A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
TJN-331 is a TGF-β1 inhibitor, which can inhibit the expression of TGF-β1 and improve anti-glomerular basement membrane nephritis. Synonyms: TJN331; TJN 331. CAS No. 219964-53-1. Molecular formula: C19H22N2O3. Mole weight: 326.4.
TK05
TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1245734-61-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117143.
TKIM
TKIM is a TREK-1 channel inhibitor with an IC 50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 326921-25-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-134559.
TL02-59
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC 50 of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC 50 s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1315330-17-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112852.
TL 102 hydrobromide
TL 102 hydrobromide is a dopamine receptor agonist. Synonyms: 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diol hydrobromide; TL 102 HBr; TL102 HBr; TL-102 HBr. Grades: 98%. CAS No. 62421-54-9. Molecular formula: C16H25NO2.HBr. Mole weight: 344.29.
TL-119
TL-119 is an antibiotic isolated from Bacillus subtilis. It is effective against gram-positive bacteria and fungi. Synonyms: Antibiotic TL-119; TL 119. CAS No. 55599-68-3. Molecular formula: C42H57N7O9. Mole weight: 803.9.
TL 13-110
TL 13-110 is an ALK inhibitor with IC50 value of 0.34 nM. It acts as a negative control for TL 13-112. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -5-isopropoxy-2-methylphenyl) piperidin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229037-09-4. Molecular formula: C49H62ClN9O9S. Mole weight: 988.59.
TL 13-22
TL 13-22 is an ALK inhibitor with IC50 value of 0.54 nM. It acts as a negative control for TL 13-22. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -3-methoxyphenyl) piperazin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229036-65-9. Molecular formula: C45H55ClN10O9S. Mole weight: 947.5.
TL310 is a novel, oral taxane with potent pre-clinical activity in taxane-resistant model systems. This is the first study to evaluate the safety, tolerability and pharmacokinetics (PK) of TL310 in pts with advanced refractory solid tumors. Synonyms: TL310; TL 310. CAS No. 352697-38-2. Molecular formula: C45H55NO16. Mole weight: 865.91.
TL4-12
TL4-12 is a potent MAP4K2 (GCK) inhibitor with IC50 value of 37 nM, suppressing IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro. Synonyms: 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1620820-12-3. Molecular formula: C25H27F3N6O2. Mole weight: 500.53.
TL8-506
TL8-506 is a benzoazepine compound as an agonist of TLR8 agonist. Synonyms: Ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate; 3H-1-Benzazepine-4-carboxylic acid, 2-amino-8-(3-cyanophenyl)-, ethyl ester; TL 8-506; TLR 8-506. Grades: ≥95%. CAS No. 1268163-15-0. Molecular formula: C20H17N3O2. Mole weight: 331.37.
TL-895
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC 50 and a K i of 1.5 nM and 11.9 nM, respectively [1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415823-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139481.
TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: TLN 232; TLN232; CAP-232; CAP 232; CAP232; H-D-Phe-Cys(1)-D-Trp-Lys-Cys(1)-Thr-NH2. CAS No. 158899-10-6. Molecular formula: C36H49N9O7S2. Mole weight: 783.96.
TLQP 21
TLQP 21. Group: Biochemicals. Grades: Purified. CAS No. 869988-94-3. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
TLQP 21
TLQP 21 is a VGF-derived peptide. TLQP 21 has been shown to protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. TLQP 21 has the potential for the prevention of early phase diet-induced diabetes. Synonyms: TLQP 21; TLQP21; TLQP-21. Grades: ≥95%. CAS No. 869988-94-3. Molecular formula: C107H170N40O26. Mole weight: 2432.7.
A cell-permeable benzotropolone compound that competes against Pam3CSK4- for TLR1/TLR2 heterodimer binding (Ki = 410nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580nM) without apparent cytotoxicity (up to 100uM and 24h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5uM and little inhibitory potency against a panel of 10 kinases at 5uM (by <11% inhibition). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??O?. US Biological Life Sciences.
