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| Product | Description | |
|---|---|---|
| HLI 373 | HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Synonyms: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride. Grades: ≥99% by HPLC. CAS No. 502137-98-6. Molecular formula: C18H23N5O2.2HCl. Mole weight: 414.33. |  |
| HLI 373 | HLI 373. Group: Biochemicals. Grades: Purified. CAS No. 502137-98-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| HLI373 dihydrochloride | HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents [1]. Antimalarial activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1782531-99-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108640A. |  |
| HLM006474 | HLM006474 is an E2F transcription factor inhibitor that suppresses binding of DNA. It can promote cell differentiation of human pluripotent stem cells (hPSCs). Synonyms: HLM-006474; 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol. Grades: >98%. CAS No. 353519-63-8. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| HLM 006474 | HLM 006474. Group: Biochemicals. Grades: Purified. CAS No. 353519-63-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| HLP6 | HLP6 is an antibacterial peptide isolated from Homo sapiens. Synonyms: Phe-Gln-Trp-Gln-Arg-Asn-Pro-Arg-Lys-Val-Arg. | |
| H-L-Phe(2-trifluoromethyl)-OH | H-L-Phe(2-trifluoromethyl)-OH. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| H-L-Phe(2-trifluoromethyl)-OH | Synonyms: L-Phe(2-CF3)-OHo-Trifluoromethyl-L-phenylalanine; (S)-2-Amino-3-(2-trifluoromethyl-phenyl)propionic acid. Grades: ≥ 99% (HPLC). CAS No. 119009-47-1. Molecular formula: C10H10F3NO2. Mole weight: 233.19. | |
| H-L-Tyr-ol HCl | Synonyms: (S)-4-(2-Amino-3-hydroxypropyl)phenol hydrochloride; L-TYROSINOL; L-Tyrosinol hydrochloride. Grades: ≥ 95%. CAS No. 87745-27-5. Molecular formula: C9H13NO2·HCl. Mole weight: 203.70. | |
| HLY78 | HLY78 is an activator of the Wnt/β-catenin pathway. It targets the DIX domain of Axin and potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction. In zebrafish embryos, HLY78 was shown to increase the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb. Synonyms: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine. Grades: ≥98%. CAS No. 854847-61-3. Molecular formula: C17H17NO2. Mole weight: 267.3. | |
| H-Lys(Abz)-Pro-Pro-pNA | H-Lys(Abz)-Pro-Pro-pNA is an internally quenched fluorogenic (FRET) substrate. CAS No. 219138-18-8. Molecular formula: C29H37N7O6. Mole weight: 579.65. | |
| H-Lys-Ala-4MβNA 2 HCl | It is a specific fluorogenic substrate for dipeptidyl peptidase II (DPP II). Synonyms: Lys-Ala 4-methoxy-beta-naphthylamide dihydrochloride. Grades: 95%. CAS No. 118357-26-9. Molecular formula: C20H30Cl2N4O3. Mole weight: 445.38. | |
| H-Lys-ala-ala-oh | H-Lys-ala-ala-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-lysyl-L-alanyl-L-alanine; Lys-Ala-Ala. Product Category: Heterocyclic Organic Compound. CAS No. 34385-54-1. Molecular formula: C12H24N4O4. Mole weight: 288.343. Purity: 0.96. IUPACName: H-Lys-Ala-Ala-OH. Product ID: ACM34385541. Alfa Chemistry ISO 9001:2015 Certified. |  |
| H-Lys-Ala-pNA 2HCl | H-Lys-Ala-pNA 2HCl, a chromogenic substrate for dipeptidyl aminopeptidase II (DPPII), is cleaved from Aspergillus fumigatus by dipeptidyl peptidase V (DPP V). Synonyms: KA-pNA dihydrochloride; L-Lysyl-N-(4-nitrophenyl)-L-alaninamide dihydrochloride; L-Alaninamide, L-lysyl-N-(4-nitrophenyl)-, hydrochloride (1:2). Grades: ≥95%. CAS No. 390366-87-7. Molecular formula: C15H23N5O4.2HCl. Mole weight: 410.30. | |
