A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the suppliers website for prices or more information.
| Product | Description | |
|---|---|---|
| S-formylglutathione hydrolase | Also hydrolyses S-acetylglutathione, but more slowly. Group: Enzymes. Enzyme Commission Number: EC 3.1.2.12. CAS No. 83380-83-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3547; S-formylglutathione hydrolase; EC 3.1.2.12; 83380-83-0. Cat No: EXWM-3547. |  |
| SF-PDI | Band gap: 2.1 eV. Alternative Names: 1-(3-Butoxycarbonylpropyl)-1-phenyl-[6.6]C61. CAS No. 1643842-69-6. Molecular formula: C125H136N4O8. Mole weight: 1822.44. SMILES: O=C1N(C(CCCCCC)CCCCCC)C(C2=C(C1=CC=C3C4=C(C(C=C5)=CC6=C5C(C=CC(C7=CC8=C9C%10=C7C%11=C%12C(C%13=CC=C%12C%10=CC=C9C(N(C(CCCCCC)CCCCCC)C8=O)=O)=C(C(N(C(CCCCCC)CCCCCC)C%13=O)=O)C=C%11)=C%14)=C%14C6%15C%16=CC=CC=C%16C%17=C%15C=CC=C%17)C=C(C(N(C(CCCCCC)CCCCCC)C. InChI: InChI=1S/C125H136N4O8/c1-9-17-25-33-45-79(46-34-26-18-10-2)126-117(130)93-67-61-87-89-63-69-97-113-101(123(136)128(121(97)134)81(49-37-29-21-13-5)50-38-30-22-14-6)75-99(109(115(89)113)91-65-71-95(119(126)132)111(93)107(87)91)77-57-59-85-86-60-58-78(74-106(86)125(105(85)73-77)103-55-43-41-53-83(103)84-54-42-44-56-104(84)125)100-76-102-114-98(122(135)129(124(102)137)82(51-39-31-23-15-7)52-40-32-24-16-8)70-64-90-88-62-68-94-112-96(72-66-92(108(88)112)110(100)116(90)114)120(133)127(118(94)131)80(47-35-27-19-11-3)48-36-28-20-12-4/h41-44,53-76,79-82H,9-40,45-52H2,1-8H3. |  |
| Sfr274 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (Hind III-digest) in 1 hour at 50°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. C↑TCGAG GAGCT↓C. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 274. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1174RE. | |
| Sfr303 I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. CCGC↑GG GG↓CGCC. Activity: 10000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Streptomyces fradiae 303. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1175RE. | |
| SFTI-1 | SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 245080-24-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10033. |  |
| SG-094 | SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922283-37-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148816. | |
| SG2057 | SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DRG16. CAS No. 260417-62-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-101160. | |
| SG3199 | SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1595275-71-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101161. | |
| SGA360 | SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 680611-86-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122208. | |
| SGA360 | SGA360. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazole; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole. Grades: Highly Purified. CAS No. 680611-86-3. Pack Sizes: 10mg. Molecular Formula: C19H17F3N2O2, Molecular Weight: 362.35. US Biological Life Sciences. |  Worldwide |
| SGA360-d5 | SGA360-d5. Group: Biochemicals. Alternative Names: 3-(2,4-Dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazol-d5; 1-Allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C19H12D5F3N2O2, Molecular Weight: 367.38. US Biological Life Sciences. | Worldwide |
| S-(γ)-Phe | S-(γ)-Phe. Alternative Names: S gamma Phe. CAS No. 916198-97-5. Molecular formula: C11H15NO2. Mole weight: 193.24. |  |
| SGC0946 | SGC0946 is a selective DOT1L inhibitor with an IC50 value of 0.3 nM. By inhibiting DOT1L, SGC0946 can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1561178-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15650. | |
| SGC0946 | SGC0946 Inhibitor. Uses: Scientific use. Product Category: T3082. CAS No. 1561178-17-3. |  |
| SGC3027 | SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2624313-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112445. | |
| SGC707 | SGC707, a chemical probe, is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1687736-54-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-19715. | |
| SGC8158 | SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC50: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3062376-84-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-114211. | |
| SGC-AAK1-1 | SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2247894-32-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123940. | |
| SGC-CAMKK2-1 | SGC-CAMKK2-1, a chemical probe, is the selective, inhibitor for calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. SGC-CAMKK2-1 inhibits AMPK phosphorylation in cell C4-2 with an IC50 of 1.6 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2561494-76-4. Pack Sizes: 5 mg. Product ID: HY-168905. | |
