A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. Uses: Scientific research. Category: Signaling pathways. CAS No. 5119-48-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2065.
Withangulatin A
Withangulatin A is the inhibitor for COX-2. Withangulatin A inhibits MAPK, NF-κB, Akt/mTOR/p70S6K pathway, exhibits antitumor, anti-inflammatory and trypanocidal activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 120824-03-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N10303.
Withania somnifera, ext.
Withania Somnifera Extract, commonly known as Ashwagandha extract, is a powerful botanical extract derived from the roots and leaves of the Withania somnifera plant and is widely recognized for its adaptogenic properties which help the body adapt to stress and normalize physiological functions. Withania Somnifera Extract contains a variety of bioactive components, including withanolides (such as Withanolide A, Withanolide D, and Withaferin A), withanosides (e.g., Withanoside IV and Withanoside VI), alkaloids (e.g., Isopelletierine and Anaferine), sitosterol, benzoic acid, and tropane alkaloids. This extract is extensively studied for its benefits in stress management anxiety relief improvements in physical performance and overall health recent research indicates that Ashwagandha supplementation can reduce cortisol levels in stressed adults demonstrating its stress-relieving properties while also showing potential in improving fertility metabolic health cognitive function and obsessive-compulsive disorders. In terms of physical performance studies have shown that Ashwagandha can enhance strength power endurance and recovery while reducing muscle fatigue and improving body composition by increasing muscle mass and reducing body fat. It has anti-inflammatory, antioxidant and anti-stress properties, and supports bone, heart and blood vessel health. Additionally Ashwagandha is recognized for its potential in managing
Withanolide A
Withanolide A. Group: Biochemicals. Alternative Names: (5α, 6α, 7α, 22R)-6, 7-epoxy-5, 20, 22-trihydroxy-1-oxo-ergosta-2, 24-dien-26-oic Acid δ-Lactone; (22R)-6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-5α-Ergosta-2,24-dien-26-oic Acid δ-Lactone; 6, 7-Epoxy-1H-cyclopenta [a]phenanthrene Ergosta-2,24-dien-26-oic Acid Deriv.; 5,20α-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide; 5α,20αF(R)-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide; Withaniol. Grades: Highly Purified. CAS No. 32911-62-9. Pack Sizes: 10mg. Molecular Formula: C28H38O6, Molecular Weight: 470.6. US Biological Life Sciences.
Worldwide
Withanolide A
Withanolide A is a steroid isolated from Ashwagandha showing anticancer activity against the SK-Br-3 cells. Grades: 98%. CAS No. 32911-62-9. Molecular formula: C28H38O6. Mole weight: 470.6.
Withanolide A
Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 32911-62-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N7028.
Withanolide B
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56973-41-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129566.
Withanone
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27570-38-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-129692.
Withanone
Withanone is an active component from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. It affords protection against excitotoxicity of neuron like cells induced by N-methyl-D-aspartate (NMDA). Alternative Names: (22R)-δ-Lactone 6α,7α-epoxy-5,17,22-trihydroxy-1-oxo-5α-ergosta-2,24-dien-26-oic Acid; NSC 179884; (5α,6α,7α,22R)-δ-Lactone 6,7-Epoxy-5,17,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic Acid; (22R)-6α,7α-Epoxy-5,17,22-trihydroxy-1-oxo-5α-ergosta-2,24-dien-26-oic acid δ-lactone; (5α,6α,7α,22R)-5,17-Dihydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione. CAS No. 27570-38-3. Molecular formula: C28H38O6. Mole weight: 470.61.
Withanoside IV
Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19)[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 362472-81-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N8693.
Withanoside V
Withanoside V is a blood-brain barrier-permeable withanolide derivative. Withanoside V binds strongly to Sudlow I (domain IIA) of human serum albumin (HSA) to form a stable complex and alter the secondary structure of albumin, thereby increasing helix content and reducing β-sheet and random coil. Withanoside V binds to Aβ (1-42) to block the interaction between monomers and subsequent aggregation. Withanoside V inhibits the viability of neuroblastoma cells, reduces the number of apoptotic cells induced by Aβ (1-42), and decreases ROS production. Withanoside V inhibits SARS-CoV-2 Mpro. Withanoside V can be used for research on Alzheimer's disease and coronavirus disease 2019[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 256520-90-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N8671.
Withaperuvin C
Withaperuvin C is a steroid isolated from Physali alkekengi. Alternative Names: (17S,22R)-6beta,14,17,20,22-Pentahydroxy-1-oxo-5beta-ergosta-2,4,24-triene-26-oic acid delta-lactone. Grades: 96.5%. CAS No. 81644-34-0. Molecular formula: C28H38O7. Mole weight: 486.605.
