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| Product | Description | |
|---|---|---|
| WWL229 | WWL229 is a selective inhibitor of carboxylesterase 3 (CES3) with an IC50 1.94 μM. WWL229 attenuates LPS (HY-D1056)-induced pro-inflammatory cytokine mRNA levels, inhibits lipolysis and adipose thermogenesis, impairs mitochondrial function, and promotes lipid storage. WWL229 can be used for the research of obesity, insulin resistance, type 2 diabetes, and lung inflammation[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338575-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120602. |  |
| WWL70 | WWL70 is a selective alpha/beta hydrolase domain 6 (ABHD6) inhibitor with an IC50 of 70 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 947669-91-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100337. | |
| WWL 70 | WWL 70. Group: Biochemicals. Grades: Purified. CAS No. 947669-91-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| WWQ-03-012 | WWQ-03-012 is a selective deSUMOylating isopeptidases DESI2 inhibitor with an IC50 of 47.3 μM. WWQ-03-012 cans induce JAK2-V617F ubiquitination-proteasome degradation with no significant effect on wild-type JAK2. WWQ-03-012 can block JAK2-STAT3/5 signaling, inhibit cell proliferation and induce apoptosis. WWQ-03-012 has a synergistic effect in combination with Ruxolitinib (HY-50856), further enhancing its killing effect on JAK2 mutant cells. WWQ-03-012 can be used for the research of cancer, such as myeloproliferative neoplasms[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3076807-15-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-180561. | |
| WX-02-23 | WX-02-23 is a small-molecule probe that stereoselectively and site-specifically binds to C258 of FOXA1 and C1111 of SF3B1. WX-02-23 remodels FOXA1's chromatin binding and pioneer activity in a DNA-dependent manner, disrupts spliceosome assembly, and enhances the thermal stability of SF3B1. WX-02-23 inhibits tumor cell proliferation and induces apoptosis. WX-02-23 can be used for research on cancers such as prostate cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2929223-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168534. | |
| WX-02-43 | WX-02-43 is a weak covalent inhibitor of SF3B1, and is the (1S,3R) enantiomer of WX-02-23 (HY-168534). WX-02-43 cannot effectively covalently modify the C258 site in the DNA-binding domain of FOXA1, and its inhibitory activity against SF3B1 is also weaker than that of WX-02-23. WX-02-43 serves as a negative control probe that fails to remodel the chromatin binding pattern and transcriptional activity of FOXA1. WX-02-43 can be used in studies on cancers such as prostate cancer to verify the specific effects of WX-02-23 on FOXA1 and SF3B1 targets[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2929223-36-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-181421. | |
| WY 14643 | WY 14643. Group: Biochemicals. Grades: Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| WY-14643 | Potent peroxisome proliferator-activated receptor (PPARalpha) activator. Activates also PPARgamma but not PPARdelta. Potent anti-hypercholesterolemic agent. Hypolipidemic compound. Lipogenesis inducer. Tumor promoter. Causes increased cell proliferation and decreased apoptosis. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress. Increases fatty acid oxidation. Directly affects insulin signaling. Increases glucose uptake. Group: Biochemicals. Grades: Highly Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C14H14ClN3O2S. US Biological Life Sciences. | Worldwide |
| WY-14643 (Pirinixic Acid) | WY-14643 (Pirinixic Acid, NSC 310038) is a potent and selective PPARα activator with an EC50 of 1.5 μM. Group: Inhibitors. Alternative Names: NSC 310038. CAS No. 50892-23-4. Pack Sizes: 50mg. Product ID: S8029. Formula: C14H14ClN3O2S. Smiles: CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)SCC(=O)O)Cl)C. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Wybutosine | Wybutosine is a highly modified nucleoside found in phenylalanine tRNA that plays a crucial role in ensuring the accuracy of protein synthesis. Its unique structure and function underscore its importance in the translation process and highlight its relevance in both basic biological research and potential clinical applications. Alternative Names: 3H-Imidazo[1,2-a]purine-7-butanoic acid, 4,9-dihydro-α-[(methoxycarbonyl)amino]-4,6-dimethyl-9-oxo-3-β-D-ribofuranosyl-, methyl ester, (S)-; Nucleoside Y; Nucleoside Y, from Saccharomycescerevisiae; Y-Nucleoside; 3H-Imidazo[1,2-a]purine-7-butanoic acid, 4,9-dihydro-α-[(methoxycarbonyl)amino]-4,6-dimethyl-9-oxo-3-β-D-ribofuranosyl-, methyl ester, (αS)-. Grades: ≥98%. CAS No. 55196-46-8. Molecular formula: C21H28N6O9. Mole weight: 508.49. |  |
