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| Product | Description | |
|---|---|---|
| AP5dT | AP5dT is an exceptional synthetic nucleoside analog, facilitating the exploration of intricate DNA replication and repair mechanisms. aP5dT can amplify the comprehension of virally-inflicted ailments (e.g., HIV, herpes) as well as diverse DNA-centric maladies. Synonyms: P1-(5'-Adenosyl) P5-[5'-(2'-deoxy-thymidyl)] pentaphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 103137-88-8. Molecular formula: C20H30N7O23P5 (free acid). Mole weight: 891.36 (free acid). |  |
| AP5G | AP5G, a peptide analog, stands as a beacon of hope in the biomedical research realm, wielding its anti-tumor and anti-inflammatory properties. Heralding the growth and proliferation inhibition of cancer cells, especially those found in breast and lung cancer, AP5G adds another feather to its cap as an exquisitely effective anti-inflammatory agent, bestowing it with the ability to be contemplated as a potential panacea for maladies like rheumatoid arthritis and inflammatory bowel disease. Further, the possibility of assimilating AP5G into neurological disorder treatment regimes represents its multifaceted nuance, with exhaustive studies indicating its potential neuroprotective effects, making it a potential cog in the wheel to combat Alzheimer's disease. Synonyms: P1-(5'-Adenosyl) P5-(5'-guanosyl) pentaphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. CAS No. 56983-24-5. Molecular formula: C20H29N10O23P5 (free acid). Mole weight: 932.37 (free acid). | |
| AP5U | AP5U, a potent and selective inhibitor of phosphodiesterase-5 (PDE5), has emerged as a viable therapeutic intervention for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). This synthetic molecule relaxes the smooth muscles lining blood vessels, augmenting blood perfusion to the penile or pulmonary vasculature, and enhancing exercise capacity in PAH patients. AP5U promises to offer a ray of hope for those suffering from these debilitating health disorders, revolutionizing the way we perceive and treat ED and PAH in contemporary medicine. Synonyms: P1-(5'-Adenosyl) P5-(5'-uridyl) pentaphosphate, Sodium salt. Grade: ≥ 95% by HPLC. CAS No. 56983-25-6. Molecular formula: C19H28N7O24P5 (free acid). Mole weight: 893.33 (free acid). | |
| AP-6 | AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1369963-51-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161949. |  |
| AP6A | AP6A is a potent vasoconstrictor. Synonyms: P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate; Diadenosine hexaphosphate; P1,P6-di(Adenosine-5')hexaphosphate; Diadenosine 5',5''''-P1,P6-hexaphosphate; AppppppA; Ap(6)A; Adenosine-(5')-hexaphospho-(5')-adenosine; Adenosine 5'-hexaphosphate 5'-ester with adenosine; P1,P6-Bis(5'-adenosyl)hexaphosphate. Grade: ≥95% by HPLC. CAS No. 56983-23-4. Molecular formula: C20H30N10O25P6. Mole weight: 996.35. | |
| AP6A Sodium salt | AP6A Sodium salt is the salt of AP6A, a potent vasoconstrictor. Synonyms: P1-(5'-Adenosyl) P6-(5'-adenosyl) hexaphosphate Sodium salt; Diadenosine hexaphosphate Sodium salt; P1,P6-di(Adenosine-5')hexaphosphate Sodium salt; Diadenosine 5',5''''-P1,P6-hexaphosphate Sodium salt; AppppppA Sodium salt; Ap(6)A Sodium salt; Adenosine-(5')-hexaphospho-(5')-adenosine Sodium salt; Adenosine 5'-hexaphosphate 5'-ester with adenosine Sodium salt; P1,P6-Bis(5'-adenosyl)hexaphosphate Sodium salt. Grade: ≥95% by HPLC. Molecular formula: C20H30N10O25P6 (free acid). Mole weight: 996.35 (free acid). | |
| AP 811 | AP 811 has been found to be an NPR3 antagonist and could restrain Na+/K+ pump activity in rabbit ventricular cardiomyocytes. Synonyms: N2-[[4-[(2-Naphthalenylcarbonyl)amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α-aspartyl-N-[(2S)-2-methylbutyl]-L-argininamide; (S)-N2-[[4-[(2-Naphthalenylcarbonyl)amino]phenyl]acetyl]-L-arginyl-L-isoleucyl-L-α-aspartyl-N-(2-methylbutyl)-L-argininamide; AP811; AP-811. Grade: ≥95% by HPLC. CAS No. 124833-45-0. Molecular formula: C46H66N12O8. Mole weight: 915.09. | |
