A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Corosolic acid. Group: Biochemicals. Alternative Names: 2alpha-Hydroxyursolic acid. Grades: Plant Grade. CAS No. 4547-24-4. Pack Sizes: 20mg. Molecular Formula: C30H48O4, Molecular Weight: 472.7. US Biological Life Sciences.
Worldwide
Corosolic acid
Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Colosolic acid. CAS No. 4547-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0280.
Corosolic acid
Corosolic acid, that is isolated from the barks of Lagerstroemia speciosa, contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts its anticancer activity against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin. Besides, Corosolic acid induced apoptosis in colorectal cancer (CRC), rendering this compound a potential anticancer agent for the treatment of CRC. Corosolic acid, as a new plant medicine for preventing and treating obesity and type II diabetes, and a functional natural health food and pharmaceutical raw material, has become a popular product in the market. Uses: Anti-angiogenic/anticancer. Synonyms: 2-A-HYDROXYURSOLIC ACID; 2ALPHA-HYDROXYURSOLIC ACID; 2,3-DIHYDROXYURS-12-EN-28-OIC ACID; HYDROXYURSOLIC ACID; COROSOLIC ACID; Corsolicacid; Corosolic; (2a,3b)-2,3-Dihydroxy-urs-12-en-28-oic acid. Grade: >98%. CAS No. 4547-24-4. Molecular formula: C30H48O4. Mole weight: 472.7.
Corps Racine. CAS No. 2110-18-1. FEMA No. 3751. VIGON Item # 503981. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, cortex pyridine.
America & Internationally
Corps Racine 1% in TEC
Corps Racine 1% in TEC. CAS No. MIXTURE. Kosher: Y. VIGON Item # 504051. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers, Cortex Pyridine.
America & Internationally
Cort108297
Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1018679-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15710.
Cortagen
Cortagen, a bioregulatory peptide, acts primarily on the brain and central nervous system to help restore balance and normal function between pro-oxidation and antioxidant processes. Cortagen is a protective and anti-aging peptide. It helps restore DNA to a more youthful state, thereby reducing aging and increasing the expression of certain genes that are silenced by age. Synonyms: L-Proline, L-alanyl-L-α-glutamyl-L-α-aspartyl-; L-Alanyl-L-α-glutamyl-L-α-aspartyl-L-proline; H-Ala-Glu-Asp-Pro-OH; H-AEDP-OH; AEDP; L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-proline; L-alanyl-L-glutamyl-L-aspartyl-L-proline. Grade: ≥95%. CAS No. 335591-03-2. Molecular formula: C17H26N4O9. Mole weight: 430.41.
Cortagine
Cortagine is a selective and potent corticotrophin releasing factor receptor 1 (CRF1) agonist with EC50 value of 0.18 nM for rat CRF1. It shows antidepressant and anxiolytic activity in the mouse model. Synonyms: cortagine; DC41887. Molecular formula: C192H323N55O63S. Mole weight: 4442.06.
Cortexolone 17 alpha-propionate
Cortexolone 17 alpha-propionate, also called as CB-03-01, belonging to the family of ester derivatives of cortexolone, is a potent and topical and peripherally selective steroid antagonist of androgen. Synonyms: CB-03-01; CB 03-01; CB03-01; [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoateCB-03-01cortexolone 17alpha-propionate. CAS No. 19608-29-8. Molecular formula: C24H34O5. Mole weight: 402.52.
Cortex Phellodendri Extract
Cortex Phellodendri Extract. CAS No. 751-03-1. Purity: 5:1-20:1. Product ID: CI-NAT-751031. Alfa Chemistry - ISO 9001:32057 Certified.
Corticatic acid c(9ci)
Corticatic acid c(9ci). CAS No. 160337-75-7. Product ID: ACM160337757. Molecular formula: C31H44O3. Alfa Chemistry - ISO 9001:32057 Certified.
Corticostatin 1
Corticostatin 1 is from Oryctolagus cuniculus. It has microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production. Synonyms: Antiadrenocorticotropin peptide I.
Corticostatin-3 precursor
Corticostatin-3 precursor is isolated from Oryctolagus cuniculus. It has antibacterial, antifungal and antiviral activities.
Corticostatin-4 precursor
Corticostatin-4 precursor is isolated from Oryctolagus cuniculus. It has antifungal and antiviral activities.
