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| Product | Description | |
|---|---|---|
| TMC-264 | TMC-264 is a STAT6 activation inhibitor produced by Phoma sp. TC 1674. It suppressed expression of IL-4 driven luciferase and germline Cepsilon mRNA with IC50 values of 0.3 and 0.4 μmol/L, respectively, and inhibited tyrosine phosphorylation of STAT6 with an IC50 value of 1.6 μmol/L. Synonyms: TMC 264. Molecular formula: C16H13ClO7. Mole weight: 352.72. |  |
| TMC-2A | TMC-2A is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 A. Molecular formula: C28H34N4O9. Mole weight: 570.6. | |
| TMC-2B | TMC-2B is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 B. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC-2C | TMC-2C is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 C. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC310911 | TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC 50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASC-09. CAS No. 1000287-05-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107123. |  |
| TMC-310911 | TMC-310911, also known as ASC-09, is an HIV protease inhibitor potentially for the treatment of HIV infection. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TMC-310911; ASC-09; TMC310911; ASC09; TMC 310911; ASC 09. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1000287-05-7. Molecular formula: C38H53N5O7S2. Mole weight: 755.99. Purity: >98%. IUPACName: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-((2-((1-cyclopentylpiperidin-4-yl)amino)-N-isobutylbenzo[d]thiazole)-6-sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate. Canonical SMILES: O=C(O[C@H]1CO[C@@]2([H])OCC[C@]21[H])N[C@@H](CC3=CC=CC=C3)[C@H](O)CN(S(=O)(C4=CC=C5N=C(NC6CCN(C7CCCC7)CC6)SC5=C4)=O)CC(C)C. Product ID: ACM1000287057. Alfa Chemistry ISO 9001:2015 Certified. |  |
| TMC-34 | TMC-34 is an macrolide antifungal antibiotic produced by Streptomyces sp. A-3030. Synonyms: TMC 34. Molecular formula: C54H93N3O17. Mole weight: 1056.3. | |
| TMC353121 | TMC353121 is a potent RSV fusion inhibitor. Its activity profile was found to be identical to the profile of JNJ-2408068. Synonyms: TMC-353121; TMC 353121; TMC353121. Grades: >98%. CAS No. 857066-90-1. Molecular formula: C32H42N6O3. Mole weight: 558.71. | |
| TMC-49A | TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Synonyms: TMC-49 A; 2-phenylethyl n-butyl carbamate. Molecular formula: C13H19NO2. Mole weight: 221.29. | |
| TMC-52A | TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM. Synonyms: TMC-52 A. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52B | TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 B. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52C | TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 C. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-52D | TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM. Synonyms: TMC-52 D. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-66 | TMC-66 is a selective endothelin conversion enzyme (ECE) inhibitor isolated from the culture broth of Streptomyces sp. A5008. Synonyms: TMC 66. Molecular formula: C29H21NO9. Mole weight: 527.5. | |
| TMC-69 | TMC-69 is an antitumor antibiotic isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. It exhibited moderate in vitro cytotoxic activity. Synonyms: TMC 69. Molecular formula: C26H31NO4. Mole weight: 421.5. | |
| TMC-86A | TMC-86A is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 5.1 and 3.7 μmol/L, respectively. Synonyms: TMC-86 A. Molecular formula: C16H26N2O6. Mole weight: 342.39. | |
| TMC-86B | TMC-86B is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 1.1 and 31 μmol/L, respectively. Synonyms: TMC-86 B. Molecular formula: C20H34N2O7. Mole weight: 414.5. | |
| TMC-89A | TMC-89A is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.39 and 7.2 μmol/L, respectively. Synonyms: TMC-89 A; N-[(2R)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-89B | TMC-89B is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.51 and 7.1 μmol/L, respectively. Synonyms: TMC-89 B; N-[(2S)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-95A | TMC-95A is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 values of 5.4nM, 200nM, and 60nM, respectively. Synonyms: TMC-95 A. CAS No. 220666-21-7. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95B | TMC-95B is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome to the same extent as TMC-95A. Synonyms: TMC-95 B. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95C | TMC-95C is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 C. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95D | TMC-95D is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 D. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-96 | TMC-96 is a proteasome inhibitor produced by Saccharothrix sp. TC 1094. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 2.9 and 3.5 μmol/L, respectively. Synonyms: TMC 96. Molecular formula: C18H32N2O6. Mole weight: 372.5. | |
