A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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| Product | Description | |
|---|---|---|
| WK-X-34 | WK-X-34 is Inhibitor of P-glycoprotein and BCRP. Synonyms: WKX34; WKX-34; WKX 34; WK-X 34; WK-X34. Grades: 98%. CAS No. 908859-10-9. Molecular formula: C35H37N3O6. Mole weight: 595.70. |  |
| WKYMVdM trifluoroacetate salt | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| WKYMVM | WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) that is expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Synonyms: Trp-Lys-Tyr-Met-Val-D-Met-NH2; Leukocyte chemoattractant peptide; W-Peptide. CAS No. 187986-17-0. Molecular formula: C41H61N9O7S2. Mole weight: 856.11. | |
| WKYMVM | WKYMVM. Group: Biochemicals. Grades: Purified. CAS No. 187986-11-4. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| WKYMVM 2TFA | WKYMVM 2TFA is a selective agonist of the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM), and FPR3 (EC50 = 3 nM) and is expressed on immune cells. It induces Ca2+ mobilization and superoxide production, as well as chemotactic migration of monocytes and neutrophils. Synonyms: H-Trp-Lys-Tyr-Met-Val-D-Met-NH2.2TFA; L-tryptophyl-L-lysyl-L-tyrosyl-L-methionyl-L-valyl-D-methioninamide trifluoroacetic acid; (2R,5S,8S,11S,14S,17S)-17-Amino-14-(4-aminobutyl)-11-(4-hydroxybenzyl)-18-(1H-indol-3-yl)-5-isopropyl-2,8-bis[2-(methylsulfanyl)ethyl]-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-1-amide trifluoroacetate; W-Peptide TFA salt; WKYMVm TFA salt. Grades: ≥95%. Molecular formula: C41H61N9O7S2.2C2HF3O2. Mole weight: 1084.16. | |
| WKYMVM trifluoroacetate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| WL 47 - dimer | WL 47 - dimer acts as a high affinity caveolin-1 (CAV1) ligand (Kd = 23 nM) to disrupt the formation of caveolin-1 oligomers. It has selectivity for CAV1 over BSA, casein and HEWL. Synonyms: WL 47 - dimer; WL47 - dimer; WL-47 - dimer. Molecular formula: C80H130N24O18S4. Mole weight: 1844.3. | |
| WLBU2 | WLBU2 is a synthetic cationic antibacterial peptide that can kill Pseudomonas aeruginosa in human serum. Synonyms: Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg. Grades: >96%. Molecular formula: C151H260N66O25. Mole weight: 3400.15. | |
| WM-1119 | WM-1119 is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 ?M for KAT6A in lymphoma cells, the binding KD values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 ?M, 0.5 ?M , respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055397-28-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102058. |  |
| WM-1119 | WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively. Synonyms: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide. CAS No. 2055397-28-7. Molecular formula: C18H13F2N3O3S. Mole weight: 389.38. | |
| WM-3835 | WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2229025-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134901. | |
| WM-662 | WM-662 is a WDR5-MYC interaction inhibitor, with an IC 50 of 18 μM. WM-662 has potential for the research of cancer, aging, and neurodegenerative disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1308257-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-154847. | |
| WM-8014 | WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC50 of 55 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055397-18-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102060. | |
| WNK1 (181-507), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| WNK1-IN-1 | WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 ?M. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 ?M. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 324022-39-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151545. | |
| WNK463 | WNK463 is an orally bioavailable pan-With-No-Lysine (K) (WNK)-kinase inhibitor with IC50s of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2012607-27-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100626. | |
| WNK463 | WNK463 is a pan-WNK-kinase catalytic activity inhibitor. Synonyms: WNK-463; WNK 463; N-Tert-butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl]piperidin-4-yl]imidazole-4-carboxamide. CAS No. 2012607-27-9. Molecular formula: C21H24F3N7O2. Mole weight: 463.46. | |
| WNK-IN-11 | WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. Uses: Scientific research. Group: Signaling pathways. CAS No. 2123489-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112094. | |