| H-Lys(Boc)-2-Cl-Trt Resin | Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: Nepsilon-Boc-L-lysine-2-chlorotrityl resin. Pack Sizes: 5g, 25g. |  |
| H-Lys(Boc)-OH | H-Lys(Boc)-OH. Group: Biochemicals. Grades: Highly Purified. CAS No. 2418-95-3. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C11H22N2O4. US Biological Life Sciences. | Worldwide |
| H-Lys(Boc)-OH-13C6,15N2 | H-Lys(Boc)-OH-13C6,15N2. Uses: Peptide synthesis. Product Category: Amino Acids. CAS No. 1809716-82-2. Mole weight: 254.25. Canonical SMILES: O[13C]([13C@]([H])([15NH2])[13CH2][13CH2][13CH2][13CH2][15NH]C(OC(C)(C)C)=O)=O. Product ID: ACM1809716822. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Lys-Gly-OH. HCl | Synonyms: (S)-2-(2,6-Diaminohexanamido)acetic acid hydrochloride. CAS No. 40719-58-2. Molecular formula: C8H18ClN3O3. Mole weight: 239.70. | |
| H-Lys-ile-oh | H-Lys-ile-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-LYSYL-L-ISOLEUCINE;H-LYS-ILE-OH. CAS No. 20556-13-2. Molecular formula: C12H25N3O3. Mole weight: 259.35. Purity: 0.95. IUPACName: (2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoic acid. Canonical SMILES: CCC(C)C(C(=O)O)NC(=O)C(CCCCN)N. Product ID: ACM20556132. Alfa Chemistry ISO 9001:2015 Certified. Categories: Lysyl-Isoleucine. | |
| H-Lys(Me)3-OH Chloride | Nε,Nε,Nε-Trimethyllysine hydrochloride is a non-protein amino acid active in the biosynthesis of carnitine. Synonyms: Lys(Me)3-OH Chloride; (S)-5-Amino-5-carboxy-N,N,N-trimethylpentan-1-aminium chloride; Nε,Nε,Nε-Trimethyllysine hydrochloride. CAS No. 55528-53-5. Molecular formula: C9H21ClN2O2. Mole weight: 224.73. | |
| H-Lys-Phe-Glu-Arg-Gln-OH | H-Lys-Phe-Glu-Arg-Gln-OH plays a broad role in targeting protein-enhanced degradation. Synonyms: L-Glutamine, L-lysyl-L-phenylalanyl-L-α-glutamyl-L-arginyl-; H-KFERQ-OH; L-lysyl-L-phenylalanyl-L-alpha-glutamyl-L-arginyl-L-glutamine. Grades: ≥95%. CAS No. 115084-19-0. Molecular formula: C31H50N10O9. Mole weight: 706.79. | |
| H-Lys-Pro-OH | H-Lys-Pro-OH has the potential as a very promising healing agent in ulcer therapy. Synonyms: Lysylproline; Lys-pro; Lysyl-Proline; L-lysyl-L-proline; KP dipeptide; Lysine Proline dipeptide; L-Proline, L-lysyl-. CAS No. 52766-27-5. Molecular formula: C11H21N3O3. Mole weight: 243.30. | |
| H-Lys(retro-glu-H)-oh | H-Lys(retro-glu-H)-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-LYS(RETRO-GLU-H)-OH. Product Category: Heterocyclic Organic Compound. CAS No. 5891-46-3. Molecular formula: C11H21N3O5. Product ID: ACM5891463. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Lys-thr-tyr-oh | H-Lys-thr-tyr-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-LYS-THR-TYR-OH. Product Category: Heterocyclic Organic Compound. CAS No. 108191-44-2. Molecular formula: C19H30N4O6. Mole weight: 410.46. Product ID: ACM108191442. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Lys-Tyr-Lys-OH | H-Lys-Tyr-Lys-OH can induce nicks at apurinic/apyrimidinic sites in circular DNA. Synonyms: Lysyl-tyrosyl-lysine; L-Lysine, N2-(N-L-lysyl-L-tyrosyl)-; (S)-6-amino-2-((S)-2-((S)-2,6-diaminohexanamido)-3-(4-hydroxyphenyl)propanamido)hexanoic acid. Grades: ≥97%. CAS No. 35193-18-1. Molecular formula: C21H35N5O5. Mole weight: 437.53. | |
