A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Tixagevimab (AZD8895) is a human monoclonal antibody that targets the SARS-CoV-2 receptor binding domain (RBD). It exhibits neutralizing activity against SARS-CoV-2 by binding to the RBD and the S-glycoprotein ectodomain and blocking S-glycoprotein-mediated binding to the receptor [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AZD8895. CAS No. 2420564-02-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99556.
Tixocortol Pivalate
Tixocortol Pivalate is a corticosteroid showing topical anti-inflammatory properties. It is marketed under the brand name Pivalone. Synonyms: Pivalone; Tixocortol 21-pivalate. Grades: >95%. CAS No. 55560-96-8. Molecular formula: C26H38O5S. Mole weight: 462.645.
Tixosil
Tixosil. Group: Polymers.
Tizanidine
Tizanidine, a short-acting drug, is an agonist at a2-adrenergic receptor reducing spasticity by increasing presynaptic inhibition of motor neurons. Uses: An agonist at a2-adrenergic receptor. Synonyms: 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-8-thia-7,9-diazabicyclo(4.3.0)nona-2,4,6,9-tetraen-5-amine; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine. Grades: ≥98%. CAS No. 51322-75-9. Molecular formula: C9H8ClN5S. Mole weight: 253.71.
Tizanidine
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 51322-75-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194.
Tizanidine-d4
Tizanidine-d 4 is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1188331-19-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0194S.
Tizanidine-d4
Labeled Tizanidine, a muscle relaxant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Tizanidine Dimer Impurity
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: N1,N2-bis(5-chlorobenzo[c][1,2,5]thiadiazol-4-yl)ethane-1,2-diamine. Molecular formula: C14H12ClN8S2. Mole weight: 427.34.
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Synonyms: Tizanidine HCl; Zanaflex; Sirdalud; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride. Grades: >98%. CAS No. 64461-82-1. Molecular formula: C9H8ClN5S·HCl. Mole weight: 290.17.
Tizanidine hydrochloride
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C9H8N5ClS ¢HCl. CAS No. 64461-82-1. Prepack ID 71395830-5g. Molecular Weight 290.17. See USA prepack pricing.
Tizanidine hydrochloride
Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 64461-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194A.
Tizanidine hydrochloride
Tizanidine hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Tizanidine, Hydrochloride
An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). Group: Biochemicals. Grades: Highly Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C?H?Cl?N?S. US Biological Life Sciences.
Worldwide
Tizanidine Impurity A
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: 4-Amino-5-chloro-2,1,3-benzothiadiazole; 5-Chloro-2,1,3-benzothiadiazol-4-amine; Tizanidine EP Impurity E. CAS No. 30536-19-7. Molecular formula: C6H4ClN3S. Mole weight: 185.64.
Tizanidine Impurity B
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: N-Acetyl Tizanidine; 1-[2-[(5-Chloro-2,1,3-benzothiadiazol-4-yl)amino]-4,5-dihydro-1H-imidazol-1-yl]-ethanone; Tizanidine USP Related Compound B. CAS No. 173532-15-5. Molecular formula: C11H10ClN5OS. Mole weight: 295.75.
Tizanidine Impurity C
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: 1-Acetylimidazolidinethione; 1-(2-Thioxo-1-imidazolidinyl)ethanone; 1-Acetyl-2-imidazolidinethione; Tizanidine USP Related Compound C. CAS No. 5391-52-6. Molecular formula: C5H8N2OS. Mole weight: 144.2.
Tizanidine Metabolite
One of the impurities of Tizanidine which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: N-(5-chloro-2,1,3-benzothiadiazol-4-yl)-guanidine; (5-Chloro-2,1,3-benzothiadiazol-4-yl)-guanidine; 2,1,3-Benzothiadiazole Guanidine Derivative. CAS No. 125292-37-7. Molecular formula: C7H6ClN5S. Mole weight: 227.68.
