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| Product | Description | |
|---|---|---|
| H-Lys-thr-tyr-oh | Heterocyclic Organic Compound. Alternative Names: H-LYS-THR-TYR-OH. CAS No. 108191-44-2. Molecular formula: C19H30N4O6. Mole weight: 410.46. Catalog: ACM108191442. |  |
| H-Lys-Tyr-Lys-OH | H-Lys-Tyr-Lys-OH can induce nicks at apurinic/apyrimidinic sites in circular DNA. Synonyms: Lysyl-tyrosyl-lysine; L-Lysine, N2-(N-L-lysyl-L-tyrosyl)-; (S)-6-amino-2-((S)-2-((S)-2,6-diaminohexanamido)-3-(4-hydroxyphenyl)propanamido)hexanoic acid. Grades: ≥97%. CAS No. 35193-18-1. Molecular formula: C21H35N5O5. Mole weight: 437.53. |  |
| H-Lys-val-ile-leu-phe-oh acetate salt | Heterocyclic Organic Compound. Alternative Names: LYS-VAL-ILE-LEU-PHE ACETATE;H-LYS-VAL-ILE-LEU-PHE-OH ACETATE SALT;H-LYS-VAL-ILE-LEU-PHE-OH ACOH;HEAD ACTIVATOR (7-11), ACETATE SALT;HEAD ACTIVATOR 7-11;HYDRA PEPTIDE FRAGMENT 7-11;H-Lys-Val-Ile-Leu-Phe-OH. CAS No. 103404-59-7. Molecular formula: C34H58N6O8. Mole weight: 678.86. Catalog: ACM103404597. | |
| H-Lys(Z)-OH | Pheromone Ingredients. Alternative Names: H-Lys(Z)-OH;1155-64-2;N6-Cbz-L-Lysine;N-Epsilon-carbobenzyloxy-L-lysine;Nepsilon-carbobenzyloxy-l-lysine;MFCD00002638;N(epsilon)-Cbz-L-lysine;N(epsilon)-Benzyloxycarbonyl-L-lysine;N~6~-[(benzyloxy)carbonyl]-L-lysine;N6-Carbobenzyloxy-L-lysine;Lysine, N6-[ (phenylmethoxy)carbonyl]-; Nepsilon-Carbobenzoxy-L-lysine; (S)-2-Amino-6- ( ( (benzyloxy)carbonyl)amino)hexanoic acid; (2S)-2-amino-6-{[ (benzyl. CAS No. 1155-64-2. Molecular formula: C14H20N2O4. Mole weight: 280.32g/mol. IUPACName: (2S)-2-amino-6- (phenylmethoxycarbonylamino)hexanoic acid. Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCCCCC(C(=O)O)N. ECNumber: 214-585-7. Catalog: ACM1155642. | |
| H-Lys(Z)-OH | H-Lys(Z)-OH is a lysine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 1155-64-2. Pack Sizes: 100 g; 500 g. Product ID: HY-W007750. |  |
| H-Lys(Z)-OMe.HCl | H-Lys(Z)-OMe.HCl is a lysine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 27894-50-4. Pack Sizes: 10 g; 25 g; 100 g. Product ID: HY-W008182. | |
| HM03 | HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 500565-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125974. | |
| HM30181 | HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under Phase I HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitax...the dose range evaluated, with the exception of the repeated administration of 360 mg, for which gastrointestinal disorders were frequently reported. The systemic exposure of HM30181 was relatively low, and dose proportional properties of HM30181 were not observed. Synonyms: 4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-; N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide; Encequidar; HM 30181; HM-30181. Grades: 98%. CAS No. 849675-66-7. Molecular formula: C38H36N6O7. Mole weight: 688.74. | |
| HM-30181 hydrochloride | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 hydrochloride; HM 30181 hydrochloride; HM30181 hydrochloride; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide hydrochloride. Grades: 98%. CAS No. 849675-88-3. Molecular formula: C38H37ClN6O7. Mole weight: 725.20. | |
| HM-30181 mesylate | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 mesylate; HM 30181 mesylate; HM30181 mesylate; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate;849675-88-3 (HM30181 HCl salt);49675-66-7 (HM30181 Free base). Grades: 98%. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. | |
