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| Product | Description | |
|---|---|---|
| AP14145 hydrochloride | AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. CAS No. 2387505-59-9. Molecular formula: C18H18ClF3N4O. Mole weight: 398.81. |  |
| AP14145 hydrochloride | AP14145 hydrochloride is a potent K Ca 2 (SK) channel negative allosteric modulator with an IC 50 of 1.1 μM for K Ca 2.2 (SK2) and K Ca 2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387505-59-9. Pack Sizes: 5 mg. Product ID: HY-120355A. |  |
| AP18 | AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 μM at human and mouse respectively. It has been used to study TRPA1 signaling in mice and rats as well as in vitro. It blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. It also blocks cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. It reverses CFA-induced mechanical hyperalgesia in mice. Uses: Ap18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. Synonyms: AP-18; AP 18; AP18. 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime; AP-18; 4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime; (NE)-N-[(Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine; (2E,3E)-4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime. Grade: 98%. CAS No. 55224-94-7. Molecular formula: C11H12ClNO. Mole weight: 209.67. | |
| AP 18 | AP 18. Group: Biochemicals. Grades: Purified. CAS No. 55224-94-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| AP-18 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| AP-18 | AP-18. Group: Biochemicals. Alternative Names: 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one Oxime. Grades: Highly Purified. CAS No. 55224-94-7. Pack Sizes: 5mg. Molecular Formula: C11H12ClNO, Molecular Weight: 209.67. US Biological Life Sciences. | Worldwide |
| AP1867 | AP1867 is a synthetic FKBP12F36V-directed ligand[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 195514-23-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114434. | |
| AP1867-2-(carboxymethoxy) | AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules. It is a ligand and a binder that contributes to the enhancer-promoter structural interactions of DNA elements. Synonyms: PROTAC FKBP12-binding moiety 2; 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid; 2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[2-(carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)-; Ortho-AP1867. Grade: ≥96%. CAS No. 2230613-03-1. Molecular formula: C38H47NO11. Mole weight: 693.78. | |
| AP1903 | AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity. Synonyms: AP1903; AP 1903; AP-1903; Rimiducid. Grade: 0.98. CAS No. 195514-63-7. Molecular formula: C78H98N4O20. Mole weight: 1411.63. | |
| AP-1/NF-κB activation inhibitor 1 | AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor with an IC50 of 1 μM. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells. Synonyms: AP-1/NF-kappaB activation inhibitor 1; 2-(Trifluoromethyl)-4-(2,5-dioxo-3-methyl-3-pyrroline-1-ylamino)pyrimidine-5-carboxylic acid ethyl ester. Grade: 99%. CAS No. 188936-12-1. Molecular formula: C13H11F3N4O4. Mole weight: 344.25. | |
| AP20187 | Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and muscle of AAV-treated NOD mice. AP20187 stimulation significantly increases hepatic glycogen content and muscular glucose uptake similarly to insulin. The homodimerizer has been widely used to study signal transduction pathways (by inducing oligomerization of cell surface receptor proteins), but it can be used to induce the activity/re-localization of any protein that is affected by oligomerization. To test the role of homodimerization in kinase activation, we constructed a fusion protein consisting of the SLK catalytic domain (amino acids 1-373) and a modified FK506 binding protein, Fv (Fv-SLK 1-373). Addition of AP20187 (an analog of FK506) enhanced the homodimerization of Fv-SLK 1-373. Synonyms: AP 20187; AP-20187. Grade: >98%. CAS No. 195514-80-8. Molecular formula: C82H107N5O20. Mole weight: 1482.75. | |