| AP 811 | AP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a K i of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 124833-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1419. | |
| ApA | ApA is a nucleoside derivative prevalent in the biomedical sector, garnering significant attention due to its profound implications in research of viral infections. Synonyms: RNA Dinucleotide (5'→3'), Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H25N10O10P (free acid). Mole weight: 596.45 (free acid). | |
| APA Amoxicillin Amide | APA Amoxicillin Amide is a derivative of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections including middle ear infections, strep throat, pneumonia, skin infections, and urinary tract infections. Synonyms: N-(Penicillan-6-yl) amoxicillinamide; Amoxicillin EP Impurity L; Amoxicillin USP Related Compound L; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]amino]-3,3-dimeth yl-7-oxo-, (2S,5R,6R)-. Grade: 95%. CAS No. 1789703-32-7. Molecular formula: C24H29N5O7S2. Mole weight: 563.65. | |
| APA Amoxicillin Amide | APA Amoxicillin Amide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug. Molecular Formula: C24H29N5O7S2, Molecular Weight: 563.65. US Biological Life Sciences. |  Worldwide |
| Apabetalone | Apabetalone (RVX-208) is an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. The IC 50 s are 87 μM and 0.51 μM for BD1 and BD2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RVX-208; RVX000222. CAS No. 1044870-39-4. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16652. | |
| Apadenoson | An A2A adenosine receptor agonist. Adjunct to nuclear myocardial perfusion imaging in patients unable to exercise adequately. Synonyms: trans-4-[3-[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester. Grade: > 95%. CAS No. 250386-15-3. Molecular formula: C23H30N6O6. Mole weight: 486.53. | |
| Apadenoson-d5 | An A2A adenosine receptor agonist. Group: Biochemicals. Alternative Names: trans-4-[3-[6-Amino-9-[N-(ethyl-d5)- β -D-ribofuranuronamidosyl) ]-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester; ATL 146e-d5; BMS 068645-d5; DWH 146e-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Apadenoson-d5 | Apadenoson-d5 is a labelled A3A adenosine receptor agonist. Synonyms: trans-4-[3-[6-Amino-9-[N-(ethyl-d5)-β-D-ribofuranuronamidosyl)]-9H-purin-2-yl]-2-propyn-1-yl]-cyclohexanecarboxylic Acid Methyl Ester. Grade: > 95%. Molecular formula: C23H25N6O6D5. Mole weight: 491.56. | |
| Apadoline | Apadoline is a third-generation topical retinoid used for the topical treatment of acne vulgaris. Adapalene binds to retinoic acid receptor (RAR)-beta and RAR-gamma; this complex subsequently binds to one of three retinoid X receptors (RXRs), which as a complex is capable of binding DNA to modulate transcriptional activity. Grade: 98% by HPLC. CAS No. 135003-30-4. Molecular formula: C23H29N3OS. Mole weight: 395.6. | |
| Apafant | Apafant. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]; WEB-2086. Product Category: Thiophenes. Appearance: Beige Solid. CAS No. 105219-56-5. Molecular formula: C22H22ClN5O2S. Mole weight: 455.96. Purity: 0.98. Product ID: ACM105219565. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Apafant | Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, ?-globin, ?-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WEB 2086. CAS No. 105219-56-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108634. | |
| Apafant | Platelet activating factor (PAF) antagonist. Group: Biochemicals. Alternative Names: 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine; WEB 2086BS; WEB 2086. Grades: Highly Purified. CAS No. 105219-56-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Apa I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (dam-dcm-, BamHI-digest) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 50-fold overdigestion with enzyme > 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 5000U; 25000U. GGGCC↑C C↓CCGGG. Activity: 50000u.a./ml. Appearance: 10 X SE-buffer Y, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Apa I gene from Acetobacter pasteurianus. Pack: 10 mM Tris-HCl (pH 7.5); 200 mM NaCl; 0.1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: RE-1021EN. |  |
