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| Product | Description | |
|---|---|---|
| Isradipine | Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure. Synonyms: DynaCirc; Prescal; Lomir; PN-200-110; PN-205-033; PN-205-034; 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester. Grades: >98%. CAS No. 75695-93-1. Molecular formula: C19H21N3O5. Mole weight: 371.39. |  |
| Isradipine | Isradipine. Group: Biochemicals. Grades: Purified. CAS No. 75695-93-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Isradipine (4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Methyl 1-Methylethyl Ester, Isrodipine, PN-200-110, Clivoten, DynaCirc, Esradin, Lomir, Prescal) | Dihydropyridine calcium channel blocker. Antihypertensive; antianginal. Group: Biochemicals. Alternative Names: 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Methyl 1-Methylethyl Ester; Isrodipine; PN-200-110; Clivoten; DynaCirc; Esradin; Lomir; Prescal. Grades: Highly Purified. CAS No. 75695-93-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Isradipine-d3 | Dihydropyridine calcium channel blocker. Antihypertensive; antianginal. Group: Biochemicals. Alternative Names: 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Methyl-d3 1-Methylethyl Ester; Isrodipine-3; PN-200-110-d3; Clivoten-d3; DynaCirc-d3; Esradin-d3; Lomir-d3; Prescal-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Isradipine Impurity A | Synonyms: 4-Benzo[1,2,5]oxadiazol-4-yl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester. Grades: > 95%. Molecular formula: C18H19N3O5. Mole weight: 357.37. | |
| Isradipine Impurity B | Synonyms: 4-Benzo[1,2,5]oxadiazol-4-yl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diisopropyl ester. Grades: > 95%. Molecular formula: C21H25N3O5. Mole weight: 399.45. | |
| Isradipine Impurity C | Synonyms: 4-Benzo[1,2,5]oxadiazol-4-yl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester. Grades: > 95%. Molecular formula: C17H17N3O5. Mole weight: 343.34. | |
| Isradipine Impurity E | Synonyms: 4-Benzo[1,2,5]oxadiazol-4-yl-2-(2-benzo[1,2,5]oxadiazol-4-yl-vinyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-isopropyl ester 3-methyl ester. Grades: > 95%. Molecular formula: C26H23N5O6. Mole weight: 501.50. | |
| Isradipine lactone | Isradipine derivative. Synonyms: 4-(2,1,3-Benzoxadiazol-4-yl)-1,4,5,7-tetrahydro-2-methyl-5-oxo-Furo[3,4-b]pyridine-3-carboxylic Acid 1-Methylethyl Ester. Grades: > 95%. CAS No. 1076198-34-9. Molecular formula: C18H17N3O5. Mole weight: 355.35. | |
| Isradipine Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. |  |
| ISRIB | ISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Synonyms: 2- (4-chlorophenoxy) -N-[4-[[2- (4-chlorophenoxy) acetyl]amino]cyclohexyl]acetamide 2- (4-chlorophenoxy) -N- (4- (2- (4-chlorophenoxy) acetamido) cyclohexyl) acetamide ISRIB compound trans-ISRIB. CAS No. 1597403-47-8. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. | |
| ISRIB | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ISRIB | ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 548470-11-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12495A. |  |
| ISRIB (mix-Isomer) | ISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Synonyms: Acetamide, N,?N'-1,?4-cyclohexanediylbis[2?-(4-chlorophenoxy)?- ISRIB compound. CAS No. 548470-11-7. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. | |
| ISRIB (trans-isomer) | ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2? phosphorylation (IC50=5 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1597403-47-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12495. | |
| ISS610 | ISS610 is a Signal transducer and activator of transcription 3 (STAT3) inhibitor. Reported has shown that aberrant activation of oncogenic signal transducer and activator of STAT3 protein signaling pathways is implicated in human cancers. Uses: Cancer. Synonyms: ((S)-2-(4-cyanobenzamido)-3-(4-(phosphonooxy)phenyl)propanoyl)-L-leucine. Grades: 98%. CAS No. 725233-55-6. Molecular formula: C23H26N3O8P. Mole weight: 503.45. | |