Worldwide
TLR2-IN-C29
TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 363600-92-4. Molecular formula: C16H15NO4. Mole weight: 285.29. Purity: >98%. IUPACName: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid. Canonical SMILES: O=C(O)C1=CC=CC(/N=C/C2=CC=CC(OC)=C2O)=C1C. Product ID: ACM363600924. Alfa Chemistry ISO 9001:2015 Certified.
TLR3, Control Peptide (Toll Like Receptor 3)
TLR3, Control Peptide (Toll Like Receptor 3). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences.
A thiophene carboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM; =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Group: Biochemicals. Alternative Names: (R) -2- (3-Chloro-6-fluorobenzo [b]thiophene-2-carboxamido) -3-phenylpropanoic Acid; CU CPT 4a. Grades: Highly Purified. CAS No. 1279713-77-7. Pack Sizes: 10mg. Molecular Formula: C18H13ClFNO3S, Molecular Weight: 377.8. US Biological Life Sciences.
A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 243984-11-4. Pack Sizes: 5mg. Molecular Formula: C??H??ClFNO?S, Primary Target: TLR4. US Biological Life Sciences.
TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It exhibits prominent immunostimulatory activities. CAS No. 1258457-59-8. Molecular formula: C22H25N5. Mole weight: 359.5.
TLR7/8 agonist 1 dihydrochloride
TLR7/8 agonist 1 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It exhibits prominent immunostimulatory activities. Synonyms: TLR7/8 agonist 1 hydrochloride. CAS No. 1620278-72-9. Molecular formula: C22H27Cl2N5. Mole weight: 432.4.
Tm3PyP26PyB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1,3,5-Tris(6-(3-(pyridin-3-yl)phenyl)pyridin-2-yl)benzene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1492917-78-8. Molecular formula: C54H36N6. Mole weight: 768.9 g/mol. Product ID: ACM1492917788. Alfa Chemistry ISO 9001:2015 Certified.
TM-5275 sodium salt
TM-5275 sodium salt is an orally bioavailable, potent and selective plasminogen activator inhibitor-1 (PAI-1). It delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Uses: Tm-5275 sodium salt delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. Synonyms: TM5275 sodium salt; TM 5275 sodium salt; TM-5275 sodium salt; 5-Chloro-2-[[2-[2-[4-(Diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt; Sodium 2-[[2-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetyl]amino]-5-chlorobenzoate. Grades: >98%. CAS No. 1103926-82-4. Molecular formula: C28H27ClN3NaO5. Mole weight: 543.98.
Tm5441
TM5441 is a plasminogen activator inhibitor-1 (PAI-1) that inhibits some tumor cell lines (IC50 = 9.7 ~ 60.3 μM). Studies indicated that it could be used to treat high-fat diet-induced obesity and adipocyte injury in mice. Uses: Tm5441 is a plasminogen activator inhibitor-1 (pai-1). Synonyms: TM-5441; TM 5441; TM5441; BMS-790052; BMS-790052; BMS790052; EBP 883; EBP-883; EBP883. 5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid. CAS No. 1190221-43-2. Molecular formula: C21H17ClN2O6. Mole weight: 428.825.
TMAD
TMAD. Group: Biochemicals. Alternative Names: 1,1'-Azobis(N,N'-dimethylformamide); N, N, N', N'-Tetra methyl azodicarboxamide. Grades: Highly Purified. CAS No. 10465-78-8. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C6H12N4O2. US Biological Life Sciences.
Worldwide
TMA-DPH
TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 115534-33-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0986.
TMAH
Tetramethylammonium hydroxide is a solid in the hydrated form or a colorless liquid with a strong ammonia-like odor. It is soluble in water. It is corrosive to metals and tissue.;Liquid. Group: Polymers. CAS No. 75-59-2. Product ID: tetramethylazanium; hydroxide. Molecular formula: 91.15g/mol. Mole weight: C4H13NO. C[N+](C)(C)C.[OH-]. InChI=1S/C4H12N.H2O/c1-5(2, 3)4;/h1-4H3;1H2/q+1;/p-1. WGTYBPLFGIVFAS-UHFFFAOYSA-M.