| SGC-CBP30 | SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Group: Inhibitors. CAS No. 1613695-14-9. Pack Sizes: 10mg. Product ID: S7256. Formula: C28H33ClN4O3. Smiles: CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)CCC4=CC(=C(C=C4)OC)Cl)CC(C)N5CCOCC5. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| SGC-CBP30 | SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613695-14-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15826. | |
| SGC-CDKL2/AAK1/BMP2K-1 | SGC-CDKL2/AAK1/BMP2K-1 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. SGC-CDKL2/AAK1/BMP2K-1 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2471972-15-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162653. | |
| SGC-CK2-1 | SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2αrespectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2470424-39-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139004. | |
| SGC-CLK-1 | SGC-CLK-1, a chemical probe, is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. SGC-CLK-1 can inhibit the growth of melanoma and glioblastoma cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAF-170. CAS No. 748142-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153708. | |
| SGC GAK 1 | SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor with >30-fold selectivity for GAK over a panel of other kinases. Alternative Names: SGC-GAK-1; BCP30478; 6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine. Grades: ≥99% by HPLC. CAS No. 2226517-76-4. Molecular formula: C18H17BrN2O3. Mole weight: 389.24. | |
| SGC-GAK-1 | SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226517-76-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122186. | |
| SGC-iMLLT | SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2255338-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112804. | |
| SGC-SMARCA-BRDVIII | SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1997319-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145446. | |
| SGC-STK17B-1 | SGC-STK17B-1, a chemical probe, is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC50: 34 nM, KD: 5.6 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2650530-00-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156350. | |
| SGD-1882 | SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PBD dimer. CAS No. 1222490-34-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101127. | |
| S-Gem | S-Gem, a thioredoxin reductase (TrxR)-dependent prodrug of Gemcitabine, is selectively activated by TrxR. Studies indicate that S-Gem exhibits lower cytotoxicity than Gemcitabine. Category: Active pharmaceutical ingredients. CAS No. 2169925-98-6. Product ID: API2169925986. Molecular formula: C13H15F2N3O6S2. Mole weight: 411.4. |  |
| SGF29-IN-1 | SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6638-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158009. | |
| SGI 1027 | SGI 1027. Group: Biochemicals. Grades: Purified. CAS No. 1020149-73-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SGI-1027 | SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. Uses: Scientific research. Category: Signaling pathways. CAS No. 1020149-73-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13962. | |
| SGI-1776 | SGI-1776 Inhibitor. Uses: Scientific use. Product Category: T3078. CAS No. 1025065-69-3. | |
| SGI-1776 free base | SGI-1776 free base is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1025065-69-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13287. | |
| SgI-29 | SgI-29 is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria and gram-negative bacteria. Alternative Names: SgI-29 (85-113); His-Asn-Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Arg-Val-Val-Ile-His-His-Lys-Gly-Gly-Lys-Ala-His. Grades: >97%. Molecular formula: C145H226N56O39. Mole weight: 3377.74. | |
| SGI-7079 | SGI-7079 Inhibitor. Uses: Scientific use. Product Category: T6982. CAS No. 1239875-86-5. | |
| SgII peptide A | SgII peptide A is an antibacterial peptide isolated from Homo sapiens. It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Alternative Names: SgII peptide A (human); Lys-Gln-Glu-Gly-Arg-Asp-His-Asp-Lys-Ser-Lys-Gly-His-Phe-His-Met-Ile-Val-Ile-His-His-Lys-Gly-Gly-Gln-Ala-His-His-Gly. Grades: >97%. Molecular formula: C142H218N52O39S. Mole weight: 3309.68. | |
| SGK1-IN-1 | SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1279829-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18607. | |
| SGK1-IN-4 | SGK1-IN-4 (compound 17a) is a highly selective, orally active SGK1 inhibitor. SGK1-IN-4 can be used for osteoarthritis research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628048-93-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142687. | |