| AP20187 | AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions. Uses: Scientific research. Group: Signaling pathways. Alternative Names: B/B Homodimerizer. CAS No. 195514-80-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13992. | |
| AP219 | AP219 is a control compound for AP39, which contains the triphenylphosphonium scaffold but lacking the H2 S-releasing portion. AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. Synonyms: (9-Carboxynonyl)triphenylphosphonium; 779282-36-9; AP219; 9-carboxynonyl(triphenyl)phosphanium; (9-Carboxynonyl)triphenyl-phosphonium; CHEMBL3582497; SCHEMBL20859564; AKOS040755143; (9-Carboxynonyl)triphenyl-phosphonium Bromide (>90%). Grade: ≥98%. CAS No. 779282-36-9. Molecular formula: C28H34O2P. Mole weight: 433.6. | |
| AP-22161 | AP-2216, designed to bind selectively to the Src SH2 domain by targeting a cysteine residue, has the potential to be further developed for treating osteoporosis. Synonyms: 4-[(2S)-2-acetamido-3-[[(5S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]amino]-3-oxopropyl]-2-formylbenzoic acid; AP-22161; AP 22161; AP22161; SCHEMBL7243003; G7VE62573J; UNII-G7VE62573J. Grade: >98%. CAS No. 268741-42-0. Molecular formula: C32H39N3O7. Mole weight: 577.67. | |
| AP2238 | AP2238 is a inhibitor of both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Uses: Cholinesterase inhibitors. Synonyms: AP-2238; AP 2238; AP2238; CHEMBL75121; UNII-545225E0BC; BDBM10949; DNC007569; 2H-1-Benzopyran-2-one, 6,7-dimethoxy-3-(4-((methyl(phenylmethyl)amino)methyl)phenyl)-; 3-[4-(N-Benzyl-N-methylaminomethyl)phenyl]-6,7-dimethoxy-2H-1-benzopyran-2-one. Grade: 98%. CAS No. 553681-56-4. Molecular formula: C26H25NO4. Mole weight: 415.48. | |
| AP-22408 | AP-22408, a Src tyrosine kinase inhibitor, is an orally bioavailable phosphotyrosine mimic resulting from a structurebased design. Synonyms: [4-[(2S)-2-acetamido-3-[[(5S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl]amino]-3-oxopropyl]-2-phosphonophenyl]phosphonic acid; AP-22408; AP 22408; AP22408; UNII-3U3L5QR4KV; CC1; AC1L9I7C; 3U3L5QR4KV; SCHEMBL7245569. Grade: >98%. CAS No. 268741-43-1. Molecular formula: C30H41N3O10P2. Mole weight: 665.61. | |
| AP23464 | AP23464 is a potent adenosine 5'-triphosphate (ATP)-based inhibitor of Src and Abl kinases. It displays antiproliferative activity against a human CML cell line and Bcr-Abl-transduced Ba/F3 cells with an IC50=14 nM. Synonyms: AP-23464; AP 23464; (4-((2-cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dimethylphosphine oxide. Grade: >98%. CAS No. 845895-51-4. Molecular formula: C30H38N5O2P. Mole weight: 475.53. | |
| AP23846 | AP23846 is a potent c-Src kinase inhibitor (IC50 approximately 0.5 nmol/L in vitro, approximately 10-fold more potent than PP2, the most widely used commercially available Src family kinase inhibitor). Synonyms: AP-23846; (4-((2-cyclopentyl-9-ethyl-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide. Grade: >98%. CAS No. 878654-51-4. Molecular formula: C20H16FN3O2. Mole weight: 439.53. | |
| AP23848 | AP23848 is a potent Bcr-Abl inhibitor. Synonyms: AP-23848; AP 23848; PF-562771; (4-((2-Cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide. Grade: >98%. CAS No. 834894-21-2. Molecular formula: C13H15N5O6. Mole weight: 531.63. | |
| AP 24534 | AP 24534. Group: Biochemicals. Grades: Purified. CAS No. 943319-70-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AP-24600 | AP-24600 is a bio-active chemical, but no detailed information has been published yet. Synonyms: AP-24600; AP 24600; AP24600; DA-12847; KB-310048; DA 12847; KB 310048; DA12847; KB310048; UNII-OZ477A282R; OZ477A282R; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid. Grade: 98%. CAS No. 1300690-48-5. Molecular formula: C16H11N3O2. Mole weight: 277.28. | |
| AP 26113 | AP 26113. Group: Biochemicals. Grades: Highly Purified. CAS No. 1350848-43-9. Pack Sizes: 1mg. Molecular Formula: C26H34ClN6O2P, Molecular Weight: 529.01. US Biological Life Sciences. | Worldwide |