| WNS Apricot Kernel Shells | WNS Apricot Kernel Shells - Apricot Kernel Shells are granules prepared from crushed apricot shells. The shells have a hard fibrous material ideal as a gentle, natural exfoliate which assists with the removal of dead skin cells. Its grit is a soft abrasive that is extremely durable, angular & multi-faceted. Categories: Apricot kernels. |  United States and all of its trading partners.. |
| WNS Walnut Shells | Walnut Shell Powder is prepared from finely crushed walnut shells. The shells have a hard fibrous material ideal as a gentle, natural exfoliant which assists with the removal of dead skin cells. Its grit is a soft abrasive that is extremely durable, angular & multi-faceted. Categories: Juglandaceae; Juglans regia. | United States and all of its trading partners.. |
| WNT-1 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| WNT-7A human | recombinant, expressed in HEK 293 cells, ?80% (SDS-PAGE), ?80% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Wnt Agonist - CAS 853220-52-7 | The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Wnt Agonist I in DMSO - CAS 853220-52-7 | The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications. Group: Fluorescence/luminescence spectroscopy. | |
| Wnt Agonist II, SKL2001 | The Wnt Agonist II, SKL2001 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide) | A cell-permeable imidazolyl-isoxazolamide that upregulates b-catenin-regulated transcription (CRT; 10-40uM) by disrupting beta-catenin and Axin interaction, thereby preventing b-catenin phosphorylation (Ser33 / Ser37 / Thr41 / Ser45) and proteasomal degradation, without affecting the activities of GSK-3alpha/beta or 18 other kinases (<8.5% inhibition by 10uM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40uM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Wnt Antagonist, C59 | Cell-permeable. A potent Wnt signaling pathway inhibitor (IC50 = <0.11nM using Wnt-Luc reporter assay). Group: Biochemicals. Alternative Names: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl) Acetamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Wnt-C59 | Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/ β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021. Cell permeable and orally bioavailable. Group: Biochemicals. Grades: Highly Purified. CAS No. 1243243-89-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Wnt-C59 | Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC 50 of 74 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C59. CAS No. 1243243-89-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15659. | |
| Wnt-C59 | Wnt-C59 is a potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It was shown to arrest stemness and suppress growth of nasopharyngeal carcinoma in mice via Wnt pathway inhibition. Synonyms: 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide. Grades: >98%. CAS No. 1243243-89-1. Molecular formula: C25H21N3O. Mole weight: 379.45. | |
| Wnt/Hedgehog/Notch Compound Library | A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4300. Categories: Wnt/Hedgehog/Notch Compounds Libraries. |  |
| Wnt Inhibitor IWP-2 | IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM. Uses: Differentiation. Synonyms: IWP 2, IWP-2, IWP2. Grades: 0.98. CAS No. 686770-61-6. Molecular formula: C22H18N4O2S3. Mole weight: 466.592. | |
| WNTinib | WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenic Wnt signaling by inhibiting KIT/MAPK and downstream EZH2 activation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APS-8-100-2. CAS No. 2770091-44-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160765. | |
| Wnt pathway inhibitor 3 | Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC 50 value of 45 nM. Wnt pathway inhibitor 3 shows antiproliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 663213-98-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153750. | |
| Wnt pathway inhibitor 4 | Wnt pathway inhibitor 4 (compound 16D) is an anticancer agent that has anti-proliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 663214-57-1. Pack Sizes: 10 mg. Product ID: HY-153753. | |
| Wogonin | Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt , and exhibits anti-inflammatory and anti-tumor effects. Uses: Scientific research. Group: Natural products. CAS No. 632-85-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0400. | |
