A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
s-(+)-Flecainide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[(2S)-2-Piperidinylmethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide. Product Category: Heterocyclic Organic Compound. CAS No. 99495-92-8. Molecular formula: C17H20F6N2O. Mole weight: 414.34. Product ID: ACM99495928. Alfa Chemistry ISO 9001:2015 Certified.
S-(+)-Flecainide
S-(+)-Flecainide. Group: Biochemicals. Alternative Names: N-[ (2S) -2-Piperidinylmethyl]-2, 5-bis (2, 2, 2-trifluoroethoxy) benzamide. Grades: Highly Purified. CAS No. 99495-92-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C17H20F6N2O3. US Biological Life Sciences.
Worldwide
S-formylglutathione hydrolase
Also hydrolyses S-acetylglutathione, but more slowly. Group: Enzymes. Enzyme Commission Number: EC 3.1.2.12. CAS No. 83380-83-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3547; S-formylglutathione hydrolase; EC 3.1.2.12; 83380-83-0. Cat No: EXWM-3547.
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (Hind III-digest) in 1 hour at 50°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. C↑TCGAG GAGCT↓C. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 274. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1174RE.
Sfr303 I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. CCGC↑GG GG↓CGCC. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 303. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1175RE.
sFRP-1 human
recombinant, expressed in HeLa cells, ?97% (SDS-PAGE), ?97% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
sFRP-1 Inhibitor - CAS 915754-88-0
The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications. Group: Fluorescence/luminescence spectroscopy.
SFTI-1
SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 245080-24-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10033.
SFXSPO
SFXSPO. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Diphenylspiro[9H-fluorene-9,9'-[9H]xanthen]-4'-ylphosphine oxide. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1508022-28-3. Molecular formula: C37H25O2P. Mole weight: 532.57 g/mol. Product ID: ACM1508022283. Alfa Chemistry ISO 9001:2015 Certified. Categories: SFX (software).
SG-094
SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2922283-37-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148816.
SG2057
SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48h period. Cures were obtained in a LOX-IMVI melanoma model following a single administration and dose-dependent activity, including regression responses, observed in SKOV-3 ovarian and HL-60 promyelocytic leukemia models following repeat dose schedules. In the advanced stage LS174T model, SG2057 administered either as a single dose, or in two repeat dose schedules, was superior to irinotecan. SG2057 is therefore a highly active antitumor agent, with more potent in vitro activity and superior in vivo activity to SG2000. Synonyms: SG-2057; SG 2057; DRG-16; (11aS,11a'S)-8,8'-(pentane-1,5-diylbis(oxy))bis(7-methoxy-2-methylene-2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5(11aH)-one). CAS No. 260417-62-7. Molecular formula: C33H36N4O6. Mole weight: 584.66.
SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1595275-71-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101161.
SGA360
SGA360. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazole; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole. Grades: Highly Purified. CAS No. 680611-86-3. Pack Sizes: 10mg. Molecular Formula: C19H17F3N2O2, Molecular Weight: 362.35. US Biological Life Sciences.
Worldwide
SGA360-d5
SGA360-d5. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazol-d5; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C19H12D5F3N2O2, Molecular Weight: 367.38. US Biological Life Sciences.
Worldwide
S-(γ)-Phe
S-(γ)-Phe. Synonyms: S gamma Phe. CAS No. 916198-97-5. Molecular formula: C11H15NO2. Mole weight: 193.24.
SGC0946 is a selective DOT1L H3K79 methyltransferase ) inhibitor, with an IC 50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1561178-17-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-15650.
Potent DOT1L methyltransferase inhibitor (KD = 0.06nm, IC50 = 0.3nm in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8nm respectively). Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SGC2085
SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 ( CARM1 ) with an IC 50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC 50 value of 5.2 μM, but not other PRMT proteins [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1821908-48-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100565.
SGC3027
SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2624313-13-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112445.
SGC-AAK1-1 is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC 50 of 270 nM and a K i of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247894-32-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123940.
SGC-CBP30 is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613695-14-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15826.
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC 50 s of 36 and 16 nM for CK2α and CK2αrespectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2470424-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139004.
SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226517-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122186.
SGC-STK17B-1 is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor ( IC 50 : 34 nM, K D : 5.6 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2650530-00-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156350.
SGD-1882
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PBD dimer. CAS No. 1222490-34-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101127.
SGD-1910
SGD-1910 is a agent-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1342820-51-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-101162.
SGF29-IN-1
SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6638-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158009.
SGI 1027
SGI 1027. Group: Biochemicals. Grades: Purified. CAS No. 1020149-73-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 ?M, 8 ?M, and 12.5 ?M for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. Uses: Scientific research. Group: Signaling pathways. CAS No. 1020149-73-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13962.
SGI-1776 free base is an inhibitor of Pim kinases, with IC 50 s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1025065-69-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13287.
SgI-29
SgI-29 is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: SgI-29 (85-113); His-Asn-Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Arg-Val-Val-Ile-His-His-Lys-Gly-Gly-Lys-Ala-His. Grade: >97%. Molecular formula: C145H226N56O39. Mole weight: 3377.74.
SgII peptide A is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: SgII peptide A (human); Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Met-Ile-Val-Ile-His-His-Lys-Gly-Gly-Gln-Ala-His-His-Gly. Grade: >97%. Molecular formula: C142H218N52O39S. Mole weight: 3309.68.
SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1279829-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18607.
SGLT2-IN-1 (Compound 5) is an inhibitor for sodium-dependent glucose cotransporter ( SGLT2 ), with IC 50 of 33 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864070-37-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-I1120.
S-(+)-Glycidyl tosylate
S-(+)-Glycidyl tosylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 70987-78-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences.
Worldwide
SGN-2FF
SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089647-47-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107366.
SGN-B6A
SGN-B6A is an ADC, which targets integrin beta-6 (ITGB6) through human IgG1 monoclonal antibody Sigvotatug (HY-P990764), and exhibits cytotoxicity against multiple integrin beta-6-positive cancer cell through mitotic inhibitor MMAE (HY-15162)[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164957.
sGnRH-A
sGnRH-A is a GnRH peptide analog that acts as a GnRH antagonist. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Arg-Trp-Leu-Pro-NHEt. CAS No. 96497-82-4. Molecular formula: C64H83N17O12. Mole weight: 1282.45.
sGnRH-A TFA
sGnRH-A is a GnRH peptide analog that acts as a GnRH antagonist. Synonyms: H-Pyr-His-Trp-Ser-Tyr-D-Arg-Trp-Leu-Pro-NHEt.CH3CO2H; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-arginyl-L-tryptophyl-L-leucyl-L-proline ethylamide acetic acid. Molecular formula: C66H87N17O14. Mole weight: 1342.53.
sgp91 ds-tat Peptide 2, scrambled
sgp91 ds-tat Peptide 2, scrambled is a scrambled sequence of NADPH oxidase inhibitor gp91 ds-tat peptide. It is used as a control peptide. Molecular formula: C98H190N50O22S. Mole weight: 2453.
SGR-1505
SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 inhibits MALT1 enzymatic activity and shows anti-proliferative activity in BTK inhibitor (BTKi)-sensitive and BTKi-resistant activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines. SGR-1505 can be used for research of B-cell lymphomas [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2661481-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160698.
sgRNA Screening Kit
sgRNA Screening Kit. Sgrna screening kit provides a simple, reliable, and rapid method for assessing sgrna efficiency before cell transduction, allowing you to identify the highly effective crispr sgrna. cas9 nuclease nls is an rna-guided endonuclease that catalyzes site-specific cleavage of double stranded dna. the location of the break is within the target sequence 3 bases from the ngg pam (protospacer adjacent motif). the design of single guide rna (sgrna) is dependent on the target region close to the pam site. even if you pick a target sequence that fulfills all of the described requirements, sgrna specificity and activity is unpredictable. therefore, it is often recommended that multiple, different sgrnas be designed to target a gene of interest. components. gencrispr cas9 nuclease. 10x reaction buffer. positive control sgrna. positive control substrate. rnase-free water. Group: Cloning Enzymes. Purity: 30 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3509.
sgRNA Synthesis Kit
sgRNA Synthesis Kit. This product is designed to synthesize grnas in vitro. in the bacterial crispr/cas9 system, the cas9 nuclease associates with two rnas, the crispr rna (crrna) and the trans-activating crrna (tracrrna), to direct sequence-specific dna cleavage. the grna (guide rna) is a fusion of the natural crrna and tracrrna components. it contains an 18-20 base variable sequence that can be changed to target any dna sequence that is adjacent to an ngg proto-spacer adjacent motif (pam) on the 3 end of the target sequence. the sgrna synthesis kit allows user to fuse their choice of 18-20 base target sequence within the grna dna sequence provided, by pcr fusion. the kit also provides materials for in-vitro transcription of the generated grna dna in order to generate grnas which can be directly used for in-vivo genome editing. Group: Cloning Enzymes. Purity: 20 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3510.
Sgs 518 oxalate
Sgs 518 oxalate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SGS 518 oxalate, CTK8E8444, 445441-27-0. Product Category: Heterocyclic Organic Compound. CAS No. 445441-27-0. Molecular formula: C21H22F2N2O3S.C2H2O4. Purity: >98 %. IUPACName: [1-methyl-3-(1-methylpiperidin-4-yl)indol-5-yl] 2,6-difluorobenzenesulfonate;oxaldehydic acid. Canonical SMILES: CN1CCC(CC1)C2=CN(C3=C2C=C(C=C3)OS(=O)(=O)C4=C(C=CC=C4F)F)C.C(=O)C(=O)O. Product ID: ACM445441270. Alfa Chemistry ISO 9001:2015 Certified.
SGS 518 oxalate
SGS 518 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 445441-27-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SGX 523
SGX 523. Group: Biochemicals. Grades: Purified. CAS No. 1022150-57-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SGX-523
SGX523 is a exquisitely selective and ATP-competitive MET inhibitor. SGX523 potently inhibits MET with an IC50 of 4 nM and is >1,000-fold selective versus other protein kinases. Antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1022150-57-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12019.
SH-42
SH-42 is a potent and selective inhibitor of human ?24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2143952-36-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143228.
SH-4-54
SH-4-54 is a STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1456632-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16975.
SH514
SH514 is an interferon regulatory factor 4 (IRF4) inhibitor with an IC50 value of 2.63 ?M. SH514 can be bound to the IRF4-DBD domain with KD values of 1.28 ?M. SH514 can be used to study multiple myeloma (MM)[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172085.