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| Product | Description | |
|---|---|---|
| Okadaic acid (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. |  Worldwide |
| Okadaic acid potassium salt | Okadaic acid potassium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: OKADAIC ACIDPOTASSIUM SALT, 155751-72-7. Product Category: Heterocyclic Organic Compound. CAS No. 155751-72-7. Molecular formula: C44H67KO13. Mole weight: 843.09. Purity: >98%. IUPACName: potassium 2-hydroxy-3-[7-hydroxy-4-[4-[4-hydroxy-2-[1-hydroxy-3-(9-methyl-5,11-dioxaspiro[5.5]undecan-10-yl)butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5-oxolane]-2-yl]but-3-en-2-yl]-2-methyl-5,11-dioxaspiro[5.5]undec-1-en-10-yl. Canonical SMILES: CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)[O-])O)O)C)O)O.[K+]. Product ID: ACM155751727. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Okadaic acid potassium salt | Okadaic acid potassium salt, originally derived from marine dinoflagellates, Prorocentrium sp., is a potent, cell permeable inhibitor of serine/threonine protein phosphatases. It inhibits protein phosphatase 1 (IC50 = 3-15 nM) and protein phosphatase 2A (IC50 = 0.1-1 nM). Synonyms: 35-Demethyl-DTX 1 Potassium Salt. CAS No. 209266-79-5. Molecular formula: C44H68O13K. Mole weight: 844.10. |  |
| Okadaic acid potassium salt from Prorocentrum concavum | ?90% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid, Potassium Salt (Halochondrine A, Potassium, OA) | Potassium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic Acid, Prorocentrum sp. (OA) | An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50=10-15nM) and protein phosphatase 2A (IC50=0.1nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. Group: Biochemicals. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid sodium salt from Prorocentrum concavum | ?90% (HPLC), film. Group: Fluorescence/luminescence spectroscopy. | |
| Okadaic Acid, Sodium salt (Halochondrine A) | Okadaic Acid, a marine toxin, polyether derivative produced by dinoflagellates, is a potent, cell-permeable, specific inhibitor of PP-1 and PP-2 serine/threonine-speci?c protein phosphatases in a variety of cell types. Salt form of okadaic acid, with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Alternative Names: 9, 10-Deepithio-9, 10-dide hydroacanthifolicin, Halochondrine A. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 100ug, 300ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
| Okadaic acid, Sodium Salt (OA, Halochondrine A, Sodium Salt) | Sodium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Okanin | Okanin, effective constituent of the flower tea Coreopsis tinctoria , attenuates LPS-induced microglial activation through inhibition of the TLR4 / NF-κB signaling pathways [1]. Uses: Scientific research. Group: Natural products. CAS No. 484-76-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N6673. |  |
| Okanin | Okanin Inhibitor. Uses: Scientific use. Product Category: TN2008. CAS No. 484-76-4. |  |
| Okicenone | Okicenone is originally isolated from Str. sp. KO-3599 and it has the effect of killing tumor cells. Synonyms: 3,4-Dihydro-4,6,9-trihydroxy-8-methyl-1(2H)-anthracenone; 1(2H)-Anthracenone, 3,4-dihydro-4,6,9-trihydroxy-8-methyl-. Grades: >98 %. CAS No. 137018-54-3. Molecular formula: C15H14O4. Mole weight: 258.27. | |
| Okilactomycin | It is originally isolated from Str. griseoflavus subsp. zamamiensis. It can resist gram-positive bacteria and inhibit leukemic cells. Synonyms: (3R,3aR,5R,6R,8R,11aS,14S,15aS)-3,3a,5,6,7,8,9,10,11,11a,14,15-Dodecahydro-3,6,8,14-tetramethyl-16-methylene-2,17-dioxo-3,5-ethano-2H-furo[2,3-o][2]benzoxacycloundecin-13-carboxylic acid; YP-02908L-A. Grades: >98%. CAS No. 111367-04-5. Molecular formula: C24H32O6. Mole weight: 416.51. | |
| Okoumal ® | Okoumal ®. CAS No. 131812-67-4. VIGON Item # 501190. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, woody dioxolane. |  America & Internationally |
| Okra extract | Okra extract. Group: Others. Purity: 0.41736111. Source: Okra or Okro, is a flowering plant in the mallow family. It is valued for its edible green seed pods. The plant is cultivated in tropical, subtropical and warm temperate regions around the world. Okra extract. Cat No: EXTC-157. |  |
