A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
InSolution SB 203580, CAS 152121-47-6, is a 1 mg/ml solution of SB 203580 in DMSO. A cell-permeable, selective, reversible inhibitor of p38 MAP kinase (IC?? = 34 nM in vitro, 600 nM in cells). Group: Fluorescence/luminescence spectroscopy.
InSolution Smoothened Agonist, SAG
Smoothened Agonist, SAG, is a 10 mM (500 μg/86 μl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H?O. Group: Fluorescence/luminescence spectroscopy.
InSolution Src Inhibitor, PP1
The Src Inhibitor, PP1 controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy.
InSolution TAPI-1
TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE. Group: Fluorescence/luminescence spectroscopy.
InSolution U0126 - CAS 109511-58-2
A potent and specific inhibitor of MEK1 and MEK2. Group: Fluorescence/luminescence spectroscopy.
InSolution Wortmannin
Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase). Group: Fluorescence/luminescence spectroscopy.
InSolution Y-27632
Y-27632A, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency. Group: Fluorescence/luminescence spectroscopy.
InSolution Y-27632 in DMSO
Y-27632 is a 10 mM solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Group: Fluorescence/luminescence spectroscopy.
InSolution Y-27632 in DMSO
Y-27632 is a 10 mM solution in DMSO. A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. Pack Sizes: 1MG. Mole weight: 247.34. Catalog: IAR42415742. Assay: ?95% (HPLC).
Insulin alpha-chain 1-13 is the human leukocyte antigen (HLA)-DR4-restricted epitope, which is composed of the first 13 amino acids of insulin A chain. Synonyms: Lys-Arg-Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu. Grade: ≥95%. CAS No. 872036-64-1. Molecular formula: C66H118N20O22S3. Mole weight: 1639.96.
insulinase
Transferred to EC 3.4.24.56. Group: Enzymes. Enzyme Commission Number: EC 3.4.99.10. CAS No. 9013-83-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4376; insulinase; EC 3.4.99.10; 9013-83-6. Cat No: EXWM-4376.
Insulin aspart
Insulin aspart (B28Asp) is a fast-acting analog of human insulin. Insulin aspart provides more rapid absorption than regular human insulin after subcutaneous administration. Insulin aspart can be used for researching diabetes [1]. Uses: Scientific research. Group: Peptides. Alternative Names: B28Asp; B28-Asp-insulin; INA-X 14; Insulin X 14. CAS No. 116094-23-6. Pack Sizes: 100 U; 300 U. Product ID: HY-108767.
Insulin aspart
Insulin aspart is an insulin analog that functions faster and lasts for a shorter time than regular insulin. Insulin aspart has been indicated for the treatment of type 1 and type 2 diabetes. Synonyms: DL-phenylalanyl-DL-valyl-DL-asparagyl-DL-glutaminyl-DL-histidyl-DL-leucyl-DL-cysteinyl-glycyl-DL-seryl-DL-histidyl-DL-leucyl-DL-valyl-DL-alpha-glutamyl-DL-alanyl-DL-leucyl-DL-tyrosyl-DL-leucyl-DL-valyl-DL-cysteinyl-glycyl-DL-alpha-glutamyl-DL-arginyl-glycyl-DL-phenylalanyl-DL-phenylalanyl-DL-tyrosyl-DL-threonyl-DL-alpha-aspartyl-DL-lysyl-DL-threonine (7->7'),(19->20')-bis(disulfide) compound with glycyl-DL-isoleucyl-DL-valyl-DL-alpha-glutamyl-DL-glutaminyl-DL-cysteinyl-DL-cysteinyl-DL-threonyl-DL-seryl-DL-isoleucyl-DL-cysteinyl-DL-seryl-DL-leucyl-DL-tyrosyl-DL-glutaminyl-DL-leucyl-DL-alpha-glutamyl-DL-asparagyl-DL-tyrosyl-DL-cysteinyl-DL-asparagine (6'->11')-disulfide; H-DL-Phe-DL-Val-DL-Asn-DL-Gln-DL-His-DL-Leu-DL-Cys(1)-Gly-DL-Ser-DL-His-DL-Leu-DL-Val-DL-Glu-DL-Ala-DL-Leu-DL-Tyr-DL-Leu-DL-Val-DL-Cys(2)-Gly-DL-Glu-DL-Arg-Gly-DL-Phe-DL-Phe-DL-Tyr-DL-xiThr-DL-Asp-DL-Lys-DL-xiThr-OH.H-Gly-DL-xiIle-DL-Val-DL-Glu-DL-Gln-DL-Cys(3)-DL-Cys(1)-DL-xiThr-DL-Ser-DL-xiIle-DL-Cys(3)-DL-Ser-DL-Leu-DL-Tyr-DL-Gln-DL-Leu-DL-Glu-DL-Asn-DL-Tyr-DL-Cys(2)-DL-Asn-OH. CAS No. 116094-23-6. Molecular formula: C256H381N65O79S6. Mole weight: 5825.53.