| IST5-002 | IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 ?M for Stat5a, 3.5 ?M for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N6-Benzyladenosine-5'-phosphate. CAS No. 13484-66-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-19527. | |
| Istamycin A | Istamycin A is produced by the strain of Str. tenjimariensis S5-939. It has strong anti-gram positive and negative bacteria action, and Istamycin B has stronger antibacterial activity than A. Synonyms: Sannamycin A; Antibiotic KA 7038I; L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-3-O-(2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranosyl)-1,4,5-trideoxy-6-O-methyl-. CAS No. 72503-79-8. Molecular formula: C17H35N5O5. Mole weight: 389.49. | |
| Istamycin B | Istamycin B is produced by the strain of Str. tenjimariensis S5-939. It has strong anti-gram positive and negative bacteria action, and Istamycin B has stronger antibacterial activity than A. Synonyms: L-chiro-Inositol, 4-amino-1-(2-amino-N-methylacetamido)-3-O-(2-amino-6-methylamino-2,3,4,6-tetradeoxy-beta-D-lyxo-hexopyranosyl)-6-O-methyl-1,4,5-trideoxy-. CAS No. 72523-64-9. Molecular formula: C17H35N5O5. Mole weight: 389.49. | |
| Istaroxime | Istaroxime, also called as PST 2744, is an inhibitor of sodium-potassium ATPase that exhibits the unique property of increasing SERCA2a activity. This has been demonstrated in sarcoplasmic reticulum vesicles from normal guinea pigs, where istaroxime incre. Synonyms: PST-2744; PST 2744; PST2744; Istaroxime; (3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochlorideIstaroxi. CAS No. 203737-93-3. Molecular formula: C21H32N2O3. Mole weight: 360.49. | |
| Istaroxime hydrochloride | Istaroxime is a adenosine triphosphatase inhibitor, inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Uses: Inhibitor of na+/k+ atpase. Synonyms: PST-2744 HCl; PST 2744 HCl; PST2744 HCl(3E,5α)-3-[(2-Aminoethoxy)imino]androstane-6,17-dione hydrochloride. Grades: ≥95%. CAS No. 374559-48-5. Molecular formula: C21H33ClN2O3. Mole weight: 396.95. | |
| Istaroxime hydrochloride | Istaroxime hydrochloride is a Na + /K + -ATPase inhibitor ( IC 50 =0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ( SERCA 2 ) activator. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PST2744 hydrochloride. CAS No. 374559-48-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15718A. | |
| Istradefyline | Istradefyline. Group: Biochemicals. Alternative Names: (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine,; 8-[ (1E) -2- (3, 4-Dimethoxyphenyl) ethenyl]-1, 3-diethyl-3, 7-dihydro-7-methyl-1H-purine-2, 6-dione. Grades: Highly Purified. CAS No. 155270-99-8. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C20H24N4O4. US Biological Life Sciences. | Worldwide |
| Istradefylline | Istradefylline is a selective A(2A) antagonist used in the treatment of Parkinsons disease. Group: Biochemicals. Alternative Names: (E) -8-[2- (3, 4-Dimethoxyphenyl) ethenyl]-1, 3-diethyl-3, 7-dihydro-7-methyl-1H-Purine-2, 6-dione; Istradefylline; KW 6002. Grades: Highly Purified. CAS No. 155270-99-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Istradefylline | Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with K i of 2.2 nM in experimental models of Parkinson's disease. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KW-6002. CAS No. 155270-99-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10888. | |
| Istradefylline | Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist (Ki=2.2 nM). Uses: Adenosine a2 receptor antagonists. Synonyms: KW6002; KW 6002; KW-6002; Istradefylline. 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione. Grades: > 95%. CAS No. 155270-99-8. Molecular formula: C20H24N4O4. Mole weight: 384.43. | |