| s-Glycidyl-4-nitrobenzene-sulfonate | s-Glycidyl-4-nitrobenzene-sulfonate. CAS No. 128712-60-0. Purity: 96%. Product ID: ACM128712600. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| S-(+)-Glycidyl tosylate | S-(+)-Glycidyl tosylate. Group: Biochemicals. Grades: Highly Purified. CAS No. 70987-78-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |
| SGN-2FF | SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089647-47-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107366. | |
| sGnRH-A | sGnRH-A is a GnRH peptide analog that acts as a GnRH antagonist. Alternative Names: H-Pyr-His-Trp-Ser-Tyr-D-Arg-Trp-Leu-Pro-NHEt. CAS No. 96497-82-4. Molecular formula: C64H83N17O12. Mole weight: 1282.45. | |
| sGnRH-A TFA | sGnRH-A is a GnRH peptide analog that acts as a GnRH antagonist. Alternative Names: H-Pyr-His-Trp-Ser-Tyr-D-Arg-Trp-Leu-Pro-NHEt.CH3CO2H; L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-arginyl-L-tryptophyl-L-leucyl-L-proline ethylamide acetic acid. Molecular formula: C66H87N17O14. Mole weight: 1342.53. | |
| sgp91 ds-tat Peptide 2, scrambled | sgp91 ds-tat Peptide 2, scrambled is a scrambled sequence of NADPH oxidase inhibitor gp91 ds-tat peptide. It is used as a control peptide. Molecular formula: C98H190N50O22S. Mole weight: 2453. | |
| SGR-1505 | SGR-1505 is an oral small molecule MALT1 inhibitor with anti-proliferative and antitumor activity.SGR-1505 inhibits MALT1 enzymatic activity to modulate NF-κB pathway gene expression.SGR-1505 induces modulation of cell cycle, DNA damage, and apoptosis-related genes in in vivo tumor samples.SGR-1505 exerts tumorostatic and regressive activity in ABC-DLBCL xenograft models.SGR-1505 can be used for the research of activated B cell-like diffuse large B cell lymphoma, non-Hodgkin B-cell lymphomas, chronic lymphocytic leukemia, and mature B cell neoplasms[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2661481-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160698. | |
| sgRNA Screening Kit | sgRNA Screening Kit. Sgrna screening kit provides a simple, reliable, and rapid method for assessing sgrna efficiency before cell transduction, allowing you to identify the highly effective crispr sgrna. cas9 nuclease nls is an rna-guided endonuclease that catalyzes site-specific cleavage of double stranded dna. the location of the break is within the target sequence 3 bases from the ngg pam (protospacer adjacent motif). the design of single guide rna (sgrna) is dependent on the target region close to the pam site. even if you pick a target sequence that fulfills all of the described requirements, sgrna specificity and activity is unpredictable. therefore, it is often recommended that multiple, different sgrnas be designed to target a gene of interest. components. gencrispr cas9 nuclease. 10x reaction buffer. positive control sgrna. positive control substrate. rnase-free water. Group: Cloning Enzymes. Purity: 30 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3509. | |
| sgRNA Synthesis Kit | sgRNA Synthesis Kit. This product is designed to synthesize grnas in vitro. in the bacterial crispr/cas9 system, the cas9 nuclease associates with two rnas, the crispr rna (crrna) and the trans-activating crrna (tracrrna), to direct sequence-specific dna cleavage. the grna (guide rna) is a fusion of the natural crrna and tracrrna components. it contains an 18-20 base variable sequence that can be changed to target any dna sequence that is adjacent to an ngg proto-spacer adjacent motif (pam) on the 3 end of the target sequence. the sgrna synthesis kit allows user to fuse their choice of 18-20 base target sequence within the grna dna sequence provided, by pcr fusion. the kit also provides materials for in-vitro transcription of the generated grna dna in order to generate grnas which can be directly used for in-vivo genome editing. Group: Cloning Enzymes. Purity: 20 reactions/kit. Storage: Store at -20 ?. Source: E.coli. Pack: 10 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol PH 7.4, at 25°C. Cat No: CE-3510. | |
| SGS 518 oxalate | SGS 518 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 445441-27-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SGX 523 | SGX 523. Group: Biochemicals. Grades: Purified. CAS No. 1022150-57-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SGX-523 | SGX523 is a exquisitely selective and ATP-competitive MET inhibitor. SGX523 potently inhibits MET with an IC50 of 4 nM and is >1,000-fold selective versus other protein kinases. Antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1022150-57-7. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12019. | |
