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HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 544467-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13025.
HIV-1 integrase inhibitor
HIV-1 integrase inhibitor is uesful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. Synonyms: (Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid. Grades: >98%. CAS No. 544467-07-4. Molecular formula: C11H9N3O4. Mole weight: 247.21.
HIV-1 integrase inhibitor 2
HIV-1 integrase inhibitor 2 is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome. It did not affect integrase-DNA binding and only weakly inhibited the catalytic activities of integrase. Synonyms: CX04328; CX-04328; CX 04328; 3-Quinolineacetic acid, 6-chloro-2-methyl-4-phenyl-a-propyl-. Grades: >98%. CAS No. 957890-42-5. Molecular formula: C21H20ClNO2. Mole weight: 353.84.
HIV-1 Protease, Recombinant
HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV. HIV protease cleaves newly synthesized viral polyproteins at the appropriate places into functional protein products as mature protein components of an infectious HIV virion. The mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional cells. Group: Enzymes. Synonyms: HIV-1 retropepsin; HIV-1 Protease (PR); cd05482. Enzyme Commission Number: EC 3.4.23.-. Purity: > 90%. Mole weight: 38.4 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31 kDa during SEC and SDS-PAGE analyses. Activity: > 1mU/mg. Stability: Stable for at least 6 months as supplied. It can be further diluted to 0.5-1 mg/ml with 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol, and stored at -80°C in aliquots. Do not keep the enzyme at 4°C or -20°C for extended time. Avoid repeated freezing and thawing cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. HIV-1 retropepsin; HIV-1 Protease (PR); cd05482; HIV1 protease. Cat No: NATE-1662.
HIV-1 retropepsin
Present in human immunodeficiency virus type 1. Contributes to the maturation of the viral particle, and is a target of antiviral drugs. Active enzyme is a dimer of identical 11-kDa subunits. Similar enzymes occur in other retroviruses. Type example of peptidase family A2. Group: Enzymes. Synonyms: human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease. Enzyme Commission Number: EC 3.4.23.16. CAS No. 144114-21-6. HIV Protease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4253; HIV-1 retropepsin; EC 3.4.23.16; 144114-21-6; human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease. Cat No: EXWM-4253.
HIV-1 TAT (48-60)
HIV-1 TAT (48-60) is a cell-penetrating peptide generated from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way. Synonyms: H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH; glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-prolyl-L-glutamine. Grades: ≥95%. Molecular formula: C70H131N35O16. Mole weight: 1719.04.
HIV-1 TAT 48-60
HIV-1 TAT 48-60 is a cell-penetrating peptide derived from human immunodeficiency virus (HIV)-1 TAT protein residues 48-60. It is used to deliver exogenous macromolecules into cells in a non-destructive way. Synonyms: H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH; glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-prolyl-L-prolyl-L-glutamine. Grades: ≥95%. Molecular formula: C70H131N35O16. Mole weight: 1719.00.
HIV-1 TAT Protein Peptide
It is a cell-permeable peptide (CPP) derived from the HIV-1 tat protein transduction domain (PTD), which has been shown to promote the entry of nucleic acids into several cell types. Synonyms: HIV-1 Tat Protein (47-57); H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; TAT (47-57); L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine. Grades: 98%. CAS No. 191936-91-1. Molecular formula: C64H118N32O14. Mole weight: 1559.83.
HIV-2 env antigen
?95% (SDS-PAGE), recombinant, expressed in E. coli, Galactosidase-tagged. Group: Fluorescence/luminescence spectroscopy.
HIV-2 Protease, an aspartyl protease (retropepsin), is essential for the life-cycle of HIV-2 sub-type virus. It is expressed in the infected cells as a part of Gag-Pol polyprotein from which it is auto-catalytically released after formation of an immature viral particle. The enzyme subsequently cleaves the other parts of viral polyproteins resulting in the maturation of the virus. In HIV-infected patients, the enzyme is subjected to intensive mutagenesis and mutants resistant to applied medicines are produced as a result of the selection pressure. The mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional ce...epsin; HIV-2 Protease (PR2); cd05482. Enzyme Commission Number: EC 3.4.23.-. Purity: > 85%. Mole weight: 38.3 kDa (1-99 aa + N-terminal GST and C-terminal Poly-his tags). It runs at ~31.5 kDa during SEC and SDS-PAGE analyses. Stability: Stable for at least 6 months as supplied. It can be further diluted to 0.5-1 mg/ml with 50 mM Sodium acetate, 100 mM NaCl, 5 mM DTT, 5 mM EDTA, pH 5.0 containing 10% glycerol, and stored at -80°C in aliquots. Do not keep the enzyme at 4°C or -20°C for extended time. Avoid repeated freezing and thawing cycles. Storage: Store at -80°C. Form: Liquid. Source: E. coli. HIV-2 retropepsin; HIV-2 Protease (PR2); cd05482; HIV2 protease. Cat No: NATE-1661.