| H-Lys-tyr-oh | H-Lys-tyr-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-LYSYL-L-TYROSINE;H-LYS-TYR-OH;L-Lys-L-Tyr-OH;Lys-Tyr-OH;N-L-Lysyl-L-tyrosine. Product Category: Heterocyclic Organic Compound. CAS No. 35978-98-4. Molecular formula: C15H23N3O4. Mole weight: 309.36. Product ID: ACM35978984. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Lys(Z)-OH | H-Lys(Z)-OH is a lysine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 1155-64-2. Pack Sizes: 100 g; 500 g. Product ID: HY-W007750. | |
| H-Lys(Z)-OMe.HCl | H-Lys(Z)-OMe.HCl is a lysine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 27894-50-4. Pack Sizes: 10 g; 25 g; 100 g. Product ID: HY-W008182. | |
| HM03 | HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 500565-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125974. | |
| HM30181 | HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitaxel in MDCK monolayers (IC(50)=35.4nM). HM30181 is currently under Phase I HM30181 is an oral P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency (IC(50)=0.63nM) among several MDR1 inhibitors, including cycloporin A, XR9576, and GF120918, and effectively blocked transepithelial transport of paclitax...the dose range evaluated, with the exception of the repeated administration of 360 mg, for which gastrointestinal disorders were frequently reported. The systemic exposure of HM30181 was relatively low, and dose proportional properties of HM30181 were not observed. Synonyms: 4H-1-Benzopyran-2-carboxamide, N-[2-[2-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-; N-[2-[2-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2H-tetrazol-5-yl]-4,5-dimethoxyphenyl]-4-oxo-4H-1-benzopyran-2-carboxamide; Encequidar; HM 30181; HM-30181. Grades: 98%. CAS No. 849675-66-7. Molecular formula: C38H36N6O7. Mole weight: 688.74. | |
| HM-30181 hydrochloride | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 hydrochloride; HM 30181 hydrochloride; HM30181 hydrochloride; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide hydrochloride. Grades: 98%. CAS No. 849675-88-3. Molecular formula: C38H37ClN6O7. Mole weight: 725.20. | |
| HM-30181 mesylate | HM30181 is a P-glycoprotein (P-gp) inhibitor developed to enhance the oral bioavailability of P-gp substrate drugs. HM30181 showed the highest potency among several MDR1 inhibitors with IC50 value of 0.63nM. HM30181 is currently under Phase I trials. Uses: Enhance the oral bioavailability of p-gp substrate drugs. Synonyms: HM-30181 mesylate; HM 30181 mesylate; HM30181 mesylate; N-(2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)-4-oxo-4H-chromene-2-carboxamide methanesulfonate;849675-88-3 (HM30181 HCl salt);49675-66-7 (HM30181 Free base). Grades: 98%. CAS No. 849675-87-2. Molecular formula: C39H40N6O10S. Mole weight: 784.84. | |
| HM43239 | HM43239 is an orally active small molecule inhibitor of FLT3 that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1, known to be involved in tumor cell proliferation and/or differentiation HM43239 monotherapy induced dose-dependent regression of tumor growth in FLT3 wild-type and FLT3 mutated leukemia cancer cell line. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HM43239; HM-43239; HM 43239. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2569527-64-4. Molecular formula: C29H33ClN6. Mole weight: 501.08. Purity: >98%. IUPACName: rel-5-Chloro-N-[3-cyclopropyl-5-[[(3R,5S)-3,5-dimethyl-1-piperazinyl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)-2-pyrimidinamine. Canonical SMILES: CC1=CC2=C(C=C1)C(C3=NC(NC4=CC(CN5C[C@@H](C)N[C@@H](C)C5)=CC(C6CC6)=C4)=NC=C3Cl)=CN2. Product ID: ACM2569527644. Alfa Chemistry ISO 9001:2015 Certified. Categories: tuspetinib. | |
