A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Prostaglandin I2, Sodium Salt (PGI2, Prostacyclin)
Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Exhibits cytoprotective and fibrinolytic properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 61849-14-7. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
prostaglandin-I synthase
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin). Group: Enzymes. Synonyms: prostacyclin synthase; prostacycline synthetase; prostagladin I2 synthetase; PGI2 synthase; PGI2 synthetase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase. Enzyme Commission Number: EC 5.3.99.4. CAS No. 65802-86-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5512; prostaglandin-I synthase; EC 5.3.99.4; 65802-86-0; prostacyclin synthase; prostacycline synthetase; prostagladin I2 synthetase; PGI2 synthase; PGI2 synthetase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase. Cat No: EXWM-5512.
Prostaglandin J2
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K i s of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC 50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: PGJ2. CAS No. 60203-57-8. Pack Sizes: 500 μg (14.95 mM * 100 μL in Methyl acetate). Product ID: HY-113366.
PROSTAGLANDINS
PROSTAGLANDINS. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PROSTAGLANDINS;Einecs 234-237-8. Product Category: Heterocyclic Organic Compound. CAS No. 11000-26-3. Product ID: ACM11000263. Alfa Chemistry ISO 9001:2015 Certified.
prostamide/prostaglandin F2α synthase
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2&alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2. Group: Enzymes. Synonyms: prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase. Enzyme Commission Number: EC 1.11.1.20. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0502; prostamide/prostaglandin F2α synthase; EC 1.11.1.20; prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase. Cat No: EXWM-0502.
prostamide/prostaglandin F2α synthase
The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2α. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2.
Prostanozol
Prostanozol. Group: Biochemicals. Alternative Names: (5a,17b)-17-[(Tetrahydro-2H-pyran-2-yl)oxy]-2'H-androst-2-eno[3,2-c]pyrazole. Grades: Highly Purified. CAS No. 1186001-41-1. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C25H38N2O2. US Biological Life Sciences.
Worldwide
Prostate Microvascular Endothelial Cells, Human (Frozen)
Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences.
Worldwide
Prostate Microvascular Endothelial Cells, Human (T-25 flask)
Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences.
Worldwide
Prostate Specific Antigen-1 (153-161)
Prostate Specific Antigen-1 (153-161) is a bioactive peptide of Prostate Specific Antigen-1. Prostate-specific antigen is a protein made by cells in the prostate gland (both normal cells and cancer cells). PSA is mostly found in semen, but a small amount is also found in blood. Synonyms: PSA-1 (153-161).
Prostate Specific Antigen (146-154)
Prostate Specific Antigen (146-154) is a truncated fragment of Prostate Specific Antigen. Prostate-specific antigen is a protein made by cells in the prostate gland (both normal cells and cancer cells). PSA is mostly found in semen, but a small amount is also found in blood. Synonyms: PSA (146-154); gamma-seminoprotein (146-154); kallikrein-3 (146-154); P-30 antigen (146-154).
Prostate-specific antigen (165-174)
Prostate-specific antigen (165-174) is a peptide corresponding to residues 165-174 of Prostatic acid phosphatase. Prostatic acid phosphatase, an enzyme produced by the prostate, may be found in increased amounts in men who have prostate cancer or other diseases. Synonyms: PAP (165-174); prostatic specific acid phosphatase (165-174).
Prostate-specific antigen (178-187)
Prostate-specific antigen (178-187) is a peptide corresponding to residues 178-187 of Prostatic acid phosphatase. Prostatic acid phosphatase, an enzyme produced by the prostate, may be found in increased amounts in men who have prostate cancer or other diseases. Synonyms: PAP (178-187); prostatic specific acid phosphatase (178-187).
Prostate Specific Antigen-?1-Antichymotrypsin Complex human
Prostatic acid phosphatase (112-120) is a peptide corresponding to residues 112-120 of Prostatic acid phosphatase. Prostatic acid phosphatase, an enzyme produced by the prostate, may be found in increased amounts in men who have prostate cancer or other diseases. Synonyms: PAP (112-120); prostatic specific acid phosphatase (112-120).