HIV-2 retropepsin
In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein. Group: Enzymes. Enzyme Commission Number: EC 3.4.23.47. CAS No. 144114-21-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4284; HIV-2 retropepsin; EC 3.4.23.47; 144114-21-6. Cat No: EXWM-4284.
Hivernal® Neo. CAS No. 300371-33-9. Kosher: Y. VIGON Item # 508452. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers.
America & Internationally
Hiv(gp120)antigenic peptide
Hiv(gp120)antigenic peptide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CYS-GLY-LYS-ILE-GLU-PRO-LEU-GLY-VAL-ALA-PRO-THR-LYS-ALA-LYS-ARG-ARG-VAL-VAL-GLN-ARG-GLU-LYS-ARG;HIV (GP120) ANTIGENIC PEPTIDE;H-CYS-GLY-LYS-ILE-GLU-PRO-LEU-GLY-VAL-ALA-PRO-THR-LYS-ALA-LYS-ARG-ARG-VAL-VAL-GLN-ARG-GLU-LYS-ARG-OH. Product Category: Heterocyclic Organic Compound. CAS No. 198636-94-1. Molecular formula: C117H211N41O31S. Mole weight: 2720.25. Product ID: ACM198636941. Alfa Chemistry ISO 9001:2015 Certified.
HIV-IN-6
HIV-IN-6 is a HIV-1 viral replication inhibitor by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301357-74-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147314.
HIV p17 Gag 77-85 is used in the research of anti-HIV. Synonyms: HIV-1 gag Protein p17 (76-84); H-Ser-Leu-Tyr-Asn-Thr-Val-Ala-Thr-Leu-OH; L-seryl-L-leucyl-L-tyrosyl-L-asparagyl-L-threonyl-L-valyl-L-alanyl-L-threonyl-L-leucine; HIV P17 GAG (77-85). Grades: ≥95%. CAS No. 147468-65-3. Molecular formula: C44H72N10O15. Mole weight: 981.10.
HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV protease, HIV virions remain uninfectious. Thus, mutation of HIV protease's active site or inhibition of its activity disrupts HIVs ability to replicate and infect additional cells, making HIV protease inhibition the subject of considerable pharmaceutical research. Group: Enzymes. Synonyms: human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease; HIV-1 retropepsin; HIV Protease Mutant; EC 3.4.23.16. Enzyme Commission Number: EC 3.4.23.16. CAS No. 144114-21-6. HIV Protease. Mole weight: mol wt ~10.8 kDa. Storage: -70°C. Form: Supplied as a solution in 0.5M Sodium Acetate, pH 4.7with 50mM Tris-HCL, 1M NaCL, 1mM EDTA, 5mM DTT and 15% glycerol. Source: E. coli. human immunodeficiency virus type 1 protease; gag protease; HIV aspartyl protease; HIV proteinase; retroproteinase; HIV-1 protease; HIV-2 protease; HIV-1 retropepsin; HIV Protease Mutant; EC 3.4.23.16. Pack: 100 unit vial containing > 100ug protein. Cat No: NATE-0344.
HIV Protease Substrate VI is a sensitive chromogenic substrate for both HIV-1 and HIV-2 proteases. Synonyms: H-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle-NH2; L-arginyl-L-valyl-L-norleucyl-4-nitro-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide; L-Norleucinamide, L-arginyl-L-valyl-L-norleucyl-4-nitro-L-phenylalanyl-L-α-glutamyl-L-alanyl-. Grades: ≥95%. CAS No. 130877-92-8. Molecular formula: C40H66N12O11. Mole weight: 891.04.
HJC-0123
HJC-0123 is a potent and selective STT 3 inhibitor. HJC0123 has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy. Synonyms: HJC 0123; HJC0123; 2-Phenyl-quinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo[b]thiophen-6-yl)-amide. Grades: 98%. CAS No. 1430420-02-2. Molecular formula: C24H16N2O3S. Mole weight: 412.46.
HJC0152
HJC0152 is a signal transducers and activators of transcription 3 ( STAT3 ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1420290-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100602.
HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor against human head and neck squamous cell carcinoma (HNSCC). Uses: Designed for use in research and industrial production. Additional or Alternative Names: HJC0152; HJC 0152; HJC-0152. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1420290-99-8. Molecular formula: C15H14Cl3N3O4. Mole weight: 406.64. Purity: >98%. IUPACName: 2-(2-Amino-ethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Hydrochloride. Canonical SMILES: O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2OCCN.[H]Cl. Product ID: ACM1420290998. Alfa Chemistry ISO 9001:2015 Certified.