| HM43239 | HM43239 is an orally active small molecule inhibitor of FLT3 that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1, known to be involved in tumor cell proliferation and/or differentiation HM43239 monotherapy induced dose-dependent regression of tumor growth in FLT3 wild-type and FLT3 mutated leukemia cancer cell line. Group: Inhibitors. Alternative Names: HM43239; HM-43239; HM 43239. CAS No. 2569527-64-4. Molecular formula: C29H33ClN6. Mole weight: 501.08. Appearance: Solid powder. Purity: >98%. IUPACName: rel-5-Chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-2-pyrimidinamine. Canonical SMILES: CC1=CC2=C (C=C1)C (C3=NC (NC4=CC (CN5C[C@@H] (C)N[C@@H] (C)C5)=CC (C6CC6)=C4)=NC=C3Cl)=CN2. Catalog: ACM2569527644. | |
| HM 50316 | HM 50316 is a high affinity fatty-acid binding protein 4 (FABP4) inhibitor (Ki < 1 nM) that selectively inhibits FABP4 over FABP3. It inhibits LPS-induced activation of murine macrophages in vitro. HM 50316 may be beneficial for the treatment of atherosclerosis, type 2 diabetes and other inflammatory and metabolic related diseases. Synonyms: HM-50316; HM 50316; HM50316. 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid. Grades: ≥98% by HPLC. CAS No. 1310361-52-4. Molecular formula: C29H23ClN2O3S. Mole weight: 515.02. | |
| HMBA AM resin | HMBA AM resin. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. |  Worldwide |
| HMB-Val-Ser-Leu-VE | HMB-val-ser-leu-VE is a potent and selective inhibitor of the trypsin-like activity of the 20S proteasome. Synonyms: Ethyl (E, 4S) -4- [ [ (2S) -3-hydroxy-2- [ [ (2S) -2- [ (3-hydroxy-2-methylbenzoyl) amino] -3-methylbutanoyl] amino] propanoyl] amino] -6-methylhept-2-enoate. Grades: ≥98%. CAS No. 862891-04-1. Molecular formula: C26H39N3O7. Mole weight: 505.6. | |
| HMDP | HMDP. Group: Biochemicals. Grades: Highly Purified. CAS No. 14255-61-9. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: CH4Na2O7P2. US Biological Life Sciences. | Worldwide |
| HmdSL-37 | HmdSL-37 is an antimicrobial peptide produced by Hylobates sp. (Gibbon, Hylobates moloch). It has antibacterial activity. Synonyms: Antibacterial protein LL-37; Ser-Leu-Gly-Asn-Phe-Phe-Arg-Lys-Ala-Arg-Lys-Lys-Ile-Gly-Glu-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Gln-His-Leu-Ile-Pro-Arg-Thr-Glu-Ala. Grades: ≥96%. | |
| H-Met-2-Cl-Trt Resin | Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: L-Methionine-2-chlorotrityl resin. Pack Sizes: 5g, 25g. |  |
| H-Met-AMC acetate salt | Synonyms: M-3170; L-Methionine 7-amido-4-methylcoumarin acetate salt; (S)-2-Amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)-4-(methylthio)butanamide acetate; (2S)-2-amino-N-(4-methyl-2-oxochromen-7-yl)-4-methylsulfanylbutanamide. Grades: 95%. CAS No. 201854-07-1. Molecular formula: C15H18N2O3S·C2H4O2. Mole weight: 366.43. | |
| H-Met-D-Met-OH | Cas No. 89680-18-2. Molecular formula: C10H20N2O3S2. Mole weight: 280.41. | |
| H-Met-Gly-Pro-AMC HCl | H-Met-Gly-Pro-AMC HCl is a fluorogenic substrate for methionine aminopeptidases 1D and 2. Synonyms: MGP-AMC HCl; L-Methionylglycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-prolinamide hydrochloride (1:1); L-Prolinamide, L-methionylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, hydrochloride (1:1). Grades: ≥95% by HPLC. CAS No. 1926163-53-2. Molecular formula: C22H28N4O5S.HCl. Mole weight: 497.01. | |