Prostatic acid phosphatase (18-26)
Prostatic acid phosphatase (18-26) is a peptide corresponding to residues 18-26 of Prostatic acid phosphatase. Prostatic acid phosphatase, an enzyme produced by the prostate, may be found in increased amounts in men who have prostate cancer or other diseases. Synonyms: PAP (18-26); prostatic specific acid phosphatase (18-26).
Prostatic acid phosphatase (299-307)
Prostatic acid phosphatase (299-307) is a peptide corresponding to residues 299-307 of Prostatic acid phosphatase. Prostatic acid phosphatase, an enzyme produced by the prostate, may be found in increased amounts in men who have prostate cancer or other diseases. Synonyms: PAP (299-307); prostatic specific acid phosphatase (299-307).
Prostatic acid phosphatase from Human, recombinant
ACPP, also known as prostatic acid phosphatase isoform PAP, is a type I integral membrane protein of the plasma membrane and lysosomes, and a secreted form also exists. The concentration of ACPP is elevated in the circulation of prostate cancer patients, making the enzyme a marker for the progression of prostate cancer. Recombinant human ACPP, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. Group: Enzymes. Synonyms: Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; ACPP; ACP-3, ACP3. Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: > 95% by SDS-PAGE. Apase. Mole weight: 41.8 kDa. Activity: >100,000 units/mg. Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -70°C. Avoid repeated freezing and thawing cycles. Form: Liquid. Source: Baculovirus. Species: Human. Prostatic acid phosphatase; PAP; prostatic specific acid phosphatase; PSAP; EC 3.1.3.2; ACP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; ACPP; ACP-3, ACP3. Cat No: NATE-1673.
Prostratin
Prostratin, a natural terpenoid compound, is a PKC activator, with a K i of 12.5 nM and shows inhibitory effect on HIV-1. Uses: Scientific research. Group: Natural products. CAS No. 60857-08-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107421.
Prosultiamine. Group: Biochemicals. Grades: Highly Purified. CAS No. 59-58-5. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Worldwide
Pro-survival Compound, DDD00033325
A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50=3.9uM), with equal or higher potency than Y-27632 in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10uM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10uM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30uM than Y-27632 without marked adverse effects for up to 120 hours. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?, Molecular Weight: 293.37. US Biological Life Sciences.
Worldwide
PROTAC AR/AR-V7 degrader-1
PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC50 values of 2.67 and 2.64 ?M for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2841308-96-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162412.
PROTAC AR Degrader-8
PROTAC AR Degrader-8 (Compound NP18) is the PROTAC degrader for androgen receptor ( AR ), that degrades AR-FL with DC 50 of 0.018 μM and 0.14 μM in 22Rv1 cell and LNCaP cell, degrades AR-V7 with DC 50 of 0.026 μM in 22Rv1 cell. PROTAC AR Degrader-8 inhibits the proliferation of cancer cell 22Rv1 and LNCaP with IC 50 of 0.038 μM and 1.11 μM. PROTAC AR Degrader-8 arrests cell cycle at G2/M phase, induces apoptosis in 22Rv1 cell. PROTAC AR Degrader-8 exhibits anticancer efficacy in mouse and zebrafish model [1]. (Pink: ligand for target protein AR ligand-33 (HY-170330); Black: linker (HY-W007731); Blue: ligand for E3 ligase Cereblon (HY-14658)). Uses: Scientific research. Group: Signaling pathways. CAS No. 3044108-04-2. Pack Sizes: 1 mg. Product ID: HY-170329.
PROTAC Bcl2 degrader-1
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 ?M; DC50, 3.0 ?M) and Mcl-1 (IC50, 11.81 ?M) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1] (Blue: CRBN ligand, Black: linker?Pink: Mcl-1/Bcl-2 inhibitor, Nap-1). Uses: Scientific research. Group: Signaling pathways. CAS No. 2378801-85-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-125876.
PROTAC B-Raf degrader 1
PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2364367-27-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111758.