Withasomniferolide B
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2365386-75-8. Pack Sizes: 1 mg. Product ID: HY-N10887.
WIZ degrader 8
WIZ degrader 8 (compound 10) is a potent and selective degrader of the transcription factor WIZ, which can potently induce HbF expression. WIZ degrader 8 can lead to WIZ degradation and induce HbF expression, and has the potential to be an inhibitor of sickle cell disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2879251-26-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-169955.
WIZ degrader 9
WIZ degrader 9 is an orally active molecular glue degrader of the WIZ transcription factor. As a molecular glue, WIZ degrader 9 recruits WIZ to the cereblon E3 ubiquitin ligase complex via its ZF7 domain, driving proteasome-dependent degradation of WIZ. WIZ degrader 9 induces hemoglobin production, reduces the level of H3K9 dimethylation across the whole genome and at the β-globin locus, upregulates the transcription of γ-globin and BGLT3, and increases the level of histone H3K9 acetylation in the promoter region of HBG1/2. WIZ degrader 9 effectively induces fetal hemoglobin production in both mice and cynomolgus monkeys. WIZ degrader 9 can be used for research on sickle cell disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2654011-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159099.
WJ460
WJ460 is a potent inhibitor of myoferlin (MYOF) that interacts directly with MYOF. WJ460 inhibits the migration and growth, induces cell cycle arrest, mitochondrial autophagy, lipid peroxidation and ferroptosis in tumor cells. WJ460 has anti-tumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1415251-36-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124632.
WKYMVm
WKYMVm is a selective formylpeptide receptor 2 (FPR2) agonist. WKYMVm has a powerful anti-inflammatory effect that can reduce lung injury and spinal cord injury. WKYMVm ameliorates obesity by regulating lipid metabolism and leptin signaling. WKYMVm is involved in the regulation of immune cells by activating FPRs. WKYMVm can promote the chemotactic migration of immune cells and inhibit the apoptosis of phagocytes. In addition, WKYMVm may play a favorable or unfavorable role in tumors, depending on the type of tumor[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WKYMVm-amide; W-Peptide. CAS No. 187986-17-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1120.
WKYMVM
WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) that is expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Alternative Names: Trp-Lys-Tyr-Met-Val-D-Met-NH2; Leukocyte chemoattractant peptide; W-Peptide. CAS No. 187986-17-0. Molecular formula: C41H61N9O7S2. Mole weight: 856.11.
WKYMVM
WKYMVM. Group: Biochemicals. Grades: Purified. CAS No. 187986-11-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
WKYMVM 2TFA
WKYMVM 2TFA is a selective agonist of the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM), and FPR3 (EC50 = 3 nM) and is expressed on immune cells. It induces Ca2+ mobilization and superoxide production, as well as chemotactic migration of monocytes and neutrophils. Alternative Names: H-Trp-Lys-Tyr-Met-Val-D-Met-NH2.2TFA; L-tryptophyl-L-lysyl-L-tyrosyl-L-methionyl-L-valyl-D-methioninamide trifluoroacetic acid; (2R,5S,8S,11S,14S,17S)-17-Amino-14-(4-aminobutyl)-11-(4-hydroxybenzyl)-18-(1H-indol-3-yl)-5-isopropyl-2,8-bis[2-(methylsulfanyl)ethyl]-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-1-amide trifluoroacetate; W-Peptide TFA salt; WKYMVm TFA salt. Grades: ≥95%. Molecular formula: C41H61N9O7S2.2C2HF3O2. Mole weight: 1084.16.
WL12
WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1886057-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3440.
WLBU2
WLBU2 is a synthetic cationic antibacterial peptide that can kill Pseudomonas aeruginosa in human serum. Alternative Names: Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg. Grades: >96%. Molecular formula: C151H260N66O25. Mole weight: 3400.15.
WLSEAGPVVTVRALRGTGSW
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-targeting peptide that specifically recognizes tenascin X on the surface of cardiomyocytes. WLSEAGPVVTVRALRGTGSW can serve as a targeting ligand to conjugate with various therapeutic carriers (drugs, genes, exosomes, nanoparticles, etc.) for research on cardiovascular diseases (such as myocardial infarction, heart failure)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 771479-86-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P3436.
WM-1119
WM-1119, a chemical probe, is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 μM for KAT6A in lymphoma cells, the binding KD values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 μM, 0.5 μM , respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055397-28-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102058.
WM-3835
WM-3835 is a potent and high-specific inhibitor of Lysine Acetyltransferase 7 (KAT7/MYST2/HBO1), which binds directly to the acetyl-CoA binding site of HBO1 33. Alternative Names: WM 3835; WM3835; 4-fluoro-N'-[(3-hydroxyphenyl)sulfonyl]-5-methyl[1,1'-biphenyl]-3-carbohydrazide. CAS No. 2229025-70-9. Molecular formula: C20H17FN2O4S. Mole weight: 400.42.
WM-3835
WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2229025-70-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134901.
WM-586
WM-586 is a covalent WDR5 inhibitor. WM-586 specifically decreases WDR5 and MYC interaction with an IC50 of 101 nM. WM-586 is used in research on a variety of cancers including neuroblastoma, breast cancer, bladder cancer and colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2894832-05-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153728.
WM-8014
WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC50 of 55 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055397-18-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102060.
W-Mo Alloy Powder
W-Mo alloy powder is an alloy powder composed of tungsten (W) and molybdenum (Mo) with spherical particle shape.
W-Mo-Ta-Nb Alloy Powder
Spherical W-Mo-Ta-Nb alloy powder is typically composed of elements such as tungsten, molybdenum, tantalum, and niobium.
WMoTaNb Alloy Powder
WMoTaNb Alloy Powder.
W-Mo-Ta-Nb-V Alloy Powder
Spherical W-Mo-Ta-Nb-V alloy powder is composed of elements such as tungsten, molybdenum, tantalum, niobium, and vanadium, typically produced through techniques like spherical powder metallurgy or mechanical alloying.
WMoTaNbV Alloy Powder
WMoTaNbV Alloy Powder.
W-Mo-Ta-Nb-Zr Alloy Powder
The W-Mo-Ta-Nb-Zr high entropy alloy is composed of five refractory metal elements, which have outstanding characteristics such as high high-temperature strength, excellent high-temperature oxidation resistance, and corrosion resistance.
W-Ni-Fe Alloy Powder
W-Ni-Fe alloy powder is composed of tungsten, nickel and iron and other elements of alloy powder, with a series of excellent physical and chemical properties.
WNK463
WNK463 is an orally bioavailable pan-With-No-Lysine (K) (WNK)-kinase inhibitor with IC50s of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2012607-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100626.
WNK-IN-11
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. Uses: Scientific research. Category: Signaling pathways. CAS No. 2123489-30-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112094.
WNS Apricot Kernel Shells
WNS Apricot Kernel Shells - Apricot Kernel Shells are granules prepared from crushed apricot shells. The shells have a hard fibrous material ideal as a gentle, natural exfoliate which assists with the removal of dead skin cells. Its grit is a soft abrasive that is extremely durable, angular & multi-faceted. Categories: Apricot kernels.
United States and all of its trading partners..
WNS Walnut Shells
Walnut Shell Powder is prepared from finely crushed walnut shells. The shells have a hard fibrous material ideal as a gentle, natural exfoliant which assists with the removal of dead skin cells. Its grit is a soft abrasive that is extremely durable, angular & multi-faceted. Categories: Juglandaceae; Juglans regia.
United States and all of its trading partners..
Wnt-C59
Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C59. CAS No. 1243243-89-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15659.
Wnt-C59
Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/ β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021. Cell permeable and orally bioavailable. Group: Biochemicals. Grades: Highly Purified. CAS No. 1243243-89-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Wnt-C59
Wnt-C59 is a potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It was shown to arrest stemness and suppress growth of nasopharyngeal carcinoma in mice via Wnt pathway inhibition. Alternative Names: 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide. Grades: >98%. CAS No. 1243243-89-1. Molecular formula: C25H21N3O. Mole weight: 379.45.
Wnt-C59 (C59)
Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells. Group: Inhibitors. CAS No. 1243243-89-1. Pack Sizes: 5mg. Product ID: S7037. Formula: C25H21N3O. Smiles: CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Wnt/Hedgehog/Notch Compound Library
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4300. Categories: Wnt/Hedgehog/Notch Compounds Libraries.
Wnt Inhibitor IWP-2
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM. Uses: Differentiation. Alternative Names: IWP 2, IWP-2, IWP2. Grades: 0.98. CAS No. 686770-61-6. Molecular formula: C22H18N4O2S3. Mole weight: 466.592.
WO2.7 nanopowder
WO2.7 nanopowder. Purity: >99.97 %.
WO3 nanopowder
WO3 nanopowder. Purity: >99 %.
Wogonin
Wogonin is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties. Uses: Antibacterial; antimicrobial; antioxidant; diuretic; anti-inflammatory; anti-tumor. Alternative Names: 5,7-dihydroxy-8-methoxy-2-phenyl-4h-1-benzopyran-4-on; 5,7-dihydroxy-8-methoxyflavone. Grades: >98%. CAS No. 632-85-9. Molecular formula: C16H12O5. Mole weight: 284.26.
Wogonin
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 632-85-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0400.
