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| Product | Description | |
|---|---|---|
| Aprepitant Impurity 6 | Aprepitant Impurity 6. Uses: For analytical and research use. Alternative Names: (2S,3S)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine. CAS No. 1242175-38-7. Molecular formula: C20H18F7NO2. Mole weight: 437.35. Catalog: APB1242175387. |  |
| Aprepitant Impurity 7 | Aprepitant Impurity 7. Uses: For analytical and research use. Alternative Names: (2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine. CAS No. 1185503-48-3. Molecular formula: C20H18F7NO2. Mole weight: 437.35. Catalog: APB1185503483. | |
| Aprepitant Impurity 7 HCl | Aprepitant Impurity 7 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: Des-(4-fluoro-1,2,4-triazol-3-one-5-methyl (2R,3S,1'S)-Aprepitant Hydrochloride. CAS No. 874460-46-5. Molecular formula: C20H19F6NO2.HCl. Mole weight: 455.82. |  |
| Aprepitant Impurity 7 (Hydrochloride) | Aprepitant Impurity 7 (Hydrochloride). Uses: For analytical and research use. Alternative Names: (2S,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride. Molecular formula: C20H18F7NO2·HCl. Mole weight: 473.81. Catalog: APB02517. | |
| Aprepitant Impurity 8 | Aprepitant Impurity 8. Uses: For analytical and research use. Alternative Names: (2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine. CAS No. 380499-06-9. Molecular formula: C20H18F7NO2. Mole weight: 437.35. Catalog: APB380499069. | |
| Aprepitant Impurity 8 HCl | Aprepitant Impurity 8 HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: Fosaprepitant Morpholine Hydrochloride; (2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride. CAS No. 1333998-27-8. Molecular formula: C20H18F7NO2.HCl. Mole weight: 473.81. | |
| Aprepitant Impurity 9 | Aprepitant Impurity 9. Uses: For analytical and research use. Alternative Names: (2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine. CAS No. 170902-80-4. Molecular formula: C20H18F7NO2. Mole weight: 437.35. Catalog: APB170902804. | |
| Aprepitant impurity A | Aprepitant impurity A is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2. Mole weight: 527.47. | |
| Aprepitant Impurity A Enantiomer | Aprepitant Impurity A Enantiomer is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2. Mole weight: 527.47. | |
| Aprepitant Impurity B Enantiomer HCl | A metabolite of Aprepitant. Synonyms: (2R,3S)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine. Grade: > 95%. CAS No. 183901-47-5. Molecular formula: C27H24F7NO2. HCl. Mole weight: 527.49 36.46. | |
| Aprepitant Impurity B HCl | Aprepitant Impurity B HCl is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Molecular formula: C27H24F7NO2.HCl. Mole weight: 563.93. | |
| Aprepitant-M3 Metabolite | Aprepitant-M3 Metabolite is a metabolite of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Uses: An active metabolite of aprepitant. Synonyms: (5S,6R)-6-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-3-morpholinone; Aprepitant-M3; 3-Morpholinone, 6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-5-(4-fluorophenyl)-, (5S,6R)-. Grade: ≥95%. CAS No. 419574-04-2. Molecular formula: C20H16F7NO3. Mole weight: 451.33. | |
| Aprepitant open ring methyl ester | Aprepitant open ring methyl ester is an impurity of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Synonyms: N-(Destriazolonomethyl) N-(Methylcarboxyacetamidohydrazono) Aprepitant; Hydrazinecarboxylic acid, 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]-, methyl ester; Methyl 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylate; Methyl 2-(2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)-1-iminoethyl)hydrazine-1-carboxylate; Aprepitant Open-Ring Methyl Ester Impurity. Grade: ≥95%. CAS No. 219821-37-1. Molecular formula: C24H25F7N4O4. Mole weight: 566.48. | |
| Aprepitant Related Compound A | Aprepitant Related Compound A. Uses: For analytical and research use. CAS No. 1148113-53-4. Mole weight: 534.43. Catalog: AP1148113534. | |
| Aprepitant Related Compound B | Aprepitant Related Compound B. Uses: For analytical and research use. CAS No. 172822-29-6. Mole weight: 534.43. Catalog: AP172822296. | |
