A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Canthin-6-one, coming from the barks of Ailanthus altissima, is antiproliferative, possibly by interfering with the G2/M transition. Proapoptotic effects might result from this disturbance of the cell cycle. Uses: Antiproliferative / antimicrobial / antiinflammatory. Alternative Names: 6H-Indolo(3,2,1-de)(1,5)naphthyridin-6-one. Grades: >98%. CAS No. 479-43-6. Molecular formula: C14H8N2O. Mole weight: 220.2.
Canthin-6-one
Canthin-6-one is an indole alkaloid, displays antibacterial and anti-inflammatory activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 479-43-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N3536.
Cantrixil
Cantrixil (TRX-E-002-1), an active enantiomer of TRX-E-002, is a second-generation super-benzopyran (SBP) compound. Cantrixil increases phosphorylated c-Jun levels resulting in caspase-mediated apoptosis in ovarian cancer cells. Cantrixil has potent pan anti-cancer activity against a broad range of cancer phenotypes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TRX-E-002-1. CAS No. 2135511-22-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-114250.
Cantuzumab is a monoclonal antibody that can binds the CanAg antigen. Cantuzumab is typically linked to one of several cytotoxic agents, yielding antibody-drug conjugates (ADC), such as Cantuzumab mertansine (HY-P99492) and Cantuzumab ravtansine (HY-P99493)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1204740-23-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99967.
Canvuparatide
Canvuparatide (MBX 2109) is a prodrug for parathyroid hormone (PTH) peptide that releases the bioactive PTH[1-32] peptide agonist that retains a fatty acylated lysine (Lys33) at the C-terminus, thereby extending the halflife of Canvuparatide. Canvuparatide can be used for the symptoms of hypoparathyroidism such as hypocalcemia and hyperphosphatemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MBX 2109. CAS No. 2925554-87-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10909.
Cap1 EGFP mRNA coated with Lipid Nanoparticles
Augment your research on DNA/RNA Delivery with the reliable Cap1 EGFP mRNA coated with Lipid Nanoparticles from CD Bioparticles Drug Delivery. Group: Mrna lipid nanoparticles.
Cap1 Fluc mRNA coated with Lipid Nanoparticles
Augment your research on DNA/RNA Delivery with the reliable Cap1 Fluc mRNA coated with Lipid Nanoparticles from CD Bioparticles Drug Delivery. Group: Mrna lipid nanoparticles.
CAP43, Inhibitor Peptide
Synthetic peptide derived from the C-terminus of CAP43 intended for use as an inhibitor of antibody binding to help distinguish between specific and non-specific binding of the corresponding antibody. Typically, inhibitor and primary antibody are mixed in a blocking buffer (e.g. PBS, pH 7.4, containing 3% non-fat dry milk or 0.1% BSA and 0.1-2% Tween 20) and pre-incubated for 5-10 min. prior to use. Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences.
Worldwide
c-(Ap-8-AET-Gp)
c-(Ap-8-AET-Gp) is an analogue of messenger c-(ApGp), the bacterial second, which is used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. c-(ApGp) plays a role in Vibrio choleraepathogenesis and activates the production of interferon via STING. Alternative Names: Cyclic (adenosine monophosphate- 8- (2- aminoethylthio)guanosine monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C22H29N11O13P2S (free acid). Mole weight: 749.6 (free acid).
c-(Ap-8-AET-Gp)-Agarose
c-(Ap-8-AET-Gp)-Agarose is the bacterial second messenger c-(ApGp) immobilized on agarose by an aminoethylthio spacer, which possibly can be used in affinity chromatography of c-(ApGp)-responsive proteins. Alternative Names: Cyclic (adenosine monophosphate- 8- (2- aminoethylthio)guanosine monophosphate), immobilized on agarose gel.
c-(Ap-8-Biotin-11-Gp)
c-(Ap-8-Biotin-11-Gp) is an analogue of the cyclic dinucleotide c-(ApGp). It is a potential tracer in immunoassays and commonly used for affinity chromatography and pull-down assays. Grades: ≥ 95% by HPLC. Molecular formula: C38H54N14O16P2S2 (free acid). Mole weight: 1089 (free acid).