| HM 50316 | HM 50316 is a high affinity fatty-acid binding protein 4 (FABP4) inhibitor (Ki < 1 nM) that selectively inhibits FABP4 over FABP3. It inhibits LPS-induced activation of murine macrophages in vitro. HM 50316 may be beneficial for the treatment of atherosclerosis, type 2 diabetes and other inflammatory and metabolic related diseases. Synonyms: HM-50316; HM 50316; HM50316. 2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid. Grades: ≥98% by HPLC. CAS No. 1310361-52-4. Molecular formula: C29H23ClN2O3S. Mole weight: 515.02. | |
| HMBA AM resin | HMBA AM resin. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| HMB-Val-Ser-Leu-VE | HMB-val-ser-leu-VE is a potent and selective inhibitor of the trypsin-like activity of the 20S proteasome. Synonyms: Ethyl (E, 4S) -4- [ [ (2S) -3-hydroxy-2- [ [ (2S) -2- [ (3-hydroxy-2-methylbenzoyl) amino] -3-methylbutanoyl] amino] propanoyl] amino] -6-methylhept-2-enoate. Grades: ≥98%. CAS No. 862891-04-1. Molecular formula: C26H39N3O7. Mole weight: 505.6. | |
| HMDP | HMDP. Group: Biochemicals. Grades: Highly Purified. CAS No. 14255-61-9. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: CH4Na2O7P2. US Biological Life Sciences. | Worldwide |
| HmdSL-37 | HmdSL-37 is an antimicrobial peptide produced by Hylobates sp. (Gibbon, Hylobates moloch). It has antibacterial activity. Synonyms: Antibacterial protein LL-37; Ser-Leu-Gly-Asn-Phe-Phe-Arg-Lys-Ala-Arg-Lys-Lys-Ile-Gly-Glu-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Gln-His-Leu-Ile-Pro-Arg-Thr-Glu-Ala. Grades: ≥96%. | |
| H-Met-2-Cl-Trt Resin | Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: L-Methionine-2-chlorotrityl resin. Pack Sizes: 5g, 25g. | |
| H-Met-amc | H-Met-amc. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Butanamide, 2-amino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-(methylthio)-, (S)-. Product Category: Heterocyclic Organic Compound. CAS No. 94367-34-7. Molecular formula: C15H18N2O3S. Mole weight: 306.39. Purity: 0.96. IUPACName: Butanamide, 2-amino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-4-(methylt. Density: 1.299±0.06 g/cm³ (20 °C, 760 mmHg). Product ID: ACM94367347. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Met-AMC acetate salt | Synonyms: M-3170; L-Methionine 7-amido-4-methylcoumarin acetate salt; (S)-2-Amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)-4-(methylthio)butanamide acetate; (2S)-2-amino-N-(4-methyl-2-oxochromen-7-yl)-4-methylsulfanylbutanamide. Grades: 95%. CAS No. 201854-07-1. Molecular formula: C15H18N2O3S·C2H4O2. Mole weight: 366.43. | |
| H-MET-ASN-OH | H-MET-ASN-OH. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MET-ASN PEPTIDE;L-METHIONYL-L-ASPARAGINE;H-MET-ASN-OH;H2N-MN-OH;MET-ASN CRYSTALLINE;Met-Asn. Product Category: Heterocyclic Organic Compound. CAS No. 36261-61-7. Molecular formula: C9H17N3O4S. Mole weight: 263.31. Product ID: ACM36261617. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Met-D-Met-OH | Cas No. 89680-18-2. Molecular formula: C10H20N2O3S2. Mole weight: 280.41. | |