| H-Met-lys-oh formiate salt | Heterocyclic Organic Compound. Alternative Names: Met-Lys formate salt, 104809-21-4. CAS No. 104809-21-4. Molecular formula: C12H25N3O5S. Mole weight: 323.41. Purity: 0.96. IUPACName: (2S) -6-amino-2- [ [ (2S) -2-amino-4-methylsulfanylbutanoyl] amino] hexanoic acid;formic acid. Catalog: ACM104809214. | |
| H-Met-Ome | Synonyms: L-Methionine methyl ester; Methionine methyl ester; Methyl methionate; H Met Ome. CAS No. 10332-17-9. Molecular formula: C6H13NO2S. Mole weight: 163.24. | |
| H-Met-Thr-OH | Synonyms: Met-Thr; L-methionyl-L-threonine; L-Met-L-Thr. CAS No. 40883-16-7. Molecular formula: C9H18N2O4S. Mole weight: 250.32. | |
| H-Met-Trp-OH TFA salt | H-Met-Trp-OH TFA salt is an incomplete breakdown product of protein digestion or protein catabolism. It is a non-competitive inhibitor of angiotensin-1 converting enzyme (ACE). Synonyms: H-Met-Trp-OH Trifluoroacetate salt; L-methionyl-L-tryptophan trifluoroacetic acid; (S)-2-((S)-2-Amino-4-(methylthio)butanamido)-3-(1H-indol-3-yl)propanoic acid compound with 2,2,2-trifluoroacetic acid (1:1). Molecular formula: C16H21N3O3S.C2HF3O2. Mole weight: 449.45. | |
| HMG-CoA | HMG-CoA is an intermediate in the mevalonate pathway. Synonyms: S-(Hydrogen 3-Hydroxy-3-methylglutarate) Coenzyme A; 3-Hydroxy-3-methylglutaryl CoA; 3-Hydroxy-3-methylglutaryl Coenzyme A; Hydroxymethylglutaryl CoA; Hydroxymethylglutaryl Coenzyme A; β-Hydroxy-β-methylglutaryl CoA; β-Hydroxy-β-methylglutaryl-coenzyme A. CAS No. 1553-55-5. Molecular formula: C27H44N7O20P3S. Mole weight: 911.66. | |
| HMHA-Gln | Synonyms: HMHA Gln; Nα-3-methyl-3-hydroxy-hexanoyl-glutamine. Molecular formula: C12H22N2O5. Mole weight: 274.31. | |
| HMMNI | HMMNI is a metabolite of dimetridazole. Dimetridazole is an antibacterial and anticoccidial agent that is once widely used for the treatment of parasitic infections in livestock. Synonyms: 2-Hydroxymethyl-1-methyl-5-nitro-1H-imidazole; (1-Methyl-5-nitroimidazol-2-yl)methanol. CAS No. 936-05-0. Molecular formula: C5H7N3O3. Mole weight: 157.1. | |
| HMN-154 | HMN-154, a novel benzenesulfonamide anticancer drug, inhibits KB (IC50= 0.0026 μg/mL) and colon38 cells (IC50= 0.003 μg/mL). Synonyms: 4-methoxy-N-[2-[(E)-2-pyridin-4-ylethenyl]phenyl]benzenesulfonamide; (E)-4-(2-(2-p-methoxy-benzene-sulfonamide) phenyl)(ethenyl ) pyridine; HMN-154; HMN 154; HMN154. CAS No. 173528-92-2. Molecular formula: C20H18N2O3S. Mole weight: 366.43. | |
| HMN-176 | HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia. Synonyms: HMN 176; HMN176; (E) -4- (2- (2- (N- ( (p-Methoxyphenyl) sulfonyl) amino) phenyl) ethenyl) pyridine 1-oxide. CAS No. 173529-10-7. Molecular formula: C20H18N2O4S. Mole weight: 382.43. | |
| HMN-176 | HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia. (Source: CANCER RESEARCH 63, 6942 -6947). Group: Inhibitors. Alternative Names: HMN176; HMN 176; HMN-176. CAS No. 173529-10-7. Molecular formula: C20H18N2O4S. Mole weight: 382.43. Appearance: Solid powder. Purity: >98%. IUPACName: (E) -4- (2- (4-methoxyphenylsulfonamido) styryl) pyridine 1-oxide. Canonical SMILES: O=S (NC1=CC=CC=C1/C=C/C2=CC=[N+] ([O-])C=C2) (C3=CC=C (OC)C=C3)=O. Catalog: ACM173529107. | |
| HMN-214 | HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events. Synonyms: HMN-214; HMN 214. CAS No. 173529-46-9. Molecular formula: C22H20N2O5S. Mole weight: 424.471. | |
| HMPA-AM Resin | HMPA-AM Resin. Group: Unsubstituted resins. Alternative Names: 4-Hydroxymethylphenoxyacetyl aminomethyl polystyrene. Pack Sizes: 5g, 25g. | |
| HM Pectin | | |