Insulin (Beef)
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Insulin β Chain Peptide (15-23)
Insulin β Chain Peptide (15-23) is a fragment of Insulin β and could be used to assay IFN-b, IL-17 production in diabetes studies. Synonyms: Insulin beta Chain Peptide (15-23); H-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-OH; L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinyl-glycyl-L-alpha-glutamyl-L-arginyl-glycine. CAS No. 247044-67-3. Molecular formula: C44H72N12O13S. Mole weight: 1009.2.
Insulin (cattle)
Insulin (cattle) is a polypeptide hormone that regulates glucose metabolism in pancreatic islet B cells. Synonyms: Insulin from bovine pancreas; Phe-Val-Asn-Gln-His-Leu-Cys-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala. Gly-Ile-Val-Glu-Gln-Cys-Cys-Ala-Ser-Val-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn (Disulfide bridge: Cys7-Cys7', Cys19-Cys20', Cys6'-Cys11'). Grade: ≥97%. CAS No. 11070-73-8. Molecular formula: C254H377N65O75S6. Mole weight: 5733.49.
Insulin(cattle)
Insulin cattle is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells. Uses: Scientific research. Group: Peptides. CAS No. 11070-73-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1156.
Insulin degludec
Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC 50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 844439-96-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108743.
Insulin Degrading Enzyme (HisoTag) from Rat, Recombinant
Insulin Degrading Enzyme (IDE) is a large zinc-binding protease of the M16A metalloprotease subfamily known to cleave multiple short polypeptides that vary considerably in sequence. IDE was first identified by its ability to degrade the B chain of the hormone insulin. This activity was observed over sixty years ago, though the enzyme specifically responsible for B chain cleavage was identified more recently. This discovery revealed considerable amino acid sequence similarity between IDE and the previously characterized bacterial protease pitrilysin, suggesting a common proteolytic mechanism. Recombinant, rat insulin degrading enzyme fused to a hisotag sequence and expressed in s. frugiperda insect cells. a metalloprotease that degrades insulin and a variety of other peptides including amyloid peptides. Group: Enzymes. Synonyms: IDE; Insulin-degrading enzyme; insulysin; insulin protease. Enzyme Commission Number: EC 3.4.24.56. Purity: >90% by SDS-PAGE. IDE. Mole weight: 110 kDa. Activity: >3 U/mg protein. Storage: < -70°C. Form: Liquid. Source: S. frugiperda. Species: Rat. IDE; Insulin-degrading enzyme; insulysin; insulin protease. Cat No: NATE-0849.
