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| Product | Description | |
|---|---|---|
| Autocamtide 2 | Autocamtide 2 is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Autocamtide II; H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine. Grade: ≥95%. CAS No. 129198-88-5. Molecular formula: C65H118N22O20. Mole weight: 1527.77. |  |
| Autocamtide 2, amide | Autocamtide 2, amide is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-NH2. Grade: ≥95%. Molecular formula: C65H119N23O19. Mole weight: 1526.79. | |
| Autocamtide 2-related inhibitory peptide | Autocamtide 2-related inhibitory peptide. Uses: For analytical and research use. CAS No. 167114-91-2. Mole weight: 1497.74. Catalog: AP167114912. |  |
| Autocamtide-2-Related Inhibitory Peptide | Autocamtide-2-related inhibitory peptide is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II) with I50 value of 40 nM. It is selective over PKC, PKA and CaM kinase IV. Synonyms: AIP; [Ala9]-Autocamtide 2. Grade: ≥97% by HPLC. CAS No. 167114-91-2. Molecular formula: C64H116N22O19. Mole weight: 1497.74. | |
| Autocamtide-2-related inhibitory peptide, myristoylated | Autocamtide-2-related inhibitory peptide, myristoylated is a CaM kinase II inhibitor. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. It blocks reinstatement of morphine-seeking behavior in vivo by pretreatment. Synonyms: AIP Myristoylated; Myr-AIP. Grade: >98%. CAS No. 201422-04-0. Molecular formula: C78H142N22O20. Mole weight: 1708.12. | |
| Autocamtide-2-related inhibitory peptide, myristoylated acetate | Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor that blocks the reinstatement of morphine-seeking behavior in vivo by pretreatment. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. Synonyms: AIP Myristoylated acetate; Myr-AIP acetate; N2-(1-Oxotetradecyl)-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-alanyl-L-leucine acetate; m-AIP acetate; Myristoylated autocamtide-2-related inhibitory peptide acetate; H-Lys(myristoyl)-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.CH3CO2H. Grade: ≥95%. Molecular formula: C80H146N22O22. Mole weight: 1768.15. | |
| Autocamtide-2-related inhibitory peptide TFA | Autocamtide-2-related inhibitory peptide TFA is a highly selective, specific and potent inhibitor of calmodulin-dependent protein kinase II (CaM kinase II). Synonyms: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.TFA; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine trifluoroacetic acid; Autocamtide-2-Related Inhibitory Peptide Trifluoroacetate; CaM kinase II inhibitor TFA salt. Grade: ≥98%. Molecular formula: C64H116N22O19.C2HF3O2. Mole weight: 1611.76. | |
| Autocamtide 2 TFA | Autocamtide 2 TFA is a highly selective synthetic peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay. Synonyms: H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH.TFA; L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-alpha-glutamyl-L-threonyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-leucine trifluoroacetic acid; Autocamtide 2 trifluoroacetate salt. Grade: ≥95%. Molecular formula: C67H119F3N22O22. Mole weight: 1641.79. | |
| Autogramin-1 | Autogramin-1 is a novel autophagy inhibitor that selectively targets the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A), and directly competes with cholesterol binding to the GRAMD1A StART domain. Synonyms: Autogramin 1; Autogramin1. Grade: >98%. CAS No. 2375541-73-2. Molecular formula: C23H27N5O5S. Mole weight: 485.56. | |
| autoinducer-2 kinase | The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. Group: Enzymes. Synonyms: lsrK (gene name). Enzyme Commission Number: EC 2.7.1.189. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3021; autoinducer-2 kinase; EC 2.7.1.189; lsrK (gene name). Cat No: EXWM-3021. |  |