PROTAC BRAF-V600E degrader-1
PROTAC BRAF-V600E degrader-1 (compound 23) is a potent PROTAC BRAF-V600E degrader whlie no degradation activity against BRAF-WT. PROTAC BRAF-V600E degrader-1 exhibits Kd values of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS) and inhibits the growth of melanoma cells[1]. (In the molecular structure, target protein ligand: BI-882370 (HY-107779), red part; E3 ubiquitin enzyme ligand: Pomalidomide (HY-10984), blue part; PROTAC linker: G007-LK (HY-12438), black part. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417296-84-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-137487.
PROTAC BRD4 Degrader-10
PROTAC BRD4 Degrader-10, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 1.3 and 18 nM, respectively. Synonyms: S-(3-(((((3R,5S)-1-((S)-15-(tert-butyl)-1-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulen-9-yl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)butan-2-yl) methanesulfonothioate. Grade: 98%. CAS No. 2417370-49-9. Molecular formula: C59H71F2N9O15S4. Mole weight: 1312.50.
PROTAC BRD4 Degrader-11
PROTAC BRD4 Degrader-11 is a PROTAC linked by ligands for von Hippel-Lindau and BRD4. It is conjugated with STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50s of 0.23 nM and 0.38 nM, respectively. Synonyms: S-((R)-1-(((((3R,5S)-1-((S)-2-(11-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamido)undecanamido)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)propan-2-yl) methanesulfonothioate. Grade: 98%. Molecular formula: C61H75F2N9O12S4. Mole weight: 1292.56.
PROTAC BRD4 Degrader-12
PROTAC BRD4 Degrader-12, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 0.39 and 0.24 nM, respectively. Synonyms: S-(3-(((((3R,5S)-1-((S)-2-(11-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamido)undecanamido)-3,3-dimethylbutanoyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)butan-2-yl) methanesulfonothioate. Grade: 98%. CAS No. 2417370-90-0. Molecular formula: C62H77F2N9O12S4. Mole weight: 1306.58.
PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-13, a PROTAC connected by ligands for von Hippel-Lindau and BRD4, can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50s of 0.025 and 6.0 nM, respectively. CAS No. 2417370-71-7. Molecular formula: C68H85F2N11O17P2S2. Mole weight: 1492.54.
PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3026420-38-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-138555.
PROTAC BRD4 Degrader-9
PROTAC BRD4 Degrader-9 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. It can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with DC50 values of 0.86 nM and 7.6 nM, respectively. Synonyms: S-(1-(((((3R,5S)-1-((S)-15-(tert-butyl)-1-(7-(3,5-difluoropyridin-2-yl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulen-9-yl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-5-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-3-yl)oxy)carbonyl)oxy)-2-methylpropan-2-yl) methanesulfonothioate. Grade: 98%. CAS No. 2417370-42-2. Molecular formula: C59H71F2N9O15S4. Mole weight: 1312.5.
PROTAC CDK2/9 Degrader-1
PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408641-24-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130709.
PROTAC ERα Degrader-1
PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha ( ERα ) degrader. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417369-94-7. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112098.
PROTAC EZH2 Degrader-1
PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2641601-67-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147525.
PROTAC GPX4 degrader-1
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 ?M in HT1080 cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2916433-81-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-149236.
PROTAC HK2 Degrader-1
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033812-84-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155008.
PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 ?M). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2488851-89-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131911.
PROTAC JAK1 degrader 1
PROTAC JAK1 degrader 1 degrader 1 (compound 10c) is an effective and selective PROTAC JAK1 degrader with a DC50 of 214 nM. PROTAC JAK1 degrader 1 has antitumor activity. (Structure Note: PINK, JAK1 ligand 1 (HY-10961); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3052553-20-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-162608.
PROTAC K-Ras Degrader-4
PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway[1]. (Pink: ligand for target protein pan-KRAS degrader 1 (HY-162960); Black: linker (HY-159790); Blue: ligand for E3 ligase VHL (HY-W998248)). Uses: Scientific research. Group: Signaling pathways. CAS No. 2938169-99-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-159788.
PROTAC KRAS G12D degrader 1
PROTAC KRAS G12D degrader 1 (compound 8o) is a potent, rapid, and selective degrader of protac KRASG12D with DC50 of 38.06 nM. PROTAC KRAS G12D degrader 1 showes significant antitumor efficacy[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033583-54-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-161176.