| Aprepitant Related Substance Impurity 49 | Aprepitant Related Substance Impurity 49. Uses: For analytical and research use. Molecular formula: C26H24F7N7O4. Mole weight: 631.51. Catalog: APB06693. | |
| Aprepitant Related Substance Impurity A | Aprepitant Related Substance Impurity A. Uses: For analytical and research use. Molecular formula: C6H7ClN6O2. Mole weight: 230.61. Catalog: APB06691. | |
| Aprepitant Related Substance Impurity B | Aprepitant Related Substance Impurity B. Uses: For analytical and research use. Molecular formula: C6H7ClN6O2. Mole weight: 230.61. Catalog: APB06692. | |
| Aprepitant (R,R,R)-Isomer (Azilsartan Impurity 41) | Aprepitant (R,R,R)-Isomer (Azilsartan Impurity 41). Uses: For analytical and research use. CAS No. 1148113-53-4. Molecular formula: C23H21F7N4O3. Mole weight: 534.43. Catalog: APB1148113534. | |
| Apricitabine | Apricitabine is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki = 0.08 μM), with Kis of 300, 12 and 112.25 μM against DNA polymerase α, β and γ, respectively. It has been used in trials studying the treatment of HIV Infections. Synonyms: Apricitabine; 160707-69-7; AVX754; AVX-754; SPD754; Apricitabine [INN]; BCH 10618; BCH-10618; SPD-754; (-)-dOTC; 4-Amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)pyrimidin-2(1H)-one; 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]pyrimidin-2-one; K1YX059ML1; SPD -754; BCH-10619; BCH-10652; BCH-10652, (-)-; AVX 754; (-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine); 2(1H)-Pyrimid. Grade: 95%. CAS No. 160707-69-7. Molecular formula: C8H11N3O3S. Mole weight: 229.26. | |
| Apricot Fruit Extract | Apricot (Prunus armeniaca) fruit extract, 20% in water-glycerin, softening and emollient, helps reduce sebum. CAS No. 68650-44-2. Product ID: CI-SC-0780. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Apricot Kernel Oil | Apricot kernel oil, light carrier oil rich in vitamins A & E, oleic and linoleic acids. SAP 180-200. Alternative Names: PERSIC OIL;APRICOT KERNEL OIL;FEMA 2150;Oils,apricot;PRUNUS ARMENIACA (APRICOT) KERNEL OIL;Prunusarmeniacakerneloil,refined;APRICOT(PRUNUSARMENIACA)KERNELOIL;PERSICOILREFINED. CAS No. 72869-69-3. Product ID: CI-SC-0359. Molecular formula: CAS: 72869-69-3. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Apricot Leaves Extract | Apricot (Prunus armeniaca) leaf extract, 20% in water-glycerin, softening, emollient, suitable for oily skin formulations. Product ID: CI-SC-0781. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Apricot oil (organic) | Apricot oil (organic). Alternative Names: Apricot kernel oil. CAS No. 72869-69-3. Purity: 0.98. Product ID: CI-EO-0001. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Apricoxib | Apricoxib. Group: Biochemicals. Alternative Names: 4-[2-(4-Ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]benzenesulfonamide; 4-Methyl-2- (4-ethoxyphenyl) -1- (4-sulfamoylphenyl) pyrrole; CS 706; R 109339; TG 01. Grades: Highly Purified. CAS No. 197904-84-0. Pack Sizes: 10mg. Molecular Formula: C19H20N2O3S, Molecular Weight: 356.44. US Biological Life Sciences. |  Worldwide |
| Apricoxib | Apricoxib is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. Synonyms: CS-701; CS 701; CS701; TG01; TG 01; TG-01; R-109339, R 109339; R109339; Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]-. CAS No. 197904-84-0. Molecular formula: C19H20N2O3S. Mole weight: 356.44. | |
| Apricoxib-d4 | Apricoxib-d4. Group: Biochemicals. Alternative Names: 4-[2-(4-Ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]benzenesulfonamide-d4; 4-Methyl-2- (4-ethoxyphenyl) -1- (4-sulfamoylphenyl) pyrrole-d4; CS 706-d4; R 109339-d4; TG 01-d4. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C19H16D4N2O3S, Molecular Weight: 360.46. US Biological Life Sciences. | Worldwide |
| Aprifloren® | Aprifloren®. CAS No. 67663-01-8. FEMA No. 3999. VIGON Item # 504567. Categories: Speciality Ingredients Suppliers, Flavors, Fragrances, Perfumers, 5-Hexyl-4-methyl-dihydro-furan-2-one, 5-Hexyldihydro-4-methylfuran-2(3H)-one |  America & Internationally |
