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| Product | Description | |
|---|---|---|
| MK6-83 | MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1062271-24-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110238. |  |
| MK-6892 | MK-6892 is a highly potential GPR109A agonist. Alternative Names: MK6892; MK 6892; MK-6892. Grades: >98%. CAS No. 917910-45-3. Molecular formula: C19H22N4O5. Mole weight: 386.4. |  |
| MK-6892 | MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A. Ki and GTPγS EC50 of MK-6892 on the Human GPR109A is 4 nM and 16 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 917910-45-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10680. | |
| MK-7246 | MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5±0.5 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1218918-62-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15853. | |
| MK-7337 | MK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with 11C can be used as a PET tracer for neurodegenerative disorders like Parkinsons disease imagination[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3056154-69-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175748. | |
| MK-7622 | MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs). MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine (HY-N0296)-induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M1 receptor modulator. CAS No. 1227923-29-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-15618. | |
| MK-7924 | MK-7924, isolated from Coronophora gregaria, is an antibiotic with nematocidal effect. And the reproductive growth tests showed that the effective concentration against Caenorhabditis elegane was 100 μg/mL. Molecular formula: C34H58O13. Mole weight: 674.81. | |
| MK800-62F1 | MK800-62F1 is produced by the strain of Streptomyces diastochromogenes MK 800-62F1. It is used to inhibit H2O2-induced apoptosis in MS-1 cells (NCI-H) and Jurkat cells (TCL-H), and camptothecin-induced apoptosis in Jurkat cells. Molecular formula: C35H58O8. Mole weight: 606.83. | |
| MK-8245 | MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC50s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1030612-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13070. | |
| MK-8353 | MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH900353. CAS No. 1184173-73-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111407. | |
| MK-8353 | MK-8353 is an orally available ERK1/2 inhibitor. It exhibited antitumor activity in patients with BRAFV600-mutant melanoma. Alternative Names: (3S)-3-(methylthio)-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide. CAS No. 1184173-73-6. Molecular formula: C37H41N9O3S. Mole weight: 691.84. | |
| MK-8527 | MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1810869-23-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158128. | |
| MK-8527 | MK-8527. CAS No. 1810869-23-8. Molecular formula: C13H13ClN4O3. Mole weight: 308.72. | |
| MK-8617 | MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1187990-87-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101023. | |
| MK-8719 | MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1382799-40-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130121. | |
| MK8722 | MK8722 is a potent and systemic pan-AMPK activator. Uses: Scientific research. Category: Signaling pathways. CAS No. 1394371-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111363. | |
| MK-8722 | MK-8722 is a potent pan-AMPK activator that improves glucose homeostasis but induces cardiac hypertrophy. AMPK has long been of interest as a target for the treatment of Type 2 Diabetes Mellitus. Alternative Names: MK 8722; MK8722. CAS No. 1394371-71-1. Molecular formula: C24H20ClN3O4. Mole weight: 449.9. | |
| MK 886 | MK 886. Group: Biochemicals. Grades: Purified. CAS No. 118414-82-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MK-886 | MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L 663536. CAS No. 118414-82-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14166. | |
| MK-886 sodium salt | MK-886 sodium salt. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C27H33ClNNaO2S. US Biological Life Sciences. | Worldwide |
| MKC3946 | MKC3946 is a potent IRE1α inhibitor, used for cancer research. Uses: Scientific research. Category: Signaling pathways. CAS No. 1093119-54-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19710. | |
| MKC-3946 | MKC-3946 is a potent inhibitor of inositol-requiring enzyme 1α (IRE1α). It inhibits XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. MKC-3946 leads to modest growth inhibition in MM cells but has no effect on normal mononuclear cells in vitro. Alternative Names: MKC-3946; MKC 3946; MKC3946; 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde. Grades: >98%. CAS No. 1093119-54-0. Molecular formula: C21H20N2O3S. Mole weight: 380.462. | |
| MKC8866 | MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50 of 0.14 μM[1]. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Orin1001. CAS No. 1338934-59-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104040. | |
| MKC8866 | MKC8866 Inhibitor. Uses: Scientific use. Product Category: T15594. CAS No. 1338934-59-0. |  |
| MKI-1 | MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MASTL Kinase Inhibitor-1. CAS No. 1190277-80-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-137552. | |
| MKK7-COV-9 | MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein-protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC50 of 4.98 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2283355-59-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122872. | |
| MKK7-JNK activator 1 | MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production). MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3100092-62-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-179044. | |
| MKT 077 | MKT-077 is used in the treatment of Alzheimers diseases and other tauopathies. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2; selectively cytotoxic in cancer cells.Biological Activity:Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Group: Biochemicals. Alternative Names: 1-Ethyl-2- [ [3-ethyl-5- (3-methyl-2 (3H) -benzothiazolylidene) -4-oxo-2-thiazolidinylidene] methyl] -pyridinium Chloride; FJ 776. Grades: Highly Purified. CAS No. 147366-41-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?OS??; Ci, Molecular Weight: 441.01. US Biological Life Sciences. | Worldwide |
| MKT 077 | MKT-077 is a cationic rhodacyanine dye. It shows antiproliferative activity against cancer cell lines with EC50s value of 1.4-2.2 μM in vitro through its ability to inhibit members of the heat shock protein 70 family of molecular chaperones. Alternative Names: MKT-077; MKT 077; MKT077; FJ-776; FJ 776; FJ776; 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride. Grades: ≥98% by HPLC. CAS No. 147366-41-4. Molecular formula: C21H22ClN3OS2. Mole weight: 432. | |