| HMR 1031 | HMR 1031 is a potent and specific integrin α4β1 or very late antigen 4 (VLA-4) receptor antagonist binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin. HMR1031 has the potential used as an inhaled drug for the treatment of asthma. Uses: Potential inhaled drug for asthma. Synonyms: HMR-1031; HMR 1031; HMR1031; Rnm7wqo98Y; (3S) -3-[[ (2S) -2-[4, 4-dimethyl-3-[[4-[ (2-methylphenyl) carbamoylamino]phenyl]methyl]-2, 5-dioxoimidazolidin-1-yl]-4-methylpentanoyl]amino]-3-phenylpropanoic acid. Grades: 98%. CAS No. 479203-71-9. Molecular formula: C35H41N5O6. Mole weight: 627.73. | |
| HMR 1098 | HMR 1098 is a KATP channel antagonist inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. HMR 1098 is an inhibitor of Kir6.2/SUR1-composed K(ATP) channels. Synonyms: HMR 1098; HMR1098; HMR-1098; 5-chloro-2-methoxy-n-[2-[4-methoxy-3- (3-methylthioureidosulfonyl) phenyl]ethyl]benzamide sodium salt. Grades: 98%. CAS No. 261717-22-0. Molecular formula: C19H21ClN3NaO5S2. Mole weight: 493.96. | |
| HMR 1556 | Potent and selective Iks channel blocker (IC50 values are 10.5 and 34nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo. Group: Biochemicals. Alternative Names: N- [ (3R, 4S) -3, 4-Dihydro-3-hydroxy-2, 2-di methyl -6- (4, 4, 4-trifluorobutoxy) -2H-1-benzopyran-4-yl] -N- methyl metanesulfonamide. Grades: Highly Purified. CAS No. 223749-46-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HMR 1556 | HMR 1556, a chromanol derivative, is a potent I Ks blocker with IC 50 s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 223749-46-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106369. | |
| HMR 1556 | HMR 1556 is a potent and selective Iks channel blocker (IC50 = 10.5 and 34 nM in canine and guinea pig ventricular myocytes, respectively). It selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. HMR 1556 also exhibits weak activity at Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. HMR 1556 is used in the treatment of proarrythmia. Uses: The treatment of proarrythmia. Synonyms: HMR-1556; HMR 1556; HMR1556.N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide. Grades: ≥98% by HPLC. CAS No. 223749-46-0. Molecular formula: C17H24F3NO5S. Mole weight: 411.44. | |
| HMR 1826 | HMR 1826 is a heterodimeric lucuronide prodrug of doxorubicin, an anthracycline antibiotic commonly used to treat various cancers. Synonyms: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-glucopyranuronosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-; (8S-cis)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-glucopyranuronosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione; Doxorubicin-glucuronide. Grades: ≥95%. CAS No. 148580-25-0. Molecular formula: C41H42N2O22. Mole weight: 914.77. | |
| HMTase Inhibitor IV, UNC0638 (2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine) | A cell-permeable quinazolinamine compound that acts as a potent and reversible inhibitor of G9a and GLP HMTases (histone methyltransferases) (IC50=<15 and 19nM for G9a and GLP, respectively) and displays ~15-fold greater selectivity over DNMT1 and minimally blocks the activities of JMJD2E (IC50=4.66uM) and SETD7, SETD8, PRMT3 and SUV39H2 (IC50>10uM). Shown to lower H3K9Me2 levels in MDA-MB231 cells (IC50=81nM; EC50=11.2uM for cell toxicity) and 6-fold more potent than the HMTase Inhibitor, BIX-01294. Also, affects the activities of adrenergic a1A, adrenergic a and muscarinicM2 by 90%, 69% and 64% and a panel of 26-receptors and ion-channels by <30% at 1uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor IX, MM-102 (Histone Methyltransferase Inhibitor IX, MM102, (S) -N- (bis (4-Fluoro phenyl ) methy l )-1- (2- (2-ethyl -2-isobutyramidobutanamid o)-5-guanidinopentanamido) cyclopentane carboxami de , TFA) | A cell-permeable peptidomimetic that prevents MLL1 (Mixed Lineage Leukemia 1) from complex assembling with WDR5 (Trp-Asp Repeat Domain 5), RbBP5 (Retinoblastoma Binding Protein 5), and ASH2L (Absent Small or Homeotic-2-Like) for enhanced H3K4 methyltransferase activity (IC50 = 0.4nM). Shown to reduce HoxA9 and Meis-1 mRNA expression in myeloblasts derived from MLL1-AF9-transduced murine bone marrow cells (50uM for 96 h) and preferentially inhibit the growth of MLL1-AF4-harboring MV4;11 and MLL1-ENL-harboring KOPN8 leukemia cultures (GI50 in 7 days = 25uM) via apoptosis induction, while exhibiting much reduced potency against BCR-ABL-dependent K562 cells (GI50 in 7 days = 84uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O? · CF?CO?H. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor VI, BRD4770 (Methyl-2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate) | A cell-permeable analog of the amino-benzimidazolo BIX-01338 and the methylester prodrug of BRD9539 that acts as an SAM-competitive inhibitor against PRC2 and G9a (IC50<6.3uM) histone methyltransferase activities, displaying little effect toward 10 other HMTases, 9 HDACs, and 100 cellular kinases. Selectively reduces H3K9me2 and H3K9me3 (EC50=5uM) histone methylation levels in pancreatic cancer cells (PANC-1) with much less or little effect toward H3K36me3, H3K4me3, H3K27me3, or H3K6me3 levels. Inhibits both anchorage-dependent and -independent PANC-1 proliferation via ATM activation and G2/M cell-cycle arrest, but not apoptosis induction (no caspase3/7 activation; 10uM, 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor V, UNC0224 (Histone Lysine Methyltransferase Inhibitor V, UNC0224, 7-(3-Dimethylaminopropoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, H2O) | A quinazolinamine compound that acts as a potent, reversible and SAM (S-adenosylmethionine) non-competitive inhibitor of methyltransferases G9a (H3K9 HMT/EHMT2; IC50=15nM; =23nM) and GLP (G9a-like protein/EHMT1; IC50=20nM). Displays 1,000-fold greater selectivity for G9a over SET7/9 (H3K4 HMTase), SET8/PreSET7 (H4K20 HMTase), PRMT3 (MTase) and JMJD2E (demethylase), and minimally affects the activities of a broad range of GPCRs, ion-channels and transporters in a 30-target selectivity panel, with the exception of muscarinic M2 receptor and histamine H1 receptors (82% and 31% inhibition at 1uM, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 1197196-48-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| HMTPD | Organic Light Emitting Diode (OLED). Alternative Names: N,N,N',N'-Tetra- (3-methy lpheny l)-3,3'-dimethy lbenzidine. CAS No. 105465-14-3. Molecular formula: C42H40N2. Mole weight: 572.78 g/mol. IUPACName: 2-methyl-4-[3-methyl-4-(3-methyl-N-(3-methylphenyl)anilino)phenyl]-N,N-bis(3-methylphenyl)aniline. Canonical SMILES: CC1=CC (=CC=C1)N (C2=C (C=C (C=C2)C3=CC (=C (C=C3)N (C4=CC=CC (=C4)C)C5=CC=CC (=C5)C)C)C)C6=CC=CC (=C6)C. Catalog: ACM105465143-2. | |
| HMTPD | HMTPD. Group: Organic light-emitting diode (oled) materials. CAS No. 105465-14-3. Product ID: 2-methyl-4-[3-methyl-4-(3-methyl-N-(3-methylphenyl)anilino)phenyl]-N,N-bis(3-methylphenyl)aniline. Molecular formula: 572.8g/mol. Mole weight: C42H40N2. CC1=CC (=CC=C1)N (C2=C (C=C (C=C2)C3=CC (=C (C=C3)N (C4=CC=CC (=C4)C)C5=CC=CC (=C5)C)C)C)C6=CC=CC (=C6)C. InChI=1S/C42H40N2/c1-29-11-7-15-37 (23-29)43 (38-16-8-12-30 (2)24-38)41-21-19-35 (27-33 (41)5)36-20-22-42 (34 (6)28-36)44 (39-17-9-13-31 (3)25-39)40-18-10-14-32 (4)26-40/h7-28H, 1-6H3. TZYPEOJJHBWOKE-UHFFFAOYSA-N. | |
