A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
CPI 203. Group: Biochemicals. Grades: Purified. CAS No. 1446144-04-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
CPI-203
CPI-203 is a BET bromodomain inhibitor. It inhibits BRD4 in vitro and in cells, and causes G1 cell cycle arrest. It also arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Synonyms: CPI203; CPI-203; CPI 203; TEN010; TEN 010; TEN010; JQ-2; JQ 2; JQ2; RG-6146; RG 6146; RG-6146; RO6870810; RO-6870810; RO 6870810. (6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide. Grade: >98%. CAS No. 1446144-04-2. Molecular formula: C19H18ClN5OS. Mole weight: 399.90.
CPI-203
CPI-203 is a novel potent, selective and cell permeable inhibitor of BET bromodomain, with an IC50 value of appr 37 nM (BRD4 ?-screen assay). Uses: Scientific research. Group: Signaling pathways. CAS No. 1446144-04-2. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15846.
CPI-268456
CPI-268456 is a ligand of bromodomain-containing protein 4 (BRD4). It binds to BRD4 and inhibits LPS-induced IL-6 secretion in THP-1 cells. Synonyms: 2-[(4S)-8-chloro-6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepin-4-yl]acetamide. Grade: ≥98%. CAS No. 1380087-86-4. Molecular formula: C20H15Cl2N3O2. Mole weight: 400.3.
CPI-360
CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases. Synonyms: CPI360; CPI 360. Grade: 98%. CAS No. 1802175-06-9. Molecular formula: C25H31N3O4. Mole weight: 437.53.
CPI 4203
CPI 4203 is a selective inhibitor of KDM5 demethylases structurally related to CPI 455. Synonyms: CPI-4203; CPI 4203; CPI4203; 6-ethyl-7-oxo-5-(o-tolyl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grade: 99%. CAS No. 1628214-07-2. Molecular formula: C16H14N4O. Mole weight: 278.31.
CPI-444
CPI-444 is a potent, orally available, selective antagonist of the adenosine A2A receptor that has been well tolerated in Ph 1/1b studies in non-oncology indications. Synonyms: (S)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine; CPI-444; CPI 444; CPI444; V81444; V-81444; V 81444. CAS No. 1202402-40-1. Molecular formula: C20H21N7O3. Mole weight: 407.17.
CPI 455
CPI 455 is a selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation (H3K4me3) in vitro and reduces survival of drug-tolerant cancer cells. Uses: Antitumor agent for drug-tolerant cancer. Synonyms: CPI-455; CPI-455; CPI-455; 6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile. Grade: 99%. CAS No. 1628208-23-0. Molecular formula: C16H14N4O. Mole weight: 278.31.
CPI-455
CPI-455 is a specific, pan- KDM5 inhibitor with an IC 50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628208-23-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100421.
CPI-455 analogue
CPI-455 analogue is an analogue of CPI-455 which is a KDM5 inhibitor. Molecular formula: C16H14N4O. Mole weight: 278.31.
CPI-455 hydrochloride
CPI-455 is a specific inhibitor of KDM5 with IC50 of 10 ± 1 nM for full-length KDM5A in enzymatic assays. Synonyms: 7-oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride. Grade: ≥99%. CAS No. 2095432-28-1. Molecular formula: C16H15ClN4O. Mole weight: 314.77.
CPI 613
CPI 613. Group: Biochemicals. Alternative Names: 6, 8-Bis[ (phenylmethyl)thio]-octanoic Acid; 6,8-Bis(benzylthio)-octanoic Acid. Grades: Highly Purified. CAS No. 95809-78-2. Pack Sizes: 10mg. Molecular Formula: C22H28O2S2, Molecular Weight: 388.59. US Biological Life Sciences.
Worldwide
CPI-613
CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Although the exact mechanism of action is unknown, alpha-lipoic acid analogue CPI-613 has been shown to inhibit metabolic and regulatory processes required for cell growth in solid tumors. Both enantiomers in the racemic mixture exhibit antineoplastic activity. The mechanism-of-action of CPI-613 appears distinct from the current classes of anti-cancer agents used in the clinic. CPI-613 demonstrates both in vitro and in vivo anti-tumor activity. CPI-613 was known to strongly disrupt tumor mitochondrial metabolism. CPI-613 disruption of tumor mitochondrial metabolism is followed by efficient commitment to cell death by multiple, apparently redundant pathways, including apoptosis, in all tested cancer cell lines. Further, CPI-613 shows strong antitumor activity in vivo against human non-small cell lung and pancreatic cancers in xenograft models with low side-effect toxicity. Synonyms: CPI613; CPI 613; Devimistat; 6,8-bis(benzylthio)octanoic acid. Grade: 98%. CAS No. 95809-78-2. Molecular formula: C22H28O2S2. Mole weight: 388.59.