| H-Met-Gly-Pro-AMC HCl | H-Met-Gly-Pro-AMC HCl is a fluorogenic substrate for methionine aminopeptidases 1D and 2. Synonyms: MGP-AMC HCl; L-Methionylglycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-prolinamide hydrochloride (1:1); L-Prolinamide, L-methionylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, hydrochloride (1:1). Grades: ≥95% by HPLC. CAS No. 1926163-53-2. Molecular formula: C22H28N4O5S.HCl. Mole weight: 497.01. | |
| H-Met-leu-oh | H-Met-leu-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Met-Leu, M9630_SIGMA, MolPort-003-958-873, CID3425788, ST5819532, 2-[(2-amino-4-methylsulfanyl-butanoyl)amino]-4-methyl-pentanoic Acid, 14486-16-9. Product Category: Heterocyclic Organic Compound. CAS No. 14486-16-9. Molecular formula: C11H22N2O3S. Mole weight: 262.37. Purity: 0.96. IUPACName: 2-[(2-amino-4-methylsulfanylbutanoyl)amino]-4-methylpentanoic acid. Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)C(CCSC)N. Product ID: ACM14486169. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Met-Ome | Synonyms: L-Methionine methyl ester; Methionine methyl ester; Methyl methionate; H Met Ome. CAS No. 10332-17-9. Molecular formula: C6H13NO2S. Mole weight: 163.24. | |
| H-Met-ser-arg-pro-ala-cys-pro-asn-asp-lys-tyr-glu-oh | H-Met-ser-arg-pro-ala-cys-pro-asn-asp-lys-tyr-glu-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (4-N,N'-DIMETHYLANILINO)-PENTAFLUOROSULFONAMIDE;H-MET-SER-ARG-PRO-ALA-CYS-PRO-ASN-ASP-LYS-TYR-GLU-OH;MET-SER-ARG-PRO-ALA-CYS-PRO-ASN-ASP-LYS-TYR-GLU;THROMBIN RECEPTOR ANTAGONIST;T1;T113242;PEPTIDE T1;Thrombin Receptor Antagonist (1). Product Category: Heterocyclic Organic Compound. CAS No. 207553-92-2. Molecular formula: C58H91N17O20S2. Mole weight: 1410.58. Product ID: ACM207553922. Alfa Chemistry ISO 9001:2015 Certified. | |
| H-Met-Thr-OH | Synonyms: Met-Thr; L-methionyl-L-threonine; L-Met-L-Thr. CAS No. 40883-16-7. Molecular formula: C9H18N2O4S. Mole weight: 250.32. | |
| H-Met-Trp-OH TFA salt | H-Met-Trp-OH TFA salt is an incomplete breakdown product of protein digestion or protein catabolism. It is a non-competitive inhibitor of angiotensin-1 converting enzyme (ACE). Synonyms: H-Met-Trp-OH Trifluoroacetate salt; L-methionyl-L-tryptophan trifluoroacetic acid; (S)-2-((S)-2-Amino-4-(methylthio)butanamido)-3-(1H-indol-3-yl)propanoic acid compound with 2,2,2-trifluoroacetic acid (1:1). Molecular formula: C16H21N3O3S.C2HF3O2. Mole weight: 449.45. | |
| HMG-CoA | HMG-CoA is an intermediate in the mevalonate pathway. Synonyms: S-(Hydrogen 3-Hydroxy-3-methylglutarate) Coenzyme A; 3-Hydroxy-3-methylglutaryl CoA; 3-Hydroxy-3-methylglutaryl Coenzyme A; Hydroxymethylglutaryl CoA; Hydroxymethylglutaryl Coenzyme A; β-Hydroxy-β-methylglutaryl CoA; β-Hydroxy-β-methylglutaryl-coenzyme A. CAS No. 1553-55-5. Molecular formula: C27H44N7O20P3S. Mole weight: 911.66. | |
| HMHA-Gln | Synonyms: HMHA Gln; Nα-3-methyl-3-hydroxy-hexanoyl-glutamine. Molecular formula: C12H22N2O5. Mole weight: 274.31. | |
| HMMNI | HMMNI is a metabolite of dimetridazole. Dimetridazole is an antibacterial and anticoccidial agent that is once widely used for the treatment of parasitic infections in livestock. Synonyms: 2-Hydroxymethyl-1-methyl-5-nitro-1H-imidazole; (1-Methyl-5-nitroimidazol-2-yl)methanol. CAS No. 936-05-0. Molecular formula: C5H7N3O3. Mole weight: 157.1. | |