HJC0197
HJC0197 is a erythromycin propionate-N-acetylcysteinate inhibitor (EPAC). IC50 value is 5.9 μM for Epac2. HJC0197 can inhibit Epac1-mediated Rap1-GDP exchange activity at 25 μM, but it has no effect on cAMP-induced type I and II PKA activity at this concentration. HJC0197 can be used to study the role of Epac signaling in chondrogenesis in chicken micromass cultures. EPAC inhibitor may prevent pancreatic cancer cell migration and invasion. Uses: Study the role of epac signaling. Synonyms: HJC0197; HJC-0197; HJC 0197. 4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1383539-73-8. Molecular formula: C19H21N3OS. Mole weight: 339.45.
HJC0350 is a potent and Epac2-specific inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1. Synonyms: HJC 0350; HJC-0350; 1-(mesitylsulfonyl)-2,4-dimethyl-1H-pyrrole. Grades: >98%. CAS No. 885434-70-8. Molecular formula: C15H19NO2S. Mole weight: 277.38.
HJC 0350
HJC 0350. Group: Biochemicals. Grades: Purified. CAS No. 885434-70-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HJM-561
HJM-561 is a selective and effective orally active EGFR PROTAC degrader. HJM-561 is able to overcome the triple EGFR mutations that are resistant to Osimertinib (HY-15772). HJM-561 exhibits potent degradation of EGFR Del19/T790M/C797S (DC50: 9.2 nM) and L858R/T790M/C797S (DC50: 5.8 nM), and has anti-tumor activity (pink: EGFR ligand (HY-12857); blue: CRBN ligand (HY-A0003); black: linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2570251-68-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156698.
HKB99
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 induces apoptosis. HKB99 inhibits the formation of invasive pseudopodia and inhibits migration. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2414908-90-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148510.
H+/K+-exchanging ATPase
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed. Group: Enzymes. Synonyms: H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase. Enzyme Commission Number: EC 3.6.3.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4647; H+/K+-exchanging ATPase; EC 3.6.3.10; H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase. Cat No: EXWM-4647.
HKI 357
HKI 357 is a potent and irreversible dual inhibitor of ErbB2 (HER2) and EGFR (IC50 = 33 and 34 nM, respectively). It inhibits EGFR autophosphorylation and proliferation of NCI-H1975 cells containing L858R and T790M mutations. Uses: Antitumor agent. Synonyms: HKI 357; HKI357; HKI-357; (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide. Grades: ≥98% by HPLC. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05.
HKI 357
HKI 357. Group: Biochemicals. Grades: Purified. CAS No. 848133-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HKI-357
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HKI-357; HKI357; HKI 357. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05. Purity: >98%. IUPACName: (E)-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide. Canonical SMILES: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C. Product ID: ACM848133175. Alfa Chemistry ISO 9001:2015 Certified.
HKOCl-3
HKOCl-3 is a highly sensitive and selective fluorescent probe for detecting hypochlorous acid.Ex: 490 nm; Em 527 nm[1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2031170-80-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130025.
HKOH-1r
HKOH-1r is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2138472-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-D1159.
HKPerox-2
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H 2 O 2 in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2245230-79-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1157.
HKPLP
HKPLP is an antibacterial peptide isolated from Hippocampus kuda. Synonyms: Phe-Leu-Gly-Leu-Ile-Phe-His-Gly-Leu-Val-His-Ala-Gly-Lys-Leu-Ile-His-Gly-Leu-Ile-His-Arg-Asn-Arg-Gly. Grades: 96.1%.
HL 010183
HL 010183 is a metformin derivative exhibiting potent antitumor effect. It inhibits proliferation and invasion of Hs578T triple-negative (TN) breast cancer cells. Uses: Antitumor agent. Synonyms: HL 010183; HL010183; HL-010183. Grades: 99%. CAS No. 1429218-03-0. Molecular formula: C14H20N6.HCl. Mole weight: 308.81.
HL1
HL1 is a ligand for tridentate Schiff bases and is a potential fluorescent probe for metal ions. HL1 exhibits photoluminescence at a weak and strong excitation wavelength of 415 nm [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 202828-10-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164055.
HL-60 Electroporation Kit
Electroporation buffer optimized for HL60 Plasmacytoma Cells. Optimized electroporation protocol provided for transfection of si/miRNA, DNA, mRNA, and small proteins. Feature high transfection efficacy and cell viability. Uses: Electroporation of DNA, RNA, protein and small molecules. Product ID: 1752.