| Istradefylline | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. | |
| Istradefylline-d3,13C | Istradefylline-d3,13C. Group: Biochemicals. Alternative Names: (E) -8-[2- (3, 4-Dimethoxyphenyl) ethenyl]-1, 3-diethyl-3, 7-dihydro-7-methyl-1H-Purine-2, 6-dione-d3, 13C; Istradefylline-d3,13C; KW 6002-d3,13C. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1913CH21D3N4O4, Molecular Weight: 388.44. US Biological Life Sciences. | Worldwide |
| Istradefylline Dimer 2 | Istradefylline Dimer 2 is a dimer of Istradefylline, which is a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 8,8'-((1R,2R,3S,4S)-2,4-Bis(3,4-dimethoxyphenyl)cyclobutane-1,3-diyl)bis(1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione); 1H-Purine-2,6-dione, 8,8'-[(1α,2α,3β,4β)-2,4-bis(3,4-dimethoxyphenyl)-1,3-cyclobutanediyl]bis[1,3-diethyl-3,7-dihydro-7-methyl-; Istradefylline Impurity 25. CAS No. 702697-27-6. Molecular formula: C40H48N8O8. Mole weight: 768.86. | |
| Istradefylline Dimer Impurity 1 | Grades: > 95%. Molecular formula: C40H50N8O8. Mole weight: 770.89. | |
| Istradefylline Dimer Impurity 2 | Grades: > 95%. Molecular formula: C40H48N8O8. Mole weight: 768.88. | |
| Istradefylline Impurity 1 | Synonyms: 3-(3,4-Dimethoxy-phenyl)-N-(6-dimethylamino-1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acrylamide. Grades: > 95%. Molecular formula: C21H28N4O5. Mole weight: 416.48. | |
| Istradefylline Impurity 2 | Synonyms: 8-[2-(3,4-Dimethoxy-phenyl)-vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-purine-2,6-dione. Grades: > 95%. CAS No. 606080-73-3. Molecular formula: C20H24N4O4. Mole weight: 384.44. | |
| Istradefylline Impurity 3 | Istradefylline Impurity 3 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C19H23N3O5. Mole weight: 373.40. | |
| Istradefylline Impurity 4 | Istradefylline Impurity 4 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C30H34N4O8. Mole weight: 578.61. | |
| Istradefylline Impurity 5 | Istradefylline Impurity 5 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C19H22N4O6. Mole weight: 402.40. | |
| Istradefylline Impurity 6 | Istradefylline Impurity 6 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Molecular formula: C19H23N3O5. Mole weight: 373.40. | |
| Istradefylline Impurity 7 | Istradefylline Impurity 7 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. CAS No. 1453190-01-6. Molecular formula: C20H24N4O4. Mole weight: 384.43. | |
| Istradefylline Impurity 8 | Istradefylline Impurity 8 is one of Istradefylline impurities, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 3,4-Dimethoxycinnamamide; 14773-40-1; 3-(3,4-Dimethoxyphenyl)propenamide; (E)-3-(3,4-dimethoxyphenyl)prop-2-enamide; (2E)-3-(3,4-dimethoxyphenyl)prop-2-enamide; 130973-10-3; CINNAMAMIDE, 3,4-DIMETHOXY-; SCHEMBL8153880; SCHEMBL8153885; 3-(3,4-Dimethoxyphenyl)acrylamide; LT0108; AKOS003421127; NCGC00385957-01; (2E)-3-(3,4-dimethoxyphenyl)-2-propenamide; NCGC00385957-01_C11H13NO3_(2E)-3-(3,4-Dimethoxyphenyl)acrylamide. CAS No. 14773-40-1. Molecular formula: C11H13NO3. Mole weight: 207.23. | |
| Istradefylline Impurity A | Synonyms: N-(1,3-Diethyl-2,6-dioxo-hexahydro-pyrimidin-4-yl)-3-(3,4-dimethoxy-phenyl)-acrylamide. Grades: > 95%. Molecular formula: C19H23N3O5. Mole weight: 373.41. | |
| Istradefylline Impurity C | Grades: > 95%. Molecular formula: C30H34N4O8. Mole weight: 578.63. | |
| Istradefylline Impurity F | Synonyms: N-(1,3-Diethyl-5-nitroso-2,6-dioxo-hexahydro-pyrimidin-4-yl)-3-(3,4-dimethoxy-phenyl)-acrylamide. Grades: > 95%. Molecular formula: C19H22N4O6. Mole weight: 402.41. | |