| Wogonin | Anti-inflammatory. Increases nitroc oxide (NO) production. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II). Antioxidant. Anti-viral. Shows anti-hepatitis B virus activity. MCP-1 inhibitor. Shows anxiolytic effect through modulation of the GABA(A) receptor complex. Antifungal. Neuroprotective. Anticancer compound. Apoptosis and cell cycle arrest inducer. Sensitizes TNFalpha- and TRAIL-induced apoptosis. Antiangiogenic. NF-kappaB inhibitor. Telomerase activity inhibitor. CDK9 inhibitor. PI3K-AKT pathway modulator. Autophagy inducer. Group: Biochemicals. Alternative Names: WOG, 5,7-Dihydroxy-8-methoxyflavone, BRN 0287152. Grades: Highly Purified. CAS No. 632-85-9. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H12O5. US Biological Life Sciences. | Worldwide |
| Wogonin | Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 632-85-9. Molecular formula: C16H12O5. Mole weight: 284.26. Purity: 0.9998. Product ID: ACM632859. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Wogonin hydrate | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Wogonoside | Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 51059-44-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0399. | |
| Wogonoside | Wogonoside has shown preclinical anticancer efficacy in various cancer models. Wogonoside has been reported to have anti-inflammatory properties. Uses: Anti-inflammatory. Synonyms: Wogonin 7-O-b-D-glucuronide; Oroxindin. Grades: >98%. CAS No. 51059-44-0. Molecular formula: C22H20O11. Mole weight: 460.39. | |
| Wogonoside | Wogonoside. Group: Biochemicals. Alternative Names: Oroxindin; Glychionide B. Grades: Plant Grade. CAS No. 51059-44-0. Pack Sizes: 20mg. Molecular Formula: C22H20O11, Molecular Weight: 460.387999999999. US Biological Life Sciences. | Worldwide |
| Wolfberry Extract | Wolfberry Extract. Applications: Wolfberry extract can be used in functional food, drinks, health care products and pharmaceuticals. Group: Others. Purity: 10:1, 20:1, 50% Polysaccharide or as required. Appearance: Brown powder. Wolfberry Extract. Cat No: EXTC-158. |  |
| Wood | Wood. CAS No. MIXTURE. VIGON Item # 507466. Categories: Speciality Ingrdients Suppliers. |  America & Internationally |
| Wood Betony Herb Powder(Stachys Officinalis (L.) Trevis)s | Wood Betony Herb Powder(Stachys Officinalis (L.) Trevis)s. |  CA, FL & NJ |
| Woods alloy | Woods alloy. Group: Alloys. Alternative Names: BISMUTH LEAD TIN CADMIUM; ALLOY ACCORDING TO WOOD; WOODS METAL; WOODS METAL; WOODS ALLOY; WOODS ALLOY; Alloy Woods ; WOODS METAL, STICK. CAS No. 76093-98-6. Product ID: bismuth; cadmium; lead; tin. Molecular formula: 546.52. Mole weight: BiCdPdSn. CQHDPRBPWAYYKI-UHFFFAOYSA-N. sticks. |  |
| Worenine | Botanical Source: Group: Biochemicals. Alternative Names: 5, 6-Dihydro-14-methylbis[1, 3]benzodioxolo[5, 6-a:5?, 6?-g]quinolizinium(1+), 9CI. 13-Methylpseudocoptisine. Grades: Plant Grade. CAS No. 38763-29-0. Pack Sizes: 10mg, 20mg. US Biological Life Sciences. | Worldwide |
| Wormwood Extract | Wormwood Extract. Applications: Used for health care products, dietary supplements, herb medecine, mainly for antibacterial. Group: Others. Synonyms: Wormwood Extract; 977032-37-3; Artemisia princes orientalis L. CAS No. 977032-37-3. Purity: 4-10:1 by TLC. Appearance: Yellow brown fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Leaf. Species: Artemisia princes orientalis L. Wormwood Extract; 977032-37-3; Artemisia princes orientalis L.; plant extract. Pack: 25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-130. | |
| Wormwood Oil | Wormwood Oil (Thujone Free). CAS No. 8008-93-3. FEMA No. 3116. Kosher: Y. VIGON Item # 509001. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers. | America & Internationally |
| Wormwood Oil American | Wormwood Oil American. CAS No. 8008-93-3. FEMA No. 3116. Kosher: Y. VIGON Item # 504105. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers. | America & Internationally |
| Wortmannin | It is an antibiotic produced by the strain of Pen. wortmanni 989. It has strong antifungal effect. It is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. Uses: Immunosuppressive agents. Synonyms: Antibiotic SL-2052; (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione; (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. Grades: 98%. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43. | |
| Wortmannin | Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19545-26-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C23H24O8. US Biological Life Sciences. | Worldwide |