| Tmcb | TMCB is a selective, ATP-competitive CK2 (casein kinase II) inhibitor with distinct Ki values of 83 nM and 21 nM for the two different catalytic CK2 subunits α and α', respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CHEMBL1233807, SureCN1759230, ABP000318, [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid, 905105-89-7, K66. Product Category: Inhibitors. CAS No. 905105-89-7. Molecular formula: C11H9Br4N3O2. Mole weight: C11H9Br4N3O2. Purity: >98 %. IUPACName: 2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid. Canonical SMILES: CN(C)C1=NC2=C(N1CC(=O)O)C(=C(C(=C2Br)Br)Br)Br. Product ID: ACM905105897. Alfa Chemistry ISO 9001:2015 Certified. Categories: TMC Bulldogs. | |
| TMCB | TMCB. Group: Biochemicals. Grades: Purified. CAS No. 905105-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TMCB | TMCB is a dual-kinase inhibitor of both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). TMCB exhibits selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki = 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2, respectively). Synonyms: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid. Grades: ≥98% by HPLC. CAS No. 905105-89-7. Molecular formula: C11H9Br4N3O2. Mole weight: 534.82. | |
| TMCz-BO | TMCz-BO. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-[1,4]Benzoxaborino[2,3,4-kl]phenoxaborin-7-yl-1,3,6,8- tetramethyl-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2170468-48-9. Molecular formula: C34H26BN4O2. Mole weight: 491.39 g/mol. Product ID: ACM2170468489. Alfa Chemistry ISO 9001:2015 Certified. | |
| TmCzTrz | TmCzTrz. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9',9''-(5-(4,6-Diphenyl-1,3,5-triazin-2-yl)benzene-1,2,3-triyl) tris(3,6-dimethyl-9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 1808158-41-9. Molecular formula: C63H48N6. Mole weight: 889.10 g/mol. Purity: 95%+. Product ID: ACM1808158419. Alfa Chemistry ISO 9001:2015 Certified. | |
| TMEM16A Activator, Eact (3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide, ANO1 Activator) | An N-aroylaminothiazole that strongly activates TMEM16A (ANO1) calcium-activated chloride channel (CaCC) at 0 Ca2+ concentration (Ca2+ independent), with the capability of producing large and sustained CaCC Cl-1 currents (EC50=3uM) in TMEM16A-expressing Fisher Rat Thyroid (FRT) Cells without elevation of cytoplasmic Ca2+ level, and in human A253 cells. Shown to increase CaCC conductance in human salivary and airway submucosal gland epithelial cells, IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine. Activation effect can be abolished by the addition of a TMEM16A inhibitor T16A-A01 at 10uM in TMEM16A-transfected cells and in cultures of human salivary gland and IL-4-treated bronchial epithelia, but not in intestine. Does not affect CFTR Cl- conductance or ENaC Na+ conductance. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TMEM16A Inhibitor, T16Ainh-A01 (2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, ANO1 Inhibitor, T16Ainh-A01, TMEM16A Antagonist, T16Ainh-A01) | An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50=1.1uM). Fully blocks CaCC current in salivary gland cells at 10uM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact at 10uM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TMG-A13 | This glucoside can effectively stabilize a variety of membrane proteins including GPCRs. Due to its high tendency to form small protein-detergent complexes (PDCs), this is a promising tool for studying protein structures using X-ray crystallography and cryo-electron microscopy. This is a good alternative to OGNG because it significantly improves protein stabilization efficiency compared to OGNG. Synonyms: Tandem malonate glucoside-A13. Grades: >99%. CAS No. 2247654-99-3. Molecular formula: C59H112O24. Mole weight: 1205.51. | |