| Oktakis-(2,6-di-O-tert-butyl-dimethylsilyl)-g-cyclodextrin | Oktakis-(2,6-di-O-tert-butyl-dimethylsilyl)-g-cyclodextrin. Product ID: 4-00137. |  |
| Oktakis-(6-O-tertbutyl-dimethylsilyl-g-cyclodextrin | Oktakis-(6-O-tertbutyl-dimethylsilyl-g-cyclodextrin. Product ID: 4-00135. | |
| Oktakis(Tetramethylammonium)-T8-Silisesquioxane | Oktakis(Tetramethylammonium)-T8-Silisesquioxane. Group: Poss nanohybrid materials. Alternative Names: OCTAKIS(TETRAMETHYLAMMONIUM)-T8-SILSESQUIOXANE; OCTAKIS(TETRAMETHYLAMMONIUM) PENTACYCLO-OCTASILOXANE-OCTAKIS(YLOXIDE) HYDRATE; Octakis (tetramethylammonium) octaprismosilsesquioxane; octakis(tetramethylammonium) pentacyclo[9.5.1.13, 9.15, 15.17, 13]octasiloxane-1. CAS No. 69667-29-4. Product ID: PSS hydrate-Octakis(tetramethylammonium) substituted. Molecular formula: 1137.83. Mole weight: 8C4H12N.O20Si8. HYWYFSRVEQSCJA-UHFFFAOYSA-N. 95%+. |  |
| OL135 | OL135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. It exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism. It increases the analgesic and hypothermic activity of anandamide. Uses: Ol135 is used as an analgesic drug. Synonyms: OL-135;1-Oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-phenylheptane;7-Phenyl-1-[5-(2-pyridinyl)-2-oxazolyl]-1-heptanone;7-Phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one. Grades: 98%. CAS No. 681135-77-3. Molecular formula: C21H22N2O2. Mole weight: 334.42. | |
| OL-135 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Olacaftor | Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator ( CFTR ) modulator extracted from patent US9782408. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-440. CAS No. 1897384-89-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112267. | |
| Olanexidine hydrochloride | Olanexidine hydrochloride is a monobiguanide compound with bactericidal activity. Olanexidine probably binds to the cell membrane, destroys membrane integrity. Olanexidine hydrochloride is active against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Olanexidine exhibits the bactericidal concentration of 109 μg/mL for Gram-positive bacilli [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 146509-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125654A. | |
| Olanzapine | Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 ( K i =7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 ( K i =11 to 31 nM), muscarinic M1-5 ( K i =1.9-25 nM), and adrenergic α1 receptor ( K i =19 nM). Olanzapine is an atypical antipsychotic [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY170053. CAS No. 132539-06-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-14541. | |
| Olanzapine | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C17H20N4S. CAS No. 132539-06-1. Prepack ID 60106881-1g. Molecular Weight 312.43. See USA prepack pricing. |  |
| Olanzapine 4-N-glucuronide | | |
| Olanzapine-d8 | 100 ?g/mL in acetonitrile, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms). | |
| Olanzapine Dimer Impurity | One of the impurities of Olanzapine. Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors. Synonyms: Olanzapine Impurity 10. Molecular formula: C29H28N6S2. Mole weight: 524.70. | |
| Olanzapine EP Impurity C | Olanzapine EP Impurity C is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: 1-(chloromethyl)-1-methyl-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazin-1-ium chloride. CAS No. 719300-59-1. Molecular formula: C18H22Cl2N4S. Mole weight: 397.36. | |
| Olanzapine hydrochloride-Bio-X | Olanzapine hydrochloride-Bio-X is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: 2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine hydrochloride; 4-Amino-2-methyl-10H-thieno[2,3-b][1,5]-benzodiazapine, Hydrochloride. CAS No. 138564-60-0. Molecular formula: C12H12ClN3S. Mole weight: 265.76. | |
| Olanzapine Impurity 25 | One of the impurities of Olanzapine. Olanzapine interacts with key receptors of interest in schizophrenia, having a nanomolar affinity for dopaminergic, serotonergic, alpha 1-adrenergic, and muscarinic receptors. Synonyms: Olanzapine impurity P. Grades: 95%. CAS No. 52833-34-8. Molecular formula: C6H6N2. Mole weight: 106.13. | |