| AP-26113 | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grade: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. | |
| AP2A | AP2A, a prized medication within the biomedical industry, has transcended the boundaries of healing, showcasing its versatility in treating numerous afflictions, including but not limited to, managing pain, alleviating inflammatory disorders, and thwarting cancer. Prized for its utmost efficacy, AP2A efficaciously binds and regulates the activity of specific enzymatic and protein molecules that initiate the cascade of these aforementioned conditions. With its potential for therapeutic use being exhaustively studied and researched, it stands as an invaluable asset in the biomedicine realm. Synonyms: P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 85065-24-3. Molecular formula: C20H26N10O13P2 (free acid). Mole weight: 676.43 (free acid). | |
| AP2Ribavirin | AP2Ribavirin, an antiviral drug, exerts its efficacy against the Hepatitis C virus (HCV) by curbing the replication of viral RNA through interference with RNA-dependent RNA polymerase. Coupled with other HCV drugs, AP2Ribavirin enhances therapeutic outcomes - serving as a frontline defense against this viral infection. Synonyms: 1,2,4-Triazole-3-carboxamide adenine dinucleotide, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C18H25N9O14P2 (free acid). Mole weight: 653.39 (free acid). | |
| AP30663 | AP30663 is a KCa2 channel inhibitor that can be used for the study of atrial fibrillation[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157557. | |
| AP39 | AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It is also used as a photosensitizer, hydrogen sulfide donor, thioredoxin inhibitor or nitroxide combination use in photodynamic therapy. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM. Grade: ≥95%. CAS No. 1429173-57-8. Molecular formula: C37H38O2PS3. Mole weight: 641.9. | |
| AP39 | AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1429061-80-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126124. | |
| AP3A - lyophilized | AP3A - lyophilized is a biomedical product that holds immense value in understanding the complex aspects of liver-specific gene expression alongside the role of essential extracellular ATP. It has a proven track record in liver disease research and liver cancer. AP3A's profound potency lies in activating P2Y purinergic receptors, thus leading to a significant surge in ATP stimulation within liver cells. AP3A's ever-efficient lyophilized form guarantees long-term storage and easy usability for laboratory experiments. Synonyms: (ApppA); P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 5959-90-0. Molecular formula: C20H27N10O16P3 (free acid). Mole weight: 756.41 (free acid). | |
| AP3A - solution | AP3A solution, a biochemical product entrenched in biomedical industry, commands center stage in studying purinergic signaling pathways, amongst others. This efficacious prodigy, a mainstay in academic research labs, abets multifarious research endeavors including, but not limited to, curing autoimmune disorders, neurodegenerative diseases, and cancer. AP3A solution, sourced from different research chemical providers, beckons an important armamentarium for scientists and researchers aiming to unearth the intricacies of cellular signaling pathways. Synonyms: (ApppA); P1-(5'-Adenosyl) P3-(5'-adenosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H27N10O16P3 (free acid). Mole weight: 756.41 (free acid). | |
| AP3G (A cap) | AP3G (A cap) is a non-functional cap analog used in the synthesis of mRNA to estimate the level of cap-independent translation. Synonyms: (ApppG); P1-(5'-Adenosyl) P3-(5'-guanosyl) triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H27N10O17P3 (free acid). Mole weight: 772.41 (free acid). | |
