A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
WS79089 B is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 79089. The activity of B is more potent than that of A and C. Synonyms: WS-79089 B; WS 79089 B; WS-79089B. CAS No. 157110-24-2. Molecular formula: C27H22O10. Mole weight: 506.5.
WS79089 C
WS79089 C is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 79089. Synonyms: WS-79089 C; WS 79089 C; WS-79089C. CAS No. 157110-25-3. Molecular formula: C29H22O10. Mole weight: 530.5.
WS9326A
WS9326A is a tachykinin antagonist from Streptomyces violaceusniger No. 9326. Synonyms: WS-9326A. Molecular formula: C54H68N8O13. Mole weight: 1037.2.
WS-9659 B
WS-9659 B is a testosterone 5 alpha-reductase inhibitor isolated from Streptomyces sp. No. 9659. It exhibits weak activity against gram-positive bacteria. Synonyms: WS-9659B; WS 9659 B. CAS No. 123313-61-1. Molecular formula: C22H23ClN2O. Mole weight: 366.9.
WS-9761 A
WS-9761 A is a non-steroidal androgen-receptor antagonist produced by Streptomyces sp. No. 9761. Synonyms: WS-9761A; WS 9761A; WS9761A. CAS No. 154163-89-0. Molecular formula: C17H16O4. Mole weight: 284.31.
WS-9761 B
WS-9761 B is a non-steroidal androgen-receptor antagonist produced by Streptomyces sp. No. 9761. Synonyms: WS-9761B; WS 9761B; WS9761B. CAS No. 154163-90-3. Molecular formula: C17H16O5. Mole weight: 300.3.
WSD0628
WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765448-96-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-162002.
WSP-1 is a selective and rapid-reaction H2S specific fluorescent dye (Ex/Em=465/515 nm). WSP-1 reacts with H2S with the releasing of fluorophore[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1352750-34-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-124409.
WSP-5
WSP-5 is a H2S-selective fluorescent probe (Ex/Em = 502/525 nm). WSP-5 enables visual monitoring of H2S released and accumulated from peptide-H2S donor conjugates in glioma cells. WSP-5 is applicable to glioma research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1593024-78-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129420.
WSPC Biotin-PEG3-DBCO
WSPC Biotin-PEG3-DBCO is a polyethylene glycol (PEG)-based PROTAC linker. WSPC Biotin-PEG3-DBCO can be used in the synthesis of a series of PROTACs. Molecular formula: C53H68N8O17S2. Mole weight: 1153.28.
WST-1
WST-1 is a kind of water-soluble tetrazolium salt. WST induces the intracellular mitochondrial dehydrogenase to conduct NADH-dependent enzyme digestion reaction, releasing the water-soluble methyl benzene product. WST-1 can be used for the detection of cell proliferation and cytotoxicity, via the determination of the light absorption value at 450 nm[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150849-52-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136976.
WST-1 (Water-soluble Tetrazolium 1)
A highly sensitive tetrazolium reagent (light red) that produces a water-soluble formazan (dark red color) in NADH and cell proliferation assays due to cleavage by mitochondrial dehydrogenase. Group: Biochemicals. Alternative Names: Water-soluble Tetrazolium 1; 4-[3-(4-Iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene Disulfonate; 5-(2,4-Disulfophenyl)-2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium Inner Salt Sodium Salt (1:1). Grades: Highly Purified. CAS No. 150849-52-8. Pack Sizes: 100mg, 250mg. US Biological Life Sciences.
Worldwide
WST-3
WST-3. Group: Biochemicals. Alternative Names: 4-[3-(4-Iodophenyl)-2-(2,4-dinitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate; 3-(2,4-Dinitrophenyl)-5-(2,4-disulfophenyl)-2-(4-iodophenyl)-2H-tetrazolium Inner Salt Sodium Sal. Grades: Highly Purified. CAS No. 515111-36-1,161617-45-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C19H10IN6NaO10S2. US Biological Life Sciences.
A highly sensitive tetrazolium reagent (light red) that produces a water-soluble formazan (dark red color). WST-3 formazan l max = 433nm; e= 3.1x10e4Suitable for detection of dehydrogenases. Group: Biochemicals. Alternative Names: 4-[3-(4-Iodophenyl)-2-(2,4-dinitrophenyl)-2H-5-tetrazolio]-1,3-benzene Disulfonate; 3-(2,4-Dinitrophenyl)-5-(2,4-disulfophenyl)-2-(4-iodophenyl)-2H-tetrazolium Inner Salt Sodium Salt; IPB. Grades: Highly Purified. CAS No. 161617-45-4. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??IN?NaO??S?, Molecular Weight: 696.34. US Biological Life Sciences.
Worldwide
WST-8
A highly sensitive tetrazolium reagent that produces a water-soluble formazan (orange color that absorbs at 460 nm) in NADH. It is newer generation formazan-based dyes which release the converted product into the medium in a soluble form allowing for a non-destructive determination of viability enabling the cells to be subject to further investigations. Group: Biochemicals. Alternative Names: 5-(2,4-Disulfophenyl)-3-(2-methoxy-4-nitrophenyl)-2-(4-nitrophenyl)-2H-tetrazolium Inner Salt Sodium Salt. Grades: Highly Purified. CAS No. 193149-74-5. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C20H13N6O11S2 Na. US Biological Life Sciences.
Worldwide
WST-8
WST-8 is a water-soluble tetrazolium dye, WST-8 enhances sensitivity of the WST-8-based assay over the conventional MTS-based assay. Uses: Scientific research. Category: Signaling pathways. CAS No. 193149-74-5. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-D0831.