| Autoinducing Peptide I | Autoinducing Peptide I is an autoinducing peptide (AIP) that activates the agr (accessory gene regulator) site to control the expression of extracellular proteins in S. aureus. Synonyms: AIP1; H-Tyr-Ser-Thr-cyclo(-Cys-Asp-Phe-Ile-Met); L-Methionine, L-tyrosyl-L-seryl-L-threonyl-L-cysteinyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-, (8→4)-thiolactone; L-Tyrosyl-L-seryl-N-{(3S,6S,9S,12S,15R)-9-benzyl-6-[(2S)-2-butanyl]-12-(carboxymethyl)-3-[2-(methylsulfanyl)ethyl]-2,5,8,11,14-pentaoxo-1-thia-4,7,10,13-tetraazacyclohexadecan-15-yl}-L-threoninamide. Grade: ≥95%. CAS No. 200010-29-3. Molecular formula: C43H60N8O13S2. Mole weight: 961.11. | |
| Autoinducing Peptide I | Autoinducing Peptide I is a cyclic octapeptide secreted by Staphylococcus aureus and can be used in vaccine research[1]. Uses: Scientific research. Category: Peptides. Alternative Names: AIP-I. CAS No. 200010-29-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4909. |  |
| Autophagy Compound Library | A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Targets include Autophagy inducers, Autophagy inhibitors, Proteasome, HIF, HDAC, Aurora Kinase, E3 Ligase, mTOR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3200. Categories: Autophagy Compounds Libraries. |  |
| Autophagy-IN-5 | Autophagy-IN-5 (Compound A9) is an inhibitor for autophagy with an EC50 of 0.736 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262888-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160896. | |
| Autophagy-IN-C1 | Autophagy-IN-C1 can induce apoptosis and block autophagy in hepatocellular carcinoma (HCC) cells. Synonyms: Autophagy-IN-C1; CHEMBL5082200; HY-141813; CS-0226365; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1S)-(6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)urea. Molecular formula: C29H28F6N4O2. Mole weight: 578.55. | |
| Autophagy inducer 3 | Autophagy inducer 3 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2691054-63-2. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146052. | |
| Autophinib | Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1644443-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101920. | |
| Autophinib | Autophinib is a novel potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin with IC50 values of 0.04 μM and 0.09 μM, respectively. Synonyms: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine. CAS No. 1644443-47-9. Molecular formula: C14H11ClN6O3. Mole weight: 346.73. | |
| Auxinole | Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression. Uses: Scientific research. Category: Signaling pathways. CAS No. 86445-22-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111444. | |
| Auxinole | Auxinole is a potent TIR1 antagonist. Auxinole binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex, suppressing auxin-responsive gene expression. Synonyms: BS-45814; HY-111444. Grade: 99%. CAS No. 86445-22-9. Molecular formula: C20H19NO3. Mole weight: 321.37. | |
| AUY954 | NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. NVP-AUY954 efficacy has been correlated with an accumulation of plasmacytoid dendritic cells (pDC), which may have therapeutic value in the treatment of multiple sclerosis. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: AUY954; AUY-954 free base; 820240-77-5; CHEMBL4579553; 820240-77-5 (free base); 3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid; 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid; N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-beta-alanine; AUY 954; GTPL2925; SCHEMBL2237377; BCP33492; BDBM50507187; AKOS040750638; NVP-AUY954; AUY-954; AUY 954; Q27074628; 3-{[2-(2-trifluoromethyl-biphenyl-4-yl)benzo[b]thiophen-5-ylmethyl]amino}propionic acid. Grade: ≥98%. CAS No. 820240-77-5. Molecular formula: C25H20F3NO2S. Mole weight: 455.5. | |