Corticostatin-6
Corticostatin-6 is from Oryctolagus cuniculus. It has microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production.
Corticostatin-related peptide LCRP
Corticostatin-related peptide LCRP is isolated from Petromyzon marinus. It may inhibit corticotropin (ACTH) stimulated steroidogenesis and the microbial actions of the corticostatins.
Corticostatin-related peptide RK-1
Corticostatin-related peptide RK-1 is isolated from Oryctolagus cuniculus. It has antimicrobial activity against E.coli and activates ion channel activity.
corticosteroid side-chain-isomerase
An epimerization at C-20 and C-21 is probably catalysed by the same enzyme. Group: Enzymes. Enzyme Commission Number: EC 5.3.1.21. CAS No. 75139-73-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5460; corticosteroid side-chain-isomerase; EC 5.3.1.21; 75139-73-0. Cat No: EXWM-5460.
Corticosterone
Extract from the adrenal cortex, is a sensitive inhibitor of monoamine transport. Uses: A sensitive inhibitor of monoamine transport. Synonyms: Corticosterone; BRN 2339601; BRN-233960; BRN233960; CCRIS 6753; CCRIS-6753; CCRIS6753; NSC 9705; NSC-9705; NSC9705; (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one. Grade: ≥98%. CAS No. 50-22-6. Molecular formula: C21H30O4. Mole weight: 346.46.
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B. CAS No. 50-22-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1618.
Corticosterone
500mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C21H30O4. CAS No. 50-22-6. Prepack ID 18552197-500mg. Molecular Weight 346.46. See USA prepack pricing.
corticosterone 18-monooxygenase
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation o one atom of oxygen into the other donor. The systematic name of this enzyme class is corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating). Other names in common use include corticosterone 18-hydroxylase, and corticosterone methyl oxidase. This enzyme participates in c21-steroid hormone metabolism. Group: Enzymes. Synonyms: corticosterone 18-hydroxylase; corticosterone methyl oxidase. Enzyme Commission Number: EC 1.14.15.5. CAS No. 37256-75-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0948; corticosterone 18-monooxygenase; EC 1.14.15.5; 37256-75-0; corticosterone 18-hydroxylase; corticosterone methyl oxidase. Cat No: EXWM-0948.
Corticosterone 21-Acetate
Corticosterone derivative. An intermediate in the biosynthesis of aldosterone, isolated from the adrenal cortex. Group: Biochemicals. Alternative Names: Cort A; NSC 81764; SKF 5654; (11 β)-21-(Acetyloxy)-11-hydroxy-pregn-4-ene-3,20-dione. Grades: Highly Purified. CAS No. 1173-26-8. Pack Sizes: 50mg. US Biological Life Sciences.
Corticosterone-d8 is a labelled Corticosterone. Synonyms: corticosterone 2,2,4,6,6,17A,21,21-D8. Grade: 98% by CP; 98% atom D. CAS No. 1271728-07-4. Molecular formula: C21H22D8O4. Mole weight: 354.51.
Corticosterone-d8
Corticosterone-d8 is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. Uses: Scientific research. Category: Signaling pathways. CAS No. 1271728-07-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B1618S.
Corticosterone impurity 1
Corticosterone impurity 1. Uses: For analytical and research use. CAS No. 20287-97-2. Molecular formula: C21H28O4. Mole weight: 344.45. Catalog: APB20287972.
Corticosterone impurity 2
Corticosterone impurity 2. Uses: For analytical and research use. CAS No. 2394-25-4. Molecular formula: C20H28O4. Mole weight: 332.44. Catalog: APB2394254.
Corticosterone (Standard)
Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard). CAS No. 50-22-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1618R.
Corticotropin-releasing factor
Corticotropin-Releasing Factor (CRF) is a neuropeptide of utmost significance is assumes a pivotal role in the intricate regulation of the physiological stress response. Synonyms: ACTH-releasing factor; ACTH-releasing hormone; Corticoliberin; Corticotropin-releasing activity; Corticotropin-releasing hormone; CRF; CRF (hormone). Grade: 95%. CAS No. 9015-71-8.