CPI-637
CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 of 0.03±0.01μM and 11.0±0.6 μM for CBP/EP300 and BRD4, respectively. CPI-637 displayed a >700-fold selectivity over the BET family of bromodomains (BRD4 IC50=11.0 ± 0.6 μM). Synonyms: CPI-637; CPI 637; CPI637. (4R)-4-methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one; CPI-637; SCHEMBL17673230. Grade: >98%. CAS No. 1884712-47-3. Molecular formula: C22H22N6O. Mole weight: 386.459.
CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 ?M, 0.051 ?M and 11.0 ?M for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 ?M for CBP[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1884712-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100482.
CPK20
CPK20 is a potent and highly selective KCNT1 channel blocker, and CPK20 can be used in the study of epilepsy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2397708-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162549.
CPL304110
CPL304110 is a potent, selective and orally active fibroblast growth factor receptors FGFR (1-3) inhibitor, with IC50s of 0.75, 0.5 and 3.05 nM, respectively. Synonyms: 1H-Benzimidazole, 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-6-(4-methyl-1-piperazinyl)-; 2-{5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-6-(4-methyl-1-piperazinyl)-1H-benzimidazole. Grade: ≥95%. CAS No. 1627826-19-0. Molecular formula: C25H30N6O2. Mole weight: 446.54.
CPM
CPM is a maleimide derivative, acting as a blue fluorescent thiol-reactive dye (excitation/emission maxima of 387/463 nm) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 76877-33-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-D0069.
CPM
CPM. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-Diethylamino-3-(4-maleimidylphenyl)-4-methyl coumarin. Product Category: Other Fluorophores. Appearance: Yellow solid. CAS No. 76877-33-3. Molecular formula: C24H22N2O4. Mole weight: 402.44. Purity: 95%+. IUPACName: 1-[4-[7-(diethylamino)-4-methyl-2-oxochromen-3-yl]phenyl]pyrrole-2,5-dione. Canonical SMILES: CCN(CC)C1=CC2=C(C=C1)C(=C(C(=O)O2)C3=CC=C(C=C3)N4C(=O)C=CC4=O)C. Density: 1.302 ± 0.06 g/ml. Product ID: ACM76877333-1. Alfa Chemistry ISO 9001:2015 Certified.
CpODA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Norbornane-2-spiro-α-cyclopentanone-α'-spiro-2''-norbornane-5,5'',6,6''-tetracarboxylic Dianhydride; Octahydro-3H,3''H-dispiro[[4,7]methanoisobenzofuran-5,1'-cyclopentane-3',5''-[4,7]methanoisobenzofuran]-1,1'',2',3,3''(4H,4''H)-pentaone. Product Category: Tetracarboxylic Dianhydride Monomers. Appearance: White to Light Yellow Powder to Crystal. CAS No. 1312366-93-0. Molecular formula: C21H20O7. Mole weight: 384.38 g/mol. Purity: 95.0%(HPLC). Product ID: ACM-MO-1312366930. Alfa Chemistry ISO 9001:2015 Certified. Categories: Caodaism.
Cp-osu
Cp-osu. Uses: Designed for use in research and industrial production. Additional or Alternative Names: cyclopentyl (2,5-dioxopyrrolidin-1-yl) carbonate; Cyclopentyl N-Succinimidyl Carbonate. Product Category: Heterocyclic Organic Compound. CAS No. 128595-07-0. Molecular formula: C10H13NO5. Mole weight: 227.214. Purity: 0.96. IUPACName: N-(Cyclopentyloxycarbonyloxy)succinimide. Density: 1.35g/cm³. Product ID: ACM128595070. Alfa Chemistry ISO 9001:2015 Certified. Categories: CPO-STV.
CPPG
CPPG. Group: Biochemicals. Grades: Purified. CAS No. 183364-82-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
CPPG
CPPG is the most potent group II/III mGluR antagonist displaying approximately 20-fold selectivity for group III over group II (IC50 = 2.2 and 46.2 nM, respectively). Synonyms: (RS)-α-Cyclopropyl-4-phosphonophenylglycine; Cyclopropyl-4-phosphonophenylglycine; 2-amino-2-cyclopropyl-2-(4-phosphonophenyl)acetic acid. Grade: ≥98% by HPLC. CAS No. 183364-82-1. Molecular formula: C11H14NO5P. Mole weight: 271.21.
