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| Product | Description | |
|---|---|---|
| Casein Kinase I Inhibitor V, LH846 (N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide)(N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide) | A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIg (IC50=290nM). Exhibits much reduced potency towards CKle and CKla isoforms (IC50=1.3 and 2.5uM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKld-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10h at 8uM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Casein kinase I isoform alpha (26-34) | Casein kinase I isoform alpha (26-34) is a peptide corresponding to residues 26-34 of Casein kinase I isoform alpha. CK1α plays a role in the mitotic spindle formation during cell division and in DNA repair mechanisms and participates in RNA metabolism. |  |
| Casein Kinase inhibitor A51 | Casein Kinase inhibitor A51 is a novel pan-specific CKI (CSNK1) inhibitor (Kd=0.5-20 nM, CKIα Kd=5.3 nM). Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Synonyms: BTX-A51; CKIα inhibitor A51. Grade: 98%. CAS No. 2079068-74-7. Molecular formula: C18H25ClN6. Mole weight: 360.88. | |
| Casein Kinase inhibitor A86 | Casein Kinase inhibitor A86 is a novel pan-specific CKI (CSNK1) inhibitor (Kd=1-10 nM, CKIα Kd=9.8 nM). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities. Synonyms: CKIα inhibitor A86. Grade: 98%. CAS No. 2079069-01-3. Molecular formula: C18H25FN6. Mole weight: 344.44. | |
| Casein Kinase Substrates 3 | Casein Kinase Substrates 3 is a substrate of casein kinase. Synonyms: Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala; L-arginyl-L-arginyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alanyl-L-methionyl-L-seryl-L-isoleucyl-L-threonyl-L-alanine; Casein Kinase I substrate. Grade: ≥95% by HPLC. CAS No. 154444-97-0. Molecular formula: C85H139N27O35S. Mole weight: 2131.24. | |
| Casein, N,N-dimethylated from bovine milk | essentially salt-free, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Casein peptide | Casein peptide is a product made by enzymatic hydrolysis from cow milk casein. Product ID: CDF4-0245. Category: Protein peptide. Product Keywords: Protein Peptides; Casein peptide; CDF4-0245; Protein peptide;. Applications: It is widely used in common food, health food and biomedicine. Product Description: Casein peptides have small molecular weight, good stability, uniform color and easy to dissolve. |  |
| Casein phosphopeptide | Casein phosphopeptide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 691364-49-5. Pack Sizes: 25 g. Product ID: HY-W250117. |  |
| Casein, Powder, Laboratory Grade, 100 g | Casein, Powder, Laboratory Grade, 100 g. Characteristic: Off-white powder, odorless. Notes: Mixture of phosphoproteins from milk; hygroscopic. Storage Code: Green; general chemical storage. Grades: chem-grade laboratory. CAS No. 9000-71-9. Product ID: 853428. -- SOLD FOR EDUCATIONAL USE ONLY -- |  |
| Casein sodium salt from bovine milk | 100g Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials. Formula: N/A. CAS No. 9005-46-3. Prepack ID 90005635-100g. See USA prepack pricing. |  |
| Casein solution from bovine milk | 5% in water. Group: Fluorescence/luminescence spectroscopy. | |
| Casein Tryptone | Tryptone is a peptide produced by the digestion of casein by the protease trypsin. It can be used in culture medium. Alternative Names: Pancreatic digest of casein. CAS No. 91079-40-2. Product ID: PIPB-0138. EINECS: 293-428-4. SMILES: CCC1(OC(=C(C(=O)O1)C=CC=CC=C2C(=O)OC3(CCC4(CC3)OC(=O)C(=CC=CC=CC5=C(OC(OC5=O)(C)CC)[O-])C(=O)O4)OC2=O)[O-])C.CC1CCC(C2(C1)OC(=C(C(=O)O2)C=CC=CC=C3C(=O)OC4(CCC5(CC4)OC(=O)C(=CC=CC=CC6=C(OC7(CC(CCC7C)C)OC6=O)[O-])C(=O)O5)OC3=O)[O-])C.CC1(OC(=O)C(=CC=CC=CC2=C(OC3(CCC4(CC3)OC(=C(C(=O)O4)C=CC=CC=C5C(=O)OC(OC5=O)(C)C)[O-])OC2=O)[O-])C(=O)O1)C.C1CCC2(CC1)OC(=O)C(=CC=CC=CC3=C(OC4(CCC5(CC4)OC(=C(C(=O)O5)C=CC=CC=C6C(=O)OC7(CCCCC7)OC6=O)[O-])OC3=O)[O-])C(=O)O2.C1=CC=C(C=C1)C2=C(C=CC(=C2)[N+]3=CC=C(C=C3)C4=CC=[N+](C=C4)C5=CC(=C(C=C5)O)C6=CC=CC=C6)O.C1=CC=C(C=C1)C2=C(C=CC(=C2)[N+]3=CC=C(C=C3)C4=CC=[N+](C=C4)C5=CC(=C(C=C5)O)C6=CC=CC=C6)O.C1=CC=C(C=C1)C2=C(C=CC(=C2)[N+]3=CC=C(C=C3)C4=CC=[N+](C=C4)C5=CC(=C(C=C5)O)C6=CC=CC=C6)O.C1=CC=C(C=C1)C2=C(C=CC(=C2)[N+]3=CC=C(C=C3)C4=CC=[N+](C=C4)C5=CC(=C(C=C5)O)C6=CC=CC=C6)O. Appearance: off-white to yellow. Category: Peptone (biochemistry). |  |