| AP3 (Nic) | AP3 (Nic), a powerful and exclusive inhibitor of phosphodiesterase 10A (PDE10A), which has been extensively investigated for its probable therapeutic usage in motor and cognitive deficits observed in Parkinson's disease and schizophrenia, exhibits neurosignaling pathways modulation characteristics. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-Ribofuranosyl-nicotinamide)] triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C21H28N7O17P3 (free acid). Mole weight: 743.41 (free acid). | |
| AP4 | AP4 is a scientifically advanced compound, standing as an exemplary research for neurodegenerative ailments, including the formidable Parkinson's disease. With remarkable efficacy, it ensnares the unruly culprit, L-alpha-amino-4-hydroxy-2,3,5-trichlorobenzene (ATCB) which is an influential enzyme breaching dopamine's metabolic fortress. Synonyms: (Adenosine-5'-tetraphosphate); Adenosine-5'-tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 1062-98-2. Molecular formula: C10H17N5O16P4 (free acid). Mole weight: 587.16 (free acid). | |
| AP4 (8-Iodo-G) | AP4 (8-Iodo-G) is a chemical compound utilized in the biomedical industry for research purposes. Studies suggest that it may have applications in treating neurological disorders such as epilepsy, as well as potential antitumor and antimicrobial effects. Further research is ongoing to determine its full therapeutic potential. Synonyms: (AP4(8I-G)); P1-(5'-Adenosyl) P4-[5'-(8-iodo)-guanosyl] tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H27IN10O20P4 (free acid). Mole weight: 978.28 (free acid). | |
| AP4A | AP4A is a signal molecule for DNA replication in mammalian cells. AP4A is used as a primer for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase. AP4A is an inhibitor of eosinophil-derived neurotoxin (EDN). Uses: Ap4a is an inhibitor of eosinophil-derived neurotoxin (edn). Synonyms: (AppppA); P1-(5'-Adenosyl) P4-(5'-adenosyl) tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 5542-28-9. Molecular formula: C20H28N10O19P4 (free acid). Mole weight: 836.39 (free acid). | |
| Ap4C | Ap4C, a nucleotide analogue, boasts the extraordinary capability of selectively activating purinergic receptor P2X receptors. Its potential applications are broad-spanning from treating inflammatory diseases to chronic pain and cancer, all of which are associated with abnormal purinergic signaling. Synonyms: P1- (5'- Adenosyl)- P4- (5'- cytidyl)- tetraphosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 1352921-13-1. Molecular formula: C19H28N8O20P4 (free acid). Mole weight: 812.4 (free acid). | |
| AP4dT | AP4dT is a novel and auspicious antiviral drug exhibiting compelling efficacy against HCV by suppressing viral RNA polymerase enzyme, thereby restraining viral genome replication. Preclinical studies suggest that AP4dT could be a potential pan-genotypic therapeutic candidate for HCV, capable of treating both genotype 1 and 3 infections alike. Synonyms: P1-(5'-Adenosyl) P4-[5'-(2'-deoxy-thymidyl)] tetraphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 13457-68-6. Molecular formula: C20H29N7O20P4 (free acid). Mole weight: 811.38 (free acid). | |
| AP4G | AP4G is a state-of-the-art biomedical compound meticulously used for studying an array of formidable neurological afflictions such as Alzheimer's, Parkinson's and epilepsy. Synonyms: (AppppG); P1-(5'-Adenosyl) P4-(5'-guanosyl) tetraphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 10527-46-5. Molecular formula: C20H28N10O20P4 (free acid). Mole weight: 852.39 (free acid). | |
| AP4U | AP4U, an innovative biomedical intervention, revolutionizes the therapeutic landscape in Parkinson's disease management. With extraordinary efficacy, this groundbreaking product exerts a profound influence on pyridoxal kinase, effectively curbing the transformation of pyridoxal into pyridoxal 5'-phosphate. Through this intricate modulation, AP4U remarkably ameliorates the debilitating symptoms of Parkinson's, presenting itself as an indispensable therapeutic remedy. Synonyms: P1-(5'-Adenosyl) P4-(5'-uridyl) tetraphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 10527-48-7. Molecular formula: C19H27N7O21P4 (free acid). Mole weight: 813.35 (free acid). | |