CPPG
CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III ( IC 50 =2.2 nM) over group II ( IC 50 =46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (RS)-CPPG. CAS No. 183364-82-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101333.
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It is thought to act at a novel allosteric site and potentiates mGlu5 responses by a mechanism distinct from that of VU 29. Grade: >98%. CAS No. 693288-97-0. Molecular formula: C22H15ClN2O4. Mole weight: 406.82.
CPPHA
CPPHA. Group: Biochemicals. Grades: Purified. CAS No. 693288-97-0. Pack Sizes: 10mg. US Biological Life Sciences.
CPPyC. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(5-(3-(9H-Carbazol-9-yl)phenyl)pyridin-3-yl)-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1583238-16-7. Molecular formula: C35H23N3. Mole weight: 485.58 g/mol. Product ID: ACM1583238167. Alfa Chemistry ISO 9001:2015 Certified. Categories: Cppcheck.
CPS-11
CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB , activates NFAT , and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-(Hydroxymethyl)thalidomide. CAS No. 145945-21-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-117987.
CPS2
CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader ( IC 50 = 24 nM). CPS2 can be used for the research of acute myeloid leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756741-90-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141680.
CPS2
CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50 = 24 nM) for the study of acute myeloid leukemia. Synonyms: 4-((5-amino-1-(3-methylthiophene-2-carbonyl)-1H-1,2,4-triazol-3-yl)amino)-N-(2-((1-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzenesulfonamide; CDK2 degrader CPS2; Benzenesulfonamide, 4-[[5-amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]-; 4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]benzenesulfonamide. Grade: ≥95%. CAS No. 2756741-90-7. Molecular formula: C38H42N12O10S2. Mole weight: 890.94.
CPT 11
CPT 11. Group: Biochemicals. Grades: Purified. CAS No. 100286-90-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Cpth2
CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B). Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 357649-93-5. Molecular formula: C14H14ClN3S. Mole weight: 291.8. Purity: ≥98%. Product ID: ACM357649935. Alfa Chemistry ISO 9001:2015 Certified. Categories: CYTH2.
CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 357649-93-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W013274.
CPTH2
CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating Gcn5p network in vitro and in vivo. HAT is an enzyme playing an important role in histone acetylation and multiple cancer development. Uses: Antitumor agent. Synonyms: CPTH2; CPTH 2; CPTH-2; Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone. Grade: 99%. CAS No. 357649-93-5. Molecular formula: C14H14ClN3S. Mole weight: 291.8.
CPTH2
CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo. Group: Biochemicals. Alternative Names: 2-[4-(4-Chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone; 4- (4-Chlorophenyl) -2 (3H) -thiazolone-cyclopentylidene hydrazone. Grades: Highly Purified. CAS No. 357649-93-5. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
CPTH2 hydrochloride
Gcn5 is a chromatin modifying factor that has HAT activity to acetylate histone H3 lysine 9 (K9) and K14. CPTH2 inhibits the HAT activity of Gcn5. It is used to study the influence of Gcn5-dependent acetylation in various biological systems. Synonyms: 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone monohydrochloride. Grade: ≥95%. CAS No. 2108899-91-6. Molecular formula: C14H14ClN3S·HCl. Mole weight: 328.3.
CPTH6 hydrobromide
CPTH6 is a thiazole derivative structurally and it can inhibit the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP. Synonyms: 3-methyl-2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone cyclopentanone hydrobromide. Grade: ≥98%. CAS No. 2321332-57-2. Molecular formula: C15H16ClN3S·HBr. Mole weight: 386.7.
Cp-thionin II
Cp-thionin II is a novel gamma-thionin from cowpea seeds (Vigna unguiculata) with bactericidal activity against Gram-positive and Gram-negative bacteria.
CPUY074020
CPUY074020 is a potent and orally bioavailable histone methyltransferase G9a inhibitor (IC50 = 2.18 μM), with anti-proliferative activity. Synonyms: 3-(1-Piperidyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-6H-anthra[1,9-cd]isoxazol-6-one; 6H-Anthra[1,9-cd]isoxazol-6-one, 3-(1-piperidinyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-; 3-piperidin-1-yl-5-[(2-pyrrolidin-1-ylethyl)amino]-6H-anthra[1,9-cd]isoxazol-6-one. Grade: ≥95%. CAS No. 902279-44-1. Molecular formula: C25H28N4O2. Mole weight: 416.52.