| HMN-154 | HMN-154, a novel benzenesulfonamide anticancer drug, inhibits KB (IC50= 0.0026 μg/mL) and colon38 cells (IC50= 0.003 μg/mL). Synonyms: 4-methoxy-N-[2-[(E)-2-pyridin-4-ylethenyl]phenyl]benzenesulfonamide; (E)-4-(2-(2-p-methoxy-benzene-sulfonamide) phenyl)(ethenyl ) pyridine; HMN-154; HMN 154; HMN154. CAS No. 173528-92-2. Molecular formula: C20H18N2O3S. Mole weight: 366.43. | |
| HMN-176 | HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia. Synonyms: HMN 176; HMN176; (E) -4- (2- (2- (N- ( (p-Methoxyphenyl) sulfonyl) amino) phenyl) ethenyl) pyridine 1-oxide. CAS No. 173529-10-7. Molecular formula: C20H18N2O4S. Mole weight: 382.43. | |
| HMN-176 | HMN-176 is an active metabolite of the synthetic antitumor compound HMN-214. HMN-176 shows potent cytotoxicity toward various human tumor cell lines, and in mitotic cells, it causes cell cycle arrest at M phase through the destruction of spindle polar bodies, followed by the induction of DNA fragmentation. However, no direct interactions of HMN-176 with tubulin are observed. Moreover, in animal models, it was observed that oral administration of the prodrug HMN-214 caused no significant nerve toxicity, a severe side effect often associated with microtubule binding agents such as Taxol and VCR.3 In Phase I clinical trials, HMN-214 has caused sensory neuropathy and ileus in some patients. However, the grade and frequency of these adverse effects were much lower than those of typical microtubule binding agents. As expected from the mechanism of action of HMN-214 (induction of G2-M arrest in dividing cells), the main adverse effect was neutropenia. (Source: CANCER RESEARCH 63, 6942 -6947). Uses: Designed for use in research and industrial production. Additional or Alternative Names: HMN176; HMN 176; HMN-176. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 173529-10-7. Molecular formula: C20H18N2O4S. Mole weight: 382.43. Purity: >98%. IUPACName: (E)-4-(2-(4-methoxyphenylsulfonamido)styryl)pyridine 1-oxide. Canonical SMILES: O=S(NC1=CC=CC=C1/C=C/C2=CC=[N+]([O-])C=C2)(C3=CC=C(OC)C=C3)=O. Product ID: ACM173529107. Alfa Ch | |
| HMN-214 | HMN-214 is an oral prodrug of HMN-176, a stilbene derivative that interferes with the subcellular spatial location of polo-like kinase-1, a serine/threonine kinase that regulates critical mitotic events. Synonyms: HMN-214; HMN 214. CAS No. 173529-46-9. Molecular formula: C22H20N2O5S. Mole weight: 424.471. | |
| HMPA-AM Resin | HMPA-AM Resin. Group: Unsubstituted resins. Alternative Names: 4-Hydroxymethylphenoxyacetyl aminomethyl polystyrene. Pack Sizes: 5g, 25g. | |
| HM Pectin | | |
| HMR 1031 | HMR 1031 is a potent and specific integrin α4β1 or very late antigen 4 (VLA-4) receptor antagonist binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin. HMR1031 has the potential used as an inhaled drug for the treatment of asthma. Uses: Potential inhaled drug for asthma. Synonyms: HMR-1031; HMR 1031; HMR1031; Rnm7wqo98Y; (3S) -3-[[ (2S) -2-[4, 4-dimethyl-3-[[4-[ (2-methylphenyl) carbamoylamino]phenyl]methyl]-2, 5-dioxoimidazolidin-1-yl]-4-methylpentanoyl]amino]-3-phenylpropanoic acid. Grades: 98%. CAS No. 479203-71-9. Molecular formula: C35H41N5O6. Mole weight: 627.73. | |