| AP5 | AP5 is a potent and selective GPR40 receptor agonist (EC50 = 0.49±0.28 nM for rat hIP1) with positive allosteric modulation of endogenous ligands (AgoPAM). Synonyms: 2H-1-Benzopyran-7-propanoic acid, β-cyclopropyl-2-[2-fluoro-4-(2-methoxy-4-pyridinyl)phenyl]-3,4-dihydro-α-methyl-, (αS,βR,2S)-. Grade: ≥95%. CAS No. 1623194-37-5. Molecular formula: C28H28FNO4. Mole weight: 461.52. | |
| AP521 | AP521 is an agonist of human 5-HT1A receptor potentially for the treatment of anxiety. Synonyms: AP-521. CAS No. 151227-08-6. Molecular formula: C20H19ClN2O3S. Mole weight: 402.89. | |
| AP5 (8-Iodo-G) | AP5 (8-Iodo-G) is a highly potent biomedical compound, diligently functioning as a discriminating antagonist specifically modulating the AMPA receptor, thereby efficaciously facilitating the exploration and innovation of novel therapeutic modalities directed towards debilitating ailments. Synonyms: (AP5(8I-G)); P1-(5'-Adenosyl) P5-[5'-(8-iodo)-guanosyl] pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H28IN10O23P5 (free acid). Mole weight: 1058.26 (free acid). | |
| AP5A | AP5A is an adenosine A2A receptor antagonist used for studying Parkinson's disease. Uses: Vasoconstrictor agents. Synonyms: P1-(5'-Adenosyl) P5-(5'-adenosyl) pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 41708-91-2. Molecular formula: C20H29N10O22P5 (free acid). Mole weight: 916.37 (free acid). | |
| AP5dT | AP5dT is an exceptional synthetic nucleoside analog, facilitating the exploration of intricate DNA replication and repair mechanisms. aP5dT can amplify the comprehension of virally-inflicted ailments (e.g., HIV, herpes) as well as diverse DNA-centric maladies. Synonyms: P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 103137-88-8. Molecular formula: C20H30N7O23P5 (free acid). Mole weight: 891.36 (free acid). | |
| AP5G | AP5G, a peptide analog, stands as a beacon of hope in the biomedical research realm, wielding its anti-tumor and anti-inflammatory properties. Heralding the growth and proliferation inhibition of cancer cells, especially those found in breast and lung cancer, AP5G adds another feather to its cap as an exquisitely effective anti-inflammatory agent, bestowing it with the ability to be contemplated as a potential panacea for maladies like rheumatoid arthritis and inflammatory bowel disease. Further, the possibility of assimilating AP5G into neurological disorder treatment regimes represents its multifaceted nuance, with exhaustive studies indicating its potential neuroprotective effects, making it a potential cog in the wheel to combat Alzheimer's disease. Synonyms: P1-(5'-Adenosyl) P5-(5'-guanosyl) pentaphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 56983-24-5. Molecular formula: C20H29N10O23P5 (free acid). Mole weight: 932.37 (free acid). | |
| AP5U | AP5U, a potent and selective inhibitor of phosphodiesterase-5 (PDE5), has emerged as a viable therapeutic intervention for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). This synthetic molecule relaxes the smooth muscles lining blood vessels, augmenting blood perfusion to the penile or pulmonary vasculature, and enhancing exercise capacity in PAH patients. AP5U promises to offer a ray of hope for those suffering from these debilitating health disorders, revolutionizing the way we perceive and treat ED and PAH in contemporary medicine. Synonyms: P1-(5'-Adenosyl) P5-(5'-uridyl) pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 56983-25-6. Molecular formula: C19H28N7O24P5 (free acid). Mole weight: 893.33 (free acid). | |
| AP-6 | AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1369963-51-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161949. | |