| Olanzapine impurity 3 (Olanzapine EP Impurity E) | Olanzapine impurity 3 (Olanzapine EP Impurity E). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1017241-36-9. Molecular formula: C17H20N4OS. Mole weight: 328.43. Catalog: APB1017241369. | |
| Olanzapine impurity Q | Olanzapine impurity Q. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-(4-(4-methylpiperazin-1-yl)-2-thioxo-1H-benzo[b][1,4]diazepin-3(2H)-ylidene)methyl acetate. CAS No. 1320360-87-9. Molecular formula: C17H20N4O2S. Mole weight: 344.43. Catalog: APB1320360879. | |
| Olanzapine impurity R | Olanzapine impurity R. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (Z)-3-(hydroxymethylene)-4-(4-methylpiperazin-1-yl)-1H-benzo[b][1,4]diazepine-2(3H)-thione. CAS No. 1320360-86-8. Molecular formula: C15H18N4OS. Mole weight: 302.39. Catalog: APB1320360868. | |
| Olanzapine ketolactam | Olanzapine ketolactam is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: (Z)-4-(4-methylpiperazin-1-yl)-3-(2-oxopropylidene)-1H-benzo[b][1,4]diazepin-2(3H)-one; (3Z)-1,3-Dihydro-4-(4-methyl-1-piperazinyl)-3-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one. CAS No. 1017241-34-7. Molecular formula: C17H20N4O2. Mole weight: 312.37. | |
| Olanzapine LIP 1 Acetyl | Olanzapine LIP 1 Acetyl is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: 1-(4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazin-1-yl)ethan-1-one. CAS No. 935272-10-9. Molecular formula: C18H20N4OS. Mole weight: 340.44. | |
| Olanzapine N-Oxide | Olanzapine N-Oxide. Uses: For analytical and research use. Group: Impurity standards. CAS No. 174794-02-6. Pack Sizes: 2.5MG. IUPAC Name: 2-methyl-4-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine. Molecular formula: C17H20N4OS. Mole weight: 328.43. Catalog: APS174794026A. SMILES: Cc1cc2C(=Nc3ccccc3Nc2s1)N4CC[N+](C)([O-])CC4. Format: Neat. Shipping: Room Temperature. | |
| Olanzapine Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Olanzapine Related Compound A | 5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile is an impurity of Olanzapine. Olanzapine impurity A (EP). Synonyms: Olanzapine impurity A;5-Methyl-2-(2-nitroanilino)-3-thiophenecarbonitrile;5-methyl-2-(2-nitroanilino)thiophene-3-carbonitrile;Olanzapine Related Compound A;3-Cyano-5-methyl-2-(2-nitroanilino)thiophene. CAS No. 138564-59-7. Molecular formula: C12H9N3O2S. Mole weight: 259.28. | |
| Olanzapine Related Compound B | Olanzapine Related Compound B is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: LY-301664; 2-Methyl-5,10-dihydro-4H-benzo[b]thieno[2,3-e][1,4]diazepin-4-one; Olanzapine EP Impurity B. Grades: >95%. CAS No. 221176-49-4. Molecular formula: C12H10N2OS. Mole weight: 230.29. | |
| Olanzapine Related Compound B | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Olanzapine Related Compound C | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Olanzapine Related Compound C | Olanzapine Related Compound C is an impurity of Olanzapine, an antipsychotic medication indicated for the treatment of schizophrenia, bipolar disorder, etc. Synonyms: Olanzapine N-Oxide; Olanzapine EP Impurity D; 2-methyl-4-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine. Grades: 95%. CAS No. 174794-02-6. Molecular formula: C17H20N4OS. Mole weight: 328.4. | |
| Olanzapine Thiolactam Impurity | Olanzapine thiolactam impurity is a degradation product formed during storage or exposure to thermal stress. Synonyms: Olanapine Ketothiolactam; RT-017506; FT-0673225; 3-[(Z)-2-hydroxyprop-1-enyl]-4-(4-methylpiperazin-1-yl)-1,5-benzodiazepine-2-thione. Grades: ≥95%. CAS No. 1017241-36-9. Molecular formula: C17H20N4OS. Mole weight: 328.43. | |
| Olanzapine USP | 2-Methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2,3-b][1,5]-benzodiazepine. Grades: USP. CAS No. 132539-06-1. Product ID: 8-01846. Molecular formula: C17H20N4S. Mole weight: 312.43. | |
| Olanzapine USP | 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-B][1,5]benzodiazepine. semi-synthetic kanamycin-derived aminoglycoside antibiotic. Grades: USP. CAS No. 132539-06-1. Product ID: 8-04678. Molecular formula: C17H20N4S. Mole weight: 312.43. | |