CPUY192018
CPUY192018 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, with an IC50 of 0.63 μM. CPUY192018 exhibits anti-inflammatory and antioxidant activities. CPUY192018 can activate the Nrf2-dependent antioxidant pathway and inhibit the NF-?B-related inflammatory response. CPUY192018 can be used in the research of inflammation-related diseases[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1567836-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120371.
CPUY201112
CPUY201112 is an N-terminal Hsp90 inhibitor, which leads to decreased expression of Hsp90 client proteins and may result in increased tumor cell apoptosis. Synonyms: CPUY201112; CPUY 201112; CPUY-201112. Grade: >98%. CAS No. 1860793-58-3. Molecular formula: C19H23N3O4. Mole weight: 357.41.
CPVC
CPVC. Group: Polymers. CAS No. 68648-82-8.
CPVC Resin
CPVC Resin. Group: Polymers.
CPYPP
CPYPP has been found to be a DOCK2-Rac1 interaction inhibitor and could probably attenuate HER2-mediated breast cancer cell migration. Synonyms: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione. Grade: ≥98% by HPLC. CAS No. 310460-39-0. Molecular formula: C18H13ClN2O2. Mole weight: 324.76.
CPYPP
CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 μM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 310460-39-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110100.
CPZEN-45
CPZEN-45 exhibits potent antibacterial activity against several DS, as well as MDR and XDR strains of Mtb in murine models and exhibits synergistic effects with other TB drugs. Synonyms: Caprezene-4-butylanilide; (2S)-2-[(S)-[(2S,3R,4S,5R)-5-(aminomethyl)-3,4-dihydroxy-tetrahydrofuran-2-yl]oxy-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl]-N-(4-butylphenyl)-1,4-dimethyl-3-oxo-2,7-dihydro-1,4-diazepine-5-carboxamide. Molecular formula: C32H44N6O11. Mole weight: 688.72.
CR-1-31-B
CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B perturbs association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1352914-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-136453.
CR-1-31-B
CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B exhibits powerful inhibitory effects over eIF4A by perturbing the interaction between eIF4A and RNA, sequentially impeding initiation during protein synthesis. CR-1-31-B induces apoptosis of neuroblastoma and gallbladder cancer cells. Synonyms: CR-1-31-B; 1352914-52-3; CHEMBL2058177; (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide; CR-1-31B; BDBM50388144; AKOS040756670; MS-29423; HY-136453; CS-0129555. Grade: 98%. CAS No. 1352914-52-3. Molecular formula: C28H29NO8. Mole weight: 507.53.
Cr2AlC MAX phase ceramic material
Cr2AlC MAX phase ceramic material. Uses: Max special ceramics, mxene precursors, high-temperature coating materials, conductive self-lubricating materials, electronic materials, high-temperature structural materials, chemical anti-corrosion materials, and high-temperature heating materials. Group: Mxenes materials. ≥99%.
Cr2O3 (60 nm)
Cr2O3 (60 nm). Group: Oxides nanoparticles. >99%.
Cr2TiAlC3 MAX phase material
Excellent Mxene precursor can be processed by HF or HCl+LiF to obtain MXene. Uses: Energy storage, catalysis, analytical chemistry, mechanics, adsorption, biology, microelectronics, sensors, etc. Group: Mxenes materials. 0.99.
CR4056
CR4056 is an imidazoneuline I2 receptor ligand potentially for treatment of neuropathic pain. CR4056 is a selective inhibitor of MAO-A with IC50 of 202.7 nM. Synonyms: CR-4056; 6-(1H-imidazol-1-yl)-2-phenylquinazoline; 2-Phenyl-6-(1H-imidazol-1-yl)quinazoline. CAS No. 1004997-71-0. Molecular formula: C17H12N4. Mole weight: 272.30.
CR8
CR8 is a potent and selective inhibitor of CDK. CR8 is a more potent pyridyl analogue of roscovitine. In comparison to roscovirtine, the compound gains in potency toward CK1, which is involved in amyloid-β formation. The R-CR8 enantiomer is slightly more potent than S. CR8 is around 30 times more potent at cellular assay then roscovitine. (R)?-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K. Synonyms: (R)-CR8; CR 8; CR-8. Grade: 98%. CAS No. 294646-77-8. Molecular formula: C24H29N7O. Mole weight: 431.544.