| Cashmeran | Cashmeran. CAS No. 33704-61-9. VIGON Item # 505040. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, musk indanone, indomuscone. |  America & Internationally |
| Cashmeran | A synthetic musk fragrance compound (polycyclic musk) used in personal care products, and can be found in the environment and the human body. Group: Biochemicals. Alternative Names: 1,2,3,5,6,7-Hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one; 6,7-Dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone; (±)-Cashmeran; DPMI. Grades: Highly Purified. CAS No. 33704-61-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor with an IC 50 of 2 uM. CASIN can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 425399-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12874. | |
| CASIN | CASIN Inhibitor. Uses: Scientific use. Product Category: T3971. CAS No. 425399-05-9. |  |
| CASIN | CASIN. Group: Biochemicals. Grades: Purified. CAS No. 425399-05-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CASIN | CASIN is a selective GTPase Cdc42 inhibitor (IC50=2 uM), reducing active levels of Cdc42 in aged hematopoietic stem cells. Uses: Cdc42 gtpase inhibitor. Synonyms: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol. Grade: >98%. CAS No. 425399-05-9. Molecular formula: C20H22N2O. Mole weight: 306.41. | |
| CASIN | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Casirivimab | Casirivimab (REGN10933) is a human monoclonal antibody that targets the SARS-CoV-2 virus, which causes COVID-19. Casirivimab is ineffective against COVID-19 variants. Casirivimab can be used in combination with Imdevimab (HY-P99342), which alters the lung response of K18-hACE2 mice to the SARS-CoV-2 δ variant, effectively reducing viral load and improving symptoms [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: REGN10933. CAS No. 2415933-42-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99341. | |
| CASK, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CaSO4-2H2O | CaSO4-2H2O. Uses: Designed for use in research and industrial production. Product Category: Graphene-like Materials Series. CAS No. 10101-41-4. Purity: 0.99995. Product ID: ACM10101414. Alfa Chemistry ISO 9001:2015 Certified. Categories: Calcium sulfate dihydrate, CaSO4·2H2O. |  |
| Casocidin-1 | Casocidin-1 is isolated from Bos taurus. Casocidin-1 inhibits the growth of E.coli and S.carnosus. It plays an important role in the capacity of milk to transport calcium phosphate. Synonyms: Alpha-S2-casein; Casocidin-I. | |
| Casopitant | Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. Uses: Antiemetics. Synonyms: GW679769; GW 679769; GW-679769; Zunrisa; Rezonic; 4-(4-Acetylpiperazin-1-yl)-N-{1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide. CAS No. 414910-27-3. Molecular formula: C30H35F7N4O2. Mole weight: 616.62. | |
| Casopitant mesylate | Casopitant mesylate. Group: Biochemicals. Alternative Names: (2R, 4S) -4- (4-Acetyl-1-piperazinyl) -N-[ (1R) -1-[3, 5-bis (trifluoromethyl) phenyl]ethyl]-2- (4-fluoro-2-methylphenyl) -N-methyl-1-piperidinecarboxamide Methanesulfonate. Grades: Highly Purified. CAS No. 414910-30-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C31H39F7N4O5S. US Biological Life Sciences. | Worldwide |
| Casopitant mesylate | Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of Substance P (HY-P0201). Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW679769B. CAS No. 414910-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14405A. | |