| HMWCNT Type1- Carbon Nanotubes Multi Walled Helical | HMWCNT Type1- Carbon Nanotubes Multi Walled Helical. Group: Nanotubes. CAS No. 308068-56-6. | |
| HN-1 | HN-1 is a cell-penetrating peptide that is absorbed only in adherent cells, not in suspended cells. Synonyms: H-Thr-Ser-Pro-Leu-Asn-Ile-His-Asn-Gly-Gln-Lys-Leu-OH; L-threonyl-L-seryl-L-prolyl-L-leucyl-L-asparagyl-L-isoleucyl-L-histidyl-L-asparagyl-glycyl-L-glutaminyl-L-lysyl-L-leucine. Grades: >98%. Molecular formula: C57H96N18O18. Mole weight: 1321.50. | |
| H-N-3-Methyl-L-histidine | 3-N-Methyl-L-histidine is a potential compound to be used as a treatment with pharmacological PPARα agonists to stimulate the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents. Synonyms: L-His(p-Me)-OH; H-His(3-Me)-OH; 3-methyl-L-histidine; H-His(p-Me)-OH; 3-N-Methyl-L-histidine; L-Histidine, 3-methyl-; METHYL-L-HISTIDINE,1-(RG). Grades: ≥ 99% (TLC). CAS No. 368-16-1. Molecular formula: C7H11N3O2. Mole weight: 169.18. | |
| HNE (4-Hydroxy-2-nonenal) | HNE is a major product of endogenous lipid peroxidation. The w-6-family (linoleic and arachidonic acids) of polyunsaturated fatty acids may produce HNE as a result of free radical attack. HNE is a highly reactive compound and it can react with several functional groups on biological material, particularly sulfydryl groups to form thioester adduct and then hemiacetals. HNE may also react with histidine and lysine residues of proteins to form stable Michael addition-type of adducts. HNE-modified proteins may display an altered biological functions. Antibodies to HNE will help to visualize the HNE-adducts. Group: Biochemicals. Grades: Highly Purified. CAS No. 75899-68-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| HNF4 Antagonist, BI6015 (2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole, Hepatocyte Nuclear Factor4 Antagonist) | A cell-permeable phenyl sulfonyl benzimidazole that is shown to dock in the ligand-binding pocket of both HNF4a and HNF4g and antagonize HNF4a DNA binding activity in HepG2 cells (by 93%; 10uM overnight), effectively inhibiting HNF4a-dependent cellular activities (Effective conc. 1 to 5uM). HNF4g inhibition by BI6015 can also lead to decreased insulin promoter binding by transactivators E47 & PDX-1 in T6PNE cells (5uM 48h). Although BI6015 is found to exhibit cancer-selective cytotoxicity toward a panel of 58 human cancer cells and Hep3B-Luc (Effective conc. 1 to 10uM), but not primary murine hepatocytes, it does cause hepatic steatosis both in vitro and in mice in vivo, limiting its use in animal studies. BI6015 also inhibits Human CYP450 2C19 and rat L-type calcium channel (by 94% and 83%, respectively, at 10uM), but not PPARg or a panel of 41 receptors/enzymes of human, mouse, and rat origin. Group: Biochemicals. Grades: Highly Purified. CAS No. 93987-29-2. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S, Molecular Weight: 331.4. US Biological Life Sciences. | Worldwide |