Corticotropin Releasing Factor Antagonist
Corticotropin Releasing Factor Antagonist is a groundbreaking biomedical compound, meticulously aiming to modulate the intricacies of the enigmatic Corticotropin Releasing Factor (CRF) system. Synonyms: alpha-Helical CRF (9-41); Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2; α-Helical corticotropin releasing factor fragment (9-41). Grade: ≥97% by HPLC. CAS No. 99658-03-4. Molecular formula: C166H274N46O53S2. Mole weight: 3826.36.
Corticotropin-releasing factor (human)
Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Human CRF; Human corticotropin-releasing factor. CAS No. 86784-80-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0086.
It is produced by the strain of Cortinarius speciosissimus, C. orellanus and C. orellanoides. It is a peptide antibiotic with vasoconstriction and renal toxicity. CAS No. 88025-84-7. Molecular formula: C58H87N13O12S. Mole weight: 1190.45.
Cortinarin B
It is produced by the strain of Cortinarius speciosissimus, C. orellanus and C. orellanoides. It is a peptide antibiotic with vasoconstriction and renal toxicity. CAS No. 89286-74-8. Molecular formula: C57H85N13O12S. Mole weight: 1176.43.
Cortinarin C
It is produced by the strain of Cortinarius speciosissimus, C. orellanus and C. orellanoides. It is a peptide antibiotic. CAS No. 88025-85-8. Molecular formula: C15H17N3O3. Mole weight: 287.31.
Cortisol 21-Benzoate
Protected Cortisol. Group: Biochemicals. Alternative Names: (11 β)-21-(Benzoyloxy)-11,17-dihydroxy-pregn-4-ene-3,20-dione; 21-Benzoyl Cortisol. Grades: Highly Purified. CAS No. 74669-84-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Cortisol 21-sulfate
Cortisol 21-sulfate. CAS No. 1253-43-6. Product ID: ACM1253436. Alfa Chemistry - ISO 9001:32057 Certified.
Cortisol-[9,11,12,12-d4]
Cortisol-[9,11,12,12-d4], is the labelled analogue of Cortisol. Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone. Synonyms: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-D4; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4); 17-Hydroxycorticosterone-9,11,12,12-d4; 17-Hydroxycorticosterone-D4; 4-Pregnene-11β,17α,21-triol-3,20-dione-D4; 4-Pregnene-11β,17α,21-triol-3,20-dione-d4 (9,11,12,12-d4); Kendall's compound F (9,11,12,12-d4); Hydrocortisone-9,11,12,12-d4. Grade: 95% by HPLC; 98% atom D. CAS No. 73565-87-4. Molecular formula: C21H26D4O5. Mole weight: 366.48.
Cortisol-[9,12,12-d3]
Cortisol-[9,12,12-d3] is the labelled analogue of Cortisol. Cortisol is a steroid hormone, in the glucocorticoid class of hormones. When used as a medication, it is known as hydrocortisone. Synonyms: Cortisol-9,12,12-D3; (11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione-d3; Cortisol-d3; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione-d3; 17α-Hydroxycorticosterone-d3; NSC 10483-d3; Hydrocortisone-d3; Acticort-d3; Cetacort-d3; Hydrasson-d3; Hydrocortisyl-d3. Grade: 98%; 98% atom D. CAS No. 115699-92-8. Molecular formula: C21H27D3O5. Mole weight: 365.48.
Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism. Group: Molecular Biology. Alternative Names: (11 β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione; Cortisol; 11 β,17,21-Trihydroxypregn-4-ene-3,20-dione; 17-Hydroxycorticosterone; 17α-Hydroxycorticosterone; NSC 10483. Grades: Highly Purified. CAS No. 50-23-7. US Biological Life Sciences.
Worldwide
cortisol O-acetyltransferase
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. Group: Enzymes. Synonyms: cortisol acetyltransferase; corticosteroid acetyltransferase; corticosteroid-21-O-acetyltransferase. Enzyme Commission Number: EC 2.3.1.27. CAS No. 9076-48-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2204; cortisol O-acetyltransferase; EC 2.3.1.27; 9076-48-6; cortisol acetyltransferase; corticosteroid acetyltransferase; corticosteroid-21-O-acetyltransferase. Cat No: EXWM-2204.