Insulin Detemir
Insulin Detemir is an artificial insulin, shows effect on controlling blood sugar levels. Insulin Detemir stimulates GLP-1 secretion as a consequence of enhanced Gcg expression by a mechanism involving activation of Akt - and/or extracellular signal-regulated kinase ( ERK )-dependent-cat and CREB signaling pathways. Insulin Detemir can be used for type 2 diabetes research [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 169148-63-4. Pack Sizes: 100 U; 300 U. Product ID: HY-109556.
Insulin efsitora alfa
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY-3209590. CAS No. 2131038-11-2. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P99665.
Insulin glargine
Insulin glargine is a long-acting insulin analog. Insulin glargine has the effect of lowering blood sugar and can be used in the research of diabetes. In addition, high doses of Insulin glargine can promote the proliferation of bladder cancer cells [1] [2] [3] [4]. Uses: Scientific research. Group: Peptides. CAS No. 160337-95-1. Pack Sizes: 100 U; 300 U. Product ID: HY-108719.
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Insulin glulisine
Insulin glulisine (HMR 1964) is a rapid-acting insulin analogue, it mimics the pharmacokinetic and pharmacodynamic profiles of physiological human insulin. Insulin glulisine can be used for the research of diabetes [1]. Uses: Scientific research. Group: Peptides. Alternative Names: HMR 1964. CAS No. 207748-29-6. Pack Sizes: 100 U. Product ID: HY-109555.
Insulin human
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Insulin (human)
Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. Synonyms: Recombinant human insulin; Insulin human; H-Phe-Val-Asn-Gln-His-Leu-Cys(1)-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys(2)-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr-OH.H-Gly-Ile-Val-Glu-Gln-Cys(3)-Cys(1)-Thr-Ser-Ile-Cys(3)-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys(2)-Asn-OH; L-phenylalanyl-L-valyl-L-asparagyl-L-glutaminyl-L-histidyl-L-leucyl-L-cysteinyl-glycyl-L-seryl-L-histidyl-L-leucyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinyl-glycyl-L-alpha-glutamyl-L-arginyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-tyrosyl-L-threonyl-L-prolyl-L-lysyl-L-threonine (7->7'),(19->20')-bis(disulfide) compound with glycyl-L-isoleucyl-L-valyl-L-alpha-glutamyl-L-glutaminyl-L-cysteinyl-L-cysteinyl-L-threonyl-L-seryl-L-isoleucyl-L-cysteinyl-L-seryl-L-leucyl-L-tyrosyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-asparagyl-L-tyrosyl-L-cysteinyl-L-asparagine (6'->11')-disulfide. Grade: 95%. CAS No. 11061-68-0. Molecular formula: C257H383N65O77S6. Mole weight: 5807.57.
Insulin (human)
Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 11061-68-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0035.
Insulin (Human)
Insulin (Human) is a peptide hormone regulating the metabolism of carbohydrates and fats. It is used in the treatment of those suffering from the diabetes type I and II metabolic disorders. Regulates the absorption of glucose from the blood to skeletal muscles and fat storage. Group: Biochemicals. Grades: Highly Purified. CAS No. 11061-68-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C257H383N65O77S6. US Biological Life Sciences.
Worldwide
Insulin-Like Growth Factor Binding Protein-2 from mouse
?95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Insulin-Like Growth Factor Binding Protein-2 human
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
Insulin-Like Growth Factor Binding Protein-3 human
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
Insulin-like Growth Factor Binding Protein-5 human
>95% (HPLC), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Insulin-like Growth Factor-I from mouse
IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Insulin-like Growth Factor-I human
IGF-I, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Insulin-like Growth Factor-II from mouse
IGF-II, recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy.
Insulin-like Growth Factor-II human
IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Insulin-like growth factor-II mRNA binding protein 3 (199-207)
Insulin-like growth factor-II mRNA binding protein 3 (199-207) is amino acids 199 to 207 fragment of Insulin-like growth factor-II mRNA binding protein 3. IGF2BP3 is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 (IGF-2) and ACTB (beta-actin). Synonyms: IGF2BP3 (199-207); IMP3 (199-207); KOC (199-207).