| HNGF6A | HNGF6A. Group: Biochemicals. Grades: Purified. CAS No. 1093111-54-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| HNGF6A | HNGF6A is a humanin analog that increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. HNGF6A enhances glucose sensing in βTC3 cells and decreases blood glucose level in Zucker diabetic fatty rats. HNGF6A is used for the prevention of endothelial dysfunction and atherosclerosis in vivo. Uses: The prevention of endothelial dysfunction and atherosclerosis. Synonyms: HNGF6A; 1093111-54-6; AKOS024458518; PD079802. CAS No. 1093111-54-6. Molecular formula: C112H198N34O31S2. Mole weight: 2581.13. | |
| HNHA | HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) (IC50 = 100 nM). HNHA exhibits activity aganist various cancers like breast cancer and anaplastic thyroid cancer (ATC). Synonyms: Histone Deacetylase Inhibitor VI; N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide. Grades: ≥98%. CAS No. 926908-04-5. Molecular formula: C17H21NO2S. Mole weight: 303.4. | |
| HNMB | HNMB is a mechanochromic luminescent material with aggregation-induced emission (AIE). It has applications for pressure sensing and mapping.In biology, pressure could direct the folding-unfolding of protein molecules, guide blood stream and even control the cell migration. The complexity with these cases makes the monitor and measurement of pressure from conventional force sensor based on classical mechanics impractical. Based on mechanical sensitive materials with ingenious design at the molecular level, a new way to detect pressure is developed. And mechanochromic luminescent (MCL) materials have formed a vital part of such materials. They are intentionally endowed with the ability to change luminescence property (e.g., emission wavelength, emission intensity and lifetime) under mechanical force, which can be readily detected by naked eyes or instruments. As molecule-based sensors, they are compatible to various flexible substrates and arbitrarily curvilinear surfaces, facilitating many applications. Group: Light emitters and dopants. Alternative Names: 4-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-3-methyl benzoic acid,Aggregation-induced emmision (AIE) materials,Mechanochromic luminescent (MCL) materials. CAS No. 2361527-29-7. Mole weight: 305.33. Catalog: ACM2361527297. | |
| H-N-Me-Ala-OH HCl | Synonyms: N-Alpha-Methyl-L-Alanine hydrochloride; (S)-2-(Methylamino)propanoic acid hydrochloride. Grades: 95%. CAS No. 65672-32-4. Molecular formula: C4H9NO2·HCl. Mole weight: 139.6. | |
| H-N-Me-D-Val-OH HCl | Synonyms: N-Methyl-D-valine hydrochloride; (2R)-3-methyl-2-(methylamino)butanoic acid hydrochloride. Grades: ≥ 98% (TLC). CAS No. 210830-32-3. Molecular formula: C6H13NO2·HCl. Mole weight: 167.7. | |
| HNMPA | HNMPA is a cell-impermeable insulin receptor tyrosine kinase inhibitor (IRTK). It inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Synonyms: Hydroxy-2-naphthalenylmethyl phosphonic acid. Grades: ≥95%. CAS No. 132541-52-7. Molecular formula: C11H11O4P. Mole weight: 238.2. | |
| HNMPA-(AM)3 | HNMPA-(AM)3 is a cell-permeable analog of HNMPA, an insulin receptor tyrosine kinase inhibitor (IRTK). It inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Synonyms: Hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester. Grades: ≥95%. CAS No. 120944-03-8. Molecular formula: C20H23O10P. Mole weight: 454.4. | |
| HNTU | Synonyms: 2-(endo-5-norbornene-2,3-dicarboxymido)-1,1,3,3-tetramethyluronium hexafluorophosphate; O-(5-Norbornene-2,3-dicarboxiMido)-N,N,N',N'-tetraMethyluronium Hexafluorophosphate; 2- (endo-5-Norbornene-2, 3-dicarboxymido-1, 1, 3, 3-tetra methyl uroniumhexafluorophosphate (HNTU); O-(endo-5-Norbornene-2,3-dicarboximido)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2-(3-NITROPHENYL)BENZO[D]IMIDAZO[2,1-B]THIAZOLE-3-CARBALDEHYDE; Hntu [2-(Endo-5-Norbornene-2,3-Dicarboxymido)-1,1,3,3-tetramethyluronium Hexafluorophosphate]. Grades: 98%. CAS No. 208462-94-6. Molecular formula: C14H20N3O3.PF6. Mole weight: 423.29. | |