c-(Ap-8-Br-Gp)
c-(Ap-8-Br-Gp) is an analogue of c-(ApGp), the potential bacterial second messenger, which is used for binding studies and as precursor for further modifications with spacers or labels. c-(ApGp) plays a role in Vibrio choleraepathogenesis and activates the production of interferon via STING. Alternative Names: Cyclic (adenosine monophosphate- 8- bromoguanosine monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H23BrN10O13P2 (free acid). Mole weight: 753.3 (free acid).
c-(Ap-8-Fluo-AET-Gp)
c-(Ap-8-Fluo-AET-Gp) is a fluorescent analogue of c-(ApGp), which can participate in Vibrio choleraepathogenesis and stimulate the production of interferon. Alternative Names: Cyclic(adenosine monophosphate-8-(2-[fluoresceinyl]aminoethylthio)guanosine monophosphate), sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C43H39N11O19P2S (free acid). Mole weight: 1107.9 (free acid).
Capacitor Grade Tantalum Wire
Capacitor Grade Tantalum Wire. Alternative Names: Capacitor Grade Tantalum Wire, Capacitor Grade Ta Wire.
Capan-1 Transfection Reagent
Transfection Reagent for Capan1 Pancreatic Carcinoma Cells. Optimized transfection protocol provided for transfection of siRNA, DNA, mRNA, and microRNA. Transfection Reagents. Transfection Enhancer. Complex Condenser. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 6413.
Nevada, Texas, USA
Capastat sulfate
Capastat sulfate. Group: Biochemicals. Grades: Highly Purified. CAS No. 1405-37-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C24H42N14O8·H2O4S. US Biological Life Sciences.
Worldwide
Capastat sulfate (Capreomycin sulfate)
1g Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C24H42N14O8 ·H2O4S. CAS No. 1405-37-4. Prepack ID 27428602-1g. Molecular Weight 752.76. See USA prepack pricing.
Cape Aloe Powder (Aloe Ferox)
Cape Aloe Powder (Aloe Ferox).
CA, FL & NJ
Capecitabine
Capecitabine is a tumor-selective fluoropyrimidine carbamate, which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU. Capecitabine treatment of HCT-15 cells causes condensation of DNA and induces apoptosis. Group: Inhibitors. Alternative Names: RO 09-1978. CAS No. 154361-50-9. Pack Sizes: 200mg. Product ID: S1156. Formula: C15H22FN3O6. Smiles: CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Capecitabine
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C15H22FN3O6. CAS No. 154361-50-9. Prepack ID 50910414-1g. Molecular Weight 359.35. See USA prepack pricing.
Capecitabine
Capecitabine. Group: Biochemicals. Grades: Purified. CAS No. 154361-50-9. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Capecitabine
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase. Uses: Scientific research. Category: Signaling pathways. CAS No. 154361-50-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0016.
Capecitabine
Capecitabine inhibits tumor growth and metastatic recurrence after resection of human hepatocellular carcinoma (HCC) in highly metastatic nude mice model. It is a chemotherapy medication used to treat breast cancer, gastric cancer and colorectal cancer. Alternative Names: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine; [1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]carbamic Acid Pentyl Ester; Capecytabine; Capiibine; Captabin; Ro 09-1978; Xeloda; Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate. Grades: ≥98% by HPLC. CAS No. 154361-50-9. Molecular formula: C15H22FN3O6. Mole weight: 359.35.
Capecitabine 2',3'-cyclic carbonate
Capecitabine 2',3'-cyclic carbonate. Group: Biochemicals. Alternative Names: 5'-Deoxy-5-fluoro-N-[ (pentyloxy) carbonyl]cytidine cyclic 2',3'-carbonate. Grades: Highly Purified. CAS No. 921769-65-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C16H20FN3O7. US Biological Life Sciences.
Worldwide
Capecitabine Benzoate (mixture of 2'(3')-benzoate isomers)
Protected Capecitabine. An antineoplastic agent. A prodrug of Doxifluridine. Alternative Names: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine Benozate. Molecular formula: C22H26FN3O7. Mole weight: 463.46.
Capecitabine-d11
Capecitabine-d11 is a deuterated compound of Capecitabine. Capecitabine has a CAS number of 154361-50-9. Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. Category: Active pharmaceutical ingredients. CAS No. 1132662-08-8. Product ID: API1132662088. Molecular formula: C15H11D11FN3O6. Mole weight: 370.42.