| HMR 1098 | HMR 1098 is a KATP channel antagonist inactivating the ATP-sensitive potassium channels (KATP) responsible for potassium efflux. HMR 1098 is an inhibitor of Kir6.2/SUR1-composed K(ATP) channels. Synonyms: HMR 1098; HMR1098; HMR-1098; 5-chloro-2-methoxy-n-[2-[4-methoxy-3- (3-methylthioureidosulfonyl) phenyl]ethyl]benzamide sodium salt. Grades: 98%. CAS No. 261717-22-0. Molecular formula: C19H21ClN3NaO5S2. Mole weight: 493.96. | |
| HMR 1556 | Potent and selective Iks channel blocker (IC50 values are 10.5 and 34nM in canine and guinea pig ventricular myocytes respectively). Selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. Also has little or no effect on Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. Potentiates E-4031-induced arrhythmias in vivo. Group: Biochemicals. Alternative Names: N- [ (3R, 4S) -3, 4-Dihydro-3-hydroxy-2, 2-di methyl -6- (4, 4, 4-trifluorobutoxy) -2H-1-benzopyran-4-yl] -N- methyl metanesulfonamide. Grades: Highly Purified. CAS No. 223749-46-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HMR 1556 | HMR 1556, a chromanol derivative, is a potent I Ks blocker with IC 50 s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 223749-46-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106369. | |
| HMR 1556 | HMR 1556 is a potent and selective Iks channel blocker (IC50 = 10.5 and 34 nM in canine and guinea pig ventricular myocytes, respectively). It selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. HMR 1556 also exhibits weak activity at Kv11.1 Kv1.5, Kv1.3, Kir2.1 and HCN2 channel currents. HMR 1556 is used in the treatment of proarrythmia. Uses: The treatment of proarrythmia. Synonyms: HMR-1556; HMR 1556; HMR1556.N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide. Grades: ≥98% by HPLC. CAS No. 223749-46-0. Molecular formula: C17H24F3NO5S. Mole weight: 411.44. | |
| HMR 1826 | HMR 1826 is a heterodimeric lucuronide prodrug of doxorubicin, an anthracycline antibiotic commonly used to treat various cancers. Synonyms: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-glucopyranuronosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-, (8S,10S)-; (8S-cis)-7,8,9,10-Tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[[[4-(β-D-glucopyranuronosyloxy)-3-nitrophenyl]methoxy]carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione; Doxorubicin-glucuronide. Grades: ≥95%. CAS No. 148580-25-0. Molecular formula: C41H42N2O22. Mole weight: 914.77. | |
| HMTase Inhibitor IV, UNC0638 (2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine) | A cell-permeable quinazolinamine compound that acts as a potent and reversible inhibitor of G9a and GLP HMTases (histone methyltransferases) (IC50=<15 and 19nM for G9a and GLP, respectively) and displays ~15-fold greater selectivity over DNMT1 and minimally blocks the activities of JMJD2E (IC50=4.66uM) and SETD7, SETD8, PRMT3 and SUV39H2 (IC50>10uM). Shown to lower H3K9Me2 levels in MDA-MB231 cells (IC50=81nM; EC50=11.2uM for cell toxicity) and 6-fold more potent than the HMTase Inhibitor, BIX-01294. Also, affects the activities of adrenergic a1A, adrenergic a and muscarinicM2 by 90%, 69% and 64% and a panel of 26-receptors and ion-channels by <30% at 1uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor IX, MM-102 (Histone Methyltransferase Inhibitor IX, MM102, (S) -N- (bis (4-Fluoro phenyl ) methy l )-1- (2- (2-ethyl -2-isobutyramidobutanamid