A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4- attenuation of human PMN chemotaxis. Group: Biochemicals. Alternative Names: 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: Highly Purified. CAS No. 146662-42-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 27897
SR 27897. Group: Biochemicals. Grades: Purified. CAS No. 136381-85-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR-3029
SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454585-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100011.
SR31527 chloride
SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 μM. SR31527 chloride decreases cell viability and colony formation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 311814-78-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118961.
SR-318
SR-318, a chemical probe, is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2413286-32-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135674.
SR3335
SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML 176. CAS No. 293753-05-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14413.
SR 33805 oxalate
SR 33805 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 121346-33-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SR 3576
SR 3576. Group: Biochemicals. Grades: Purified. CAS No. 1164153-22-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR-3576
SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164153-22-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107596.
SR-3677
SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1072959-67-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13300.
SR 3677 dihydrochloride
SR 3677 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1072959-67-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR-4370
SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1816294-67-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111400.
SR-4559
SR-4559 is a α/β hydrolase domain-containing protein 5 (ABHD5) ligand. SR-4559 activates adipose triglyceride lipase (ATGL) and stimulates lipolysis by inhibiting ABHD5-PLIN interactions in adipocytes and muscle cells. SR-4559 can be used for metabolic diseases like Chanarin Dorfman syndrome research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 847939-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-111953.
SR-4835
SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2387704-62-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-130250.
SR 48692. Group: Biochemicals. Grades: Purified. CAS No. 146362-70-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 49059
SR 49059. Group: Biochemicals. Grades: Purified. CAS No. 150375-75-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SR 49059
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150375-75-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18345.
SR 57227A
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 77145-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102064.
SR 57227 hydrochloride
SR 57227 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 77145-61-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR 58611A hydrochloride
SR 58611A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 121524-09-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SR59230A
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist[1] with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 174689-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-100672.
SR 59230A hydrochloride
SR 59230A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1135278-41-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375421-09-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131454.
SR7826
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC50 of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1 than ROCK and JNK kinases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219728-20-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19353.
SR8278
SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254944-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14415.
SR 8278
SR 8278. Group: Biochemicals. Alternative Names: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 1254944-66-5. Pack Sizes: 10mg. Molecular Formula: C18H19NO3S2, Molecular Weight: 361.48. US Biological Life Sciences.
Worldwide
SR9009
SR9009 is a REV-ERBα/β agonist with IC50s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1379686-30-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16989.
SR9011
SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1379686-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16988.
SR9011 hydrochloride
SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070014-94-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16988A.
SR9243
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613028-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16972.
SR 95531 hydrobromide
SR 95531 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 104104-50-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SRA880
SRA880 is a non-peptide and selective somatostatin sst(1) receptor antagonist. SRA880 exhibits antidepressant-like effects when in combination with Imipramine (HY-B1490A) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 573984-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-123499.
SRC-1 NR box peptide
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 227929-80-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P5464.
Src Antibody [H13N7]
Src,v-Src. Group: Antibodies. Alternative Names: Src,v-Src. Pack Sizes: 20ul. Product ID: F0262. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years.
United States; Europe
Src I1
Src I1. Group: Biochemicals. Grades: Purified. CAS No. 179248-59-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Src Inhibitor 1
Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Src Kinase Inhibitor 1; Src-l1. CAS No. 179248-59-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101053.
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1629138-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-100347.
SRI-011381 (C381)
SRI-011381 (C381) is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.C381 physically targets the lysosome, promotes lysosomal acidification, increases breakdown of lysosomal cargo, and improves lysosome resilience to damage. Group: Inhibitors. Alternative Names: C381. CAS No. 1629138-41-5. Pack Sizes: 5mg. Product ID: S6654. Formula: C20H31N3O.  . Smiles: C1CCC(CC1)NC(=O)N(CC2CCNCC2)CC3=CC=CC=C3. Storage Conditions: 3 years -20°C powder.
United States; Europe
SRI-011381 hydrochloride
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects, with blood-brain barrier permeability[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070014-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-100347A.
SRI 31215 TFA
SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1832686-44-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114363A.
SRI-37330
SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2322245-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142114.
SRI-37330 hydrochloride
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2322245-49-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-141623.
SRI 37892
SRI 37892 is a small molecule compound inhibitor of Frizzled protein 7 (Fzd7) with inhibitory activity against cancer cell proliferation (IC50=2μM). SRI 37892 significantly blocks Wnt/Fzd7 signaling. SRI 3789 can be used in the research of developing cancer therapeutic agents [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1030769-75-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-117002.
SRI-41315
SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613509-49-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150090.