| AP6A | AP6A is a potent vasoconstrictor. Synonyms: P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate; Diadenosine hexaphosphate; P1,P6-di(Adenosine-5')hexaphosphate; Diadenosine 5',5''''-P1,P6-hexaphosphate; AppppppA; Ap(6)A; Adenosine-(5')-hexaphospho-(5')-adenosine; Adenosine 5'-hexaphosphate 5'-ester with adenosine; P1,P6-Bis(5'-adenosyl)hexaphosphate. Grade: ≥95% by HPLC. CAS No. 56983-23-4. Molecular formula: C20H30N10O25P6. Mole weight: 996.35. | |
| AP6A Sodium salt | AP6A Sodium salt is the salt of AP6A, a potent vasoconstrictor. Synonyms: P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate Sodium salt; Diadenosine hexaphosphate Sodium salt; P1,P6-di(Adenosine-5')hexaphosphate Sodium salt; Diadenosine 5',5''''-P1,P6-hexaphosphate Sodium salt; AppppppA Sodium salt; Ap(6)A Sodium salt; Adenosine-(5')-hexaphospho-(5')-adenosine Sodium salt; Adenosine 5'-hexaphosphate 5'-ester with adenosine Sodium salt; P1,P6-Bis(5'-adenosyl)hexaphosphate Sodium salt. Grade: ≥95% by HPLC. Molecular formula: C20H30N10O25P6 (free acid). Mole weight: 996.35 (free acid). | |
| AP 811 | AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K i of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 124833-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1419. | |
| AP 811 | AP 811 has been found to be an NPR3 antagonist and could restrain Na+/K+ pump activity in rabbit ventricular cardiomyocytes. Synonyms: N2-[[4-[(2-Naphthalenylcarbonyl)amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α-aspartyl-N-[(2S)-2-methylbutyl]-L-argininamide; (S)-N2-[[4-[(2-Naphthalenylcarbonyl)amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α-aspartyl-N-(2-methylbutyl)-L-argininamide; AP811; AP-811. Grade: ≥95% by HPLC. CAS No. 124833-45-0. Molecular formula: C46H66N12O8. Mole weight: 915.09. | |
| ApA | ApA is a nucleoside derivative prevalent in the biomedical sector, garnering significant attention due to its profound implications in research of viral infections. Synonyms: RNA Dinucleotide (5'→3'), Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H25N10O10P (free acid). Mole weight: 596.45 (free acid). | |
| APA Amoxicillin Amide | APA Amoxicillin Amide is a derivative of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections including middle ear infections, strep throat, pneumonia, skin infections, and urinary tract infections. Synonyms: N-(Penicillan-6-yl) amoxicillinamide; Amoxicillin EP Impurity L; Amoxicillin USP Related Compound L; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]amino]-3,3-dimeth yl-7-oxo-, (2S,5R,6R)-. Grade: 95%. CAS No. 1789703-32-7. Molecular formula: C24H29N5O7S2. Mole weight: 563.65. | |
| APA Amoxicillin Amide | APA Amoxicillin Amide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug. Molecular Formula: C24H29N5O7S2, Molecular Weight: 563.65. US Biological Life Sciences. | Worldwide |
| Apabetalone | Apabetalone (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC 50 s are 87 μM and 0.51 μM for BD1 and BD2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RVX-208; RVX000222. CAS No. 1044870-39-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16652. | |
| Apadenoson | An A2A adenosine receptor agonist. Adjunct to nuclear myocardial perfusion imaging in patients unable to exercise adequately. Synonyms: trans-4-[3-[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester. Grade: > 95%. CAS No. 250386-15-3. Molecular formula: C23H30N6O6. Mole weight: 486.53. | |
| Apadenoson-d5 | Apadenoson-d5 is a labelled A3A adenosine receptor agonist. Synonyms: trans-4-[3-[6-Amino-9-[N-(ethyl-d5)-β-D-ribofuranuronamidosyl)]-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester. Grade: > 95%. Molecular formula: C23H25N6O6D5. Mole weight: 491.56. | |
| Apadenoson-d5 | An A2A adenosine receptor agonist. Group: Biochemicals. Alternative Names: trans-4-[3-[6-Amino-9-[N-(ethyl-d5)- β -D-ribofuranuronamidosyl) ]-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester; ATL 146e-d5; BMS 068645-d5; DWH 146e-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Apadoline | Apadoline is a third-generation topical retinoid used for the topical treatment of acne vulgaris. Adapalene binds to retinoic acid receptor (RAR)-beta and RAR-gamma; this complex subsequently binds to one of three retinoid X receptors (RXRs), which as a complex is capable of binding DNA to modulate transcriptional activity. Grade: 98% by HPLC. CAS No. 135003-30-4. Molecular formula: C23H29N3OS. Mole weight: 395.6. | |