| SH-42 | SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143952-36-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143228. | |
| SH-4-54 | SH-4-54 is a CNS-penetrant STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1456632-40-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-16975. | |
| SH-4-54 | SH-4-54 is a potent STAT inhibitor with KD values of 300 nM and 464 nM for STAT3 and STAT5, respectively. It potently kills glioblastoma brain cancer stem cells (BTSCs). Alternative Names: 4-[(4-cyclohexylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid. Grades: >98%. CAS No. 1456632-40-8. Molecular formula: C29H27F5N2O5S. Mole weight: 610.59. | |
| SH514 | SH514 is an orally active IRF4 inhibitor (IC50 = 2.63 μM). SH514 binds to the IRF4-DBD domain, thereby inhibiting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 can inhibit the proliferation of IRF4-high-expressing NCI-H929 and MM.1R cells, and displays no cytotoxicity for normal cells. SH514 significantly downregulates the expression of IRF4 downstream target genes concentration-dependently. SH514 inhibits the expression of cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC in Multiple Myeloma cells. SH514 can induce DNA damage and increase the expression of γH2AX. SH514 effectively inhibits the proliferation of multiple myeloma tumors [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3099543-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172085. | |
| SH-5 (D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate) | A cell-permeable inhibitor of Akt activation without affecting the activation of the upstream kinase PDK1 or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt. Group: Biochemicals. Alternative Names: D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| SH6 | SH6 is a transcription factor ZBTB7A degrader. SH6 is promising for research of β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2619408-35-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-178486. | |
| SH-6 (D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate) | A cell-permeable inhibitor of Akt activation without affecting the activation of the upstream kinase PDK1 or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt. Group: Biochemicals. Alternative Names: D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| SHA 68 | SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 847553-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108625. | |
| SHA 68 | SHA 68. Group: Biochemicals. Grades: Purified. CAS No. 847553-89-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Shaddock powder | Shaddock powder. Group: Others. Source: Shaddock (scientific name: Citrus maxima), also known as pomelo, Hong Luan, grapefruit, purple inside. Shaddock powder fragrance, sweet, cool moist, nutrient-rich, high medicinal value, is one of the people eating the fruit, but also the medical profession recognized the fruit of the most therapeutic effect. Grapefruit and grapefruit peel tea also has practical value, and can be used as medicine. Shaddock powder. Cat No: EXTC-146. | |
| Shancigusin I | Shancigusin I is found in Bletilla striata. Grades: > 95%. CAS No. 1435488-35-9. Molecular formula: C28H34O14. Mole weight: 594.56. | |
| shanzhiside | shanzhiside. Group: Biochemicals. Grades: Plant Grade. CAS No. 29836-27-9. Pack Sizes: 10mg. Molecular Formula: C16H24O11, Molecular Weight: 392.36. US Biological Life Sciences. | Worldwide |
| Shanzhiside methylester | Shanzhiside methylester. Group: Biochemicals. Grades: Plant Grade. CAS No. 64421-28-9. Pack Sizes: 20mg. Molecular Formula: C17H26O11, Molecular Weight: 406.38. US Biological Life Sciences. | Worldwide |
| Shanzhiside methyl ester | Shanzhiside methyl ester. Group: Biochemicals. CAS No. 64421-28-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Shark Cartilage Powder | Shark Cartilage Powder. |  CA, FL & NJ |
| Shatavarin IV | Shatavarin IV is a steroidal saponin present in roots of Asparagus racemosus (Liliaceae) known for its anticancer activity. Alternative Names: β-D-Glucopyranoside, (3β,5β,25S)-spirostan-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→2)]-; (3β,5β,25S)-Spirostan-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→2)]-β-D-glucopyranoside; Asparanin B; Curillin H. Grades: 95%. CAS No. 84633-34-1. Molecular formula: C45H74O17. Mole weight: 887.07. | |
| Shatavarin IV | Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Asparanin B. CAS No. 84633-34-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N8804. | |
Our database is helping our users find suppliers everyday.