S-ribosylhomocysteine lyase
Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. Group: Enzymes. Synonyms: S-ribosylhomocysteinase; LuxS. Enzyme Commission Number: EC 4.4.1.21. CAS No. 37288-63-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5323; S-ribosylhomocysteine lyase; EC 4.4.1.21; 37288-63-4; S-ribosylhomocysteinase; LuxS. Cat No: EXWM-5323.
SRPIN340
SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SRPK inhibitor. CAS No. 218156-96-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13949.
SRPIN340
SRPIN340. Group: Biochemicals. Grades: Purified. CAS No. 218156-96-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Srpk1-IN-1
Srpk1-IN-1 (compound 12) is a potent inhibitor of SRPK1, with IC50 of 0.3 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2408444-93-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160586.
SRPKIN-1
SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089226-94-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-116856.
SRPK Inhibitor, SRPIN340 (N- (2-Piperidin-1-yl-5- (trifluoromethyl) phenyl) isonicotinamide, Serine-Arginine-Rich Protein Kinase Inhibitor, SR Protein Kinase Inhibitor, SR Protein Phosphorylation Inhibitor 340, (SRPIN)340)
A cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8uM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases. Shown to effectively counteract IGF-1-induced anti-angiogenic to pro-angiogenic VEGF isoforms switch both in cultures in vitro (1h 10uM SRPIN340 prior to 12h IGF-1 stimulation of PCIPs) and in a murine hypoxia-induced retinal neovascularization model in vivo (10pmol/uL/eye intraocular SRPIN340 injection) by inhibiting PKC/SRPK signaling-dependent, alternate splicing factor ASF- (SF2; splicing factor 2) mediated VEGF pro-mRNA PSS (proximal splice site) selection. Suppresses RNA virus Sindbis propagation (IC50 = 60uM in Vero cultures) and HCV-JFH1 replication (1 & 10uM SRPIN340 in Huh7.5.1 cultures). Exhibits no toxicity toward rats (2g/kg p.o. for 2 wks), CHO (5mg/ml for 24h), or Huh7 (30uM for 48h). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SRS16-86
SRS16-86 is a potent inhibitor of ferroptosis[1]. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research[2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1793052-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135430.
SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 925434-55-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10532.
SRT 1720 Hydrochloride
SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy. Group: Inhibitors. CAS No. 1001645-58-4. Pack Sizes: 5mg. Product ID: S1129. Formula: C25H23N7OS.HCl. Smiles: C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl. Storage Conditions: 2 years -80 in solvent.
United States; Europe
SRT1720 Hydrochloride
SRT1720 Hydrochloride. Group: Biochemicals. Alternative Names: N-[2-[3- (1-piperazinylmethyl) imidazo[2, 1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Hydrochloride. Grades: Highly Purified. CAS No. 1001645-58-4. Pack Sizes: 5mg. Molecular Formula: C25H23N7OS xHCl, Molecular Weight: 469.56. US Biological Life Sciences.
Worldwide
SRT 2104
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntingtons disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1093403-33-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15262.
SRT 2183
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1001908-89-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-19759.
SRT3109
SRT3109 is an antagonist of CXCR2, with a pIC50 of 8.2, and used in the research of chemokine mediated diseases. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD-5122. CAS No. 1204707-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15462.
SRX3177
SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of <2.5 nM (CDK4), 3.3 nM (CDK6), 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ) , respectively. SRX3177 blocks the interaction between the SARS-CoV-2 E protein and the BRD2/4 BD1 domain, restores E protein-attenuated NF-κB activity. SRX3177 exerts broad cytotoxic activity against cancer cells. SRX3177 can be used for the study of anti-SARS-CoV-2 and cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2241237-51-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153894.
SRX3207
SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2254693-15-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136198.
SS-208
SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AVS100. CAS No. 2245942-72-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126330.
SS-228Y
SS-228Y is an antibiotic produced by Chainia Sp. It is active against gram-positive bacteria and Ehrlich's ascites carcinoma. Synonyms: Antibiotic SS-228 Y; SS-228 Y. Grade: 95%. CAS No. 56257-16-0. Molecular formula: C19H14O6. Mole weight: 338.31.
SS-56C
SS-56C is an aminoglycoside antibiotic produced by Streptomyces eurocidicus. It exhibits activity against gram-positive and gram-negative bacteria. Synonyms: SS-56 C. CAS No. 39471-55-1. Molecular formula: C19H35N3O14. Mole weight: 529.5.
SS-56D
SS-56D is an aminoglycoside antibiotic produced by Streptomyces eurocidicus. It exhibits activity against gram-positive and gram-negative bacteria. Synonyms: SS-56 D. Molecular formula: C19H35N3O13. Mole weight: 513.49.