Insulin-like growth factor-II mRNA binding protein 3 (515-523)
Insulin-like growth factor-II mRNA binding protein 3 (515-523) is amino acids 199 to 207 fragment of Insulin-like growth factor-II mRNA binding protein 3. IGF2BP3 is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 (IGF-2) and ACTB (beta-actin). Synonyms: IGF2BP3 (515-523); IMP3 (515-523); KOC (515-523).
Insulin lispro is a recombinant human insulin analogue and is one of three rapid-acting insulin analogues available. Insulin lispro can be used for the research of hyperglycaemia in diabetes mellitus [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 133107-64-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-109530.
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Insulin Receptor (IR), Positive Control
Positive control for I7661-22H Insulin Receptor. Group: Molecular Biology. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences.
Worldwide
Insulin Receptor, phosphorylated (Tyr1150/1151) (IR), Positive Control
Positive control for I7661-22T Insulin Receptor, phosphorylated (Tyr1150/1151). Group: Molecular Biology. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences.
Worldwide
Insulin Receptor Substrate 1, pS616, Negative Control Peptide
Insulin Receptor Substrate 1, pS616, Negative Control Peptide. Group: Molecular Biology. Pack Sizes: 1x100ug. US Biological Life Sciences.
Worldwide
Insulin receptor substrate-2 (989-1007)
A peptide fragment of Insulin receptor substrate-2. Insulin receptor substrate-2 is essential for maturation and survival of photoreceptor cells. Synonyms: Irs2 (989-1007).
Insulin solution human
Chemically defined, recombinant, expressed in Saccharomyces cerevisiae, sterile-filtered, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Insulin solution (human)
Insulin solution (human) is a polypeptide hormone that regulates the level of glucose. Insulin solution (human) can be used for the diabetes mellitus [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 11061-68-0. Pack Sizes: 10 mg. Product ID: HY-P0035A.
Insulin (swine)
Insulin (swine) is a porcine-derived insulin used in diabetes research [1]. Uses: Scientific research. Group: Peptides. CAS No. 12584-58-6. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-P3479.
Insulin-Transferrin-Selenium, 100X
Insulin-Transferrin-Selenium, 100X (ITS-G) is a mixture of Insulin, transferrin, and sodium selenite that is a general supplement designed for use in classic media such as DMEM, RPMI-1640, and nutrient media such as Ham's F-12, DMEM/F-12. Insulin-Transferrin-Selenium is added to basal medium to reduce the amount of fetal calf serum required to culture cells[1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: ITS-G. Pack Sizes: 10 mL. Product ID: HY-150287.
insulysin
A 110 kDa cytosolic enzyme, known from mammals and the fruit fly, Drosophila melanogaster. Inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. In peptidase family M16 (pitrilysin family). Group: Enzymes. Synonyms: insulinase; insulin-degrading enzyme; insulin protease; insulin proteinase; insulin-degrading neutral proteinase; insulin-specific protease; insulin-glucagon protease; metalloinsulinase; IDE. Enzyme Commission Number: EC 3.4.24.56. CAS No. 9013-83-6. IDE. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4338; insulysin; EC 3.4.24.56; 9013-83-6; insulinase; insulin-degrading enzyme; insulin protease; insulin proteinase; insulin-degrading neutral proteinase; insulin-specific protease; insulin-glucagon protease; metalloinsulinase; IDE. Cat No: EXWM-4338.
INT
INT (Iodonitrotetrazolium chloride) is a biochemical reagent mainly used in the iodonitrotetrazolium chloride (INT) colorimetric method to assess the metabolic activity of cells and the activity of enzymes [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Iodonitrotetrazolium chloride; p-Iodonitrotetrazolium Violet. CAS No. 146-68-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15920.
INT-777
INT-777 is a potent TGR5 agonist with an EC50 of 0.82 ?M[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-EMCA. CAS No. 1199796-29-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15677.