| TMI 005 | TMI 005, also known as Apratastat, is a matrix metalloproteinase/tumour necrosis factor-α convertase (MMP/TACE) inhibitor for the treatment of rheumatoid arthritis. It inhibits secretion of soluble TNF-α and downregulates multiple MMPs, which is involved in cartilage destruction and bone erosions of RA. Uses: The treatment of rheumatoid arthritis. Synonyms: TMI-005; TMI005; TMI 005; XMT-1191; XMT 1191; XMT1191. Apratastat; (3S)-N-hydroxy-4-[4-(4-hydroxybut-2-ynoxy)phenyl]sulfonyl-2,2-dimethylthiomorpholine-3-carboxamide. Grades: 99%. CAS No. 287405-51-0. Molecular formula: C17H22N2O6S2. Mole weight: 414.5. | |
| TMI 1 | TMI 1 is a dual inhibitor of Adam 17 (TACE) and MMP inhibitor (IC50 = 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). TMI 1 suppresses TNF-α production in an acute LPS-mouse model. TMI 1 exhibits selective cytotoxicity to tumor cells and cancer stem cells in vitro, and induces apoptosis in a breast cancer in vivo model. Synonyms: TMI-1; TMI-1; TMI-1; (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide. Grades: ≥98% by HPLC. CAS No. 287403-39-8. Molecular formula: C17H22N2O5S2. Mole weight: 398.49. | |
| TMI-1 | TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) ( IC 50 of 8.4 nM), ADAM-TS-4 , ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors ( TNF-α , IL-1β , IL-6 ) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WAY-171318. CAS No. 287403-39-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-101448. | |
| TM N1324 | TM N1324 is an orally bioavailable, potent and selective GPR39 agonist. It inhibits the release of ghrelin and somatostatin from primary gastric mucosa cells in vitro. Synonyms: 4-(2-Chloro-4-fluorophenyl)-1,4,5,7-tetrahydro-3-methyl-1-(9H-purin-6-yl)-6H-pyrazolo[3,4-b]pyridin-6-one. Grades: ≥98% by HPLC. CAS No. 1144477-35-9. Molecular formula: C18H13ClFN7O. Mole weight: 397.79. | |
| TMN 355 | TMN 355 is a potent cyclophilin A inhibitor (IC50 = 1.52 nM), displaying 27-fold potency against cyclosporin A. Synonyms: TMN 355; TMN355; TMN-355; 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide. Grades: ≥98% by HPLC. CAS No. 1186372-20-2. Molecular formula: C21H14ClFN2O2. Mole weight: 380.8. | |
| TMN 355 | TMN 355. Group: Biochemicals. Grades: Purified. CAS No. 1186372-20-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TMP-153 | TMP-153 is an Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 values of 5-10 nM in various animals. It inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively). Synonyms: N-(4-(2-Chlorophenyl)-6,7-dimethyl-3-quinolyl)-N'-(2,4-difluorophenyl)urea; 1-[4-(2-chlorophenyl)-6,7-dimethylquinolin-3-yl]-3-(2,4-difluorophenyl)urea. Grades: ≥95%. CAS No. 128831-46-9. Molecular formula: C24H18ClF2N3O. Mole weight: 437.9. | |
| TMP195 | TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor (IC50s = 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively), and is >100 fold selective over other HDACs (IC50 >10 μM). Synonyms: TMP195; TMP-195; TMP 195; N-[2-methyl-2-(2-phenyl-1,3-oxazol-4-yl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; N-(2-Methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide; TFMO 2. CAS No. 1314891-22-9. Molecular formula: C23H19F3N4O3. Mole weight: 456.42. | |
| TMP269 | TMP269 is a highly potent, selective and cell-permeable class IIa HDAC inhibitor with IC50 values of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. Synonyms: TMP269; TMP 269; TMP-269; N-((4-(4-Phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide. Grades: 98%. CAS No. 1314890-29-3. Molecular formula: C25H21F3N4O3S. Mole weight: 514.523. | |
| TMP269 | TMP269 Inhibitor. Uses: Scientific use. Product Category: T1857. CAS No. 1314890-29-3. |  |
| TMP778 | TMP778 is a selective RORγt inverse agonist. TMP778 can selectively block mouse Th17 cell differentiation in vitro and impair Th17 cell development in vivo upon immunization with the myelin antigen MOG35-55 plus complete Freund's adjuvant. In addition, TMP778 can repress the expression of more than 150 genes, most of which fall outside the canonical Th17 transcriptional signature and are linked to a variety of inflammatory pathologies in humans. Synonyms: TMP778; TMP 778; TMP-778; 2- (2- ( (S)- (3, 5-dimethylisoxazol-4-yl) (hydroxy)methyl)benzofuran-5-yl)-N- ( (S)- (2, 4-dimethylphenyl) (phenyl)methyl)acetamide. Grades: 98%. CAS No. 1422171-08-1. Molecular formula: C31H30N2O4. Mole weight: 494.59. | |
| TMPA | TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPK&alpha. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258275-73-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18555. | |
| TMPA | TMPA is an antagonist of nuclear receptor Nur77 (Kd = 1.45 ± 0.35 μM) and LKB1 interaction. Synonyms: ethyl 2-(2,3,4-trimethoxy-6-octanoylphenyl)acetate; ethyl 2-(2,3,4-trimethoxy-6-(1-octanoyl)phenyl)acetate. CAS No. 1258275-73-8. Molecular formula: C21H32O6. Mole weight: 380.48. | |
| TMP-CP | TMP-CP is a non-hydrolytic analogue of thymidine-5'-diphosphate and an inhibitor of thymidine kinase. It is also used as a starting structure in the synthesis of α/β hydrolysis-resistant tri- and polyphosphates. Synonyms: Thymidine- 5'- O- (α, β- methylene)diphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 55065-40-2. Molecular formula: C11H18N2O10P2 (free acid). Mole weight: 400.2 (free acid). | |
| TMPD dihydrochloride | TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases [1] [2]. TMPD dihydrochloride is also a complex IV substrate [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 637-01-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W012145. | |
| TMPEOTA 28961-43-5 | TMPEOTA 28961- - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY. |  North America & APAC |
| TMPH hydrochloride | TMPH hydrochloride is a potent and non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). It produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). TMPH hydrochloride has the potential to treat progressive neurodegenerative disease such as globoid cell leukodystrophy (GLD) or Krabbe disease. Synonyms: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate. Grades: ≥98% by HPLC. CAS No. 849461-91-2. Molecular formula: C16H31NO2.HCl. Mole weight: 305.88. | |
| TMPH inhibitor | TMPH is an inhibitor of CNS nicotinic receptor. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal α (i.e., α3 and α4) and β subunits (β2 and β4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (α1β1γδ) or α7 receptors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TMPH; TMPH inhibitor. Product Category: Inhibitors. Appearance: To be determined. CAS No. 849461-90-1. Molecular formula: C16H31NO2. Mole weight: 269.43. Purity: >98%. IUPACName: 2,2,6,6-Tetramethyl-4-piperidinyl heptanoate. Canonical SMILES: CCCCCCC(OC1CC(C)(C)NC(C)(C)C1)=O. Product ID: ACM849461901-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: TPH inhibitor. | |
| TmPPPyTz | TmPPPyTz. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,4,6-Tris(3'-(pyridin-3-yl)biphenyl-3-yl)-1,3,5-triazine. Product Category: Organic Light Emitting Diode (OLED). CAS No. 939430-31-6. Molecular formula: C54H36N6. Mole weight: 768.9 g/mol. Product ID: ACM939430316. Alfa Chemistry ISO 9001:2015 Certified. | |
| TMPTA | 1kg Pack Size. Group: Building Blocks, Organics. Formula: C15H20O6. CAS No. 15625-89-5. Prepack ID 90027098-1kg. Molecular Weight 296.32. See USA prepack pricing. |  |
| TMPTA | 500g Pack Size. Group: Building Blocks, Organics. Formula: C15H20O6. CAS No. 15625-89-5. Prepack ID 90027098-500g. Molecular Weight 296.32. See USA prepack pricing. | |
| Tmpyp | Tmpyp. Group: other materials. Alternative Names: 5,10,15,20-TETRAKIS-(N-METHYL-4-PYRIDYL)-21,23H-PORPHYRIN TETRATOSYLATE; 5,10,15,20-TETRAKIS (1-METHYL-4-PYRIDINIO) PORPHINE TETRA (P-TOLUENESULFONATE); 5,10,15,20-TETRAKIS(1-METHYL-4-PYRIDINIO)-PORPHYRIN TETRA(P-TOLUENESULFONATE); 5,10,15,20-TETRAKIS(1-METH. CAS No. 36951-72-1. Product ID: 4-methylbenzenesulfonate; 5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,22-dihydroporphyrin. Molecular formula: 1363.6. Mole weight: C72< / sub>H66< / sub>N8< / sub>O12< / sub>S4< / sub>. AKZFRMNXBLFDNN-UHFFFAOYSA-K. >95 %. |  |
| TMPyP4 tosylate | TMPyP4 tosylate is a cationic porphyrin. TMPyP4 stacks with G tetrads to stabilize quadruplex DNA, and inhibits telomerase activity (IC50 ≤ 50 μM). TMPyP4 inhibits cell proliferation and induces apoptosis in three myeloma cell lines. Synonyms: 5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate); Tmpyp tetratosylate. Grades: ≥95% by HPLC. CAS No. 36951-72-1. Molecular formula: C72H66N8O12S4. Mole weight: 1363.6. | |
| TMPyP4 tosylate | TMPyP4 tosylate. Group: Biochemicals. Grades: Purified. CAS No. 36951-72-1. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| TMPyP4 Tosylate | TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Meso-Tetrakis(N-Methyl-4-Pyridyl)Porphine Tetrakis(P-Toluenesulfonate). Product Category: Inhibitors. Appearance: Soild. CAS No. 36951-72-1. Molecular formula: C72H74N8O12S4. Mole weight: 1371.66. Purity: 0.98. Product ID: ACM36951721-4. Alfa Chemistry ISO 9001:2015 Certified. | |
| TmPyPB | TmPyPB. Uses: Electron-transport and hole/exciton-blocking materail with high electron mobility (10-4-10-3 cm2 v-1 s-1) and high triplet energy level (2.75 ev) for highly efficient phosphorescent oleds application. Group: Organic light-emitting diode (oled) materials. Alternative Names: 1,3,5-Tri(m-pyridin-3-ylphenyl)benzene,1,3,5-Tris(3-pyridyl-3-phenyl)benzene,Tm3PyPB. CAS No. 921205-03-0. Pack Sizes: 1, 5 g in glass bottle. Product ID: 3-[3-[3,5-bis(3-pyridin-3-ylphenyl)phenyl]phenyl]pyridine. Molecular formula: 537.65. Mole weight: C39H27N3. C1 (C2=CC=CC (C3=CN=CC=C3)=C2)=CC (C4=CC=CC (C5=CN=CC=C5)=C4)=CC (C6=CC=CC (C7=CN=CC=C7)=C6)=C1. 1S/C39H27N3/c1-7-28 (34-13-4-16-40-25-34)19-31 (10-1)37-22-38 (32-11-2-8-29 (20-32)35-14-5-17-41-26-35)24-39 (23-37)33-12-3-9-30 (21-33)36-15-6-18-42-27-36/h1-27H, CINYXYWQPZSTOT-UHFFFAOYSA-N. CINYXYWQPZSTOT-UHFFFAOYSA-N. | |
| TMRM Perchlorate | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: T668. CAS No. 115532-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0984A. | |
| TMR PA | TMR PA. Group: Others. Purity: >99%. Mole weight: 946.904. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PA; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3- phosphate (ammonium salt). Cat No: FLBZ-157. |  |
| TMR PC | TMR PC. Group: Others. Purity: >99%. Mole weight: 1015.021. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PC; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-Diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine. Cat No: FLBZ-151. | |
| TMR PE | TMR PE. Group: Others. Purity: >99%. Mole weight: 972.941. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PE; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3- phosphoethanolamine. Cat No: FLBZ-156. | |
| TMR PS | TMR PS. Group: Others. Purity: >99%. Mole weight: 1033.981. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PS; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-Dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3- phospho-L-serine (ammonium salt). Cat No: FLBZ-149. | |
| TMS | TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC 50 of 6 nM and a K i value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC 50 =300 nM) and CYP1A2 (IC 50 =3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (E)-2,3',4,5'-tetramethoxystilbene. CAS No. 24144-92-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19340. | |
| TMS | TMS is a selective, competitive inhibitor of cytochrome P450 1B1 which has a very high degree of selectivity for P450 1B1 versus both P450 1A1 (>50-fold) and P450 1A2 (>520-fold). In vitro it inhibits cancer cell growth. Synonyms: 1-[(E)-2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene 2,3',4,5'-tetramethoxystilbene 2,4,3',5'-tetramethoxystilbene 3,5,2',4'-tetramethoxy-trans-stilbene TMS cpd. Grades: >98 %. CAS No. 24144-92-1. Molecular formula: C18H20O4. Mole weight: 300.35. | |
| TMS | TMS. Group: Biochemicals. Grades: Purified. CAS No. 24144-92-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TN1 | TN1 is a potent fetal hemoglobin ( HbF ) inducer. Uses: Scientific research. Group: Signaling pathways. CAS No. 289479-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-100826. | |
| Tn-16 | TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 μM. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 33016-12-5. Molecular formula: C19H18N2O2. Mole weight: 306.36. Canonical SMILES: O=C(NC(C/1=O)CC2=CC=CC=C2)C1=C(C)/NC3=CC=CC=C3. Product ID: ACM33016125. Alfa Chemistry ISO 9001:2015 Certified. Categories: TN 162. | |
| Tn5 Transposase | Tn5 Transposase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 308064-67-7. Pack Sizes: 25 U. Product ID: HY-E70347. | |
| Tn5 Transposase | Tn5 Transposase is a hyperactive form of Tn5 transposase. This enzyme can be used to randomly insert Tn5 transposon into target DNA. Robust Tn5 Transposase recognizes inside end sequences, outside end sequences and mosaic end sequences of Tn5 transposon. Applications: In vitro transgenic experiment;construction of random library for second-generation sequencing. Group: Enzymes. Synonyms: Transposase. Storage: Store at -20°C. Source: E.coli. Tn5 Transposase; Transposase. Cat No: NATE-1629. | |
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