| Istradefylline M8 | Istradefylline M8 is one of Istradefylline metabolites, a selective A(2A) antagonist used in the treatment of Parkinson's disease. Synonyms: 8-[(E)-2-(3,4-Dimethoxyphenyl)vinyl]-3-ethyl-1-(2-hydroxyethyl)-7-methyl-3,7-dihydro-1H-purine-2,6-dione; 1H-Purine-2,6-dione, 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-3-ethyl-3,7-dihydro-1-(2-hydroxyethyl)-7-methyl-; (E)-8-(3,4-dimethoxystyryl)-3-ethyl-1-(2-hydroxyethyl)-7-methyl-1H-purine-2,6(3H,7H)-dione. CAS No. 1798429-54-5. Molecular formula: C20H24N4O5. Mole weight: 400.43. | |
| Istradefylline M8 | Istradefylline M8. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C20H24N4O5, Molecular Weight: 400.43. US Biological Life Sciences. | Worldwide |
| Istradefylline M8-d3,13C | Istradefylline M8-d3,13C. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1913CH21D3N4O5, Molecular Weight: 404.44. US Biological Life Sciences. | Worldwide |
| Istradefylline (Standard) | Istradefylline (Standard) is the analytical standard of Istradefylline. This product is intended for research and analytical applications. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with K i of 2.2 nM in experimental models of Parkinson's disease. Uses: Scientific research. Group: Signaling pathways. CAS No. 155270-99-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10888R. | |
| ISX-3 | ISX-3 is a potent anti-adipogenic and pro-osteogenic agent. ISX-3 increases the expression of PPAR&gamma. ISX-3 has the potential for the research of osteopenia and osteoporosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912789-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148694. | |
| ISX 9 | ISX 9. Group: Biochemicals. Grades: Purified. CAS No. 832115-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ISX-9 | ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca 2+ influx through both voltage-gated Ca 2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Isoxazole 9. CAS No. 832115-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12323. | |
| IT-143A | IT-143A is a bacterial metabolite produced by the strain of Streptomyces sp. IT-143. It is active against the bacterium M. luteus (MIC = 6.25 μg/ml) and the fungi A. fumigatus and T. rubrum in vitro (MICs = 12.5-25 μg/ml). Synonyms: IT-143-A. Grades: >95% by HPLC. CAS No. 183485-32-7. Molecular formula: C29H43NO4. Mole weight: 469.65. | |
| IT-143-A | IT-143-A is produced by the strain of Streptomyces sp.IT-143. It has activity against individual gram-positive bacteria (Micrococcus gaminerae) and individual fungi (Aspergillus fumigatus). And it is also cytotoxic to KB cells. Synonyms: IT-143A. Molecular formula: C29H43NO4. Mole weight: 469.65. | |
| IT-143-B | IT-143-B is produced by the strain of Streptomyces sp.IT-143. It has activity against individual gram-positive bacteria (Micrococcus gaminerae) and individual fungi (Aspergillus fumigatus). And it is also cytotoxic to KB cells. Synonyms: IT-143B. Grades: ≥95%. CAS No. 183485-34-9. Molecular formula: C28H41NO4. Mole weight: 455.63. | |
| IT1t | IT1t is a selective CXCR4 antagonist with IC50 value of 1.1 nM in calcium mobilization assays.It may be potential useful as anti-HIV agent. Uses: Anti-hiv agent. Synonyms: N,N'-Dicyclohexylcarbamimidothioic Acid (5,6-Dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl Ester;1092776-63-0 (HCl salt). Grades: 98%. CAS No. 864677-55-4. Molecular formula: C21H34N4S2. Mole weight: 406.65. | |
| IT1t dihydrochloride | IT1t dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1092776-63-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| IT1t dihydrochloride | IT1t dihydrochloride is a potent and orally CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Synonyms: N,N'-Dicyclohexylcarbamimidothioic acid (5,6-dihydro-6,6-dimethylimidazo[2,1-b]thiazol-3-yl)methyl ester dihydrochloride; IT1t; IT1t dihydrochloride. Grades: ≥98% (HPLC). CAS No. 1092776-63-0. Molecular formula: C21H34N4S2.2HCl. Mole weight: 479.57. | |
