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This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC 2.7.1.158, inositol-pentakisphosphate 2-kinase. Group: Enzymes. Synonyms: IpK2; IP3/IP4 6-/3-kinase; IP3/IP4 dual-specificity 6-/3-kinase; IpmK; ArgRIII; AtIpk2α; AtIpk2β; inositol polyphosphate 6-/3-/5-kinase. Enzyme Commission Number: EC 2.7.1.151. CAS No. 9077-69-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2982; inositol-polyphosphate multikinase; EC 2.7.1.151; 9077-69-4; IpK2; IP3/IP4 6-/3-kinase; IP3/IP4 dual-specificity 6-/3-kinase; IpmK; ArgRIII; AtIpk2α; AtIpk2β; inositol polyphosphate 6-/3-/5-kinase. Cat No: EXWM-2982.
Inositol Powder
Inositol Powder.
CA, FL & NJ
inositol-tetrakisphosphate 1-kinase
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP. Group: Enzymes. Synonyms: 1D-myo-inositol-tetrakisphosphate 1-kinase; inositol-trisphosphate 6-kinase; 1D-myo-inositol-trisphosphate 6-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase; inositol-trisphosphate 5-kinase; 1D-myo-inositol-trisphosphate 5-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase. Enzyme Commission Number: EC 2.7.1.134. CAS No. 187175-98-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2966; inositol-tetrakisphosphate 1-kinase; EC 2.7.1.134; 187175-98-0; 1D-myo-inositol-tetrakisphosphate 1-kinase; inositol-trisphosphate 6-kinase; 1D-myo-inositol-trisphosphate 6-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase; inositol-trisphosphate 5-kinase; 1D-myo-inositol-trisphosphate 5-kinase; ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase. Cat No: EXWM-2966.
inositol-tetrakisphosphate 5-kinase
The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate. Group: Enzymes. Synonyms: 1D-myo-inositol-tetrakisphosphate 5-kinase. Enzyme Commission Number: EC 2.7.1.140. CAS No. 123940-40-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2971; inositol-tetrakisphosphate 5-kinase; EC 2.7.1.140; 123940-40-9; 1D-myo-inositol-tetrakisphosphate 5-kinase. Cat No: EXWM-2971.
inositol-trisphosphate 3-kinase
Activated by Ca2+. Three isoforms have been shown to exist. Group: Enzymes. Synonyms: 1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase. Enzyme Commission Number: EC 2.7.1.127. CAS No. 106283-10-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2963; inositol-trisphosphate 3-kinase; EC 2.7.1.127; 106283-10-7; 1D-myo-inositol-trisphosphate 3-kinase; Ins(1,4,5)P3 3-kinase. Cat No: EXWM-2963.
Inotersen sodium
Inotersen (ISIS-420915) sodium is a 2?-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ISIS-420915 sodium. CAS No. 1432726-13-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132608.
Inotilone
A potent COX-2 inhibitor. Inotilone is used for treating degenerative conditions from overexpression of iNOS. Group: Biochemicals. Alternative Names: (2E) -2-[ (3, 4-Dihydroxyphenyl) methylene]-5-methyl-3 (2H) -furanone. Grades: Highly Purified. CAS No. 906366-79-8. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Inotodiol
Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-?B signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-? production (IC50s in BMMC and BMDM is 0.7 ?M and 3.0 ?M), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5]. Uses: Scientific research. Group: Natural products. CAS No. 35963-37-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120149.
Inotuzumab
Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4, κ antibody that targets human CD22. Inotuzumab can be linked to a toxic agent ozogamicin as an antibody-drug conjugate (ADC). Inotuzumab can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Humanized Anti-CD22 Recombinant Antibody. CAS No. 1660159-36-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99264.
Indium Phosphide/Zinc Sulfide (InP/ZnS) Quantum Dots are core-shell high-luminosity semiconductor crystals with an inner core of Indium Phosphide encapsulated by an outer core of Zinc Sulfide. InP/ZnS quantum dots can be stabilized with oleylamine ligands and are soluble in various organic solvents such as toulene. Uses: Inp/zns core shell nanocrystals are cadmium free/heavy metal free quantum dots suitable for different applications like light emitting diodes (leds; display; biomedical applications. the toxicity of cd compounds and the corresponding regulations worldwide makes these inp/zns quantum dots as more desirable alternatives for consumer applications. Group: Quantum dots. Alternative Names: CFQD, Cadmium free core shell quantum dots, Cadmium free quantum dots, Core/Shell heavy metal free quantum dots, Fluorescent nanocrystals. Mole weight: InP-ZnS. IndiumPhosphide / ZincSulfideQuantumDot-530nm|IndiumPhosphide / ZincSulfideQuantumDot-560nm|IndiumPhosphide / ZincSulfideQuantumDot-590nm|IndiumPhosphide / ZincSulfideQuantumDot-620nm|IndiumPhosphide / ZincSulfideQuantumDot-650nm.