| AUZ 454 | AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 8.2 nM. AUZ 454 (K03861) inhibits CDK2 activity by competing with binding of activating cyclins. Uses: Scientific research. Category: Signaling pathways. Alternative Names: K03861. CAS No. 853299-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15004. | |
| AV-153 | AV-153, a derivative of 1,4-dihydropyridine (1,4-DHP), has antimutagenic and anticancer activity. It intercalates to DNA in a single strand break, reduces DNA damage and stimulates DNA repair in human cells in vitro. It interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. Synonyms: 3,5-Diethyl 1,4-dihydro-2,6-dimethyl-2,6-dimethyl-3,4,5-pyridinetricarboxylate monosodium salt; 3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-2,6-dimethyl-, 3,5-diethyl ester, monosodium salt; 2,6-Dimethyl-1,4-dihydro-3,5-bis(ethoxycarbonyl)pyridine-4-carboxylic acid sodium salt; Sodium 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylate. CAS No. 27296-05-5. Molecular formula: C14H18NNaO6. Mole weight: 319.29. | |
| AV-153 free base | AV-153 free base, a derivative of 1,4-dihydropyridine (1,4-DHP), has antimutagenic and anticancer activity. It intercalates to DNA in a single strand break, reduces DNA damage and stimulates DNA repair in human cells in vitro. It interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. Synonyms: 2,6-Dimethyl-1,4-dihydro-pyridine-3,4,5-tricarboxylic acid 3,5-diethyl ester; 3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydro-4-pyridinecarboxylic acid; 3,4,5-Pyridinetricarboxylic acid, 1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester; 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid. Grade: ≥95%. CAS No. 19350-66-4. Molecular formula: C14H19NO6. Mole weight: 297.30. | |
| AV-412 | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Synonyms: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. | |
| AV-412 Tosylate | AV-412 is a dual EGFR/ErbB2 kinase inhibitor. It completely inhibits the tumor growth of both H1650 and H1975 xenografts in nude mice. It is proved that AV-412 suppresses tumor growth via the inhibition of EGFR. Besides that, AV-412 also shows antitumor effects against various tumor models expressing EGFR, ErbB2 or both receptors, such as breast cancer KPL-4, prostate cancer DU145 and lung cancer LC-376. Uses: Antineoplastic agents. Synonyms: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate); MP-412; MP 412; MP412; AV-412; AV 412; AV412; AV-412 tosylate. Grade: >98%. CAS No. 451493-31-5. Molecular formula: C41H44ClFN6O7S2. Mole weight: 851.41. | |
| Ava10-Terlipressin | An impurity of Terlipressin. Terlipressin is a synthetic vasopressin analogue primarily used to improve kidney function in adults with hepatorenal syndrome (HRS), a condition that causes kidney problems in individuals with severe liver disease. It acts as a vasoconstrictor, predominantly in the splanchnic circulation, which helps increase arterial pressure and reduce portal venous pressure. Synonyms: Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Ava-Lys-Gly-NH2(Cys4&Cys9 bridge); [Ava10]-Terlipressin; GGGCYFQNC-Ava-KG-NH2(Cys4&Cys9 bridge); Ava(10)-Terlipressin; [5-Aminovaleric acid]10-Terlipressin; H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Ava-Lys-Gly-NH2 (Disulfide bridge: Cys4-Cys9); Glycyl-glycyl-glycyl-L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-5-aminopentanoate-L-lysyl-glycinamide (4->9)-disulfide. Grade: ≥95%. Molecular formula: C52H76N16O15S2. Mole weight: 1229.39. | |