Tizanidine Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Tizanidine Related Compound B
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Tizanidine Related Compound C
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 173903-47-4. Molecular formula: C10H7N3O4S. Mole weight: 265.243. Purity: 0.97. Canonical SMILES: O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2O. Product ID: ACM173903474. Alfa Chemistry ISO 9001:2015 Certified.
Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC 50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells [1] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TIZ. CAS No. 173903-47-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12687.
Tizoxanide
Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. It reduces the growth of the disease-causing parasites, L. mexicana and T. cruzi, in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM)3, and inhibits hepatitis B and hepatitis C virus replication (EC50s both=0.15 μM). Uses: Anti-infective agents. Synonyms: TIZ; NSC-697856; NSC697856; NSC697856; Tizoxanide; Desacetylnitazoxanide; Desacetyl-nitazoxanide. Grades: >98%. CAS No. 173903-47-4. Molecular formula: C10H7N3O4S. Mole weight: 265.25.
Tizoxanide
A metabolite of Nitazoxonide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Tizoxanide Glucuronide Sodium Salt
One of the metabolite impurities of Nitazoxanide, which is a hepatitis B as well as hepatitis C virus inhibitor and could exhibit potential effect in studies of tuberculosis. Synonyms: 2-[[(5-Nitro-2-thiazolyl)amino]carbonyl]phenyl β-D-Glucopyranosiduronic Acid Monosodium Salt. CAS No. 221287-83-8. Molecular formula: C16H14N3NaO10S. Mole weight: 463.35.
Tizoxanide sulfate
One of the metabolite impurities of Nitazoxanide, which is a hepatitis B as well as hepatitis C virus inhibitor and could exhibit potential effect in studies of tuberculosis. Synonyms: 2-Sulfooxy-N-(5-nitro-2-thiazolyl)benzamide. CAS No. 1391053-06-7. Molecular formula: C10H7N3O7S2. Mole weight: 345.31.
TiZrVTa High-Entropy Alloy
Unlike most current alloy materials, high-entropy alloys are alloy materials that contain equimolar or approximately equimolar elements. TiZrVTa High-Entropy Alloy is composed of Ti, Zr, V, and Ta. Uses: Military use, replace part of superalloy. Group: High entropy alloys. Pack Sizes: Our TiZrVTa High-Entropy Alloy is carefully handled during storage and transportation to preserve the quality of our product in its original condition.
TJ-M2010-5
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway[1][2]. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI)[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357471-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139397.
TJN-331
TJN-331 is a TGF-β1 inhibitor, which can inhibit the expression of TGF-β1 and improve anti-glomerular basement membrane nephritis. Synonyms: TJN331; TJN 331. CAS No. 219964-53-1. Molecular formula: C19H22N2O3. Mole weight: 326.4.
TK05
TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1245734-61-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117143.
TK-129
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3031476-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151483.
TK216
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1903783-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122903.
TKIM
TKIM is a TREK-1 channel inhibitor with an IC 50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 326921-25-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-134559.
TL02-59
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC 50 of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC 50 s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1315330-17-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112852.
TL 102 hydrobromide
TL 102 hydrobromide is a dopamine receptor agonist. Synonyms: 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diol hydrobromide; TL 102 HBr; TL102 HBr; TL-102 HBr. Grades: 98%. CAS No. 62421-54-9. Molecular formula: C16H25NO2.HBr. Mole weight: 344.29.
TL-119
TL-119 is an antibiotic isolated from Bacillus subtilis. It is effective against gram-positive bacteria and fungi. Synonyms: Antibiotic TL-119; TL 119. CAS No. 55599-68-3. Molecular formula: C42H57N7O9. Mole weight: 803.9.
TL 13-110
TL 13-110 is an ALK inhibitor with IC50 value of 0.34 nM. It acts as a negative control for TL 13-112. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -5-isopropoxy-2-methylphenyl) piperidin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229037-09-4. Molecular formula: C49H62ClN9O9S. Mole weight: 988.59.
TL 13-22
TL 13-22 is an ALK inhibitor with IC50 value of 0.54 nM. It acts as a negative control for TL 13-22. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -3-methoxyphenyl) piperazin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229036-65-9. Molecular formula: C45H55ClN10O9S. Mole weight: 947.5.
TL-1A human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
TL310 is a novel, oral taxane with potent pre-clinical activity in taxane-resistant model systems. This is the first study to evaluate the safety, tolerability and pharmacokinetics (PK) of TL310 in pts with advanced refractory solid tumors. Synonyms: TL310; TL 310. CAS No. 352697-38-2. Molecular formula: C45H55NO16. Mole weight: 865.91.
TL4-12
TL4-12 is a potent MAP4K2 (GCK) inhibitor with IC50 value of 37 nM, suppressing IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro. Synonyms: 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1620820-12-3. Molecular formula: C25H27F3N6O2. Mole weight: 500.53.
TL8-506
TL8-506 is a benzoazepine compound as an agonist of TLR8 agonist. Synonyms: Ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate; 3H-1-Benzazepine-4-carboxylic acid, 2-amino-8-(3-cyanophenyl)-, ethyl ester; TL 8-506; TLR 8-506. Grades: ≥95%. CAS No. 1268163-15-0. Molecular formula: C20H17N3O2. Mole weight: 331.37.
TL8-506
TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1268163-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-20457.
TL-895
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC 50 and a K i of 1.5 nM and 11.9 nM, respectively [1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415823-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139481.
TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: TLN 232; TLN232; CAP-232; CAP 232; CAP232; H-D-Phe-Cys(1)-D-Trp-Lys-Cys(1)-Thr-NH2. CAS No. 158899-10-6. Molecular formula: C36H49N9O7S2. Mole weight: 783.96.
TLQP 21
TLQP 21 is a VGF-derived peptide. TLQP 21 has been shown to protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. TLQP 21 has the potential for the prevention of early phase diet-induced diabetes. Synonyms: TLQP 21; TLQP21; TLQP-21. Grades: ≥95%. CAS No. 869988-94-3. Molecular formula: C107H170N40O26. Mole weight: 2432.7.
TLQP 21
TLQP 21. Group: Biochemicals. Grades: Purified. CAS No. 869988-94-3. Pack Sizes: 1mg. US Biological Life Sciences.
A cell-permeable benzotropolone compound that competes against Pam3CSK4- for TLR1/TLR2 heterodimer binding (Ki = 410nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580nM) without apparent cytotoxicity (up to 100uM and 24h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5uM and little inhibitory potency against a panel of 10 kinases at 5uM (by <11% inhibition). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??O?. US Biological Life Sciences.
Worldwide
TLR2-IN-C29
TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 363600-92-4. Molecular formula: C16H15NO4. Mole weight: 285.29. Purity: >98%. IUPACName: 3-[[(2-Hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-benzoic acid. Canonical SMILES: O=C(O)C1=CC=CC(/N=C/C2=CC=CC(OC)=C2O)=C1C. Product ID: ACM363600924. Alfa Chemistry ISO 9001:2015 Certified.
TLR3, Control Peptide (Toll Like Receptor 3)
TLR3, Control Peptide (Toll Like Receptor 3). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences.
A thiophene carboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM; =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Group: Biochemicals. Alternative Names: (R) -2- (3-Chloro-6-fluorobenzo [b]thiophene-2-carboxamido) -3-phenylpropanoic Acid; CU CPT 4a. Grades: Highly Purified. CAS No. 1279713-77-7. Pack Sizes: 10mg. Molecular Formula: C18H13ClFNO3S, Molecular Weight: 377.8. US Biological Life Sciences.
Worldwide
TLR-3 human
recombinant, expressed in HEK 293 cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.