Cortisol sulfate sodium
Cortisol sulfate sodium (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate sodium is a specific ligand for intracellular transcortin[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cortisol 21-sulfate sodium. CAS No. 1852-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N8460A.
cortisol sulfotransferase
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. Group: Enzymes. Synonyms: glucocorticosteroid sulfotransferase; glucocorticoid sulfotransferase. Enzyme Commission Number: EC 2.8.2.18. CAS No. 59782-20-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3376; cortisol sulfotransferase; EC 2.8.2.18; 59782-20-6; glucocorticosteroid sulfotransferase; glucocorticoid sulfotransferase. Cat No: EXWM-3376.
Cortisone
Glucocorticoid, anti-inflammatory agent. Group: Biochemicals. Alternative Names: 17,21-Dihydroxy-pregn-4-ene-3,11,20-trione; 17-Hydroxy-11-dehydrocorticosterone; 11-Dehydro-17-hydroxycorticosterone; Adrenalex; Compound E; Cortisate; Cortivite; Cortogen; Cortone; NSC 9703. Grades: Highly Purified. CAS No. 53-06-5. Pack Sizes: 5g. US Biological Life Sciences.
Worldwide
Cortisone
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E. CAS No. 53-06-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-17461.
Cortisone acetate
Cortisone acetate (Cortone) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid. It can be used for various inflammations, allergic diseases, bovine ketonemia, sheep pregnancy toxemia, etc. Uses: Anti-inflammatory agents. Synonyms: NSC 49420; NSC49420; NSC-49420. Grade: >98%. CAS No. 50-04-4. Molecular formula: C23H30O6. Mole weight: 402.48.
Cortisone Acetate
Cortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone. Group: Biochemicals. Alternative Names: 17,21-Dihydroxypregn-4-ene-3,11,20-trione 21 acetate; Cortone 21-Acetate; 21-Acetoxy-17α-hydroxy-3,11,20-triketopregnene-4; Cortone Acetate; 21-Acetoxy-17α-hydroxypregn-4-ene-3,11,20-trione; Irisone acetate; NSC 49420; 4-Pregnene-17a,21-diol-3,11,20-trione 21-Acetate; Adreson; Artriona; Biocort Acetate; Compound E Acetate; Corlin; Cortadren; Cortelan; Cortistab; Cortisyl; Cortisyl Artriona; Incortin; Ricortex; Scheroson. Grades: Highly Purified. CAS No. 50-04-4. Pack Sizes: 10g. US Biological Life Sciences.
Worldwide
Cortisone Acetate
Cortisone acetate (17-hydroxy-11-dehydrocorticosterone), a 21-carbon steroid hormone, is one of the main hormones released by the adrenal gland in response to stress. Category: Active pharmaceutical ingredients. CAS No. 50-04-4. Product ID: API50044. Molecular formula: C23H30O6. Mole weight: 402.481. Appearance: Powder.
Cortisone-d2 is a labelled Cortisone. Cortisone is a natural glucocorticoid used as an anti-inflammatory drug. Synonyms: 4-Pregnen-17α,21-diol-3,11,20-trione-1,2-d2. Grade: > 95%. Molecular formula: C21H26O5D2. Mole weight: 362.46.
Cortisone (Standard)
Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Hydroxy-11-dehydrocorticosterone(Standard); Kendall's compound E (Standard). CAS No. 53-06-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-17461R.
cortisone sulfate
cortisone sulfate. CAS No. 912-25-4. Product ID: ACM912254. Alfa Chemistry - ISO 9001:32057 Certified.
Cortistatin 14
Cortistatin 14. Group: Biochemicals. Grades: Purified. CAS No. 193829-96-8. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Cortistatin-14
Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 186901-48-4. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P1932.
Cortistatin 14, human, rat acetate
Cortistatin 14 is an endogenous neuropeptide similar to somatostatin-14 in structure and function. It is mainly expressed in the cortex and hippocampus. It shows potency at all somatostatin receptors, but prevents somatostatin-14 binding. It binds to the growth hormone secretagog receptor (GHS-R1a). It displays sleep-modulating and neuronal depressant properties in vivo. Synonyms: CST-14, human, rat acetate. Molecular formula: C83H117N19O21S2. Mole weight: 1781.1.
Cortistatin 14 (mouse, rat)
Cortistatin-14 is an endogenous neuropeptide expressed in the cortex and hippocampus. Synonyms: Cortistatin-14; H-PRO-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-SER-SER-CYS-LYS-OH; CST-14; CST-14 (RAT). Grade: 98%. CAS No. 186901-48-4. Molecular formula: C81H113N19O19S2. Mole weight: 1721.01.