| Olaparib | Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC 50 s of 5 and 1 nM for PARP1 and PARP2 , respectively. Olaparib is an autophagy and mitophagy activator [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD2281; KU0059436. CAS No. 763113-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g. Product ID: HY-10162. | |
| Olaparib | 500mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C24H23FN4O3. CAS No. 763113-22-0. Prepack ID 90027882-500mg. Molecular Weight 434.46. See USA prepack pricing. | |
| Olaparib | Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.PARP1 acts as a critical molecule in the repair of DNA single-strand breaks (SSBs) and plays an important role in maintaining DNA integrity. de Murcia, J., et al. "Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells." Proc. Natl. Acad. Sci. USA 94: 7303-7307 (1997).PARP inhibitors inhibit PARP1 during S-phase and...num drugs." Proc. Natl. Acad. Sci. USA 105: 17079-17084 (2008).Long-term treatment with olaparib caused the development of drug resistance, which was induced by up-regulation of Abcb1a/b genes encoding P-glycoprotein efflux pumps. The resistance to... Group: Biochemicals. Alternative Names: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone; AZD-2281; KU 0059436; KU-59436; 1- (Cyclopropylcarbonyl) -4- [5- [ (3, 4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine. Grades: Highly Purified. CAS No. 763113-22-0. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 434.46. US Biological Life Sciences. | Worldwide |
| Olaparib | Olaparib, also known as AZD-2281 or KU-59436, is a small-molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Synonyms: AZD2281; AZD-2281; AZD 2281; KU59436; KU-59436; KU 59436; KU0059436; KU-0059436; KU 0059436; Olaparib. trade name Lynparza; 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one. Grades: >98%. CAS No. 763113-22-0. Molecular formula: C24H23FN4O3. Mole weight: 434.471. | |
| Olaparib Impurity 1 | An impurity of Olaparib, which selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks. Synonyms: 4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one. Grades: > 95%. Molecular formula: C24H24N4O3. Mole weight: 416.48. | |
| Olaparib Impurity 2 | An impurity of Olaparib, which selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks. Synonyms: 6-chloro-4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one. Grades: > 95%. Molecular formula: C24H22ClFN4O3. Mole weight: 468.92. | |
| Olaparib Impurity 4 | Olaparib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1021298-68-9. Molecular formula: C16H10FN3O. Mole weight: 279.27. Catalog: APB1021298689. | |
| Olaparib Impurity 5 | Olaparib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 16859-59-9. Molecular formula: C8H6O3. Mole weight: 150.13. Catalog: APB16859599. | |
| Olaparib Impurity 66 | Olaparib Impurity 66. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1090982-59-4. Molecular formula: C10H16N2O2. Mole weight: 196.25. Catalog: APB1090982594. | |
| Olaparib (Standard) | Olaparib (Standard) is the analytical standard of Olaparib. This product is intended for research and analytical applications. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD2281 (Standard); KU0059436 (Standard). CAS No. 763113-22-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10162R. | |
| Olaquindox | analytical standard. Group: Application areaspharma & vet compounds & metabolitesstandards for environmental regulatory methodsenvironmental food contaminantspharma & vet compounds & metabolites. | |
| Olaquindox | Olaquindox, as one of the antimicrobial growth accelerants, is usually used in livestock production to improve feed efficiency. Olaquindox induced apoptosis of HepG2 cells through a caspase-9 dependent mitochondrial pathway. Besides, Olaquindox also induces autophagy in HepG2 cells and that Olaquindox-induced apoptosis can be enhanced by 3-methyladenine. Olaquindox-induced autophagy in HepG2 cells is upregulated by Beclin 1 but downregulated by ROS-dependent JNK. Uses: Antimicrobial growth accelerant. Synonyms: N-(2-HYDROXYETHYL)-3-METHYL-2-QUINOXALINECARBOXAMIDE 1,4-DIOXIDE;OLAGUINDOX; OLAQUINDOX;2-(n-(2-hydroxyethyl)karbamoyl)-3-methylchinoxalin-1,4-dioxid; 2-quinoxalinecarboxamide,n-(2-hydroxyethyl)-3-methyl-,1,4-dioxide;bayernox;bayonox; bisergon. Grades: >98%. CAS No. 23696-28-8. Molecular formula: C12H13N3O4. Mole weight: 263.25. | |