| WYC-210 | WYC-210, a Tazarotene derivative, is a retinoid compound with lower anticancer activity[1]. WYC-210 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2131803-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136554. | |
| WYE-132 | WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WYE-125132. CAS No. 1144068-46-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10044. | |
| WYE-23 | WYE-23 is a mTOR inhibitor, and IC50 is 0.45 nM. It is selective to PI3Kα and IC50 is 661 nM. WYE-23 has antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1062169-46-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-118712. | |
| WYE-354 | WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1062169-56-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12034. | |
| WYE-687 | WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer. Group: Biochemicals. Alternative Names: Methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-6-yl)phenylcarbamate Acid. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| WYE 687 Dihydrochloride (Potent and Selective mTOR Inhibitor, N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyr idinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyr imidin-6-yl]phenyl]-carbamic acid methyl ester hydrochloride) | Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7nm). Displays selectivity for mTOR over PI 3-Kalpha (~100-fold) and PI 3-Kgamma (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1alpha expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| wyosine | Wyosine is a compound commonly found in transfer RNA (tRNA) molecules. It plays a significant role in stabilizing the anticodon loop of tRNA aiding in accurate protein synthesis. Wyosine has been studied in various diseases, such as cancer and viral infections, due to its involvement in tRNA function and cellular processes. Alternative Names: 9H-Imidazo[1,2-a]purin-9-one, 3,4-dihydro-4,6-dimethyl-3-b-D-ribofuranosyl-; {3H-Diimidazo[1,2-a:4',5'-d]pyrimidin-9-one} 4,9-dihydro-4,6-dimethyl-3-B-D-ribofuranosyl-; 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4,6-dimethyl-imidazo[1,2-a]purin-9-one. CAS No. 52662-10-9. Molecular formula: C14H17N5O5. Mole weight: 335.32. | |
| WZ-4002 | WZ-4002 is an EGFR phosphorylation inhibitor with selectivity for EGFR T790M. It has a framework of pyrimidine compound which is different from other EGFR inhibitors. WZ-4002 exhibits anti-tumor activity. Uses: Protein kinase inhibitors. Alternative Names: WZ4002; N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; WZ 4002. CAS No. 1213269-23-8. Molecular formula: C25H27ClN6O3. Mole weight: 494.98. | |
| WZ4003 | WZ4003 exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50 against T790M containing Ba/F3 cells. Alternative Names: WZ4003; WZ-4003; WZ 4003. Grades: >98%. CAS No. 1214265-58-3. Molecular formula: C25H29ClN6O3. Mole weight: 496.99. | |
| WZ4003 | WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1214265-58-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-15802. | |
| WZ 4003 | WZ 4003. Group: Biochemicals. Grades: Purified. CAS No. 1214265-58-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| WZ811 | WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55778-02-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15478. | |
| WZ 811 | WZ 811. Group: Biochemicals. Grades: Purified. CAS No. 55778-02-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| WZB117 | WZB117 is a glucose transporter 1 (Glut1) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223397-11-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19331. | |
| WZB 117 | WZB 117 is a GLUT inhibitor (Ki(app) = 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively) that inhibits passive glucose transport in human erythrocytes and cancer cell lines. It decreases extracellular lactate and intracellular ATP levels. WZB 117 was shown to attenuate erythrocyte 3-O-metylglucose (3MG) uptake in vitro (Ki = 6 μM) and inhibits tumor growth in a nude mouse model. Alternative Names: WZB117; WZB-117; WZB 117; 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate). Grades: ≥98% by HPLC. CAS No. 1223397-11-2. Molecular formula: C20H13FO6. Mole weight: 368.31. | |
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