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| Product | Description | |
|---|---|---|
| Proxyfan oxalate | Proxyfan oxalate. Group: Biochemicals. Grades: Purified. CAS No. 177708-09-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Pro-xylane | Pro-xylane - Product ID: NST-10-141. Category: Glycosides. Alternative Names: C-?-D-Xylopyranoside-2-hydroxypropane. Purity: 98%. Test method: HPLC. CAS No. 439685-79-7. Pack Sizes: 5g, 10g, 25g, 50g. Appearance: White Powder. Molecular formula: C8H16O5. Mole weight: 192.21. Storage: +2 +8 °C. |  |
| Pro-xylane (30% in water) | Pro-xylane (30% in water) (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane (30% in water) has potential skin anti-aging properties and is eco-friendly, biodegradable, and can be used in cosmetic research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hydroxypropyl tetrahydropyrantriol. CAS No. 439685-79-7. Pack Sizes: 50 mg (1.56 M * 166.67 μL in Water); 100 mg (1.56 M * 333.33 μL in Water). Product ID: HY-108036. |  |
| Proxylphylline | Proxylphylline. Group: Biochemicals. Grades: Highly Purified. CAS No. 603-00-9. Pack Sizes: 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |
| Proxymetacaine HCl | anti-cancer agent. CAS No. 5875-6-9. Product ID: 8-04402. Molecular formula: C16H12N2O3Cl. Mole weight: 330.85. Reference: Oncology 71, 292, 2006. |  |
| Proxymetacaine hydrochloride | Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM. Uses: Proparacaine hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. Synonyms: Proxymetacaine hydrochloride. Grades: 95%. CAS No. 5875-6-9. Molecular formula: C16H26N2O3.HCl. Mole weight: 330.85. |  |
| Proxyphylline | Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator [1]. Uses: Scientific research. Group: Natural products. CAS No. 603-00-9. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B1742. | |
| Proxyphylline | Proxyphylline is a metabolite of theophylline in human plasma. It acts as a selective antagonist of A1 adenosine receptors, and exhibits vasodilatory and cardiac stimulatory effects. Uses: Bronchodilator agents. Synonyms: NSC 163343; Proxiphylline; Purophyllin; Monophylline; 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione. Grades: ≥98%. CAS No. 603-00-9. Molecular formula: C10H14N4O3. Mole weight: 238.2. | |
| PrP 106-126 (human) | Prion Protein 106-126 (human), a peptide fragment of the cellular prion protein PrP, is used as a model to investigate neurodegeneration in prion diseases. It exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Synonyms: Prion Protein Fragment 106-126 Human; Prion Protein 106-126 (human); Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly; L-lysyl-L-threonyl-L-asparagyl-L-methionyl-L-lysyl-L-histidyl-L-methionyl-L-alanyl-glycyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-glycyl-L-alanyl-L-valyl-L-valyl-glycyl-glycyl-L-leucyl-glycine. Grades: ≥95%. CAS No. 148439-49-0. Molecular formula: C80H138N26O24S2. Mole weight: 1912.24. | |
| PRP-194 | PRP-194 is a pyrrolopyridine derivative with molecule weight 194.66. Currently there is no formal name with this intermediate, and we temporally call this product as PRP-194. PRP-194 is an important intermediate for the synthesis of fluorescent dyes. Synonyms: PRP 194; PRP194; 5-chloro-2,3,3-trimethyl-3H-pyrrolo[2,3-b]pyridine. CAS No. 596085-87-9. Molecular formula: C10H11ClN2. Mole weight: 194.66. | |
| PRT-060318 | PRT-060318, also known as PRT318 or P142-76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT. Synonyms: PRT-060318; PRT 060318; PRT060318; PRT318; P1426. CAS No. 1194961-19-7. Molecular formula: C18H24N6O. Mole weight: 340.431. | |
| PRT-060318 dihydrochloride | PRT-060318, also known as PRT318 or P142-76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT-060318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT. Synonyms: PRT-060318 2HCl; PRT318 dihydrochloride; PRT318 2HCl. Molecular formula: C18H24N6O·2HCl. Mole weight: 413.34. | |
| PRT062607 | PRT062607 is a highly specific and potent inhibitor of spleen tyrosine kinase (Syk) (IC50 = 1-2 nM). Synonyms: PRT-062607; PRT 062607; P505-15; PRT-2607; PRT 2607; PRT2607; BIIB 057; 4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide; 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-; 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide. Grades: >98%. CAS No. 1370261-96-3. Molecular formula: C19H23N9O. Mole weight: 393.45. | |
| PRT062607 Hydrochloride | PRT062607 is a highly selective and orally available Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than other kinases including Fgr, Lyn, FAK, Pyk2 and Zap70. Synonyms: PRT062607 HCl; P505-15 HCl; P505-15 hydrochloride; BIIB057 HCl; BIIB057 hydrochloride; 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, hydrochloride (1:x); 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride. Grades: ≥95%. CAS No. 1439908-97-0. Molecular formula: C19H23N9O.xHCl. Mole weight: 393.45 (free base). | |