| Aprindine | Aprindine is a Class 1b antiarrhythmic agent as a cardiac depressant used in arrhythmias. Uses: A cardiac depressant used in arrhythmias. Synonyms: N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine. Grade: ≥98%. CAS No. 37640-71-4. Molecular formula: C22H30N2. Mole weight: 322.48. | |
| Aprindine HCl | Aprindine HCl. CAS No. 33237-74-0. Tyger suppliers of organic specialty chemicals & custom chemical synthesis. |  |
| Aprindine hydrochloride | Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies. Synonyms: N1-(2,3-Dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-1,3-propanediamine Hydrochloride; N-(2,3-Dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-1,3-propanediamine; Amidonal; Aspenon; Compd 83846; Fibocil; Fiboran; MS 5075; NSC 284614; Ritmusin. Grade: 95%. CAS No. 33237-74-0. Molecular formula: C22H31ClN2. Mole weight: 358.95. | |
| Aprindine Hydrochloride | Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally. Group: Biochemicals. Alternative Names: N1-(2,3-Dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-1,3-propanediamine Hydrochloride; N-(2,3-Dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-1,3-propanediamine; Amidonal; Aspenon; Compd 83846; Fibocil; Fiboran; MS 5075; NSC 284614; Ritmusin. Grades: Highly Purified. CAS No. 33237-74-0. Pack Sizes: 50mg. Molecular Formula: C??H??ClN?, Molecular Weight: 358.95. US Biological Life Sciences. | Worldwide |
| Aprinocarsen sodium | Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ISIS 3521 sodium. CAS No. 331257-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148413. |  |
| Aprocitentan | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACT-132577. CAS No. 1103522-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15895. | |
| Aprocitentan-d4 | Aprocitentan-d4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACT-132577-d4. CAS No. 2748196-51-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15895S. | |
| a-Prodine hydrochloride | a-Prodine hydrochloride. Group: Biochemicals. Alternative Names: (3R,4S)-rel-1,3-dimethyl-4-phenyl-4-piperidinol 4-propanoate hydrochloride; cis-(±)-1,3-Dimethyl-4-phenyl-4-piperidinol propanoate hydrochloride; (±)-Alphaprodine hydrochloride. Grades: Highly Purified. CAS No. 561-78-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C16H24ClNO2. US Biological Life Sciences. | Worldwide |
| a-Propylphenylacetonitrile | Clear liquid, 97%. Synonym: 2-Phenylpentanonitrile. CAS No. 5558-78-1. Pack Sizes: Typically in stock: 5g, 25g. Mole weight: 159.23. MP/BP: B.P. 125-128/13 mm. Order No: FR-0337. |  Frinton Laboratories |
| Aprotinin | Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion. Group: Inhibitors. CAS No. 9087-70-1. Pack Sizes: 10mg. Product ID: S7377. Formula: C284H432N84O79S7. Smiles: CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C(=O)NC(C(=O)NCC(=O)N6CCCC6C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3)CC(=O)O)CCC(=O)O)C)CO)CCCCN)CC7=CC=CC=C7)CC(=O)N)CC(=O)N)CCCNC(=N)N)CCCCN)C)CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CCC(=O)N)C(C)O)CC8=CC=CC=C8)C(C)C)CC9=CC=C(C=C9)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)C)CCCCN)C(C)O)CC1=CC=C(C=C1)O)CCC(=O)O)CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)N)C(=O)NCC(=O)NCC(=O)NC(C)C(=O)O)C(C)O)CCCNC(=N)N)CCSC)CC(C)C)C)CCCCN)C)CC(=O)N)CC1=CC=C(C=C1)O)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)CCCNC(=N)N)C(C)CC. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Aprotinin | Aprotinin is the small protein bovine pancreatic trypsin inhibitor (BPTI). It is an antifibrinolytic molecule that inhibits trypsin and related proteolytic enzymes. It is a competitive serine protease inhibitor which blocks the active sites of enzyme by forming stable complexes with. It is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges. It is used as a medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. It is used clinically to prevent postoperative blood loss and reduce transfusion requirements in those procedures which employ extracorporeal circulation. It is also used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest. It was temporarily withdrawn worldwide in 2007. It was reverted its previous standpoint regarding aprotinin by the European Medicines Agency (EMA) scientific committee in February 2012. Uses: Aprotinin is used as medication administered by injection to reduce bleeding during complex surgery, such as heart and liver surgery. it is used clinically to prevent postoperative blood loss and reduce transfusion requirements in those procedures which employ extracorporeal circulation. it is also used as a protein purification tool to prevent proteases present in tissue sample | |