Cortistatin 14 (mouse, rat)
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CST-14 (mouse, rat). CAS No. 193829-96-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1212.
Cortistatin-14 trifluoroacetate salt
Cortistatin-14 (TFA) is a neuropeptide which is structural similar to somatostatin-14 and it binds and exerts its function via the somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) shows anticonvulsive, neuroprotective effect and remarkable anti-inflammatory properties. Cortistatin-14 is an endogenous neuropeptide agonist of somatostatin receptors (IC50s = 0.5-18.2 nM for human SST1-SST5 receptors expressed in CCL39 cells). Grade: ≥95%. Molecular formula: C81H113N19O19S2·xCF3COOH. Mole weight: 1721.01.
Cortistatin-17 (human)
Cortistatin-17, a structural analogue of somatostatin, binds to all somatostatin receptor subtypes (SSTR) in a manner similar to rat cortistatin. Its inhibition on the cAMP production of forskolin-stimulated in chinese hamster ovary cells expressing SSTR2-5 are dose-dependent, but slightly less efficient than somatostatin-14. Like rat cortistatin, it affects sleep and wake patterns in rats. It reduces light slow wave sleep (SWS1) and increases deep slow wave sleep (SWS2) in a dose-dependent manner. Administration of the peptide causes a temporary flattening of cortical and hippocampal electroencephalograms. Synonyms: H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bridge: Cys5-Cys16); L-alpha-aspartyl-L-arginyl-L-methionyl-L-prolyl-D-cysteinyl-D-arginyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-D-phenylalanyl-D-seryl-L-seryl-L-cysteinyl-L-lysine (5->16)-disulfide; L-α-Aspartyl-L-arginyl-L-methionyl-N-[(4R,7S,10R,13R,16S,19S,22R,25S,28S,31S,34R. Grade: 95%. CAS No. 189450-19-9. Molecular formula: C96H139N27O24S3. Mole weight: 2151.53.
Cortistatin-17 (human)
Cortistatin-17 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189450-19-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5011.
Cortistatin 29 (1-13)
Neuropeptide with neuronal depressant and sleep-modulating properties. Synonyms: Glp-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp. Molecular formula: C68H107N24O21. Mole weight: 1596.80.
Cortistatin-29 (human)
Cortistatin-29 (human), an anti-inflammatory and immunomodulatory factor, has potential multistep therapeutic effects in the treatment of septic shock and Crohn's disease. Synonyms: Pyr-Glu-Gly-Ala-Pro-Pro-Gln-Gln-Ser-Ala-Arg-Arg-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bridge: Cys17-Cys28); L-Lysine, 5-oxo-L-prolyl-L-α-glutamylglycyl-L-alanyl-L-prolyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-seryl-L-alanyl-L-arginyl-L-arginyl-L-α-aspartyl-L-arginyl-L-methionyl-L-prolyl-L-cysteinyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-, cyclic (17→28)-disulfide; CST (human). Grade: ≥95%. CAS No. 1815618-16-6. Molecular formula: C149H223N47O42S3. Mole weight: 3440.86.
Cortistatin-29 (rat)
Cortistatin-29 is a neuropeptide that has structurally similarity to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Synonyms: Pyr-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH (Disulfide bridge: Cys17-Cys28); 5-oxo-L-prolyl-L-α-glutamyl-L-arginyl-L-prolyl-L-prolyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-prolyl-L-histidyl-L-arginyl-L-α-aspartyl-L-lysyl-L-lysyl-L-prolyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-seryl-L-seryl-L-cysteinyl-L-lysine, cyclic (17→28)-disulfide; L-pyroglutamyl-L-alpha-glutamyl-L-arginyl-L-prolyl-L-prolyl-L-leucyl-L-glutaminyl-L-glutaminyl-L-prolyl-L-prolyl-L-histidyl-L-arginyl-L-alpha-aspartyl-L-lysyl-L-lysyl-L-prolyl-D-cysteinyl-D-lysyl-L-asparagyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-D-phenylalanyl-D-seryl-L-seryl-L-cysteinyl-L-lysine (17->28)-disulfide. Grade: ≥95%. CAS No. 1815618-17-7. Molecular formula: C161H240N46O41S2. Mole weight: 3540.05.
Cortistatin-8
Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PCFWKTCK. CAS No. 485803-62-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1139.