H-L-Beta-homothr-oh hcl. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (3R,4R)-3-Amino-4-hydroxypentanoic acid hydrochloride, 336182-14-0, L-beta-Homo-Thr-OH HCl, 03767_FLUKA, L-beta-Homothreonine hydrochloride, MolPort-003-925-341, AKOS006282796, AK-23909, BR-23909, KB-207532, W5530, (3R,4R)-3-AMINO-4-HYDROXYPENTANOIC ACID HCL. Product Category: Heterocyclic Organic Compound. CAS No. 336182-14-0. Molecular formula: C5H11NO3.HCl. Mole weight: 169.6. Purity: 0.95. IUPACName: (3R,4R)-3-amino-4-hydroxypentanoic acid;hydrochloride. Canonical SMILES: CC(C(CC(=O)O)N)O.Cl. Product ID: ACM336182140. Alfa Chemistry ISO 9001:2015 Certified.
HLCL61
HLCL61 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor. It is used for treatment of acute myeloid leukemia. It resulted in significantly increased expression of miR-29b and consequent suppression of Sp1 and FLT3 in acute myeloid leukemia cells. Uses: Hlcl61 is used for treatment of acute myeloid leukemia. Synonyms: HLCL-61; HLCL 61; 9-Ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine. Grades: 98%. CAS No. 586395-74-6. Molecular formula: C23H24N2O. Mole weight: 344.19.
HLCL-61 hydrochloride
The hydrochloride salt form of HLCL-61, an effective inhibitor of PRMT5, could probably useful in the treatment of acute myeloid leukemia. Uses: The hydrochloride salt form of hlcl-61 is an effective inhibitor of prmt5 and could probably useful in the treatment of acute myeloid leukemia. Synonyms: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride; HLCL61; HLCL 61; HLCL-61. Grades: 98%. CAS No. 1158279-20-9. Molecular formula: C23H25ClN2O. Mole weight: 380.91.
HLCL65 hydrochloride
HLCL65 hydrochloride is a first-in-class inhibitor of PRMT5. HLCL65 selectively inhibits Th1 cell proliferation (IC50 value 1.1 μM). In vivo, HLCL65 suppresses recall T cell responses and reduces inflammation in delayed-type hypersensitivity and clinical disease in experimental autoimmune encephalomyelitis mouse models; In vitro, HLCL65 effectively inhibits symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples. Synonyms: HLCL65 hydrochloride; HLCL 65 hydrochloride; HLCL-65 hydrochloride; 1-(6-bromo-9-ethylcarbazol-3-yl)-N-[(2-methoxyphenyl)methyl]methanamine hydrochloride. Grades: 99%. Molecular formula: C23H23BrN2O.HCl. Mole weight: 459.81.
H-Leu-2-Cl-Trt Resin
Alfa Chemistry's amino acid 2-Cl-Trt resins are available in loadings ranging from 0.4 to 0.7 mmol/g. Since the linked amino acids are N-protected, these resins can be used without pretreatment. Group: Amino acid 2-cl-trt resins. Alternative Names: L-Leucine-2-chlorotrityl resin. Pack Sizes: 5g, 25g.
H-Leu-Gly-Leu-Leu-Leu-Arg-His-Leu-Arg-His-His-Ser-Asn-Leu-Leu-Ala-Asn-Ile-OH, the peptide sequence B18 derived from membrane-associated sea urchin sperm protein-binding proteins, triggers fusion between lipid vesicles. It has many similarities with viral fusion peptides. Grades: ≥95%. CAS No. 222557-92-8. Molecular formula: C94H160N32O22. Mole weight: 2090.48.
H-Leu-Gly-OH
H-Leu-Gly-OH is a Glycine (HY-Y0966) derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 686-50-0. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 100 g. Product ID: HY-W016075.
H-Leu-his-leu-oh
H-Leu-his-leu-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-LEU-HIS-LEU-OH. Product Category: Heterocyclic Organic Compound. CAS No. 126828-33-9. Molecular formula: C18H31N5O4. Mole weight: 381.47. Product ID: ACM126828339. Alfa Chemistry ISO 9001:2015 Certified.
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Synonyms: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride. Grades: ≥99% by HPLC. CAS No. 502137-98-6. Molecular formula: C18H23N5O2.2HCl. Mole weight: 414.33.
HLI 373
HLI 373. Group: Biochemicals. Grades: Purified. CAS No. 502137-98-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
HLI373 dihydrochloride
HLI373 dihydrochloride is an efficacious Hdm2 inhibitor. HLI373 dihydrochloride inhibits the ubiquitin ligase activity of Hdm2. HLI373 dihydrochloride is effective in inducing apoptosis of several tumor cells that are sensitive to DNA-damaging agents [1]. Antimalarial activity [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1782531-99-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108640A.
HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC50 of 29.8 ?M in A375 cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 353519-63-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16667.
HLM006474
HLM006474 is an E2F transcription factor inhibitor that suppresses binding of DNA. It can promote cell differentiation of human pluripotent stem cells (hPSCs). Synonyms: HLM-006474; 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol. Grades: >98%. CAS No. 353519-63-8. Molecular formula: C25H25N3O2. Mole weight: 399.48.