| Casopitant Mesylate | Casopitant Mesylate is a potent, selective and orally active neurokinin 1 (NK1) receptor antagonist binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. Uses: Active tachykinin nk1 receptor antagonist. Synonyms: (2R,4S)-4-(4-acetylpiperazin-1-yl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide; methanesulfonic acid. Grade: ≥98%. CAS No. 414910-30-8. Molecular formula: C31H39F7N4O5S. Mole weight: 712.72. | |
| CASP3 Activator 1541 | CASP3 Activator 1541 is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Synonyms: 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid (3-imidazo[1,2-a]pyridin-2-yl-phenyl)-amide; Procaspase-3 activator 1541. Grade: 95%. CAS No. 1100353-03-4. Molecular formula: C24H17N3O4. Mole weight: 411.41. | |
| CASP8 (476-484) | CASP8 is a caspase protein, encoded by the CASP8 gene. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Synonyms: Caspase 8 (476-484). | |
| CASP8-IN-1 | CASP8-IN-1 (Compound 63-R) is a selective inhibitor for caspase 8 ( CASP8 ), with an IC 50 of 0.7 μM. CASP8-IN-1 inhibits FasL-induced apoptosis in cell Jurkat [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956368-39-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153161. | |
| caspase-1 | From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Cleaves pro-interleukin-1β (pro-IL-1β) to form mature IL-1β, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-γ-inducing factor. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mi...proteinase; ICE. Enzyme Commission Number: EC 3.4.22.36. CAS No. 122191-40-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4211; caspase-1; EC 3.4.22.36; 122191-40-6; interleukin 1β-converting enzyme; protease VII; protease A; interleukin 1β precursor proteinase; interleukin 1 converting enzyme; interleukin 1β-converting endopeptidase; interleukin-1β convertase; interleukin-1β converting enzyme; interleukin-1β precursor proteinase; prointerleukin 1β protease; precursor interleukin-1β converting enzyme; pro-interleukin 1β proteinase; ICE. Cat No: EXWM-4211. |  |
| caspase-10 | Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62). Like caspase-8, caspase-10 contains two tandem death effector domains (DEDs) in its N-terminal prodomain, and these play a role in procaspase activation. The enzyme has many overlapping substrates in common with caspase-8, such as RIP (the cleavage of which impairs NF-κB survival signalling and starts the cell-death process) and PAK2 (associated with some of the morphological features of apoptosis, such as cell rounding and apoptotic body formation). Bid, a Bcl2 protein, can be cleaved by caspase-3 (EC 3.4.22.56), caspase-8 and caspase-10 at Lys-Gln-Thr-Asp? ...u-Thr-Asp? to yield a p13 fragment that is not N-myristoylated. Belongs in peptidase family C14. Group: Enzymes. Synonyms: FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Enzyme Commission Number: EC 3.4.22.63. CAS No. 189088-85-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4239; caspase-10; EC 3.4.22.63; 189088-85-5; FLICE2, Mch4; CASP-10; ICE-like apoptotic protease 4; apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1β-converting enzyme 2. Cat No: EXWM-4239. | |
| caspase-11 | This murine enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36), caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Like caspase-5, but unlike caspase-4, this enzyme can be induced by lipopolysaccharide. This enzyme not only activates caspase-1, which is required for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, but it also activates caspase-3 (EC 3.4.22.56), which leads to cellular apoptosis under pathological conditions. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-11. Enzyme Commission Number: EC 3.4.22.64. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4240; caspase-11; EC 3.4.22.64; CASP-11. Cat No: EXWM-4240. | |