WT-1 (0201) is a fragment of Wilms' tumor gene WT1, which is overexpressed in leukemias and various types of solid tumors. Synonyms: H-Arg-Met-Phe-PNA-Pro-Tyr-Leu-OH.
WT-1 (2402)
WT-1 (2402) is a fragment of Wilms' tumor gene WT1, which is overexpressed in leukemias and various types of solid tumors. Synonyms: H-Cys-Tyr-Thr-Trp-Asn-Gln-Met-Asn-Leu-OH; L-cysteinyl-L-tyrosyl-L-threonyl-L-tryptophyl-L-asparagyl-L-glutaminyl-L-methionyl-L-asparagyl-L-leucine. Molecular formula: C51H73N13O15S2. Mole weight: 1172.3.
WT-161
WT-161 is a potent and selective HDAC6 inhibitor with an IC50 of 0.40 nM[1]. WT-161 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1206731-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100871.
W-Ti-Zr-Nb-Ta Alloy Powder
W-Ti-Zr-Nb-Ta alloy powder is a high-entropy alloy powder composed of multiple metal elements.
WT-TTR inhibitor 1 (Compound 21) is a wild-type Transthyretin (WT-TTR) inhibitor with 29.05% inhibition at 100 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23983-05-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153577.
Wu-5
Wu-5 is a USP10 inhibitor that can inhibit FLT3 and AMPK pathways, induce FLT3-ITD degradation and induce apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2630378-05-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153886.
Wulignan A1
Wulignan A1. Group: Biochemicals. Grades: Plant Grade. CAS No. 117047-76-4. Pack Sizes: 5mg. Molecular Formula: C20H22O5, Molecular Weight: 342.39. US Biological Life Sciences.
Worldwide
WWL113
WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 947669-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110148.
WWL 113
WWL 113. Group: Biochemicals. Grades: Purified. CAS No. 947669-86-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
WWL229
WWL229 is a selective inhibitor of carboxylesterase 3 (CES3) with an IC50 1.94 μM. WWL229 attenuates LPS (HY-D1056)-induced pro-inflammatory cytokine mRNA levels, inhibits lipolysis and adipose thermogenesis, impairs mitochondrial function, and promotes lipid storage. WWL229 can be used for the research of obesity, insulin resistance, type 2 diabetes, and lung inflammation[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338575-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120602.
WWL70
WWL70 is a selective alpha/beta hydrolase domain 6 (ABHD6) inhibitor with an IC50 of 70 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 947669-91-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100337.
WWL 70
WWL 70. Group: Biochemicals. Grades: Purified. CAS No. 947669-91-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
WWQ-03-012
WWQ-03-012 is a selective deSUMOylating isopeptidases DESI2 inhibitor with an IC50 of 47.3 μM. WWQ-03-012 cans induce JAK2-V617F ubiquitination-proteasome degradation with no significant effect on wild-type JAK2. WWQ-03-012 can block JAK2-STAT3/5 signaling, inhibit cell proliferation and induce apoptosis. WWQ-03-012 has a synergistic effect in combination with Ruxolitinib (HY-50856), further enhancing its killing effect on JAK2 mutant cells. WWQ-03-012 can be used for the research of cancer, such as myeloproliferative neoplasms[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3076807-15-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-180561.
WX-02-23
WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2929223-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168534.
WX-02-43
WX-02-43 is a weak covalent inhibitor of SF3B1, and is the (1S,3R) enantiomer of WX-02-23 (HY-168534). WX-02-43 cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23. WX-02-43 serves as a negative control probe that fails to remodel the chromatin binding pattern and transcriptional activity of FOXA1. WX-02-43 can be used in studies on cancers such as prostate cancer to verify the specific effects of WX-02-23 on FOXA1 and SF3B1 targets[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2929223-36-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-181421.
WY 14643
WY 14643. Group: Biochemicals. Grades: Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
WY-14643
Potent peroxisome proliferator-activated receptor (PPARalpha) activator. Activates also PPARgamma but not PPARdelta. Potent anti-hypercholesterolemic agent. Hypolipidemic compound. Lipogenesis inducer. Tumor promoter. Causes increased cell proliferation and decreased apoptosis. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress. Increases fatty acid oxidation. Directly affects insulin signaling. Increases glucose uptake. Group: Biochemicals. Grades: Highly Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C14H14ClN3O2S. US Biological Life Sciences.
Worldwide
WY-14643 (Pirinixic Acid)
WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM. Group: Inhibitors. Alternative Names: NSC 310038. CAS No. 50892-23-4. Pack Sizes: 50mg. Product ID: S8029. Formula: C14H14ClN3O2S. Smiles: CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)SCC(=O)O)Cl)C. Storage Conditions: 2 years -80 in solvent.
United States; Europe
WYC-210
WYC-210, a Tazarotene derivative, is a retinoid compound with lower anticancer activity[1]. WYC-210 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2131803-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136554.
WYE-132
WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WYE-125132. CAS No. 1144068-46-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10044.
WYE-23
WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. WYE-23 has antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1062169-46-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-118712.
WYE-354
WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1062169-56-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12034.
WYE-687
WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer. Group: Biochemicals. Alternative Names: Methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-6-yl)phenylcarbamate Acid. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 5mg. US Biological Life Sciences.
Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7nm). Displays selectivity for mTOR over PI 3-Kalpha (~100-fold) and PI 3-Kgamma (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1alpha expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
WZ4003
WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1214265-58-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-15802.
WZ 4003
WZ 4003. Group: Biochemicals. Grades: Purified. CAS No. 1214265-58-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
WZ811
WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55778-02-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15478.
WZ 811
WZ 811. Group: Biochemicals. Grades: Purified. CAS No. 55778-02-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
WZB117
WZB117 is a glucose transporter 1 (Glut1) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223397-11-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19331.