| HNTU [2-(endo-5-Norbornene-2,3-dicarboxymido)-1,1,3,3-tetramethyluronium hexafluorophosphate] | HNTU [2-(endo-5-Norbornene-2,3-dicarboxymido)-1,1,3,3-tetramethyluronium hexafluorophosphate]. Group: Biochemicals. Grades: Highly Purified. CAS No. 208462-94-6. Pack Sizes: 1g, 2g, 5g. US Biological Life Sciences. | Worldwide |
| H-Nva-OEt HCl | Synonyms: Ethyl (2S)-2-Aminopentanoate Hydrochloride; L-Norvalineethylesterhydrochloride. Grades: 95%. CAS No. 40918-51-2. Molecular formula: C7H15NO2·HCl. Mole weight: 181.7. | |
| H-Nva-OMe HCl | Synonyms: (S)-Methyl 2-aminopentanoate hydrochloride. Grades: 99%. CAS No. 56558-30-6. Molecular formula: C6H13NO2·HCl. Mole weight: 167.6. | |
| HO-3867 | HO-3867 is a selective and potent STAT3 inhibitor that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 exhibited minimal toxicity toward noncancerous cells and tissues but induced apoptosis in ovarian cancer cells. Synonyms: HO 3867; EX-A2319; (3E,5E)-3,5-bis[(4-fluorophenyl)methylidene]-1-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]piperidin-4-one. Grades: >98%. CAS No. 1172133-28-6. Molecular formula: C28H30F2N2O2. Mole weight: 464.557. | |
| HO-4120 | Site-directed spin labeling of a genetically encoded unnatural amino acid. Group: Biochemicals. Alternative Names: 3-[(Aminooxy)methyl]-2,5-dihydro-2,2,5,5-tetramethyl-. Grades: Highly Purified. CAS No. 1214132-82-7. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| HO-4120, 90% | HO-4120, 90%. Group: Biochemicals. Alternative Names: 3-[(Aminooxy)methyl]-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-yloxy. Grades: Highly Purified. CAS No. 1214132-82-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C9H17N2O2. US Biological Life Sciences. | Worldwide |
| HO-4120, 90% | Heterocyclic Organic Compound. Alternative Names: 3-[(Aminooxy)methyl]-2,5-dihydro-2,2,5,5-tetramethyl-. CAS No. 1214132-82-7. Molecular formula: C9H17N2O2. Mole weight: 185.25. Appearance: Orange Oil. Purity: 0.96. IUPACName: O-[(1-hydroxy-2,2,5,5-tetramethylpyrrol-3-yl)methyl]hydroxylamine. Catalog: ACM1214132827. | |
| HOAT | HOAT is a commonly used peptide bond forming agent that may become an impurity in drug synthesis, but is not mutagenic. HOAT can be used for peptide fragment polycondensation and can also inhibit the racemization of peptide polycondensation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39968-33-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Z0275. | |
| HOBt (anhydrous);N-Hydroxybenzotriazole | HOBt (anhydrous);N-Hydroxybenzotriazole. CAS No: 2592-95-2 |  Sarchem Laboratories New Jersey NJ |
| HOBt Hydrate | Developed by W. König and R. Geiger in 1970 was the most popular additive during the last decades. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: Hydroxybenzotriazole hydrate. CAS No. 123333-53-9. |  Luxembourg Bio Technologies |
| HOBt Hydrate in AcN | Designed to limit epimerization and increase efficiency during peptide synthesis and to ensure easy of use and safe shipping. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: Hydroxybenzotriazole hydrate in AcN. CAS No. 123333-53-9. | Luxembourg Bio Technologies |
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