PROTAC YAP degrader-1
PROTAC YAP degrader-1 (compound YZ-6) is a PROTAC targeting YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 is composed of PROTAC target protein ligand NSC682769 (HY-168017) (red part) and E3 ubiquitin ligase ligand + Linker conjugate (R,S,R)-AHPC-PEG2-C2-boc (HY-168019) (blue+black part), in which the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3058483-58-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168016.
proTAME
proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1362911-19-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124955.
Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 9009-65-8. Pack Sizes: 100 mg. Product ID: HY-107911.
Protamine sulfate salt
Protamine sulfate salt. Group: Biochemicals. Alternative Names: Salmine Sulfate. Grades: Highly Purified. CAS No. 53597-25-4. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
Protamine sulfate salt from salmon
Grade II. Group: Fluorescence/luminescence spectroscopy.
Protamine sulfate salt Salmon
Protamine sulfate salt Salmon. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences.
Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 141136-85-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2518.
Protease-Activated Receptor-2 Activating Peptide
LIGRL-NH2 is a PAR2 activator with EC50 value of ~5 μM. It can be used to explore signaling through PAR2 in cells. Synonyms: Thrombin Receptor-Like 1 (1-6) amide (mouse, rat); SLIGRL amide; Proteinase Activated Receptor 2 (1-6) amide (mouse, rat); Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat); PAR-2 (1-6) amide (mouse, rat); Ser-Leu-Ile-Gly-Arg-Leu-NH2; L-Seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucinamide. Grade: 98%. CAS No. 171436-38-7. Molecular formula: C29H56N10O7. Mole weight: 656.82.
Protease-Activated Receptor-2, amide
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. Uses: Scientific research. Group: Peptides. CAS No. 190383-13-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0283.
Protease-Activated Receptor-4 is an agonist of proteinase-activated receptor-4 (PAR4). Synonyms: PAR-4 (1-6) amide (mouse); H-Gly-Tyr-Pro-Gly-Lys-Phe-NH2; glycyl-L-tyrosyl-L-prolyl-glycyl-L-lysyl-L-phenylalaninamide. Grade: ≥95%. CAS No. 245443-52-1. Molecular formula: C33H46N8O7. Mole weight: 666.77.
Protease-Activated Receptor-4
Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4). Uses: Scientific research. Group: Peptides. CAS No. 245443-52-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0297.
Protease enzyme for fermentation
A protease enzyme used in food processing applications to break down and increase the solubility, dispersability, palatability and digestibility of proteins. Applications: Fermentation enhancement. Group: Enzymes. Synonyms: Protease enzyme; for fermentation; protease; Fuel Alcohol; Alcohol and Starch Enzymes; Fermentation enhancement; enhancement; Starch Enzymes. CAS No. 37259-58-8. Protease. Appearance: inquire. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: ASE-3112.
Protease for baking
A protease enzyme used to produce food-protein hydrolysates with reduced viscosity, improved solubility, flavor, nutritional, and emulsifying characteristics. Applications: For biscuits and crackers. Group: Enzymes. Synonyms: Protease for baking; granulated protease enzyme; For Biscuits and Crackers; BAK-1723. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: BAK-1723.
Protease for flavors
Protease used in a neutral to alkaline environment. Used to develop savory flavors and to debitter protein hydrolysates. Applications: Flavors in high-protein flours used in baking. Group: Enzymes. CAS No. 37259-58-8. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: PRO-1827.
Protease for Medical
Protease enzyme used in medical and surgical instrument cleaning products to remove protein-containing, organic materials such as blood, mucus, feces and foods. Applications: Laundry. Group: Enzymes. Synonyms: Protease; Medical and surgical instrument; cleaning; Protease enzyme; surgical instrument; Detergents; Protease for Medical; DETE-2630. CAS No. 37259-58-8. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: DETE-2630.
Protease for special flours
A protease enzyme for the treatment of special flours for biscuit and cracker making, which require low-protein levels. Applications: For biscuits and crackers. Group: Enzymes. Synonyms: Protease for special flours; protease enzyme; For Biscuits and Crackers; BAK-1722. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: BAK-1722.