| Apalcillin | Apalcillin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-dimethyl-7-oxo-hyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-(2s-(2-al;4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((((4-hydroxy-1,5-napht;5-alpha,6-beta(s*)))-ph;APALCILLIN;Lumota;(2S,5R,6R)-6α-[[(R)-(4-Hydroxypyrido[3,2-b]pyridin-3-ylcarb. Product Category: Heterocyclic Organic Compound. CAS No. 63469-19-2. Molecular formula: C25H23N5O6S. Mole weight: 521.5466. Product ID: ACM63469192. Alfa Chemistry ISO 9001:2015 Certified. | |
| Apalutamide | Apalutamide (ARN-509) is a potent and competitive androgen receptor ( AR ) antagonist, binding AR with an IC 50 of 16 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARN-509. CAS No. 956104-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16060. | |
| Apalutamide | Apalutamide is a potent and competitive androgen receptor (AR) antagonist with potential antineoplastic activity. It binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. Synonyms: ARN-509; Apalutamide; ARN 509; JNJ56021927; JNJ-56021927; JNJ 56021927; ARN509. Grade: 98%. CAS No. 956104-40-8. Molecular formula: C21H15F4N5O2S. Mole weight: 477.43. | |
| Apalutamide | Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM. CAS No. 956104-40-8. Product ID: API956104408. Mole weight: 477.435. Category: Active Pharmaceutical Ingredients. |  |
| Apalutamide Dithio Impurity | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: 4-[7-[6-Cyano-5-(trifluoromethyl)-3-pyridinyl]-6,8-dithioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide; 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dithioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide; Apalutamide Impurity 27; Apalutamide Disulphur impurity. Grade: ≥95%. CAS No. 2649802-40-2. Molecular formula: C21H15F4N5OS2. Mole weight: 493.50. | |
| Apalutamide Impurity 1 | Apalutamide Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-6,8-dioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide. CAS No. 1332391-92-0. Molecular formula: C21H15F4N5O3. Mole weight: 461.37. Catalog: APB1332391920. |  |
| Apalutamide Impurity 16 | Apalutamide Impurity 16. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-N-methylbenzamide. CAS No. 1332389-57-7. Molecular formula: C21H16F3N5O2S. Mole weight: 459.10. Catalog: APB1332389577. | |
| Apalutamide Impurity 3 | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: 4-[[1-[[6-cyano-5-(trifluoromethyl)-3-pyridyl]carbamoyl]cyclobutyl]amino]-2-fluoro- N-methyl-benzamide. Grade: 95%. CAS No. 1950587-20-8. Molecular formula: C20H17F4N5O2. Mole weight: 435.37. | |
| Apalutamide Impurity 4 | An impurity of Apalutamide, an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: Apalutamide Di-(2-fluoro-N-methylbenzamide); 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-(3-fluoro-4-(methylcarbamoyl)phenyl)-N-methylbenzamide. Grade: 95%. CAS No. 2894796-76-8. Molecular formula: C29H21F5N6O3S. Mole weight: 628.58. | |
| Apalutamide metabolite M4 | Apalutamide metabolite M4 is a metabolite of Apalutamide, which is an androgen receptor inhibitor used in the treatment of prostate cancer. Synonyms: Apalutamide-COOH; Apalutamide Acid Impurity; 4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3,4]octan-5-yl)-2-fluorobenzoic acid. CAS No. 1332391-04-4. Molecular formula: C20H12F4N4O3S. Mole weight: 464.39. | |
| Apamin | from bee venom, ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Apamin | synthetic, ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Apamin | Apamin. Group: Biochemicals. Grades: Purified. CAS No. 24345-16-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Apamin | Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1]. Uses: Scientific research. Group: Peptides. Alternative Names: Apamine. CAS No. 24345-16-2. Pack Sizes: 500 ?g; 1 mg. Product ID: HY-P0256. | |