| Caspase-12 Inhibitor Z-ATAD-FMK | Caspase-12 Inhibitor Z-ATAD-FMK is a cell-permeable peptide inhibitor of Caspase 12. Grade: >95%. Molecular formula: C24H33N4O9F. Mole weight: 540.54. | |
| Caspase-13 Inhibitor Z-LEED-FMK | Caspase-13 Inhibitor Z-LEED-FMK is a synthetic peptide inhibitor that inhibits the activity of caspase-13 and related caspases. Grade: >95%. Molecular formula: C32H45FN4O12. Mole weight: 696.7. | |
| Caspase-1 from Human, Recombinant | Caspase 1/Interleukin-1 converting enzyme is an enzyme that proteolytically cleaves other proteins, such as the precursor forms of the inflammatory cytokines interleukin 1β and interleukin 18, into active mature peptides. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. Studies of a similar protein in mouse suggest a role in the pathogenesis of Huntington's disease. Alternative splicing of the gene results in five transcript variants encoding distinct isoforms. Recent studies implicated caspase 1 in promoting CD4 T-cell death and inflammation by HIV, two signature events that fuel HIV disease progression to AIDS. Recombinant, human caspase-1 fused at the n-terminus to a hisotag sequence and expressed in e. coli useful for the study of enzyme regulation, cleavage of target substrates, and inhibitor screening. Group: Enzymes. Synonyms: CASP1; ICE; IL1BC; P45; Caspase 1; Interleukin-1; IL-1β Converting Enzyme. Purity: >90% by SDS-PAGE. Caspase-1. Mole weight: 10 kDa and 20 kDa. Activity: >25,000 units/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: E. coli. Species: Human. CASP1; ICE; IL1BC; P45; Caspase 1; Interleukin-1; IL-1β Converting Enzyme. Cat No: NATE-0813. | |
| Caspase-1/ICE Inhibitor Z-WEHD-FMK | Z-WEHD-FMK is an inhibitor of caspase-1, caspase-5 and cathepsin B, which can inhibit cell apoptosis in a variety of biological systems. Synonyms: CASPASE-1 INHIBITOR TFA SALT; Z-WEHD-FMK-TFA; Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK-TFA. Grade: >99%. CAS No. 210345-00-9. Molecular formula: C37H42FN7O11. Mole weight: 763.78. | |
| Caspase-1 Inhibitor I - CAS 143313-51-3 | The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor I, Cell-Permeable | The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor II - CAS 178603-78-6 | The Caspase-1 Inhibitor II, also referenced under CAS 178603-78-6, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor IV - CAS 154674-81-4 | The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-1 Inhibitor VI | Caspase-1 Inhibitor VI, Z-YVAD-FMK, is a potent, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Group: Fluorescence/luminescence spectroscopy. | |
| caspase-2 | Caspase-2 is an initiator caspase, as are caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63). Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. Two forms of caspase-2 with antagonistic effects exist: caspase-2L induces programmed cell death and caspase-2S suppresses cell death. Caspase-2 is activated by caspase-3 (EC 3.4.22.56), or by a caspase-3-like protease. Activation involves cleavage of the N-terminal prodomain, followed by self-proteolysis between the large and small subunits of pro-caspase-2 and further proteolysis into smaller fragments. Proteolysis occurs at Asp residues and the ...s a substrate of the large isoform of pro-caspase-2 (caspase-2L) but not of the short isoform (caspase-2S). Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICH-1; NEDD-2; caspase-2L; caspase-2S; neural precursor cell expressed developmentally down-regulated protein 2; CASP-2; NEDD2 protein. Enzyme Commission Number: EC 3.4.22.55. CAS No. 182372-14-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4230; caspase-2; EC 3.4.22.55; 182372-14-1; ICH-1; NEDD-2; caspase-2L; caspase-2S; neural precursor cell expressed developmentally down-regulated protein 2; CASP-2; NEDD2 protein. Cat No: EXWM-4230. | |