| IT1t dihydrochloride | IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC 50 of 2.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092776-63-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101458A. | |
| IT-62-B | IT-62-B is originally isolated from Streptomyces sp. IT-62. It had moderate anti-Gram-positive bacteria activity (MIC 6.25-12.5 μg/mL), and anti-L1210, P388, adriamycin-resistant P388 and KB tumor cells activity. Molecular formula: C39H47NO15. Mole weight: 769.79. | |
| IT 901 | IT 901, a bioactive naphthalenethiobarbiturate derivative, potently inhibits the NF-κB subunit c-Rel with IC50 value of 3 μM. It shows its anticancer properties in Hematologic Malignancies by inhibiting the oxidative stress response in lymphoma cells. It suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. It did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. It is used for the treatment of human B-cell lymphoma and reveals antitumor properties in vitro and in vivo. It is also a novel therapeutic agent to ameliorate graft-versus-host disease. Synonyms: IT-901; IT 901; IT901; 5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione. Grades: ≥98% by HPLC. CAS No. 1584121-99-2. Molecular formula: C17H14N2O4S. Mole weight: 342.37. | |
| IT-901 | IT-901 is an orally active and potent NF-?B subunit c-Rel inhibitor with an IC50 of 0.1 ?M, 3 ?M for NF-?B DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors and ameliorate graft-versus-host disease (GVHD)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1584121-99-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124179. | |
| I-TAC (CXCL11) from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Itacitinib | Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1 with an IC 50 of 2 nM for human JAK1. Itacitinib shows >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB039110. CAS No. 1334298-90-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16997. | |
| Itacitinib | Itacitinib is a potent and selective JAK1 inhibitor developed for the treatment of Graft-versus-host disease and non-small cell lung cancer. Synonyms: INCB 039110; 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile. Grades: >98%. CAS No. 1334298-90-6. Molecular formula: C26H23F4N9O. Mole weight: 553.51. | |
| Itacitinib adipate | Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis. Uses: Scientific research. Group: Signaling pathways. CAS No. 1334302-63-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16997A. | |
| Itaconate-alkyne | Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate[1]. Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ITalk. CAS No. 2454181-83-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133870. | |
| Itaconic acid | analytical standard. Group: Natural compounds. | |
| Itaconic acid | 1kg Pack Size. Group: Organics. Formula: C5H6O4. CAS No. 97-65-4. Prepack ID 10565984-1kg. Molecular Weight 130.1. See USA prepack pricing. |  |
| Itaconic acid | Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect [1] [2] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Methylenesuccinic acid. CAS No. 97-65-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-Y0520. | |
| Itaconic acid | Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. Group: Biochemicals. Alternative Names: 2-Methylenebutanedioic Acid; Methylenesuccinic Acid; 2-Methylenebutanedioic Acid; 2-Methylenesuccinic Acid; 2-Propene-1,2-dicarboxylic Acid; 4-Hydroxy-2-methylene-4-oxobutanoic Acid; Methylenebutanedioic Acid; NSC 3357; Propylenedicarboxylic Acid. Grades: Highly Purified. CAS No. 97-65-4. Pack Sizes: 1g, 5g. Molecular Formula: C?H?O?. US Biological Life Sciences. | Worldwide |
| Itaconic Acid | Itaconic Acid. We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner. |  California |
| Itaconic Acid | Itaconic Acid. CAS No. 97-65-4. Molecular formula: C5H6O4. |  |
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