| Apamin, Bee Venom - CAS 24345-16-2 | Polypeptide neurotoxin known to pass through the blood-brain barrier. Group: Fluorescence/luminescence spectroscopy. | |
| APAO | Liquid; OtherSolid. Group: Polymers. CAS No. 9010-79-1. Product ID: ethene; prop-1-ene. Molecular formula: 70.13g/mol. Mole weight: C5H10. CC=C.C=C. InChI=1S/C3H6.C2H4/c1-3-2;1-2/h3H, 1H2, 2H3;1-2H2. HQQADJVZYDDRJT-UHFFFAOYSA-N. |  |
| APAO for bitumen modification | Liquid; OtherSolid. Group: Polymers. CAS No. 9010-79-1. Product ID: ethene; prop-1-ene. Molecular formula: 70.13g/mol. Mole weight: C5H10. CC=C.C=C. InChI=1S/C3H6.C2H4/c1-3-2;1-2/h3H, 1H2, 2H3;1-2H2. HQQADJVZYDDRJT-UHFFFAOYSA-N. | |
| APAO for plastic modification | Liquid; OtherSolid. Group: Polymers. CAS No. 9010-79-1. Product ID: ethene; prop-1-ene. Molecular formula: 70.13g/mol. Mole weight: C5H10. CC=C.C=C. InChI=1S/C3H6.C2H4/c1-3-2;1-2/h3H, 1H2, 2H3;1-2H2. HQQADJVZYDDRJT-UHFFFAOYSA-N. | |
| Apatamide impurity 36 | Apatamide impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-fluoro-4-hydroxy-N-methylbenzamide. CAS No. 1243392-80-4. Molecular formula: C8H8FNO2. Mole weight: 169.15. Catalog: APB1243392804. | |
| Apatamide impurity 8 | Apatamide impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1415552-04-3. Molecular formula: C9H6F3N3S. Mole weight: 245.22. Catalog: APB1415552043. | |
| Apatamide impurity 9 | Apatamide impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1513077-71-8. Molecular formula: C10H16N2O3. Mole weight: 212.25. Catalog: APB1513077718. | |
| Apatinib | Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Synonyms: Rivoceranib; YN968D1. Grade: 98%. CAS No. 811803-05-1. Molecular formula: C24H23N5O. Mole weight: 397.48. | |
| Apatinib-d8 free base | Apatinib-d 8 (free base) is the deuterium labeled Apatinib free base[1]. Apatinib free base (YN968D1 free base) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 (IC50=1 nM). Apatinib free base (YN968D1 free base) is an anti-angiogenic drug for the research of advanced or metastatic gastric cancer. Apatinib free base (YN968D1 free base) potently inhibits Ret, c-Kit and c-Src with IC50s of 13, 429 and 530 nM, respectively. It also inhibits cellular phosphorylation of VEGFR-2, c-kit and PDGFRβ[2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: YN968D1-d8 free base. CAS No. 2468771-43-7. Pack Sizes: 1 mg. Product ID: HY-13342AS. | |
| Apatinib-d8 hydrochloride | Apatinib-d 8 (hydrochloride) is the deuterium labeled Apatinib hydrochloride[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 2468771-44-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13342S. | |
| Apatinib mesylate | Apatinib mesylate is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. Uses: Antineoplastic agents. Synonyms: YN968D1. Grade: >98%. CAS No. 1218779-75-9. Molecular formula: C25H27N5O4S. Mole weight: 493.58. | |
| Apatorsen sodium | Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein. Uses: Scientific research. Group: Signaling pathways. Alternative Names: OGX-427 sodium. CAS No. 915443-09-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145722. | |
| Apaziquone | Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. Synonyms: 1H-INDOLE-4,7-DIONE, 5-(1-AZIRIDINYL)-3-(HYDROXYMETHYL)-2-(3-HYDROXY-1-PROPENYL)-1-METHYL-, (E)-; APAZIQUONE. CAS No. 141304-51-0. Molecular formula: C15H18O3. Mole weight: 246.3. | |
| Apaziquone | Apaziquone. Group: Biochemicals. Alternative Names: 5-(1-Aziridinyl)-3-(hydroxymethyl)-2-[(1E)-3-hydroxy-1-propen-1-yl]-1-methyl-1H-indole-4,7-dione; Apaziquone; EO 9; EO 9 (pharmaceutical); NSC 382456; NSC 382459; (E)-5-(1-Aziridinyl)-3-(hydroxymethyl)-2-(3-hydroxy-1-propenyl)-1-methyl-1H-Indole-4,7-dione. Grades: Highly Purified. CAS No. 114560-48-4. Pack Sizes: 2.5mg. Molecular Formula: C15H16N2O4, Molecular Weight: 288.3. US Biological Life Sciences. | Worldwide |