| Ava23-Calcitonin (salmon) | An impurity of Calcitonin (salmon). Calcitonin (salmon) is a synthetic form of the hormone calcitonin, derived from salmon. It is a potent 32-amino acid peptide used primarily to manage bone health and calcium regulation. Calcitonin (salmon) is used to treat conditions such as postmenopausal osteoporosis, Paget's disease, and hypercalcemia. Synonyms: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Ava-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Cys1&Cys7 bridge); Ava Calcitonin; [Ava23]-Calcitonin (salmon); CSNLSTCVLGKLSQELHKLQTY-Ava-RTNTGSGTP-NH2(Cys1&Cys7 bridge); L-Cysteinyl-L-seryl-L-asparagyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-5-aminopentanoate-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide (1->7)-disulfide; Proline ring opening calcitonin (salmon); Calcitonin (salmon) (Proline ring opening); [5-Aminovaleric acid]23-calcitonin (salmon). Grade: ≥95%. Molecular formula: C145H242N44O48S2. Mole weight: 3433.91. | |
| Avacincaptad pegol | To treat geographic atrophy secondary to age-related macular degeneration. Category: Active pharmaceutical ingredients. Synonyms: ARC1905. CAS No. 1491144-00-3. Product ID: API1491144003. Molecular formula: C395H492N142O262P39F21((CH2)2O)n. Mole weight: 56 kDa. |  |
| Avacincaptad pegol | Avacincaptad pegol (Izervay) is a selective inhibitor targeting complement component C5, and is a pegylated ribonucleic acid aptamer. Avacincaptad pegol inhibits the cleavage of C5 into pro-inflammatory C5a and C5b, which forms the membrane attack complex (C5b-9), thereby reducing inflammatory cell recruitment and retinal cell damage. Avacincaptad pegol can slow the growth of geographic atrophy (GA) lesions and reduce the risk of persistent vision loss. Avacincaptad pegol can be used in research of geographic atrophy associated with age-related macular degeneration (AMD) and has been approved by the FDA[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Izervay. CAS No. 1613641-69-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148457. | |
| Avacincaptad pegol sodium | Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARC1905. CAS No. 1491144-00-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-147080. | |
| Avacopan | Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC50 of 0.1 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCX168. CAS No. 1346623-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17627. | |
| Avadomide | Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC 122. CAS No. 1015474-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100507. | |
| Avadomide hydrochloride | Avadomide hydrochloride. Alternative Names: CC 122 hydrochloride. CAS No. 1398053-45-6. Product ID: ACM-MG-1398053456. Molecular formula: C14H15ClN4O3. Mole weight: 322.75. IUPAC Name: 3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione;hydrochloride. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Avagacestat | Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM. Avagacestat can be used for Alzheimer disease research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-708163. CAS No. 1146699-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50845. | |
| Avagacestat | BMS-708163 is a potent and orally bioavailable inhibitor of γ-secretase that more potently inhibits the cleavage of APP (IC50 = 0.30 nM) to Aβ40 than signaling through Notch (IC50s = 58 nM). Uses: Gamma secretase inhibitors and modulators. Synonyms: Avagacestat; BMS 708163; (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide. Grade: >98%. CAS No. 1146699-66-2. Molecular formula: C20H17ClF4N4O4S. Mole weight: 520.89. | |