Wogonin
Anti-inflammatory. Increases nitroc oxide (NO) production. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II). Antioxidant. Anti-viral. Shows anti-hepatitis B virus activity. MCP-1 inhibitor. Shows anxiolytic effect through modulation of the GABA(A) receptor complex. Antifungal. Neuroprotective. Anticancer compound. Apoptosis and cell cycle arrest inducer. Sensitizes TNFalpha- and TRAIL-induced apoptosis. Antiangiogenic. NF-kappaB inhibitor. Telomerase activity inhibitor. CDK9 inhibitor. PI3K-AKT pathway modulator. Autophagy inducer. Group: Biochemicals. Alternative Names: WOG, 5,7-Dihydroxy-8-methoxyflavone, BRN 0287152. Grades: Highly Purified. CAS No. 632-85-9. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H12O5. US Biological Life Sciences.
Worldwide
Wogonoside
Wogonoside. Group: Biochemicals. Alternative Names: Oroxindin; Glychionide B. Grades: Plant Grade. CAS No. 51059-44-0. Pack Sizes: 20mg. Molecular Formula: C22H20O11, Molecular Weight: 460.387999999999. US Biological Life Sciences.
Worldwide
Wogonoside
Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51059-44-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0399.
Wogonoside
Wogonoside has shown preclinical anticancer efficacy in various cancer models. Wogonoside has been reported to have anti-inflammatory properties. Uses: Anti-inflammatory. Alternative Names: Wogonin 7-O-b-D-glucuronide; Oroxindin. Grades: >98%. CAS No. 51059-44-0. Molecular formula: C22H20O11. Mole weight: 460.39.
Wolfberry Extract
Wolfberry Extract. Applications: Wolfberry extract can be used in functional food, drinks, health care products and pharmaceuticals. Group: Others. Purity: 10:1, 20:1, 50% Polysaccharide or as required. Appearance: Brown powder. Wolfberry Extract. Cat No: EXTC-158.
Botanical Source: Group: Biochemicals. Alternative Names: 5, 6-Dihydro-14-methylbis[1, 3]benzodioxolo[5, 6-a:5?, 6?-g]quinolizinium(1+), 9CI. 13-Methylpseudocoptisine. Grades: Plant Grade. CAS No. 38763-29-0. Pack Sizes: 10mg, 20mg. US Biological Life Sciences.
Worldwide
Wormwood Extract
Wormwood Extract. Applications: Used for health care products, dietary supplements, herb medecine, mainly for antibacterial. Group: Others. Synonyms: Wormwood Extract; 977032-37-3; Artemisia princes orientalis L. CAS No. 977032-37-3. Purity: 4-10:1 by TLC. Appearance: Yellow brown fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Leaf. Species: Artemisia princes orientalis L. Wormwood Extract; 977032-37-3; Artemisia princes orientalis L.; plant extract. Pack: 25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-130.
It is an antibiotic produced by the strain of Pen. wortmanni 989. It has strong antifungal effect. It is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. Uses: Immunosuppressive agents. Alternative Names: Antibiotic SL-2052; (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione; (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. Grades: 95%. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43.
Wortmannin
Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19545-26-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C23H24O8. US Biological Life Sciences.
Worldwide
Wortmannin
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SL-2052; KY-12420. CAS No. 19545-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10197.
Wortmannin (SL-2052)
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. Wortmannin also inhibits PLK1 activity. Group: Inhibitors. Alternative Names: KY 12420, SL-2052, BRN 0067676, NSC 627609. CAS No. 19545-26-7. Pack Sizes: 5mg. Product ID: S2758. Formula: C23H24O8. Smiles: CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C. Storage Conditions: 2 years -80 in solvent.
United States; Europe
WP1066
WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3. WP1066 can cross the blood-brain barrier[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 857064-38-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15312.
WP9QY
WP9QY is an inhibitor targeting TNFα and RANKL, which blocks the TNFα-TNFR1 interaction and inhibits TNFα-mediated apoptosis, cytotoxicity and bone destruction. WP9QY inhibits osteoclastogenesis and promotes osteoblast differentiation, induces chondrocyte proliferation and glycosaminoglycan production, and synergizes with TGF-β3 to promote chondrogenesis. WP9QY effectively repairs full-thickness articular cartilage defects in rabbits via intra-articular injection, and inhibits methylmercury-induced reduction of NeuN-positive cells in mouse brain slices. WP9QY can be applied to the research of diseases related to methylmercury-induced neuronal death, cartilage injury, osteoarthritis and bone loss[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 199999-60-5. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P2612.
WR 1065
WR 1065. Group: Biochemicals. Grades: Purified. CAS No. 14653-77-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
WR99210
WR99210 is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains (including Pyrimethamine< (HY-18062)-resistant P. falciparum strains) as well as T. gondii[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL 6231 free base. CAS No. 47326-86-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116387.