| Wortmannin | from Penicillium funiculosum, ?98% (HPLC and TLC). Group: Fluorescence/luminescence spectroscopychiral moleculesenzyme activators, inhibitors & substrates. | |
| Wortmannin | Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC 50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC 50 s of 5.8 and 48 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: SL-2052; KY-12420. CAS No. 19545-26-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10197. | |
| Wortmannin | Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Wartmannin. Product Category: Inhibitors. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43. Purity: 0.98. Product ID: ACM19545267. Alfa Chemistry ISO 9001:2015 Certified. | |
| Wortmannin - CAS 19545-26-7 | Wortmannin, CAS 19545-26-7, is a cell-permeable, potent, selective, and irreversible inhibitor of PI3-Kinase (IC?? = 5 nM). Does not affect any upstream signaling events. Group: Fluorescence/luminescence spectroscopy. | |
| Wortmannin-Rapamycin Conjugate | Wortmannin is a potent inhibitor of PI3K enzymes, and rapamycin blocks mTOR. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Synonyms: Wortmannin-Rapamycin Conjugate; 1067892-47-0; AKOS040755180. Grades: ≥98%. CAS No. 1067892-47-0. Molecular formula: C88H131N3O23. Mole weight: 1598.9. | |
| Wortmannin, Ready Made Solution | from Penicillium funiculosum, ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| WP-1034 | WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP). Synonyms: WP1034; WP 1034; (R,E)-2-cyano-3-(4-nitrophenyl)-N-(1-phenylethyl)acrylamide. CAS No. 857064-42-7. Molecular formula: C18H15N3O3. Mole weight: 321.33. | |
| WP1066 | WP1066 is an inhibitor of JAK2 and STAT3 , and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3. Uses: Scientific research. Group: Signaling pathways. CAS No. 857064-38-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15312. | |
| WP1066 | WP1066 is a JAK2 and STAT3 inhibitor. It was shown to inhibit proliferation and induce apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Synonyms: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide. Grades: >98%. CAS No. 857064-38-1. Molecular formula: C17H14BrN3O. Mole weight: 356.223. | |
| WP1066 ((2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide) | A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway. Group: Biochemicals. Grades: Purified. CAS No. 857064-38-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| WP1130 | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Group: Fluorescence/luminescence spectroscopy. | |
| WP1130 (Degrasyn) | A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| WP1130 ( (S, E) -3- (6-Bromopyridin-2-yl) -2-cyano-N- (1-phenylbutyl) acrylamide, Degrasyn) | Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination. Group: Biochemicals. Grades: Highly Purified. CAS No. 856243-80-6. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| WP631 methanesulfonate | ?97% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| WP900 hydrochloride | ?95% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| WP9QY | WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.). Uses: Scientific research. Group: Peptides. CAS No. 199999-60-5. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P2612. | |
| WP BUTYL (C4) REVERSE PHASE MEDIA | WP BUTYL (C4) REVERSE PHASE MEDIA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BAKERBOND WIDE-PORE(TM) BUTYL(C4) 15 MICROM PREP H MN;BAKERBOND(TM) WIDE-PORE BUTYL(C4);BAKERBOND(TM) BUTYL (C4);BUTYL (C4) NARROW-PORE MEDIA-REVERSE PHASE;WP BUTYL (C4) REVERSE PHASE MEDIA. Product Category: Heterocyclic Organic Compound. CAS No. 126850-01-9. Product ID: ACM126850019. Alfa Chemistry ISO 9001:2015 Certified. | |
| WQ3810 | WQ3810 is a newly developed fluoroquinolone withunique substituents at the N1 and C7 positions of the quinolone ringfor the treatment of antibiotic-resistant infections. Synonyms: 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-8-methyl-4-oxo-7-[3-(propan-2-ylamino)azetidin-1-yl]quinoline-3-carboxylic acid; 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-(isopropylamino)azetidin-1-yl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; WQ-3810; WQ 3810; WQ3810. CAS No. 888032-58-4. Molecular formula: C22H22F3N5O3. Mole weight: 461.44. | |
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