o)-5-guanidinopentanamido) cyclopentane carboxami de , TFA) | A cell-permeable peptidomimetic that prevents MLL1 (Mixed Lineage Leukemia 1) from complex assembling with WDR5 (Trp-Asp Repeat Domain 5), RbBP5 (Retinoblastoma Binding Protein 5), and ASH2L (Absent Small or Homeotic-2-Like) for enhanced H3K4 methyltransferase activity (IC50 = 0.4nM). Shown to reduce HoxA9 and Meis-1 mRNA expression in myeloblasts derived from MLL1-AF9-transduced murine bone marrow cells (50uM for 96 h) and preferentially inhibit the growth of MLL1-AF4-harboring MV4;11 and MLL1-ENL-harboring KOPN8 leukemia cultures (GI50 in 7 days = 25uM) via apoptosis induction, while exhibiting much reduced potency against BCR-ABL-dependent K562 cells (GI50 in 7 days = 84uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O? · CF?CO?H. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor VI, BRD4770 (Methyl-2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate) | A cell-permeable analog of the amino-benzimidazolo BIX-01338 and the methylester prodrug of BRD9539 that acts as an SAM-competitive inhibitor against PRC2 and G9a (IC50<6.3uM) histone methyltransferase activities, displaying little effect toward 10 other HMTases, 9 HDACs, and 100 cellular kinases. Selectively reduces H3K9me2 and H3K9me3 (EC50=5uM) histone methylation levels in pancreatic cancer cells (PANC-1) with much less or little effect toward H3K36me3, H3K4me3, H3K27me3, or H3K6me3 levels. Inhibits both anchorage-dependent and -independent PANC-1 proliferation via ATM activation and G2/M cell-cycle arrest, but not apoptosis induction (no caspase3/7 activation; 10uM, 72h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| HMTase Inhibitor V, UNC0224 (Histone Lysine Methyltransferase Inhibitor V, UNC0224, 7-(3-Dimethylaminopropoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, H2O) | A quinazolinamine compound that acts as a potent, reversible and SAM (S-adenosylmethionine) non-competitive inhibitor of methyltransferases G9a (H3K9 HMT/EHMT2; IC50=15nM; =23nM) and GLP (G9a-like protein/EHMT1; IC50=20nM). Displays 1,000-fold greater selectivity for G9a over SET7/9 (H3K4 HMTase), SET8/PreSET7 (H4K20 HMTase), PRMT3 (MTase) and JMJD2E (demethylase), and minimally affects the activities of a broad range of GPCRs, ion-channels and transporters in a 30-target selectivity panel, with the exception of muscarinic M2 receptor and histamine H1 receptors (82% and 31% inhibition at 1uM, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 1197196-48-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| HMTPD | HMTPD. Group: Organic light-emitting diode (oled) materials. CAS No. 105465-14-3. Product ID: 2-methyl-4-[3-methyl-4-(3-methyl-N-(3-methylphenyl)anilino)phenyl]-N,N-bis(3-methylphenyl)aniline. Molecular formula: 572.8g/mol. Mole weight: C42H40N2. CC1=CC (=CC=C1)N (C2=C (C=C (C=C2)C3=CC (=C (C=C3)N (C4=CC=CC (=C4)C)C5=CC=CC (=C5)C)C)C)C6=CC=CC (=C6)C. InChI=1S/C42H40N2/c1-29-11-7-15-37 (23-29)43 (38-16-8-12-30 (2)24-38)41-21-19-35 (27-33 (41)5)36-20-22-42 (34 (6)28-36)44 (39-17-9-13-31 (3)25-39)40-18-10-14-32 (4)26-40/h7-28H, 1-6H3. TZYPEOJJHBWOKE-UHFFFAOYSA-N. | |
| HMWCNT Type1- Carbon Nanotubes Multi Walled Helical | HMWCNT Type1- Carbon Nanotubes Multi Walled Helical. Group: Nanotubes. CAS No. 308068-56-6. | |
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