| PRT4165 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PRT4165 | PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. Synonyms: PRT4165; PRT-4165; PRT 4165. Grades: 98%. CAS No. 31083-55-3. Molecular formula: C15H9NO2. Mole weight: 235.24. | |
| PRT 4165 | PRT 4165. Group: Biochemicals. Grades: Purified. CAS No. 31083-55-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Prucalopride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Prucalopride | Prucalopride is a potent and selective 5-HT4 receptor agonist. Prucalopride is a gastroprokinetic drug with the brand name Resolor, developed for the treatment of constipation and irritable bowel syndrome. Studies indicates that it is promisingly to be a candidate therapy of Alzheimer's disease and chronic intestinal pseudo-obstruction. Uses: Gastroprokinetic drug. Synonyms: Resolor; 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide. Grades: 99%. CAS No. 179474-81-8. Molecular formula: C18H26ClN3O3. Mole weight: 367.87. | |
| Prucalopride | Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pK i s of 8.6 and 8.1 for human 5-HT4a/4b receptors , respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 179474-81-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14151. | |
| Prucalopride Dimer Impurity | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C26H30Cl2N4O5. Mole weight: 549.46. | |
| Prucalopride Hydroxy Impurity | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C18H26ClN3O4. Mole weight: 383.88. | |
| Prucalopride Impurity 1 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C18H24ClN3O3. Mole weight: 365.86. | |
| Prucalopride Impurity 10 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C19H26ClN3O4. Mole weight: 395.89. | |
| Prucalopride Impurity 3 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C30H46ClN3O13. Mole weight: 692.17. | |
| Prucalopride Impurity 4 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. CAS No. 1599434-55-5. Molecular formula: C17H24ClN3O3. Mole weight: 353.85. | |
| Prucalopride Impurity 5 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C20H28ClN3O4. Mole weight: 409.92. | |
| Prucalopride Impurity 6 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Synonyms: Prucalopride Impurity 6; 1608459-56-8; PRUCALOPRIDESUCCINATE IMPURITY 13; 4-amino-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide; BCP33675; PRUCALOPRIDESUCCINATEIMPURITY13; 4-Amino-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran -7-carboxamide. Grades: > 95%. CAS No. 1608459-56-8. Molecular formula: C18H27N3O3. Mole weight: 333.43. | |
| Prucalopride Impurity 7 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C20H29N3O4. Mole weight: 375.47. | |
| Prucalopride Impurity 8 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C12H12ClNO4. Mole weight: 269.69. | |
| Prucalopride Impurity 9 | An impurity of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Grades: > 95%. Molecular formula: C14H12ClN3O3. Mole weight: 305.72. | |
| Prucalopride N-Oxide | A metabolite of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Synonyms: N-Oxo Prucalopride; 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-1-oxido-4-piperidinyl]-7-benzofurancarboxamide. Grades: > 95%. CAS No. 1900715-98-1. Molecular formula: C18H26ClN3O4. Mole weight: 383.88. | |
| Prucalopride succinate | Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pK i s of 8.6 and 8.1 for human 5-HT4a/4b receptors , respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R-108512. CAS No. 179474-85-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12694. | |
| Prucalopride Succinate | Prucalopride is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. Group: Biochemicals. Alternative Names: 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide Butanedioic Acid; R 108512; Resolor. Grades: Highly Purified. CAS No. 179474-85-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Prucalopride Succinate | A derivative of Prucalopride. Prucalopride is a selective, high affinity 5-HT4 receptor agonist. It has been tested for the treatment of chronic intestinal pseudo-obstruction. Synonyms: 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate; R-108512; R 108512; R108512; Prucalopride Succinate; Resolor; Resotran. Grades: > 95%. CAS No. 179474-85-2. Molecular formula: C18H26ClN3O3 C4H6O4. Mole weight: 458.97. | |
| Prucalopride Succinate-13CD3 | Prucalopride Succinate-13CD3 is the labeled analogue of Prucalopride Succinate (P838950). Prucalopride is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C2113CH29D3ClN3O7, Molecular Weight: 489.97. US Biological Life Sciences. | Worldwide |
| Prulifloxacin | Prulifloxacin prevents bacterial DNA replication, transcription, repair and recombination through inhibition of bacterial DNA gyrase. Uses: Anti-bacterial agents. Synonyms: NM441; NM 441; NM-441; 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-; 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid; (±)-7-[4-[(Z)-2,3-Dihydroxy-2-butenyl]-1-piperazinyl]-6-fluoro-1-methyl-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid, cyclic carbonate; Quisnon; Sword. Grades: >98%. CAS No. 123447-62-1. Molecular formula: C21H20FN3O6S. Mole weight: 461.46. | |
| Prulifloxacin | Prulifloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Prulifloxacin is a prodrug for active metabolite, Ulifloxacin. Antibacterial. Group: Biochemicals. Alternative Names: 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-. Grades: Highly Purified. CAS No. 123447-62-1. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Prulifloxacin | Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NM441. CAS No. 123447-62-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0024. | |
| Prunasin | Prunasin is a inhibitor of DNA Polymerase β [1]. Uses: Scientific research. Group: Natural products. CAS No. 99-18-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1548. | |
| prunasin β-glucosidase | Highly specific; does not act on amygdalin, linamarin or gentiobiose. (cf. EC 3.2.1.21 β-glucosidase). Group: Enzymes. Synonyms: prunasin hydrolase. Enzyme Commission Number: EC 3.2.1.118. CAS No. 9023-41-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3801; prunasin β-glucosidase; EC 3.2.1.118; 9023-41-0; prunasin hydrolase. Cat No: EXWM-3801. |  |
| Prune Fruit Powder | Prune Fruit Powder. |  CA, FL & NJ |
| Prunella | Prunella. CAS No. MIXTURE. VIGON Item # 502833. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, herbaceous. |  America & Internationally |
| Prunetin | ?98.0% (TLC). Group: Chemical class. | |
| Prunetin | Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 552-59-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2597. | |
| Prunetin | Botanical Source: Group: Biochemicals. Alternative Names: Padmakastein, Prunusetin. Grades: Plant Grade. CAS No. 552-59-0. Pack Sizes: 5mg, 10mg. US Biological Life Sciences. | Worldwide |
| Prunin | Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC 50 of 5.5 μM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Naringenin 7-0-glucoside. CAS No. 529-55-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N1549. | |
| Prunin | Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 μM. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 529-55-5. Molecular formula: C21H22O10. Mole weight: 434.39. Purity: 0.9992. Canonical SMILES: O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13. Product ID: ACM529555. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Prussian Blue | 25g Pack Size. Group: Research Organics & Inorganics, Salts, Stains & Indicators. Formula: Fe4[Fe(CN)6]3. CAS No. 14038-43-8. Prepack ID 79912360-25g. Molecular Weight 859.24. See USA prepack pricing. |  |
| Prussian blue insoluble | Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Iron(III) ferrocyanide; Milori blue. CAS No. 14038-43-8. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-106594A. | |
| Prussian blue insoluble, Technical grade | Prussian blue insoluble, Technical grade. Group: Biochemicals. Grades: Purified. CAS No. 14038-43-8. Pack Sizes: 50g, 100g. US Biological Life Sciences. | Worldwide |
| Pruvanserin | Pruvanserin (EMD 281014 free acid) is a selective 5-HT2A receptor antagonist. Pruvanserin alleviates tactile allodynia in diabetic rats. Pruvanserin can also be used for research of insomnia [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EMD 281014 free acid; LY 2422347. CAS No. 443144-26-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106246. | |
| Pruvanserin Hydrochloride (EMD 281014) | Pruvanserin Hydrochloride is a new class of selective, non-basic 5-HT2A receptor antagonists. Group: Biochemicals. Alternative Names: 1-[ (3-Cyano-1H-indol-7-yl) carbonyl]-4-[2- (4-fluorophenyl) ethyl]piperazine Monohydrochloride; EMD 281014; LSN 2420586; LY 2422347 HCl; LY 2422347 HCl; 7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile hydrochloride. Grades: Highly Purified. CAS No. 443144-27-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C22H22ClFN4O, Molecular Weight: 412.89. US Biological Life Sciences. | Worldwide |
| Pruvonertinib | YK-029A is an orally active inhibitor of mutant EGFR , targeting to both the T790M mutations (EGFR T790M ) and exon 20 insertion of EGFR (EGFRex20ins). YK-029A exhibits significant antitumor activity, and results tumor regression in EGFRex20ins-driven PDX models [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YK-029A. CAS No. 2064269-82-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-155537. | |
| PRX-07034 hydrochloride | PRX-07034 is a potent and selective 5-HT6 receptor antagonist. It was shown to improve cognition and memory in rats. Synonyms: PRX-07034; PRX07034; PRX 07034; PRX-07034 HCl; N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloride. Grades: ≥98% by HPLC. CAS No. 903580-39-2. Molecular formula: C21H28ClN3O4S·HCl. Mole weight: 490.44. | |
| PRX-07034 hydrochloride | PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a K i = 4-8 nM and an IC 50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 903580-39-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14559. | |
| PRX 08066 | PRX 08066, a selective 5-hydroxytryptamine receptor 2B(5-HT2BR) antagonist, causes selective vasodilation of pulmonary arteries. Its IC50 value is 3.4 nM. It can potentially inhibit the pathologic 5-HT-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (PAH). It reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. It shows effects on the vascular muscularization induced by 5-HT in the in vitro studies. It inhibits 5-HT-induced mitogen-activated protein kinase activation and markedly reduces thymidine incorporation in Chinese hamster ovary cells expressing the human 5-HT2BR in vitro. It decrea...ts and mice without affecting the systemic mean arterial pressure in the animals. It is also found to have anti-proliferative and anti-fibrotic effects. It was developed by Allergan company and is in clinical phase 2 with no progression. Uses: Prx 08066 can potentially inhibit the pathologic 5-ht-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (pah). it is also found to have anti-proliferative and anti-fibrotic effects. Synonyms: PRX-08066; PRX 08066; PRX08066. 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]methyl]-2-fluorobenzonitrile. Grades: >98%. CAS No. 866206-54-4. Molecular formula: C19H17ClFN5S. Mole weight: 401.89. | |
| PRX-08066 | PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3. Uses: Scientific research. Group: Signaling pathways. CAS No. 866206-54-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15472. | |
| PRX-08066 maleic acid | PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 value of 3.4 nM. Synonyms: PRX-08066 maleate; 5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile (2Z)-2-Butenedioate. CAS No. 866206-55-5. Molecular formula: C19H17ClFN5S·C4H4O4. Mole weight: 517.96. | |
| Przewalskinic acid A | Przewalskinic acid A is found in the Salvia przewalskii Maxim herb. Synonyms: Przewalskinic acid A; 136112-75-9; (2R,3R)-4-[(E)-2-carboxyethenyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid; 7-Epiblechnic acid; HY-N5057. Grades: >98%. CAS No. 136112-75-9. Molecular formula: C18H14O8. Mole weight: 358.3. | |
| Przewalskinic acid A | Przewalskinic acid A. Group: Biochemicals. CAS No. 136112-75-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PS10 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PS10 | PS10 is a novel, potent and ATP-competitive pan- PDK inhibitor, inhibits all PDK isoforms with IC 50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 ( K d = 239 nM) than for Hsp90 (K d = 47 μM) [1]. PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy [2].PDK: pyruvate dehydrogenase kinase. Uses: Scientific research. Group: Signaling pathways. CAS No. 1564265-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121744. | |
| PS-1145 | PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells. Synonyms: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide; PS-1145; PS 1145; PS1145. Grades: 98%. CAS No. 431898-65-6. Molecular formula: C17H11ClN4O. Mole weight: 322.75. | |
| PS 1145 dihydrochloride | PS 1145 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1049743-58-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PS 1145 dihydrochloride | PS 1145 is a highly specific small-molecule IKK inhibitor (IC50 = 100 nM). Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo. Effects of PS 1145 on proliferation and apoptosis correlated with inhibition of interleukin (IL)-6, cyclin D1, D2, inhibitor of apoptosis (IAP)-1 and IAP-2 gene expression and decreased IL-6 protein level. Synonyms: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide; PS 1145 dihydrochloride; PS-1145 dihydrochloride; PS1145 dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1049743-58-9. Molecular formula: C17H11ClN4O.2HCl. Mole weight: 395.67. | |
| PS-1145 dihydrochloride | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| PS210 | PS210 is a potent and selective PDK1 activator with a K d of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1 , inhibiting the phosphorylation and activation of S6K [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1221962-86-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121629. | |
| PS372424 hydrochloride | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PS423 | PS423 is a prodrug of PS210, acting as a substrate-selective inhibitor of PDK1 , inhibiting the phosphorylation and activation of S6K. PS210 is a potent and selective PDK1 activator targeting the PIF binding pocket of PDK1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1221964-37-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124060. | |
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