Capecitabine-[d11]
Capecitabine-[d11] is the labelled analogue of Capecitabine, which is an antineoplastic agent and a prodrug of Doxifluridine. Alternative Names: capecitabine D11; 5'-Deoxy-5-fluoro-N-[(pentyl-d11-oxy)carbonyl]cytidine; [1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]carbamic Acid Pentyl Ester-d11; Capecitibine-d11; Capecytabine-d11; Capiibine-d11; Captabin-d11. Grades: 96%; ≥98% atom D. CAS No. 1132662-08-8. Molecular formula: C15H11D11FN3O6. Mole weight: 370.42.
An isotopically labeled antineoplastic agent. A prodrug of doxifluridine. Group: Biochemicals. Alternative Names: 5-Deoxy-5-fluoro-N-[ (pentyloxy) carbonyl]cytidine-d11. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Capecitabine EP Impurity F
Capecitabine EP Impurity F. Uses: For analytical and research use. CAS No. 921769-65-5. Molecular formula: C16H20FN3O7. Mole weight: 385.35. Catalog: APB921769655.
Capecitabine Impurity 1
Capecitabine Impurity 1. Uses: For analytical and research use. Molecular formula: C14H16FN3O7. Mole weight: 357.29. Catalog: APB07464.
Capecitabine impurity 10
Capecitabine impurity 10. Uses: For analytical and research use. Alternative Names: (2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-methyltetrahydrofuran-3-yl acetate. Molecular formula: C11H14FN3O5. Mole weight: 287.24. Catalog: APB04190.
Capecitabine impurity 12
Capecitabine impurity 12. Uses: For analytical and research use. Alternative Names: (2R,3S,4R,5R)-5-(5-fluoro-2-oxo-4-(((pentyloxy)carbonyl)amino)pyrimidin-1(2H)-yl)-4-hydroxy-2-methyltetrahydrofuran-3-yl acetate. Molecular formula: C17H24FN3O7. Mole weight: 401.39. Catalog: APB04189.
Capecitabine Impurity 17
Capecitabine Impurity 17. Uses: For analytical and research use. Alternative Names: (2S,3S,4S,5S)-5-methyltetrahydrofuran-2,3,4-triyl triacetate. Molecular formula: C11H16O7. Mole weight: 260.24. Catalog: APB04188.
Capecitabine Impurity 18
Capecitabine Impurity 18. Uses: For analytical and research use. Alternative Names: (2S,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyltetrahydrofuran-3,4-diyl diacetate. Molecular formula: C13H16FN3O6. Mole weight: 329.28. Catalog: APB04187.
Capecitabine Impurity 19
Capecitabine Impurity 19. Uses: For analytical and research use. Alternative Names: pentyl (1-((2S,3R,4S,5R)-4-(((2S,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)oxy)-3-hydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate. Molecular formula: C20H30FN3O9. Mole weight: 475.47. Catalog: APB04186.
Capecitabine Impurity 2
Capecitabine Impurity 2. Uses: For analytical and research use. Molecular formula: C16H24FN3O5. Mole weight: 357.38. Catalog: APB07465.
Capecitabine Impurity 3
Capecitabine Impurity 3. Uses: For analytical and research use. Molecular formula: C25H36FN3O10. Mole weight: 557.57. Catalog: APB07463.
Capecitabine Impurity 4
Capecitabine Impurity 4. Uses: For analytical and research use. CAS No. 2230479-30-6. Molecular formula: C13H16FN3O6. Mole weight: 329.28. Catalog: APB2230479306.
Capecitabine impurity 6
Capecitabine impurity 6. Uses: For analytical and research use. Alternative Names: (3R,4S,5R,6R)-6-(hydroxymethyl)-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-one. Molecular formula: C15H34O6Si3. Mole weight: 394.68. Catalog: APB04193.
Capecitabine Impurity 7
Capecitabine Impurity 7. Uses: For analytical and research use. Alternative Names: pentyl (1-((2R,3R,4S,5R)-4-(((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)oxy)-3-hydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate. CAS No. 1262133-68-5. Molecular formula: C20H30FN3O9. Mole weight: 475.47. Catalog: APB1262133685.