TMAH-25 (Tetramethylammonium hydroxide aq. solution). Group: Acids and alkalis. CAS No. 75-59-2.
TMB
TMB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,3',5,5'-Tetramethylbenzidine,BMblue,SureBlueTMB,TMBBlottingPlus,TMBsubstrate,TMBZ. Product Category: Other Fluorophores. Appearance: White to light yellow powder. CAS No. 54827-17-7. Molecular formula: C16H20N2. Mole weight: 240.34. Purity: 99%+. IUPACName: 4-(4-amino-3,5-dimethylphenyl)-2,6-dimethylaniline. Canonical SMILES: CC1=CC(=CC(=C1N)C)C2=CC(=C(C(=C2)C)N)C. Density: 1 g/ml. Product ID: ACM54827177-2. Alfa Chemistry ISO 9001:2015 Certified.
TMB
TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species ( ROS/RNS ), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue; Sure Blue TMB. CAS No. 54827-17-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930.
TMB 8 hydrochloride
TMB 8 is a PKC inhibitor and intracellular calcium antagonist. It also acts as a noncompetitive, functional antagonist at diverse nicotinic acetylcholine receptor (nAChR) subtypes. Synonyms: 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate;hydrochloride. Grades: ≥ 98 %. CAS No. 53464-72-5. Molecular formula: C22H38ClNO5. Mole weight: 431.99.
TMB dihydrochloride
TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue dihydrochloride; Sure Blue TMB dihydrochloride. CAS No. 64285-73-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930A.
TMC-135A
TMC-135A is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60 with IC50 values of 0.07, 0.88, 0.11, 0.20, 0.15 and 0.05 μmol/L, respectively. Synonyms: TMC-135 A. Molecular formula: C39H49N3O8S. Mole weight: 719.9.
TMC-135B
TMC-135B is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60. Synonyms: TMC-135 B. Molecular formula: C39H49N3O8S. Mole weight: 719.9.
TMC-154
TMC-154 is an antibiotic produced by Gliocladium sp. TC 1282. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC 154. Molecular formula: C41H72O14. Mole weight: 789.
TMC-169
TMC-169 is an antibiotic of the aspochalasin group produced by Aspergillus flavipes TC 1446. It has cytotoxicity. Synonyms: TMC 169. Molecular formula: C24H35NO3. Mole weight: 385.5.
TMC-171A
TMC-171A is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 A. Molecular formula: C41H72O15. Mole weight: 805.
TMC-171B
TMC-171B is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 B. Molecular formula: C41H72O15. Mole weight: 805.
TMC-171C
TMC-171C is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 C. Molecular formula: C41H72O15. Mole weight: 805.
TMC-1A
TMC-1A is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 A. Molecular formula: C28H36N2O7. Mole weight: 512.6.
TMC-1B
TMC-1B is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 B. Molecular formula: C28H36N2O7. Mole weight: 512.6.
TMC-1C
TMC-1C is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 C. Molecular formula: C30H38N2O7. Mole weight: 538.6.
TMC-1D
TMC-1D is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 D. Molecular formula: C30H40N2O7. Mole weight: 540.6.
TMC-205
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines, activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region. Uses: Transcriptional up-regulator. Synonyms: TMC-205; TMC 205; TMC205. 6-(3-methylbuta-1,3-dienyl)-1H-indole-3-carboxylic acid. Grades: ≥98%. CAS No. 403646-00-4. Molecular formula: C14H13NO2. Mole weight: 227.26.
TMC-256A1
TMC-256A1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 25 μmol/L. Synonyms: TMC-256 A1. CAS No. 3773-18-0. Molecular formula: C15H12O5. Mole weight: 272.25.
TMC-256C1
TMC-256C1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 1.7 μmol/L. Synonyms: TMC-256 C1. Molecular formula: C15H12O5. Mole weight: 272.25.
TMC-260
TMC-260 is an inhibitor of IL-4 signal transduction produced by Acremonium kiliense Grütz TC 1703. It inhibited the IL-4 driven luciferase activity with IC50 values of 9 μmol/L. Synonyms: TMC 260. Molecular formula: C17H27NO5. Mole weight: 325.4.