| Caspase 2 human | ?95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-2 Inhibitor I | The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 2 Substrate (ICH-1), chromogenic | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| caspase-3 | Caspase-3 is an effector/executioner caspase, as are caspase-6 (EC 3.4.22.59) and caspase-7 (EC 3.4.22.60). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Procaspase-3 can be activated by caspase-1 (EC 3.4.22.36), caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) as well as by the serine protease granzyme B. Caspase-3 can activate procaspase-2 (EC 3.4.22.55). Activation occurs by inter-domain cleavage followed by removal of the N-terminal prodomain. Although Asp-Glu-(Val/Ile)-Asp is thought to be the preferred cleavage sequence, the enzyme can accommodate different residues at P2 and P3 of the substrate. Like caspase-2, a hydrophobic residue at P5 of caspase-3 leads to more efficient hydrolysis, e.g. (Val/Leu)-Asp-Val-Ala-Asp? is a better substrate than Asp-Val-Ala-Asp?. This is not the case for caspase-7. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CPP32; apopain; yama protein. Enzyme Commission Number: EC 3.4.22.56. CAS No. 169592-56-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4231; caspase-3; EC 3.4.22.56; 169592-56-7; CPP32; apopain; yama protein. Cat No: EXWM-4231. | |
| Caspase-3/7 Inhibitor I | Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 with Ki(app) of 3.1 μM and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. Grade: ≥98%. CAS No. 1110670-49-9. Molecular formula: C14H16N2O5S. Mole weight: 324.4. | |
| Caspase-3/7 Inhibitor I - CAS 220509-74-0 | The Caspase-3/7 Inhibitor I, also referenced under CAS 220509-74-0, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3/7 Inhibitor II - CAS 775289-20-8 | The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 3 human | ?90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine-tagged), buffered aqueous glycerol solution, ?1.0 units/mg protein. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 3 Human, Recombinant | Caspase 3 is a member of the CED-3 subfamily of caspases and is responsible for the cleavage of many key proteins such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP), the inhibitor of caspase-activated deoxyribonuclease (ICAD), and gelsolin, a protein involved in apoptosis regulation. Caspase 3 is considered to be an effector caspase, activating pro-caspase 6 and pro-caspase 9 in vitro. Caspase 3 can be activated by caspase 8, caspase 6, and granzyme B. Human recombinant c-terminal histidine tagged caspase 3 is a fully active protein consisting of 17 kda and 13.5 kda subunits; the 13.5 kda subunit contains the histidine tag. Applications: Caspase-3 is a caspase prote...ve enzyme. this protein cleaves and activates caspases 6 and 7; and the protein itself is processed and activated by caspases 8, 9, and 10. it is the predominant caspase involved in the cleavage of amyloid-beta 4a precursor protein, which is associated with neuronal death in alzheimer's disease. alternative splicing of this gene results in two transcript variants that encode the same protein. caspase-3 shares many of the typical characteristics common to all currently-known caspases. for example, its active site contains a cysteine residue (cys-163) and histidine residue (his-121) that stabilize the peptide bond cleavage of a protein sequence to the carboxy-terminal side of an | |
| Caspase-3 Inhibitor I - CAS 169332-60-9 | The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor I, Cell-Permeable | The Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor II - CAS 210344-95-9 | The Caspase-3 Inhibitor II, also referenced under CAS 210344-95-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor III - CAS 285570-60-7 | The Caspase-3 Inhibitor III, also referenced under CAS 285570-60-7, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Inhibitor VII - CAS 745046-84-8 | The Caspase-3 Inhibitor VII, also referenced under CAS 745046-84-8, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate I, Colorimetric - CAS 1177131-27-9 | Colorimetric substrate for caspase-3 (Km = 9.7 μM) and related cysteine proteases. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 | Fluorogenic caspase-3 substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate IV, Fluorogenic - CAS 1177935-21-5 | Fluorogenic caspase-3 substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate IX, Fluorogenic | A non-fluorescent peptidyl (DEVD)-Rhodamine 110-bisamide that acts as a highly sensitive, photostable caspase-3 fluorogenic substrate. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-3 Substrate VII, Fluorogenic | Fluorogenic caspase-3 substrate. Group: Fluorescence/luminescence spectroscopy. | |
| caspase-4 | This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but, unlike caspase-1, it is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1&beta. Both this enzyme and caspase-5 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17). The caspase-1 inhibitor Ac-Tyr-Val-Ala-Asp-CHO can also inhibit this enzyme, but more slowly. Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICErelII; ICErel-II; Ich-2; transcript X; TX; TX protease; caspase 4; CASP-4. Enzyme Commission Number: EC 3.4.22.57. CAS No. 182762-08-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4232; caspase-4; EC 3.4.22.57; 182762-08-9; ICErelII; ICErel-II; Ich-2; transcript X; TX; TX protease; caspase 4; CASP-4. Cat No: EXWM-4232. | |
| Caspase-4 Inhibitor I - CAS 402832-01-3 | The Caspase-4 Inhibitor I, also referenced under CAS 402832-01-3, controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase-4 Inhibitor I, Cell-Permeable | The Caspase-4 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Caspase 4 Inhibitor (ICH-2) | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| caspase-5 | This enzyme is part of the family of inflammatory caspases, which also includes caspase-1 (EC 3.4.22.36) and caspase-4 (EC 3.4.22.57) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation. The enzyme is able to cleave itself and the p30 caspase-1 precursor, but is very inefficient at generating mature interleukin-1β (IL-1β) from pro-IL-1&beta. Both this enzyme and caspase-4 can cleave pro-caspase-3 to release the small subunit (p12) but not the large subunit (p17). Unlike caspase-4, this enzyme can be induced by lipopolysaccharide. Belongs in peptidase family C14. Group: Enzymes. Synonyms: ICErel-III; Ich-3; ICH-3 protease; transcript Y; TY; CASP-5. Enzyme Commission Number: EC 3.4.22.58. CAS No. 192465-11-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4233; caspase-5; EC 3.4.22.58; 192465-11-5; ICErel-III; Ich-3; ICH-3 protease; transcript Y; TY; CASP-5. Cat No: EXWM-4233. | |
| Caspase-5-derived FSP (67-75) | Caspase-5-derived FSP (67-75). | |
| Caspase-5 Inhibitor I | Z-WEHD-FMK is a cell-permeable, potent, irreversible caspase-5 inhibitor, that also inhibits the activity of Caspase 1, 4, and 8. Group: Fluorescence/luminescence spectroscopy. | |
| caspase-6 | Caspase-6 is an effector/executioner caspase, as are caspase-3 (EC 3.4.22.56) and caspase-7 (EC 3.4.22.60). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Caspase-6 can cleave its prodomain to produce mature caspase-6, which directly activates caspase-8 (EC 3.4.22.61) and leads to the release of cytochrome c from the mitochondria. The release of cytochrome c is an essential component of the intrinsic apoptosis pathway. The enzyme can also cleave and inactivate lamins, the intermediate filament scaffold proteins of the nuclear envelope, leading to nuclear fragmentation in the final phases of apoptosis. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CASP-6; apoptotic protease Mch-2; Mch2. Enzyme Commission Number: EC 3.4.22.59. CAS No. 182372-15-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4234; caspase-6; EC 3.4.22.59; 182372-15-2; CASP-6; apoptotic protease Mch-2; Mch2. Cat No: EXWM-4234. | |
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