| APC-100 | APC-100 is an orally available, vitamin E derivative and androgen receptor (AR) antagonist with potential anti-oxidant, chemopreventative and antineoplastic activity. APC-100 binds to ARs in target tissues thereby inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. APC-100 may ultimately lead to an inhibition of growth in both AR-dependent and AR-independent prostate tumor cells. Uses: Antioxidants. Synonyms: 2,2,5,7,8-Pentamethyl-6-chromanol; Chromanol; 6-Hydroxy-2,2,5,7,8-pentamethylchroman; APC100; 3,4-Dihydro-2,2,5,7,8-pentamethyl-2H-1-Benzopyran-6-ol. Grade: 98%. CAS No. 950-99-2. Molecular formula: C14H20O2. Mole weight: 220.312. | |
| APC 366 | APC 366. Group: Biochemicals. Grades: Purified. CAS No. 158921-85-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| APC 366 | APC 366, an inhibitor of tryptase, has been found to reduce airway inflammation and block postchallenge airway hyperresponsiveness in vivo. Synonyms: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide. Grade: >98%. CAS No. 158921-85-8. Molecular formula: C22H28N6O4. Mole weight: 440.5. | |
| APC 366 | APC 366 is a selective inhibitor of mast cell tryptase ( K i =7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 158921-85-8. Pack Sizes: 5 mg. Product ID: HY-105999. | |
| APC-366 hydrochloride | APC-366, an amino acid derivative, has been found to be a mast cell tryptase inhibitor and was once studied against asthma by Celera Genomics Group. Ki: 7.1 μM. Synonyms: APC 366; APC 366; APC 366; AC1L42OR; N-(1-Hydroxy-2-naphthoyl)-L-arginine-L-prolinamide; 158921-85-8. Grade: 98%. CAS No. 178925-65-0. Molecular formula: C22H29ClN6O4. Mole weight: 477. | |
| APC 366 trifluoroacetate salt | APC 366 is a mast cell tryptase inhibitor with Ki of 7.1 μM for human recombinant enzyme. It is a selective inhibitor of mast cell tryptase, which has been shown to inhibit antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma. APC 366 can reduce maximum contractile response to histamine in isolated bronchial tissue from ovalbumin-sensitized guinea pigs. It can also reduce airway resistance and increases dynamic lung compliance in A. suum antigen-challenged pigs. Grade: ≥95%. Molecular formula: C22H28N6O4·xCF3COOH. Mole weight: 440.50. | |
| AP C5 | AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor with pIC50 of 7.2, which displays >20-fold selectivity for PKG2 over PKG1 and PKA. Synonyms: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine; AP-C5; APC5. Grade: ≥98%. CAS No. 2234272-10-5. Molecular formula: C16H13N5. Mole weight: 275.31. | |
| APC-6336 | APC-6336 is a Hepatitis C virus NS3 protein inhibitor. Synonyms: (2R)-2-[[2-[(6-carbamoyl-1H-benzimidazol-2-yl)methyl]-3-methylbenzimidazole-5-carbonyl]amino]-3-phosphonopropanoic acid; APC-6336; APC 6336; APC6336; UNII-4124YUO44Z; CRA-6336; 4124YUO44Z. Grade: >98%. CAS No. 263870-19-5. Molecular formula: C21H21N6O7P. Mole weight: 500.4. | |
| a-(p-Chlorophenyl)cinnamonitrile | White crystals. CAS No. 3695-93-0. Pack Sizes: Typically in stock: 10g, 50g. Mole weight: 239.7. MP/BP: M.P. 114-116. Order No: FR-0877. |  Frinton Laboratories |
| Apcin | Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 300815-04-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110287. | |
| Apcin | Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C), which is a large multimeric complex. It functions as a ubiquitin ligase, initiating the metaphase-anaphase transition and regulating ordered transitions through the cell cycle by controlling the ubiquitin-mediated proteolysis of cell cycle proteins. It competitively binds to the D-box binding site of Cdc20 and prevents substrate recognition and ubiquitylation required for continuation of mitosis. It synergistically increases apoptosis in multiple myeloma cells in combination with proTAME (prodrug of TAME). It also prolongs mitotic duration in RPE1 cells in combination with proTAME in vitro. It blocks mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Synonyms: 3-(2-Methyl-5-nitro-imidazol-1-yl)-N-(2,2,2-trichloro-1-phenylamino-ethyl)-propionamide; 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate; [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester. Grade: ≥98% by HPLC. CAS No. 300815-04-7. Molecular formula: C13H14Cl3N7O4. Mole weight: 438.65. | |