| Avanafil | Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM. Applications: Ed. Category: Other apis. Synonyms: 4-[[(3-Chloro-4-Methoxyphenyl)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;Avanafil PDE5 inhibitor. CAS No. 330784-47-9. Product ID: API330784479. Molecular formula: C23H26ClN7O3. Mole weight: 483.95. SMILES: C1(N2CCC[C@H]2CO)=NC=C(C(NCC2=NC=CC=N2)=O)C(NCC2=CC=C(OC)C(Cl)=C2)=N1. InChIKey: WEAJZXNPAWBCOA-INIZCTEOSA-N. Appearance: Solid. | |
| Avanafil | A phosphodiesterase. Group: Biochemicals. Alternative Names: (S) -2- (2-Hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) -5-[ (2-pyrimidinylmethyl) carbamoyl]pyrimidine; 4-[[ (3-Chloro-4-methoxyphenyl) methyl]amino]-2-[ (2S) -2- (hydroxymethyl) -1-pyrrolidinyl]-N- (2-pyrimidinylmethyl) -5-pyrimidinecarboxamide; TA 1790. Grades: Highly Purified. CAS No. 330784-47-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Avanafil | Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TA1790. CAS No. 330784-47-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18252. | |
| Avanafil | A phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. Synonyms: TA-1790; TA 1790; TA1790; Avanafil; trade name: Stendra; Spedra. Grade: 99%. CAS No. 330784-47-9. Molecular formula: C23H26ClN7O3. Mole weight: 483.95064. | |
| Avanafil Dichloride Impurity | Avanafil Dichloride Impurity. Uses: For analytical and research use. Molecular formula: C23H25Cl2N7O3. Mole weight: 518.4. Catalog: APB06512. | |
| Avanafil Impurity 1 | Avanafil Impurity 1. Uses: For analytical and research use. Alternative Names: (3,5-dichloro-4-methoxyphenyl)methanamine. Molecular formula: C8H9Cl2NO. Mole weight: 206.07. Catalog: APB02660. | |
| Avanafil Impurity 1 | Avanafil Impurity 1. Uses: For analytical and research use. CAS No. 372117-54-9. Molecular formula: C18H22ClN5O3. Mole weight: 391.86. Catalog: APB372117549. | |
| Avanafil Impurity 10 | Avanafil Impurity 10. Uses: For analytical and research use. CAS No. 1562434-91-6. Molecular formula: C14H14ClN3O4S. Mole weight: 355.79. Catalog: APB1562434916. | |
| Avanafil Impurity 10 | Avanafil Impurity 10. Uses: For analytical and research use. Alternative Names: (S)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-4-((4-methoxybenzyl)amino)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. CAS No. 330784-50-4. Molecular formula: C23H27N7O3. Mole weight: 449.51. Catalog: APB330784504. | |
| Avanafil Impurity 11 | Avanafil Impurity 11. Uses: For analytical and research use. Alternative Names: (3-chloro-4-methoxyphenyl)methanamine. Molecular formula: C8H10ClNO. Mole weight: 171.62. Catalog: APB02651. | |
| Avanafil Impurity 12 | Avanafil Impurity 12. Uses: For analytical and research use. Alternative Names: (4-methoxyphenyl)methanamine. Molecular formula: C8H11NO. Mole weight: 137.18. Catalog: APB02650. | |
| Avanafil Impurity 12 | Avanafil Impurity 12. Uses: For analytical and research use. CAS No. 330786-34-0. Molecular formula: C14H14ClN3O3S. Mole weight: 339.79. Catalog: APB330786340. | |
| Avanafil Impurity 13 | Avanafil Impurity 13 is an impurity of Avanafil, a medication prescribed for treating erectile dysfunction. Synonyms: 1,4,5,6-tetrahydropyrimidin-2-ylmethanamine; Avanafil Related Compound 1. Grade: > 95%. CAS No. 759408-08-7. Molecular formula: C5H11N3. Mole weight: 113.16. | |
| Avanafil Impurity 13 | Avanafil Impurity 13. Uses: For analytical and research use. Alternative Names: 4-(aminomethyl)-2-chlorophenol. Molecular formula: C7H8ClNO. Mole weight: 157.60. Catalog: APB02652. | |
| Avanafil Impurity 13 | Avanafil Impurity 13. Uses: For analytical and research use. CAS No. 36167-94-9. Molecular formula: C8H9Cl2NO. Mole weight: 206.07. Catalog: APB36167949. | |
| Avanafil Impurity 14 | Avanafil Impurity 14. Uses: For analytical and research use. CAS No. 759408-08-7. Molecular formula: C5H11N3. Mole weight: 113.16. Catalog: APB759408087. | |