Intedanib
Intedanib. Group: Biochemicals. Grades: Highly Purified. CAS No. 656247-17-5. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C31H33N5O4. US Biological Life Sciences.
Worldwide
Integracin A
It is an unusual ester of two structurally related alkylresorcinols first isolated from fungus, cytonaema sp. It is a potent inhibitor of HIV-1. Synonyms: Benzoic acid, 2-[(8R)-8-(acetyloxy)undecyl]-4,6-dihydroxy-, (1R)-8-(3,5-dihydroxyphenyl)-1-propyloctyl ester. Grade: >95% by HPLC. CAS No. 224186-03-2. Molecular formula: C37H56O8. Mole weight: 628.84.
Integracin A
Integracin A is an unusual ester of two structurally related alkylresourcinols first isolated from a fungus, Cytonaema sp. in 2002 as a potent inhibitor of HIV-1. With the exception of this intial report, Integracin A has received little or no further attention. Group: Biochemicals. Grades: Highly Purified. CAS No. 224186-03-2. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Integracin B
Integracin B is an unusual ester of two structurally related alkylresourcinols first isolated from a fungus, Cytonaema sp. in 2002 as a potent inhibitor of HIV-1 integrase. With the exception of this intial report, Integracin B has received little or no further attention. Group: Biochemicals. Grades: Highly Purified. CAS No. 224186-05-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Integracin B
It is an unusual ester of two structurally related alkylresorcinols first isolated from fungus, cytonaema sp. It is a potent inhibitor of HIV-1. Synonyms: 2,4-Dihydroxy-6-[(8R)-8-hydroxyundecyl]benzoic Acid (1R)-8-(3,5-Dihydroxyphenyl)-1-propyloctyl Ester. Grade: >95% by HPLC. CAS No. 224186-05-4. Molecular formula: C35H54O7. Mole weight: 586.80.
Integrator complex subunit 12 (329-345)
Integrator complex subunit 12 (329-345) is a fragment of Integrator complex subunit 12. It is a component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Synonyms: Int12 (329-345).
A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin avb3 (IC50=1.74pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37°C, a process which is mediated by caveolin and clathrin. At 10u/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50ug/ml. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Integrin Binding Peptide
Integrin Binding Peptide is derived by fibronectin. Integrin Binding Peptide can be used for PEG hydrogel preparation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 278792-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2532.
Integrin Binding Peptide
Integrin Binding Peptide is a peptide containing the cell adhesion sequence RGDSP, which is easily conjugated to carriers via Npys or maleimide chemistry. Synonyms: Ac-Gly-Cys-Gly-Tyr-Gly-Arg-Gly-Asp-Ser-Pro-Gly-NH2; N-acetyl-glycyl-L-cysteinyl-glycyl-L-tyrosyl-glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-seryl-L-prolyl-glycinamide; Glycinamide, N-acetylglycyl-L-cysteinylglycyl-L-tyrosylglycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-prolyl-. Grade: ≥95%. CAS No. 278792-07-7. Molecular formula: C42H63N15O16S. Mole weight: 1066.12.
Integrin ?v?3 Antagonist, P11
The Integrin ?v?3 Antagonist, P11 controls the biological activity of Integrin ?v?3. Group: Fluorescence/luminescence spectroscopy.
Intepirdine
Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63; exhibits >100-fold selectivity over other receptors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-742457; GSK-742457; RVT-101. CAS No. 607742-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14339.
Interferon-?A human
?95%, suitable for cell culture, buffered aqueous solution, recombinant, expressed in E. coli. Group: Fluorescence/luminescence spectroscopy.
A nonpeptidic thiophenylmethanamine compound that binds interferon-a (Kd= 4uM for human IFN-a) and prevents IFN-a and IFNAR interaction-dependent IFN-a production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC50<4.5uM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (<4.5uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.