| MKT-077 | MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity[1]. MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FJ-776. CAS No. 147366-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15096. | |
| ML00253764 | ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 681847-92-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124740. | |
| ML 00253764 hydrochloride | ML 00253764 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-00253764 hydrochloride | ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. ML-00253764 can cross blood-brain barrier[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1706524-94-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110123. | |
| ML-030 | ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1013750-77-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103050. | |
| ML089 | ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 μM. ML089 can be used for the research of congenital disorder of glycosylation Ia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1306638-12-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138802. | |
| ML-098 | ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-7345532. CAS No. 878978-76-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19800. | |
| ML-099 | ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-888706. CAS No. 496775-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124306. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 186826-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML115 | ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 912798-42-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111152. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML130 | ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. Alternative Names: ML 130; ML-130; Nodinitib-1; Noditinib-1; 1-Tosyl-1H-benzo[d]imidazol-2-amine. Grades: >98%. CAS No. 799264-47-4. Molecular formula: C14H13N3O2S. Mole weight: 287.34. | |
| ML 130 | ML 130. Group: Biochemicals. Grades: Purified. CAS No. 799264-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML132 | ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 value of 0.023 nM. ML132 has good stability and can be used as a caspase 1 molecular probe. ML132 is applicable to research in the fields of anticancer and anti-inflammatory studies[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NCGC-00183434. CAS No. 1230628-71-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12412. | |
| ML 133 hydrochloride | ML 133 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1222781-70-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML133 hydrochloride | ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1222781-70-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100230A. | |
| ML141 | ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-2950007. CAS No. 71203-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-12755. | |
| ML 141 | ML 141. Group: Biochemicals. Grades: Purified. CAS No. 71203-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145. Group: Biochemicals. Grades: Purified. CAS No. 1164500-72-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM)[1]. ML 145 has no significant activity for GPR35 at either rodent ortholog[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164500-72-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107536. | |
| ML154 | ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NCGC84. CAS No. 1345964-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108626. | |
| ML 154 | ML 154. Group: Biochemicals. Grades: Purified. CAS No. 1345964-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 161 | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. Group: Biochemicals. Alternative Names: ML161; 2-Bromo-N- [3- [ (1-oxobutyl) amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 423735-93-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML162 | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1035072-16-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-100002. | |
| ML162 | ML162 Inhibitor. Uses: Scientific use. Product Category: T8970. CAS No. 1035072-16-2. | |
| ML167 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID44968231; NCGC00188654. CAS No. 1285702-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15951. | |
| ML 171 | ML 171. Group: Biochemicals. Grades: Purified. CAS No. 6631-94-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| ML179 | ML179 (SR-1309) is a inverse LRH1/NR5A2 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883548-87-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110329. | |
| ML 179 | ML 179. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-180 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115613. | |
| ML 190 | ML 190. Group: Biochemicals. Grades: Purified. CAS No. 1355244-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-193 | ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinsons disease (PD) rats[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID 1261822. CAS No. 713121-80-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110125. | |
| ML198 | ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1380716-06-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117861. | |
| ML 202 | ML 202. Group: Biochemicals. Grades: Purified. CAS No. 1221186-52-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML204 | ML204 is a novel and potential TRPC4 Channel inhibitor. ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. Alternative Names: 4-Methyl-2-piperidin-1-ylquinoline; ML204; ML 204; ML-204. Grades: > 98%. CAS No. 5465-86-1. Molecular formula: C15H18N2. Mole weight: 226.323. | |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML 204 | ML 204. Group: Biochemicals. Grades: Purified. CAS No. 5465-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-210 | ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1360705-96-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100003. | |
| ML-210 | ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity. Group: Inhibitors. Alternative Names: CID 49766530. CAS No. 1360705-96-9. Pack Sizes: 5mg. Product ID: S0788. Formula: C22H20Cl2N4O4. Smiles: CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| ML-211 | ML-211 is a potent dual inhibitor of LYPLA1 and LYPLA2 enzymes, with an IC50 value of 17 nM against LYPLA1, 30 nM against LYPLA2, and 10 nM against ABHD11[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2205032-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128035. | |
| ML213 | ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 489402-47-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101843. | |
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