Capecitabine impurity 8
Capecitabine impurity 8. Uses: For analytical and research use. Alternative Names: (2R,3R,4R,5R)-2-((1-((2R,3R,4R,5R)-3,4-diacetoxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)amino)-5-methyltetrahydrofuran-3,4-diyl diacetate. Molecular formula: C22H28FN3O11. Mole weight: 529.47. Catalog: APB04192.
Capecitabine impurity 9
Capecitabine impurity 9. Uses: For analytical and research use. Alternative Names: (2R,3S,4R,5R)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-2-methyltetrahydrofuran-3-yl acetate. Molecular formula: C11H14FN3O5. Mole weight: 287.24. Catalog: APB04191.
Capecitabine Impurity C
Capecitabine Impurity C. Uses: For analytical and research use. Alternative Names: (2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyltetrahydrofuran-3,4-diyl diacetate. CAS No. 161599-46-8. Molecular formula: C13H16FN3O6. Mole weight: 329.28. Catalog: APB161599468.
Capecitabine impurity D
A Capecitabine analog which shows antitumor activity. Alternative Names: 5'-Deoxy-5-fluoro-N4-[(2-methylbutoxy)carbonyl]cytidine; 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine; Capecitabine EP Impurity D; 2-Methylbutyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate; 5'-Deoxy-5-fluoro-N4-(2-methyl-1-butyloxycarbonyl)cytidine. Grades: ≥95%. CAS No. 910129-15-6. Molecular formula: C15H22FN3O6. Mole weight: 359.35.
Capecitabine Impurity E
Capecitabine Impurity E. Uses: For analytical and research use. Alternative Names: isopentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate. CAS No. 162204-30-0. Molecular formula: C15H22FN3O6. Mole weight: 359.35. Catalog: APB162204300.
Capecitabine impurity F
It is an impurity of Capecitabine and is used as an antitumor agent. Alternative Names: 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine; [1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl]-carbamic Acid 3-Methylbutyl Ester; 5'-Deoxy-5-fluoro-N-[(3-methylbutoxy)carbonyl]cytidine; Isopentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate; 5'-Deoxy-5-fluoro-N4-(3-methyl-1-butyloxycarbonyl)cytidine; Capecitabine impurity E. Grades: ≥95%. CAS No. 162204-30-0. Molecular formula: C15H22FN3O6. Mole weight: 359.35.
Capecitabine impurity G
Capecitabine impurity G. Uses: For analytical and research use. Alternative Names: pentyl (1-((2R,3R,4S,5R)-4-(((2S,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)oxy)-3-hydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate. CAS No. 1262133-64-1. Molecular formula: C20H30FN3O9. Mole weight: 475.47. Catalog: APB1262133641.
Capecitabine Impurity G
Capecitabine Impurity G. Uses: For analytical and research use. Alternative Names: (2R,3R,4R,5R)-2-(5-fluoro-2-oxo-4-(((pentyloxy)carbonyl)amino)pyrimidin-1(2H)-yl)-5-methyltetrahydrofuran-3,4-diyl diacetate. CAS No. 162204-20-8. Molecular formula: C19H26FN3O8. Mole weight: 443.42. Catalog: APB162204208.
Capecitabine impurity H
Capecitabine impurity H. Uses: For analytical and research use. Alternative Names: pentyl (1-((2R,3R,4R,5R)-3-(((2S,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)oxy)-4-hydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate. CAS No. 1262133-66-3. Molecular formula: C20H30FN3O9. Mole weight: 475.47. Catalog: APB1262133663.
Capecitabine Impurity M
Capecitabine Impurity M is an impurity of its parent compound Capecitabine, which is an anti-neoplastic agent and a prodrug of Doxifluridine. Alternative Names: Methyl [1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-ox-carbamic Acid Ester. CAS No. 296248-49-2. Molecular formula: C11H14FN3O6. Mole weight: 303.24.
Capecitabine Impurity N
Capecitabine Impurity N. Uses: For analytical and research use. Alternative Names: (2R,3R,4R,5R)-2-(5-fluoro-2-oxo-4-(((pentyloxy)carbonyl)amino)pyrimidin-1(2H)-yl)-4-hydroxy-5-methyltetrahydrofuran-3-yl acetate. CAS No. 1262133-69-6. Molecular formula: C17H24FN3O7. Mole weight: 401.39. Catalog: APB1262133696.