| Apafant | Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, ?-globin, ?-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WEB 2086. CAS No. 105219-56-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108634. | |
| Apafant | Apafant. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]; WEB-2086. Product Category: Thiophenes. Appearance: Beige Solid. CAS No. 105219-56-5. Molecular formula: C22H22ClN5O2S. Mole weight: 455.96. Purity: 0.98. Product ID: ACM105219565. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Apafant | Platelet activating factor (PAF) antagonist. Group: Biochemicals. Alternative Names: 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine; WEB 2086BS; WEB 2086. Grades: Highly Purified. CAS No. 105219-56-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Apa I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (dam-dcm-, BamHI-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 50-fold overdigestion with enzyme > 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 5000U; 25000U. GGGCC↑C C↓CCGGG. Activity: 50000u.a./ml. Appearance: 10 X SE-buffer Y, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Apa I gene from Acetobacter pasteurianus. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: RE-1021EN. |  |
| Apalcillin | Apalcillin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-dimethyl-7-oxo-hyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-(2s-(2-al;4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((((4-hydroxy-1,5-napht;5-alpha,6-beta(s*)))-ph;APALCILLIN;Lumota;(2S,5R,6R)-6α-[[(R)-(4-Hydroxypyrido[3,2-b]pyridin-3-ylcarb. Product Category: Heterocyclic Organic Compound. CAS No. 63469-19-2. Molecular formula: C25H23N5O6S. Mole weight: 521.5466. Product ID: ACM63469192. Alfa Chemistry ISO 9001:2015 Certified. | |
| Apalutamide | Apalutamide is a potent and competitive androgen receptor (AR) antagonist with potential antineoplastic activity. It binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. Synonyms: ARN-509; Apalutamide; ARN 509; JNJ56021927; JNJ-56021927; JNJ 56021927; ARN509. Grade: 98%. CAS No. 956104-40-8. Molecular formula: C21H15F4N5O2S. Mole weight: 477.43. | |
| Apalutamide | Apalutamide (ARN-509) is a potent and competitive androgen receptor ( AR ) antagonist, binding AR with an IC 50 of 16 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARN-509. CAS No. 956104-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16060. | |
| Apalutamide Dithio Impurity | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: 4-[7-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-6,8-dithioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide; 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dithioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide; Apalutamide Impurity 27; Apalutamide Disulphur impurity. Grade: ≥95%. CAS No. 2649802-40-2. Molecular formula: C21H15F4N5OS2. Mole weight: 493.50. | |
| Apalutamide Impurity 1 | Apalutamide Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide. CAS No. 1332391-92-0. Molecular formula: C21H15F4N5O3. Mole weight: 461.37. Catalog: APB1332391920. | |
| Apalutamide Impurity 16 | Apalutamide Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide. CAS No. 1332389-57-7. Molecular formula: C21H16F3N5O2S. Mole weight: 459.10. Catalog: APB1332389577. | |
| Apalutamide Impurity 3 | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: 4-[[1-[[6-cyano-5-(trifluoromethyl)-3-pyridyl]carbamoyl]cyclobutyl]amino]-2-fluoro- N-methyl-benzamide. Grade: 95%. CAS No. 1950587-20-8. Molecular formula: C20H17F4N5O2. Mole weight: 435.37. | |
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