| Aprotinin | Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 9087-70-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0017. | |
| Aprotinin | Aprotinin Inhibitor. Uses: Scientific use. Product Category: T3359. CAS No. 9087-70-1. |  |
| Aprotinin | Aprotinin. CAS No. 9087-70-1. Cenik is your partner of choice for specialised chemicals. We don't just provide products - we supply solutions to your technical and regulatory specifications. |  |
| Aprotinin | 25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C284H432N84O79S7. CAS No. 9087-70-1. Prepack ID 16927557-25mg. Molecular Weight 6511.45. See USA prepack pricing. |  |
| Aprotinin, Bovine (Pancreatic trypsin inhibitor) | Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes, dissociating at pH >10 or <3. Effective concentration is equimolar with protease. Group: Biochemicals. Alternative Names: Antikrein; Antilysin; Antilysine; Aprostat; Aprotinin; BPTI; BPTI Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bayer A 128; Bovine Basic Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Bovine Trypsin Inhibitor; Fosten; Kallikrein-trypsin Inactivator; Kiker 52G; Kir Richter; Kunitz Pancreatic Trypsin Inhibitor; Kunitz Protease Inhibitor; Kunitz Trypsin Inhibitor; Kunitz-type Inhibitor; Kunitz-type Proteinase Inhibitor; Kunitz-type Trypsin Inhibitor; Onquinin; Pancreatic Basic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor (Kunitz); Protease Inhibitor, Kunitz Type; RP 9921; Repulson; Trasuylol; Trasylol; Trazinin; Triazinin; Trypsin Inhibitor, Trasylol; Trypsin-kallikrein Inhibitor (Kunitz); Zymofren. Grades: Highly Purified. CAS No. 9087-70-1. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C???H???N??O??S?, Molecular Weight: 6511.45. US Biological Life Sciences. | Worldwide |
| Aprutumab | Aprutumab (BAY 1179470) is a fully human fibroblast growth factor receptor 2 (FGFR2)-specific monoclonal antibody. Aprutumab induces FGFR2 endocytosis and degradation in cancer cells expressing FGFR2. Aprutumab serves as the targeted monoclonal antibody component of the antibody-drug conjugate BAY 1187982 (HY-141600) and mediates the endocytosis of the antibody-drug conjugate into FGFR2-positive cells. Aprutumab can be used for the research of FGFR2-positive solid tumors, including studies on gastric cancer and triple-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 1179470. CAS No. 1634620-63-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99007. | |
| Aprutumab | Aprutumab is a humanized monoclonal antibody directed against FGFR2. Aprutumab has been used in the research of solid tumors. Synonyms: BAY 1179470; BAY-1179470; BAY1179470. CAS No. 1634620-63-5. | |
| Aprutumab ixadotin | Aprutumab ixadotin (BAY 1187982) is the first antibody-drug conjugate (ADC) to target FGFR2 and the first to use Auristatin-based payload. Aprutumab ixadotin contains a fully human anti-FGFR2 monoclonal antibody (Aprutumab) (HY-P99007) conjugated by lysine side chains to a non-cleavable linker and via this an innovative Auristatin W derivative. Aprutumab ixadotin can be used for the study of advanced solid tumors, such as FGFR2-positive gastric cancer and triple-negative breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 1187982. CAS No. 1708947-48-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141600. | |
| APS-2-79 | APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2002381-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100627. | |
| APS-2-79 | APS-2-79 is a small molecule antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site, and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2). Synonyms: 6,7-Dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine; APS-2-79; APS 2-79; APS2-79; APS-279; APS 279; APS279. CAS No. 2002381-25-9. Molecular formula: C23H21N3O3. Mole weight: 387.43. | |
