted, smokey, bitter. EC No: 307-315-3. Origin: Indonesia.
New Jersey
Coffee Seed Extract
Coffee (Coffea arabica) seed extract, dissolved in water, glycerin, and propanediol; contains proteins, polysaccharides, methylxanthines, sucrose, lipids, caffeine, trigonelline, and minerals. Product ID: CI-SC-0662. Alfa Chemistry - ISO 9001:32057 Certified.
COG 1333 is a fragment of ApoE that exhibits anti-inflammatory and neuroprotective effects and could also be an antagonist at α7 nicotinic acetylcholine receptors. Synonyms: COG133; COG-133; Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu. Grade: 98%. CAS No. 514200-66-9. Molecular formula: C97H181N37O19. Mole weight: 2169.73.
COG 133
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 514200-66-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1050.
COG 133 acetate
COG 133 acetate is a fragment of ApoE that exhibits anti-inflammatory and neuroprotective effects and could also be an antagonist at α7 nicotinic acetylcholine receptors. Synonyms: Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2.CH3CO2H; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide acetic acid; L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-, acetate (1:1). Grade: ≥95%. CAS No. 2763583-75-9. Molecular formula: C99H185N37O21. Mole weight: 2229.76.
COG 133 TFA
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC50 of 445 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2828432-37-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1050A.
COG 133 TFA
COG133 is a peptide fragment of ApoE that corresponds to residues 133-149 of the ApoE LDL receptor-binding domain and an antagonist of α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 720 nM). It suppresses TNF-α and nitric oxide (NO) release in BV-2 microglia when used at concentrations ranging from 10 to 50 μM. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-, 2,2,2-trifluoroacetate (1:1); Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2.TFA; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-leucinamide trifluoroacetic acid. Grade: 98%. CAS No. 2828432-37-5. Molecular formula: C99H182F3N37O21. Mole weight: 2283.78.
COG1410
COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 878009-24-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2136.
COG-1410
COG-1410 is an apolipoprotein E (apoE) peptide mimetic containing the amino acid sequence of the receptor-binding domain apoE. CAS No. 878009-24-6. Molecular formula: C64H121N21O14. Mole weight: 1408.8.
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1534358-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114304.
COH000
COH000 is an allosteric and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme). COH000 targets a cryptic pocket distinct from the active site that is completely buried in all previous SUMO E1 structures. Synonyms: (1R,4S)-Dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate. CAS No. 1534358-79-6. Molecular formula: C25H25NO5. Mole weight: 419.47.