InP/ZnS Sulphide-PEG-COOH. Group: Inp/zns quantum dots. CAS No. 22398-80-7. 99.9%.
INS018 055
INS018 055 (compound 112) is a TNIK and MAP4K4 inhibitor with IC 50 values of 12-120, 12-120 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TNIK&MAP4K4-IN-2. CAS No. 2828567-39-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160623.
Ins(1,3,4,5)P4 Biotin
Ins(1,3,4,5)P4 Biotin is an analog of Ins(1,3,4,5)P4 labelled with biotin through a three-carbon linker at the 1-position on the inositol ring. Inositol phosphates are important signaling molecules involved in numerous cellular functions. Synonyms: Inositol 1,3,4,5-tetrakisphosphate Biotin. Grade: >95%. Molecular formula: C25H41N4Na7O21P4S. Mole weight: 1050.49.
Ins(1,4,5)P3 Biotin
Ins(1,4,5)P3 Biotin is an analog of Ins(1,4,5)P3 labelled with biotin through a three-carbon linker at the 1-position on the inositol ring. Inositol phosphates are important signaling molecules involved in numerous cellular functions. Synonyms: Inositol 1,4,5-trisphosphate Biotin. Grade: >95%. Molecular formula: C25H42N4Na5O18P3S. Mole weight: 926.55.
INSA
INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2962939-33-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157036.
InsB 9-23
INSB (9-23) is an insulin B-chain peptide that can be used to treat many autoimmune diseases, such as type 1 diabetes. Synonyms: Insulin B chain (9-23); Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly; L-seryl-L-histidyl-L-leucyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinyl-glycyl-L-alpha-glutamyl-L-arginyl-glycine. Grade: ≥95%. Molecular formula: C72H116N20O22S. Mole weight: 1645.87.
Insignin. CAS No. 108598-79-4. Molecular formula: C17H22O4. Mole weight: 290.35.
In-situ multilayer NbOx-Nb2C MXene heterojunction
1) Excellent conductivity to ensure the rapid transfer of charges. 2) Stable structure to promote ion transmission and sulfur loading. 3) Sufficient active sites to achieve anchoring of polysulfides and uniform nucleation of Li2S. 4) Higher tap density improves the volumetric energy density of the battery. Obtaining such a versatile high-density host requires reasonable material selection and design. Uses: Energy storage, catalysis, analytical chemistry, mechanics, adsorption, biology, microelectronics, sensors, etc. Group: Mxenes materials. 0.99.
In-situ multilayer TiO2-Ti3C2 MXene
In-situ multilayer TiO2-Ti3C2 MXene. Uses: Catalysis, degradation and other fields. Group: Mxenes materials.
1) Excellent conductivity to ensure the rapid transfer of charges. 2) Stable structure to promote ion transmission and sulfur loading. 3) Sufficient active sites to achieve anchoring of polysulfides and uniform nucleation of Li2S. 4) Higher tap density improves the volumetric energy density of the battery. Obtaining such a versatile high-density host requires reasonable material selection and design. Uses: Energy storage, catalysis, analytical chemistry, mechanics, adsorption, biology, microelectronics, sensors, etc. Group: Mxenes materials. 0.99.
In-situ multilayer VOx-V2C MXene heterojunction
1) Excellent conductivity to ensure the rapid transfer of charges. 2) Stable structure to promote ion transmission and sulfur loading. 3) Sufficient active sites to achieve anchoring of polysulfides and uniform nucleation of Li2S. 4) Higher tap density improves the volumetric energy density of the battery. Obtaining such a versatile high-density host requires reasonable material selection and design. Uses: Energy storage, catalysis, analytical chemistry, mechanics, adsorption, biology, microelectronics, sensors, etc. Group: Mxenes materials. 0.99.
A Kenpaullone analog that acts as a potent and ATP-competitive inhibitor of GSK-3&beta. Group: Fluorescence/luminescence spectroscopy.