| APS-2-79 HCl | APS-2-79 is a MAPK antagonist which can modulate KSR-dependent MAPK signalling by antagonizing RAF heterodimerization and the conformational changes required for phosphorylation and activation of KSR-bound MEK. APS-2-79 was found to bind to the KSR active site with an IC50 value of 120 nM, antagonizing MEK (MAPKK) phosphorylation by RAF. Synonyms: APS-2-79 HCl; APS2-79 HCl; APS 2-79 HCl; APS-279 HCl; APS279 HCl; APS 279 HCl; SCHEMBL18153640; AKOS032944984; CS-6151; 6,7-dimethoxy-N-(2-methyl-4-phenoxyphenyl)quinazolin-4-amine; hydrochloride. Grade: 99.26 %. CAS No. 2002381-31-7. Molecular formula: C23H21N3O3.HCl. Mole weight: 423.89. | |
| APS6-45 | APS6-45 is an orally active tumor-calibrated inhibitor (TCI) that strongly inhibits RAS pathway signaling in human MTC cell lines TT and MZ-CRC-1. Synonyms: 4-(4-(3-(2-fluoro-5-(perfluoropropan-2-yl)phenyl)ureido)phenoxy)-N-methylpicolinamide; APS645; APS6 45; APS-645; APS 645. Grade: >98%. CAS No. 2188236-41-9. Molecular formula: C23H16F8N4O3. Mole weight: 548.39. | |
| APS sodium salt | APS is an active sulfate ester of 5'-AMP, which is used in pyrosequencing and bioluminescence applications. Synonyms: Adenosine- 5'- O- phosphosulfate, sodium salt. Grade: 85%. CAS No. 102029-95-8. Molecular formula: C10H14N5O10PS (free acid). Mole weight: 427.3 (free acid). | |
| Aptazapine | Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is a α2-adrenergic receptor antagonist. It is also a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Uses: Antidepressant. Synonyms: CGS 7525 A; 2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine; 71576-41-5 (maleate). Grade: 98%. CAS No. 71576-40-4. Molecular formula: C16H19N3. Mole weight: 253.35. | |
| Aptazapine maleate | Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is a α2-adrenergic receptor antagonist. It is also a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Uses: Antidepressant. Synonyms: (+-)-1,3,4,14b-Tetrahydro-2-methyl-2H,10H-pyrazino(1,2-a)pyrrolo(2,1-c)(1,4)benzodiazepine maleate (1:1). Grade: 98%. CAS No. 71576-41-5. Molecular formula: C16H19N3.C4H4O4. Mole weight: 369.42. | |
| APTO-253 | APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor[1][2]. APTO-253 has antiarthritic activity[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LOR-253; LT-253. CAS No. 916151-99-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16291. | |
| APTO-253 hydrochloride | APTO-253, also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis. Synonyms: APTO 253 hydrochloride; APTO253 hydrochloride; LOR253 hydrochloride; LOR-253 hydrochloride; LOR 253 hydrochloride. CAS No. 1422731-37-0. Molecular formula: C22H15ClFN5. Mole weight: 403.85. | |
| APTS@ Fe2O3 Nanoparticles | APTS@ Fe2O3 Nanoparticles. CAS No. 1317-61-9. |  |
| APTSTAT3-9R | APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. STAT3 has been reported to promote the proliferation, survival, metastasis, immune escape, as well as drug resistance of cancer cells, making it a promising target for various diseases. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets. Treatment of various types of cancer cells with APTSTAT3-9R blocked STAT3 phosphorylation and reduced expression of STAT targets, including cyclin D1, Bcl-xL, and survivin. As a result, APTSTAT3-9R suppressed the viability and proliferation of cancer cells. Furthermore, intratumoral injection of APTSTAT3-9R exerted potent antitumor activity in both xenograft and allograft tumor models. Synonyms: H-DL-His-Gly-DL-Phe-DL-Gln-DL-Trp-DL-Pro-Gly-DL-Ser-DL-Trp-DL-xiThr-DL-Trp-DL-Glu-DL-Asn-Gly-DL-Lys-DL-Trp-DL-xiThr-DL-Trp-DL-Lys-Gly-DL-Ala-DL-Tyr-DL-Gln-DL-Phe-DL-Leu-DL-Lys-Gly-Gly-Gly-Gly-DL-Ser-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-DL-Arg-OH; HGFQWPGSWXWENGKWXWKGAYQFLKGGGGSRRRRRRRRR; DL-histidyl-glycyl-DL-phenylalanyl-DL-glutaminyl-DL-tryptophyl-DL-prolyl-glycyl-DL-seryl-DL-. Grade: 99.31 %. Molecular formula: C223H330N80O51. Mole weight: 4947.51. | |