| Avanafil Impurity 14 | Avanafil Impurity 14. Uses: For analytical and research use. Alternative Names: N-(3-chloro-4-methoxybenzyl)acetamide. Molecular formula: C10H12ClNO2. Mole weight: 213.66. Catalog: APB02648. | |
| Avanafil Impurity 15 | Avanafil Impurity 15. Uses: For analytical and research use. Alternative Names: ethyl 2,4-dihydroxypyrimidine-5-carboxylate. Molecular formula: C7H8N2O4. Mole weight: 184.15. Catalog: APB02649. | |
| Avanafil Impurity 15 | Avanafil Impurity 15. Uses: For analytical and research use. CAS No. 1202002-16-1. Molecular formula: C10H11N5. Mole weight: 201.23. Catalog: APB1202002161. | |
| Avanafil Impurity 16 | Avanafil Impurity 16. Uses: For analytical and research use. Alternative Names: 2,4-dihydroxypyrimidine-5-carboxylic acid. Molecular formula: C5H4N2O4. Mole weight: 156.1. Catalog: APB02647. | |
| Avanafil Impurity 17 | Avanafil Impurity 17. Uses: For analytical and research use. Alternative Names: 4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid. Molecular formula: C14H15N3O3S. Mole weight: 305.35. Catalog: APB02646. | |
| Avanafil Impurity 17 | Avanafil Impurity 17. Uses: For analytical and research use. CAS No. 2250242-12-5. Molecular formula: C20H26N4O4. Mole weight: 386.45. Catalog: APB2250242125. | |
| Avanafil Impurity 18 | Avanafil Impurity 18. Uses: For analytical and research use. Alternative Names: 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid compound with methane (1:1). Molecular formula: C15H17Cl2N3O3S. Mole weight: 390.28. Catalog: APB02786. | |
| Avanafil Impurity 19 | Avanafil Impurity 19. Uses: For analytical and research use. Alternative Names: ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-hydroxypyrimidine-5-carboxylate. Molecular formula: C15H16ClN3O4. Mole weight: 337.76. Catalog: APB02782. | |
| Avanafil Impurity 19 | Avanafil Impurity 19. Uses: For analytical and research use. CAS No. 2250243-52-6. Molecular formula: C20H26N4O4. Mole weight: 386.45. Catalog: APB2250243526. | |
| Avanafil Impurity 2 | Avanafil Impurity 2. Uses: For analytical and research use. Alternative Names: (2-chloro-4-methoxyphenyl)methanamine. Molecular formula: C8H10ClNO. Mole weight: 171.62. Catalog: APB02658. | |
| Avanafil Impurity 2 | Avanafil Impurity 2. Uses: For analytical and research use. CAS No. 211230-35-2. Molecular formula: C16H19N3O3S. Mole weight: 333.41. Catalog: APB211230352. | |
| Avanafil Impurity 20 | Avanafil Impurity 20. Uses: For analytical and research use. Alternative Names: ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)pyrimidine-5-carboxylate. Molecular formula: C16H18ClN3O4S. Mole weight: 383.85. Catalog: APB02783. | |
| Avanafil Impurity 21 | Avanafil Impurity 21. Uses: For analytical and research use. Alternative Names: ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfonyl)pyrimidine-5-carboxylate. Molecular formula: C16H18ClN3O5S. Mole weight: 399.85. Catalog: APB02784. | |
| Avanafil Impurity 22 | Avanafil Impurity 22. Uses: For analytical and research use. Alternative Names: ethyl 4-((3,5-dichloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)pyrimidine-5-carboxylate. Molecular formula: C16H17Cl2N3O4S. Mole weight: 418.29. Catalog: APB02781. | |
| Avanafil Impurity 23 | Avanafil Impurity 23. Uses: For analytical and research use. Alternative Names: 2-hydroxy-4-((4-methoxybenzyl)amino)pyrimidine-5-carboxylic acid. Molecular formula: C13H13N3O4. Mole weight: 275.26. Catalog: APB02780. | |
| Avanafil Impurity 24 | Avanafil Impurity 24. Uses: For analytical and research use. Alternative Names: 4-((3-chloro-4-methoxybenzyl)amino)-2-hydroxypyrimidine-5-carboxylic acid. Molecular formula: C13H12ClN3O4. Mole weight: 309.71. Catalog: APB02779. | |
| Avanafil Impurity 25 | