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| Product | Description | |
|---|---|---|
| Vupanorsen sodium | Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IONIS ANGPT-L3Rx sodium; ISIS 703802 sodium. CAS No. 2172852-12-7. Pack Sizes: 1 mg. Product ID: HY-153497A. |  |
| Vutiglabridin | Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent[1]. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HSG4112. CAS No. 1800188-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145605. | |
| Vutrisiran | Vutrisiran (ALN-TTRsc02) is a liver-directed, investigational, small interfering ribonucleic acid (siRNA) agent. Vutrisiran can be used for transthyretin (TTR)-mediated amyloidosis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-TTRsc02. CAS No. 1867157-35-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132589. | |
| Vutrisiran | Vutrisiran is a liver-directed, investigational, small interfering ribonucleic acid (siRNA) agent. It can be used for transthyretin (TTR)-mediated amyloidosis research. Alternative Names: ALN-TTRsc02. Grades: 98% by SEC-HPLC. CAS No. 1867157-35-4. Molecular formula: C530H715F9N171O323P43S6. Mole weight: 16345 (AS: 7556.3; SS: 8788.7 ). |  |
| Vutrisiran sodium | Vutrisiran sodium is a small interfering ribonucleic acid (siRNA) agent. It has been indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults. Alternative Names: ALN-TTRsc02 sodium; Amvuttra sodium; Votrisiran sodium; (Um-sp-(2'-deoxy-2'-fluoro)C-sp-Um-Um-Gm-(2'-deoxy-2'-fluoro)G-Um-Um-(2'-deoxy-2'-fluoro)A-Cm-Am-Um-Gm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-Um-Cm-Cm-Cm-Am-sp-Um-sp-Cm), complex with RNA (Um-sp-Gm-sp-Gm-Gm-Am-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Gm-Um-Am-Am-Cm-Cm-Am-Am-Gm-Am) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] (1:1) sodium salt. Molecular formula: C530H672F9N171Na43O323P43S6. Mole weight: 17,290 Da. | |
| VV261 | VV261 is an orally active prodrug of 4'-fluorouridine. VV261 inhibits viral RNA-dependent RNA polymerase. VV261 exhibits antiviral activity against CCHFV, SFTSV and LCMV. VV261 can be used in research related to viral infections[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3003864-86-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172918. | |
| Vv-AMP1 | Vv-AMP1 is an antibacterial peptide isolated from Vit is vinifera. It has activity against fungi. Alternative Names: Arg-Thr-Cys-Glu-Ser-Gln-Ser-His-Arg-Phe-Lys-Gly-Thr-Cys-Val-Arg-Gln-Ser-Asn-Cys-Ala-Ala-Val-Cys-Gln-Thr-Glu-Gly-Phe-His-Gly-Gly-Asn-Cys-Arg-Gly-Phe-Arg-Arg-Arg-Cys-Phe-Cys-Thr-Lys-His-Cys. Molecular formula: C216H343N81O64S8. Mole weight: 5355.08. | |
| VVD 065 | VVD 065 is an orally active KEAP1-dependent NRF2 molecular glue degrader with a KEAP1 KD of 65 nM. VVD 065 covalently engages KEAP1 at Cys151, allosterically stabilizes KEAP1-CUL3 complex formation and enhances NRF2 polyubiquitination and proteasomal degradation. VVD 065 can be used for the research of esophageal squamous cell carcinoma, lung cancer, head-and-neck cancer, uterine cancers[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034876-85-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169766. | |
| VVD-118313 | VVD-118313 (compound 5a) is a potent, selective JAK1 inhibitor. VVD-118313 targets an isoform-restricted allosteric cysteine to block JAK1-dependent trans-phosphorylation and cytokine signaling. VVD-118313 can be used for research of cancer[1]. VVD-118313 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2875046-27-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151385. | |
| VVD-130037 | VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-3605349. CAS No. 3034880-93-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159641. | |
| VVD-214 | VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 μM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RO7589831; VVD-133214. CAS No. 3026500-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158116. | |
| VVD-442 | VVD-442 is an inhibitor targeting PI3Kα. VVD-442 covalently binds to Cys242 in the RAS-binding domain of PI3K p110α, induces conformational changes, and disrupts the interaction between PI3K p110α and RAS proteins. VVD-442 also blocks RAS-mediated PI3K activation. VVD-442 can be used in research related to RAS-mutant cancers and HER2-overexpressing cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055318-88-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-176811. | |
| VVD-699 | VVD-699 is a covalent blocker of the RAS-p110α interaction with oral activity. VVD-699 inhibits activation of PI3Kα (IC50: 104 nM in H358 cells). VVD-699 inhibits phosphorylated AKT. VVD-699 can be used for the research of KRAS mutant/amplified cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055319-82-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-173405. | |
| VVD-849 | VVD-849 is a RAS ligand. VVD-849 covalently binds to Cys242 in the RAS-binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT (S473) in HER2-overexpressing tumors. VVD-849 can be used for the research of cancers such as breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055321-14-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-176812. | |
| VX-11e | VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 896720-20-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14178. | |
| VX-150 | VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1793080-72-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139346. | |
| VX-166 | VX-166 is a caspase inhibitor and can be used as a novel potential treatment for sepsis. VX-166 can also reduce fibrosis in an animal model of nonalcoholic steatohepatitis. Uses: Sepsis. Alternative Names: VX166, VX 166, VX-166; (S)-3-((S)-2-(3-((methoxycarbonyl)amino)-2-oxopyridin-1(2H)-yl)butanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid. Grades: 98%. CAS No. 800408-39-3. Molecular formula: C22H21F4N3O8. Mole weight: 531.41. | |
| VX-445 (Elexacaftor) | Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.This is a compound which is not chiral purity. Group: Inhibitors. CAS No. 2216712-66-0. Pack Sizes: 5mg. Product ID: S8851. Formula: C26H34F3N7O4S. Smiles: CC1CC(N(C1)C2=C(C=CC(=N2)N3C=CC(=N3)OCC(C)(C)C(F)(F)F)C(=O)NS(=O)(=O)C4=CN(N=C4C)C)(C)C. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| VX-661 | VX-661 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator used in combination with Ivacaftor in the treatment of cystic fibrosis. Alternative Names: 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]cyclopropanecarboxamide; VX 661; VX661; Tezacaftor. Grades: 98%. CAS No. 1152311-62-0. Molecular formula: C26H27F3N2O6. Mole weight: 520.50. | |
| VX 702 | VX 702. Group: Biochemicals. Grades: Purified. CAS No. 479543-46-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| VX-702 | VX-702. Group: Biochemicals. Alternative Names: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide. Grades: Highly Purified. CAS No. 745833-23-2. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C19H12F4N4O2. US Biological Life Sciences. | Worldwide |
| VX-702 | VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38β[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 745833-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10401. | |
| VX-765 | VX-765. Group: Biochemicals. Alternative Names: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide; Belnacasan. Grades: Highly Purified. CAS No. 273404-37-8. Pack Sizes: 5mg. Molecular Formula: C24H33ClN4O6, Molecular Weight: 509. US Biological Life Sciences. | Worldwide |
| VX-809 (Lumacaftor) | Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation,EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3. Group: Inhibitors. Alternative Names: VRT 826809. CAS No. 936727-05-8. Pack Sizes: 5mg. Product ID: S1565. Formula: C24H18F2N2O5. Smiles: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| VX-809 (Lumacaftor) | VX-809 (Lumacaftor). Group: Biochemicals. Alternative Names: 3- [6- [ [ [1- (2, 2-Difluoro-1, 3-benzodioxol-5-yl) cyclopropyl] carbonyl] amino] -3-methyl-2-pyridinyl] benzoic Acid; Lumacaftor; VRT 826809. Grades: Highly Purified. CAS No. 936727-05-8. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 452.51. US Biological Life Sciences. | Worldwide |
| VX-984 | VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M9831. CAS No. 1476074-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19939S. | |
| VY-3-135 | VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1824637-41-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145953. | |
| VZ185 | VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2306193-61-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114322. | |
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