| Olaquindox | Olaquindox, a quinoxalin derivative, is an orally active antibiotic. Olaquindox stimulates growth and decreases intestinal mucosal immunity of piglets [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 23696-28-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0465. | |
| Olaquindox | A growth stimulant. Group: Biochemicals. Alternative Names: N- (2-Hydroxyethyl) -3- methyl -2-quinoxalinecarboxamide . Grades: Highly Purified. CAS No. 23696-28-8. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C??H??N?O?, Form: Supplied as a yellow. US Biological Life Sciences. | Worldwide |
| Olaquindox | Olaquindox - Agriculture Chemicals. SUPPLIERS TO BUSINESS CUSTOMERS ONLY. |  North America & APAC |
| Olaquindox-d4 | A growth stimulant. Group: Biochemicals. Alternative Names: N- (2-Hydroxyethyl-d4) -3- methyl -2-quinoxalinecarboxamide d4; NSC 634933-d4. Grades: Highly Purified. CAS No. 1189487-82-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Olaquindox-(ethylene-d4) | analytical standard. Group: Application areas. | |
| olaratumab | Olaratumab is a monoclonal antibody used for the treatment of solid tumors. In combination with doxorubicin, it can be used for the treatment of adults with advanced soft-tissue sarcoma (STS) who cannot be cured by cancer surgery or radiation therapy. Uses: The treatment of solid tumors. CAS No. 1024603-93-7. Molecular formula: C6554H10076N1736O2048S40. Mole weight: 147200. | |
| Olaratumab | Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha ( PDGFRα ) human monoclonal IgG1 antibody with antitumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IMC-3G3; LY3012207. CAS No. 1024603-93-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9922. | |
| Olcegepant | Olcegepant is a potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist. Olcegepant displays high affinity for human CGRP receptors and exhibits no significant affinity for 75 other receptors. Olcegepant may a be viable option for the treatment of acute migraines. Group: Biochemicals. Alternative Names: 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)piperazine; N- [ (1R) -2- [ [ (1S) -5-Amino-1- [ [4- (4-pyridinyl) -1-piperazinyl] carbonyl] pentyl] amino] -1- [ (3, 5-dibromo-4-hydroxyphenyl) methyl] -2-oxoethyl] -4- (1, 4-dihydro-2-oxo-3 (2H) -quinazolinyl) -1-piperidinecarboxamide; BIBN 4096BS; BIBN 4096. Grades: Highly Purified. CAS No. 204697-65-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Olcegepant | Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIBN-4096; BIBN 4096BS. CAS No. 204697-65-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10095. | |
| Olcegepant | Olcegepant, also called as BIBN4096BS or BIBN 4096, is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor(IC50= 0.03 nM) and has been shown to block all effects of infused CGRP (2) and should ef. Synonyms: BIBN-4096; BIBN4096; BIBN 4096; BIBN-4096BS; BIBN4096BS; BIBN 4096BS; Olcegepant; N-[(2R)-1-[[(2S)-6-amino-1-oxo-1-(4-pyridin-4-ylpiperazin-1-yl)hexan-2-yl]amino]-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide; Olcegepant; Olcegepant [INN]; BIBN-4096BS; BIBN 4096 BS; BIBN4096BS; CHEMBL2071; CHEMBL 2071; CHEMBL-2071. CAS No. 204697-65-4. Molecular formula: C38H47Br2N9O5. Mole weight: 869.65. | |
| Olcegepant hydrochloride | Olcegepant hydrochloride is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with 150-fold selective over the peptidic antagonist CGRP8-37 (IC50 = 0.03 nM, Ki = 14.4 pM for human CGRP). Synonyms: N-[(2R)-1-[[(2S)-6-amino-1-oxo-1-(4-pyridin-4-ylpiperazin-1-yl)hexan-2-yl]amino]-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl]-4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxamide;hydrochloride; Olcegepant (hydrochloride); Olcegepant hydrochloride. CAS No. 586368-06-1. Molecular formula: C38H47Br2N9O5.HCl. Mole weight: 906.11. | |
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