InSolution Akt Inhibitor IV
The Akt Inhibitor IV controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
The Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Akt Inhibitor V, Triciribine - CAS 35943-35-2
The Akt Inhibitor V, Triciribine, also referenced under CAS 35943-35-2, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Akt Inhibitor X - CAS 925681-41-0
The Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Casein Kinase II Inhibitor I
The Casein Kinase II Inhibitor I controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6
The Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Casein Kinase I Inhibitor, D4476
The Casein Kinase I Inhibitor, D4476 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Caspase-3 Inhibitor I, Cell-Permeable
The Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Caspase-3 Inhibitor II
The Caspase-3 Inhibitor II controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Caspase-8 Inhibitor II
The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Caspase-9 Inhibitor I
The Caspase-9 Inhibitor I controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Caspase Inhibitor I
The Caspase Inhibitor I controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Caspase Inhibitor VI
The Caspase Inhibitor VI, also referenced under CAS 161401-82-7, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Cdk1 Inhibitor IV, RO-3306
The Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
The cFMS Receptor Tyrosine Kinase Inhibitor controls the biological activity of cFMS Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Epoxomicin, Synthetic
Epoxomicin, Synthetic, is a 1 mM solution of Epoxomicin, Synthetic (Cat. No. 324800) in DMSO. Group: Fluorescence/luminescence spectroscopy.
InSolution ERK Inhibitor II, FR180204
The ERK Inhibitor II, FR180204, also referenced under CAS 865362-74-9, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution GM 6001
GM 6001, CAS 142880-36-2, is a 10 mM (1 mg/257 μl) solution of GM6001 in DMSO. A potent, cell-permeable, broad-spectrum inhibitor of MMPs. Group: Fluorescence/luminescence spectroscopy.
InSolution GSK-3 Inhibitor IX - CAS 667463-62-9
The GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution GSK-3 Inhibitor XVI, CHIR99021 - CAS 252917-06-9
GSK-3 Inhibitor XVI, CHIR99021, CAS 252917-06-9, is a 25 mM solution in DMSO. A cell-permeable, ATP-competitive inhibitor of GSK-3 (IC?? = 10 & 6.7 nM for GSK-3? and GSK-3?, respectively). Group: Fluorescence/luminescence spectroscopy.
InSolution H-89, Dihydrochloride
H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM). Group: Fluorescence/luminescence spectroscopy.
InSolution JAK Inhibitor I - CAS 457081-03-7
The JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution JNK Inhibitor II
The JNK Inhibitor II, also referenced under CAS 129-56-6, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Leptomycin B, Streptomyces sp. - CAS 87081-35-4
An antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1. Group: Fluorescence/luminescence spectroscopy.
InSolution LY 294002 - CAS 154447-36-6
LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 μM). Group: Fluorescence/luminescence spectroscopy.
InSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9
The MEK1/2 Inhibitor III, PD0325901, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution MG-132 - CAS 133407-82-6
MG-132, CAS 133407-82-6, is provided as a 10 mM solution in DMSO. Acts as a potent, reversible proteasome inhibitor (Ki = 4 nM). Group: Fluorescence/luminescence spectroscopy.
InSolution MG-132 in EtOH, ?95% by HPLC
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex. Group: Fluorescence/luminescence spectroscopy.
InSolution p38 MAP Kinase Inhibitor III
The p38 MAP Kinase Inhibitor III controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution PARP Inhibitor VIII, PJ34
The PARP Inhibitor VIII, PJ34 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy.
InSolution PD 98059 - CAS 167869-21-8
PD 98059, CAS 167869-21-8, is a 5 mg/ml solution in DMSO. A a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK). Group: Fluorescence/luminescence spectroscopy.
InSolution PKR Inhibitor - CAS 608512-97-6
The PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution PP1 Analog - CAS 221243-82-9
A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src compared to wild-type v-Src. Group: Fluorescence/luminescence spectroscopy.
InSolution PP2
PP2, 172889-27-9, is a 10 mM solution of PP2 (Cat. No. 529573) in DMSO. A potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases. Group: Fluorescence/luminescence spectroscopy.
InSolution Q-VD-OPh, Non-O-methylated
Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC?? = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively). Group: Fluorescence/luminescence spectroscopy.
InSolution Raf1 Kinase Inhibitor I
The Raf1 Kinase Inhibitor I controls the biological activity of Raf1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Rapamycin
Rapamycin, CAS 53123-88-9, is a 5 mM (500 μg/109 μl) solution of Rapamycin (Cat. No. 553210) in DMSO. Selectively inhibits mTOR and blocks activation of p70 S6 Kinase (IC?? = 50 pM). Group: Fluorescence/luminescence spectroscopy.
InSolution Rapamycin in EtOH
The Rapamycin, also referenced under CAS 53123-88-9, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution Ratjadone A, Synthetic - CAS 163564-92-9
A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Group: Fluorescence/luminescence spectroscopy.
InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9
The RNA Polymerase III Inhibitor, also referenced under CAS 577784-91-9, controls the biological activity of RNA Polymerase III. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy.