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| Product | Description | |
|---|---|---|
| SR15006 | SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) with an IC50 of 41.6 nM in DLD-1/pGL4.18hKLF5p cells)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2505001-54-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139691. |  |
| SR 16584 | SR 16584. Group: Biochemicals. Alternative Names: 1,3-Dihydro-1-[(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one. Grades: Highly Purified. CAS No. 1150153-86-8. Pack Sizes: 10mg. Molecular Formula: C17H22N2O, Molecular Weight: 270.37. US Biological Life Sciences. |  Worldwide |
| SR1664 | SR1664 is a PPARγ antagonist. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50=80 nM; Ki= 28.67 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338259-05-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12483. | |
| SR 1664 | SR 1664. Group: Biochemicals. Grades: Purified. CAS No. 1338259-05-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 16832 | SR 16832 is a dual-site covalent, orthosteric and allosteric PPARγ antagonist. SR 16832 activates the TGF-β signaling pathway and upregulates the expression of Vimentin and Fibronectin (Fibronectin). SR 16832 is toxic to bronchial epithelium. SR 16832 can be used in research related to type 2 diabetes and pulmonary fibrosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2088135-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112247. | |
| SR17018 | SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC50 of 97 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2134602-45-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111454. | |
| SR 18292 | SR 18292 is an inhibitor of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). It reduces blood glucose, potently increases hepatic insulin sensitivity, and improves glucose homeostasis in dietary and genetic mouse models of type 2 diabetes. Alternative Names: 1-[Tert-butyl-[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)propan-2-ol. Grades: ≥95%. CAS No. 2095432-55-4. Molecular formula: C23H30N2O2. Mole weight: 366.5. |  |
| SR-18292 | SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095432-55-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101491. | |
| SR18662 | SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2505001-62-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136530. | |
| SR 202 | SR 202. Group: Biochemicals. Grades: Purified. CAS No. 76541-72-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR2211 | SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1359164-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16998. | |
| SR 2640 Hydrochloride | Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4- attenuation of human PMN chemotaxis. Group: Biochemicals. Alternative Names: 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: Highly Purified. CAS No. 146662-42-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 27897 | SR 27897. Group: Biochemicals. Grades: Purified. CAS No. 136381-85-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-3029 | SR-3029, a small molecule inhibitor that targets specificly CK1δ/CK1ε, was effective at reducing the growth of breast cancer in multiple mouse models without any signs of major toxicity. IC50=97 nM. Alternative Names: N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amine;SR-3029; SR 3029; SR3029;SCHEMBL15243359; SCHEMBL17132207; CS-5672; CS 5672; CS5672; HY-100011; 1454585-06-8. CAS No. 1454585-06-8. Molecular formula: C23H19F3N8O. Mole weight: 480.45. | |
| SR-3029 | SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454585-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100011. | |
| SR31527 chloride | SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 μM. SR31527 chloride decreases cell viability and colony formation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 311814-78-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118961. | |
| SR-318 | SR-318, a chemical probe, is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2413286-32-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135674. | |
| SR3335 | The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It has no effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor α. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. Alternative Names: ML-176; SR 3335; SR-3335; ML176; ML 176. Grades: >98%. CAS No. 293753-05-6. Molecular formula: C13H9F6NO3S2. Mole weight: 405.34. | |
| SR3335 | SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML 176. CAS No. 293753-05-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14413. | |
| SR 33805 oxalate | SR 33805 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 121346-33-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR 3576 | SR 3576. Group: Biochemicals. Grades: Purified. CAS No. 1164153-22-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-3576 | SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164153-22-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107596. | |
| SR-3677 | SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1072959-67-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13300. | |
| SR 3677 dihydrochloride | SR 3677 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1072959-67-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-4370 | SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1816294-67-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111400. | |
| SR-4559 | SR-4559 is a α/β hydrolase domain-containing protein 5 (ABHD5) ligand. SR-4559 activates adipose triglyceride lipase (ATGL) and stimulates lipolysis by inhibiting ABHD5-PLIN interactions in adipocytes and muscle cells. SR-4559 can be used for metabolic diseases like Chanarin Dorfman syndrome research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 847939-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-111953. | |
| SR-4835 | SR-4835 Inhibitor. Uses: Scientific use. Product Category: T8325. CAS No. 2387704-62-1. |  |
| SR-4835 | SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2387704-62-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-130250. | |
| SR 48692 | SR 48692. Group: Biochemicals. Grades: Purified. CAS No. 146362-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 49059 | SR 49059. Group: Biochemicals. Grades: Purified. CAS No. 150375-75-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SR 49059 | SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150375-75-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18345. | |
| SR 57227A | SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 77145-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102064. | |
| SR 57227 hydrochloride | SR 57227 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 77145-61-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR 58611A hydrochloride | SR 58611A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 121524-09-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR59230A | SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 174689-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-100672. | |
| SR 59230A hydrochloride | SR 59230A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1135278-41-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SR-717 | SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375421-09-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131454. | |
| SR-717 | SR-717 Inhibitor. Uses: Scientific use. Product Category: T8655. CAS No. 2375421-09-1. | |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes (STING) for treating cancer. Alternative Names: SR 717 lithium; SR717 lithium. Grades: >98%. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. | |
| SR7826 | SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC50 of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1 than ROCK and JNK kinases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219728-20-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19353. | |
| SR8278 | SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254944-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14415. | |
| SR 8278 | SR 8278. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 1254944-66-5. Pack Sizes: 10mg. Molecular Formula: C18H19NO3S2, Molecular Weight: 361.48. US Biological Life Sciences. | Worldwide |
| SR9009 | SR9009 is a REV-ERBα/β agonist with IC50s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1379686-30-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16989. | |
| SR9011 | SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1379686-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16988. | |
| SR9011 hydrochloride | SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070014-94-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16988A. | |
| SR9243 | SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613028-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16972. | |
| SR 95531 hydrobromide | SR 95531 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 104104-50-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SRA880 | SRA880 is a non-peptide and selective somatostatin sst(1) receptor antagonist. SRA880 exhibits antidepressant-like effects when in combination with Imipramine (HY-B1490A) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 573984-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-123499. | |
| SRC-1 NR box peptide | SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 227929-80-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P5464. | |
| Src Antibody [H13N7] | Src,v-Src. Group: Antibodies. Alternative Names: Src,v-Src. Pack Sizes: 20ul. Product ID: F0262. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| Src I1 | Src I1. Group: Biochemicals. Grades: Purified. CAS No. 179248-59-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Src Inhibitor 1 | Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Src Kinase Inhibitor 1; Src-l1. CAS No. 179248-59-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101053. | |
| SREBP1 Antibody [J19N8] | SREBP1 Antibody [J19N8]. Group: Antibodies. CAS No. Pack Sizes: 20uL. Product ID: F1581. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| SRI-011381 | SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1629138-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-100347. | |
| SRI-011381 (C381) | SRI-011381 (C381) is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.C381 physically targets the lysosome, promotes lysosomal acidification, increases breakdown of lysosomal cargo, and improves lysosome resilience to damage. Group: Inhibitors. Alternative Names: C381. CAS No. 1629138-41-5. Pack Sizes: 5mg. Product ID: S6654. Formula: C20H31N3O. . Smiles: C1CCC(CC1)NC(=O)N(CC2CCNCC2)CC3=CC=CC=C3. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| SRI-011381 hydrochloride | SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects, with blood-brain barrier permeability[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070014-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-100347A. | |
| SRI 31215 TFA | SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1832686-44-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114363A. | |
| SRI-37330 | SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2322245-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142114. | |
| SRI-37330 hydrochloride | SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2322245-49-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-141623. | |
| SRI 37892 | SRI 37892 is a small molecule compound inhibitor of Frizzled protein 7 (Fzd7) with inhibitory activity against cancer cell proliferation (IC50=2μM). SRI 37892 significantly blocks Wnt/Fzd7 signaling. SRI 3789 can be used in the research of developing cancer therapeutic agents [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1030769-75-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-117002. | |
| SRI-41315 | SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613509-49-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150090. | |
| S-ribosylhomocysteine lyase | Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. Group: Enzymes. Synonyms: S-ribosylhomocysteinase; LuxS. Enzyme Commission Number: EC 4.4.1.21. CAS No. 37288-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5323; S-ribosylhomocysteine lyase; EC 4.4.1.21; 37288-63-4; S-ribosylhomocysteinase; LuxS. Cat No: EXWM-5323. |  |
| Srpin340 | Srpin340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. Srpin340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. Alternative Names: SRPIN-340; SRPIN 340. Grades: 99.82%. CAS No. 218156-96-8. Molecular formula: C18H18F3N3O. Mole weight: 349.35. | |
| SRPIN340 | SRPIN340. Group: Biochemicals. Grades: Purified. CAS No. 218156-96-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SRPIN340 | SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SRPK inhibitor. CAS No. 218156-96-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13949. | |
| Srpk1-IN-1 | Srpk1-IN-1 (compound 12) is a potent inhibitor of SRPK1, with IC50 of 0.3 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2408444-93-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160586. | |
| SRPKIN-1 | SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089226-94-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-116856. | |
| SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340) | A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SRS16-86 | SRS16-86 is a potent inhibitor of ferroptosis[1]. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research[2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1793052-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135430. | |
| SRT1720 | SRT1720 Inhibitor. Uses: Scientific use. Product Category: T2412. CAS No. 1001645-58-4. | |
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