| APX001A | APX001A is a first-in-class small-molecule inhibitor of the conserved fungal Gwt1 protein. APX001A is active against the major fungal pathogens, i.e., Candida (except Candida krusei), Aspergillus, and hard-to-treat molds, including Fusarium and Scedosporium. Synonyms: MGX; Manogepix; E1210. CAS No. 936339-60-5. Molecular formula: C21H18N4O2. Mole weight: 358.39. | |
| APX-115 | APX-115 is a first-in-class pan-NADPH oxidase (Nox) inhibitor. Study shows that APX-115 might be a promising therapeutic agent for the treatment of diabetic nephropathy because of its pan-NOX inhibitory activity, including its NOX5 inhibitory activity, and also owing to its anti-inflammatory effect. Synonyms: Ewha-18278; Isuzinaxib hydrochloride; 3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol hydrochloride. Grade: 99%. CAS No. 1395946-75-4. Molecular formula: C17H17N3O.HCl. Mole weight: 315.80. | |
| APX-115 | APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ewha-18278. CAS No. 1395946-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120801. | |
| APX2009 | APX2009 is a specific APE1/REF-1 redox inhibitor with anticancer activities which decreases the proliferative, migratory, and invasive properties of breast cancer cell and induces apoptosis in breast cancer cell[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1415030-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-120069. | |
| APX2039 | APX2039 is a brain-penetrant and orally active Gwt1 protein inhibitor. APX2039 inhibits an early step in fungal glycosylphosphatidylinositol anchor biosynthesis. APX2039 can be used for the research of cryptococcal meningitis and invasive mycosis caused by Talaromyces marneffei[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2342606-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147110. | |
| APY0201 | APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production. Uses: Scientific research. Category: Signaling pathways. CAS No. 1232221-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15982. | |
| APY0201 | APY0201 Inhibitor. Uses: Scientific use. Product Category: T2061. CAS No. 1232221-74-7. | |
| APY0201 | APY0201, an effective IL-12/23 inhibitor, has been found to have potential use in the treatment of inflammation. IC50 = 5.2 nM. Synonyms: APY0201; APY-0201; APY 0201. Grade: 98%. CAS No. 1232221-74-7. Molecular formula: C23H23N7O. Mole weight: 413.48. | |
| APY29 | Allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity. Synonyms: APY29; APY-29; APY 29; N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine. Grade: >98%. CAS No. 1216665-49-4. Molecular formula: C17H16N8. Mole weight: 332.36. | |
| APY 29 | APY 29. Group: Biochemicals. Grades: Purified. CAS No. 1216665-49-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Apyramide | Apyramide is a non-steroidal anti-inflammatory agent (NSAID) that is a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable, non-selective inhibitor of COX1 and COX2. Synonyms: 4-(Acetylamino)phenyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate; 1-(p-Chlorobenzoyl)-2-methyl-5-methoxyindole-3-p-acetamidophenol acetate; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid 4-(acetylamino)phenyl ester; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 4-(acetylamino)phenyl ester. Grade: ≥95%. CAS No. 68483-33-0. Molecular formula: C27H23ClN2O5. Mole weight: 490.93. | |
| apyrase | Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyse NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyse ATP, by hydrolysing both ATP and ADP. The eukaryotic enzymes requires Ca2+, but Mg2+ can substitute. Most of the ecto-ATPases that occur on the cell surface and hydrolyse extracellular nucleotides belong to this enzyme family. Group: Enzymes. Synonyms: ATP-diphosphatase; adenosine diphosphatase; ADPase; ATP diphosphohydrolase [ambiguous]. Enzyme Commission Number: EC 3.6.1.5. CAS No. 9000-95-7. Apyrase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4623; apyrase; EC 3.6.1.5; 9000-95-7; ATP-diphosphatase; adenosine diphosphatase; ADPase; ATP diphosphohydrolase [ambiguous]. Cat No: EXWM-4623. |  |
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