| Apcin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Apcin-A | Apcin-A is an anaphase-promoting complex (APC) inhibitor. Apcin-A interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Synonyms: Apcin-A; 1683617-62-0; 3-Aminopropyl (2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl)carbamate; starbld0000888; SCHEMBL22567019; EX-A5236; AKOS030257613; MS-25252; HY-130841; CS-0114386. CAS No. 1683617-62-0. Molecular formula: C10H14Cl3N5O2. Mole weight: 342.61. | |
| APcK110 | KIT inhibitor; inhibits phosphorylation of KIT, STAT3, STAT5 and Akt. Suppresses proliferation of OCI/AML3 cells (IC50 = 175 nM). Caspase-dependant apoptosis inducer. Synonyms: APcK 110; APcK-110; 6-(3,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine. Grade: >98%. CAS No. 1001083-74-4. Molecular formula: C34H49N5O6. Mole weight: 349.36. | |
| APcK 110 | APcK 110. Group: Biochemicals. Grades: Purified. CAS No. 1001083-74-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ApCp | ApCp, an avant-garde and unprecedented compound, used for studying an array of ailments, encompassing malignant neoplasms and immune-mediated disorders. Uses: Enzyme inhibitors. Synonyms: Adenosine, 5'-[hydrogen P-(phosphonomethyl)phosphonate]; Adenosine, 5'-(trihydrogen methylenediphosphonate); Adenosine, 5'-[hydrogen (phosphonomethyl)phosphonate]; Adenosine, 5'-methylenediphosphonate; α,β-Methylene adenosine 5'-diphosphate; α,β-Methylene-ADP; α,β-Methylene adenosine diphosphate; Adenosine α,β-methylenediphosphate; α,β-Methylene-5'-ADP; Adenosine 5'-(α,β-methylene)diphosphate; MethADP; AMPCP; 5'-Adenylyl methylenephosphonate. Grade: ≥ 95% by HPLC. CAS No. 3768-14-7. Molecular formula: C11H17N5O9P2. Mole weight: 425.23. | |
| APCP-363 | APCP-363 a bio-active chemical. Uses: Apcp-363 a bio-active chemical. Synonyms: CP-363; CP 363; CP363; APCP-363; APO-363; APCP 363; APO 363; APCP363; APO363; UNII-N1969I6FAP. 3-hydroxy-2-(1-methoxyethyl)-1,6-dimethylpyridin-4-one. Grade: ≥98%. CAS No. 340023-40-7. Molecular formula: C10H15NO3. Mole weight: 197.23. | |
| ApCpp | ApCpp is a highly intriguing and intricate biochemical compound with multifaceted role as a substrate for diverse enzymes. It has promising applications in research of ailments such as cancer, neurodegenerative disorders and metabolic syndromes of varied etiologies. Synonyms: (AMPCPP); Adenosine-5'-[(α,β)-methyleno]triphosphate, Sodium salt; α,β-Methyleneadenosine-5'-triphosphate. Grade: ≥ 98% by HPLC. CAS No. 7292-42-4. Molecular formula: C11H18N5O12P3 (free acid). Mole weight: 505.21 (free acid). | |
| ApCpp (Nic) | ApCpp (Nic) is a cutting-edge biomedical compound fostering a pivotal role in bolstering cellular energy compoundion. apCpp (Nic) is acutely augments mitochondrial function. Synonyms: P1-(5'-Adenosyl) P3-[5'-(1-β D-ribofuranosyl-nicotinamide)] [(α,β)-methyleno]triphosphate, Sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C22H30N7O16P3 (free acid). Mole weight: 741.43 (free acid). | |
| APD334 | This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920; 2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grade: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49. | |
| APD597 (JNJ-38431055) | APD597, also known as JNJ-38431055, is a potent and selective GPR119 agonist, which is potential useful for the treatment of type 2 diabetes. GPR119 agonists mediate a unique nutrient-dependent dual elevation of both insulin and glucagon like peptide 1/glucose-dependent insulinotropic peptide levels in vivo. Synonyms: APD597; APD-597; APD 597; JNJ-38431055; JNJ 38431055; JNJ38431055. Grade: 98%. CAS No. 897732-93-3. Molecular formula: C21H29N5O6S. Mole weight: 479.55. | |
| APD668 | APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively. Synonyms: APD668; APD-668; APD 668; JNJ28630368; JNJ-28630368; JNJ 28630368. Grade: 0.99. CAS No. 832714-46-2. Molecular formula: C21H24FN5O5S. Mole weight: 477.511. | |
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