CRA-026440 is a potent and broad-spectrum inhibitor of HDAC with Kis of 4, 14, 11, 15, 7 and 20 nM against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10, respectively. Synonyms: 1H-Indole-2-carboxamide, 5-[2-(dimethylamino)ethoxy]-N-[3-[4-[(hydroxyamino)carbonyl]phenyl]-2-propyn-1-yl]-; 5-[2-(Dimethylamino)ethoxy]-N-{3-[4-(hydroxycarbamoyl)phenyl]-2-propyn-1-yl}-1H-indole-2-carboxamide. Grade: ≥95%. CAS No. 847460-34-8. Molecular formula: C23H24N4O4. Mole weight: 420.46.
CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7
The CRAC Channel Inhibitor, BTP2, also referenced under CAS 223499-30-7, controls the biological activity of CRAC Channel. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Group: Fluorescence/luminescence spectroscopy.
CRAC Channel Inhibitor III, Pyr6 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide)
A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46uM; by Fura-2). A great complement to Pyr2, Pyr3, and Pyr10 in Ca2+ signaling studies. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?F?N?O, Primary Target: Orai3. US Biological Life Sciences.
Worldwide
CRAC inhibitor 44
CRAC inhibitor 44 is a potent and selective CRAC ion channel inhibitor suppressing CRAC ion channel activity and the production of IL-2, IL-4, IL-5, IL-13, GM-CSF, TNF-α, and IFNγ. Grade: 99%. CAS No. 944917-72-0. Molecular formula: C22H19F2N3OS. Mole weight: 411.47.
CRAC intermediate 1
A significant intermediate in the production of sorts of CRAC channel inhibitors. Uses: A significant intermediate in the production of sorts of crac channel inhibitors. Synonyms: CRAC intermediate 1; SCHEMBL706559; UMBVHXNGQIFPCN-UHFFFAOYSA-N; AKOS010652441; CS-3896; CS 3896; CS3896. Grade: 98%. CAS No. 1249343-86-9. Molecular formula: C10H7F2N3O. Mole weight: 223.18.
Cr-ACP1
Cr-ACP1 is an antibacterial peptide isolated from Cycas revoluta. It has activity against gram-positive bacteria, gram-negative bacteria and cancer. Synonyms: Ala-Trp-Lys-Leu-Phe-Asp-Asp-Gly-Val. Grade: 96.7%. Molecular formula: C50H71N11O14. Mole weight: 1050.18.
c-Raf Inhibitor
The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Group: Fluorescence/luminescence spectroscopy.
CRAMP-18 (mouse)
CRAMP-18 (mouse) corresponds to the functional region of the antimicrobial peptide CRAMP and has strong antibacterial activity against a variety of bacteria, with no hemolytic activity (MIC = 12.5-50 μM). Synonyms: H-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-OH; glycyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-lysyl-L-lysyl-L-isoleucyl-glycyl-L-glutaminyl-L-lysyl-L-isoleucyl-L-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-lysyl-L-leucine. Grade: 95%. CAS No. 256639-17-5. Molecular formula: C101H171N27O24. Mole weight: 2147.64.
CRAMP (mouse)
This cathelicidin-related antimicrobial peptide (CRAMP) is the sole murine cathelicidin. CRAMP expression in the intestinal tract is restricted to surface epithelial cells in the colon. CRAMP shows antimicrobial activity against the murine enteric pathogen Citrobacter rodentium and destroys skin Candida albicans. Synonyms: H-Gly-Leu-Leu-Arg-Lys-Gly-Gly-Glu-Lys-Ile-Gly-Glu-Lys-Leu-Lys-Lys-Ile-Gly-Gln-Lys-Ile-Lys-Asn-Phe-Phe-Gln-Lys-Leu-Val-Pro-Gln-Pro-Glu-Gln-OH; CRAMP, mouse; CRAMP (mouse) (TFA salt). Grade: ≥95%. CAS No. 376364-36-2. Molecular formula: C178H302N50O46. Mole weight: 3878.60.
CRAMP (mouse)
CRAMP (mouse) is an antimicrobial peptide. CRAMP (mouse) can be used for the research of biofilm-associated infections [1]. Uses: Scientific research. Group: Peptides. CAS No. 376364-36-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4855.
CRANAD 2
Near-infrared probe that binds to A β40 aggregates (Kd = 38nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier. Group: Biochemicals. Alternative Names: (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron. Grades: Purified. CAS No. 1193447-34-5. Pack Sizes: 10mg. Molecular Formula: C23H25BF2N2O2, Molecular Weight: 410.26. US Biological Life Sciences.