Capecitabine Related Compound A
Capecitabine Related Compound A. Uses: For analytical and research use. CAS No. 66335-38-4. Mole weight: 245.21. Catalog: AP66335384.
Capecitabine Related Compound B
Capecitabine Related Compound B. Uses: For analytical and research use. CAS No. 3094-9-5. Mole weight: 246.19. Catalog: AP3094095-A.
Capecitabine Related Compound C
Capecitabine Related Compound C. Uses: For analytical and research use. CAS No. 921769-65-5. Mole weight: 385.34. Catalog: AP921769655.
Capistruin is isolated from Burkholderia thailandensis E264. It exhibits antimicrobial activity against closely related Burkholderia and Pseudomonas strains.
Capivasertib
Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD5363. CAS No. 1143532-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15431.
Caplacizumab
Caplacizumab is a humanized anti-von Willebrand factor (vWF) antibody that inhibits interaction between vWF multimers and platelets. Caplacizumab can be used for the treatment of thrombotic thrombocytopenic purpura (TTP). Alternative Names: Cablivi; ALX-0681; ALX-0081. CAS No. 915810-67-2.
Caplacizumab (His Tag)
Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALX-0681; ALX-0081. CAS No. 915810-67-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99227.
Capmatinib
Capmatinib is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. Category: Active pharmaceutical ingredients. CAS No. 1029712-80-8. Product ID: API1029712808. Molecular formula: C23H17FN6O. Mole weight: 412.42.
Capmatinib
Capmatinib (INC280; INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INC280; INCB28060. CAS No. 1029712-80-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13404.
Capmatinib 2HCl
Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro. Category: Active pharmaceutical ingredients. CAS No. 1197376-85-4. Product ID: API1197376854. Molecular formula: C23H19Cl2FN6O. Mole weight: 485.34.
Capmatinib 2HCl.H2O
Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity. Category: Active pharmaceutical ingredients. CAS No. 1865733-40-9. Product ID: API1865733409. Molecular formula: C23H21Cl2FN6O2. Mole weight: 503.36.
Capmatinib dihydrochloride hydrate
Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate. CAS No. 1865733-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13404C.
Capmatinib (INC280)
Capmatinib is a novel, ATP-competitive inhibitor of c-MET with IC50 of 0.13 nM in a cell-free assay, inactive against RONβ, as well as EGFR and HER-3. Capmatinib (INCB28060) inhibits Wnt/β-catenin and EMT signaling pathways and induces apoptosis in diffuse gastric cancer positive for c-MET amplification. Phase 1. Group: Inhibitors. Alternative Names: INC280, NVP-INC280, INCB28060. CAS No. 1029712-80-8. Pack Sizes: 10mg. Product ID: S2788. Formula: C23H17FN6O. Smiles: CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Capmatinib xHCl
Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM). Category: Active pharmaceutical ingredients. CAS No. 1029714-89-3. Product ID: API1029714893. Molecular formula: C23H18ClFN6O. Mole weight: 448.89.
Capoamycin
Capoamycin is a quinone antibiotic produced by Streptomyces capoamus. It has anti-Gram-positive bacteria and yeast activity, has differentiation-inducing effect on mouse bone marrow leukemia cells Ml, and inhibits Ehrlich ascites carcinoma. Alternative Names: Capomycin; 2,4-Decadienoic acid, 4'-ester with 9-(2,6-dideoxy-beta-D-arabino-hexopyranosyl)-4a,12b-dihydro-4a,8,12b-trihydroxy-3-methylbenz(a)anthracene-1,7,12(4H)-trione. CAS No. 97937-29-6. Molecular formula: C35H38O10. Mole weight: 618.67.
Caprazamycin
Caprazamycin is a liponucleoside antibiotic isolated from Streptomyces sp. MK730-62F2. CAS No. 327164-11-4. Molecular formula: C53H87N5O22. Mole weight: 1146.28.
capreomycidine synthase
A pyridoxal 5'-phosphate protein. The enzyme is involved in the biosynthesis of the cyclic pentapeptide antibiotic viomycin. Group: Enzymes. Synonyms: VioD (ambiguous). Enzyme Commission Number: EC 4.2.1.145. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4986; capreomycidine synthase; EC 4.2.1.145; VioD (ambiguous). Cat No: EXWM-4986.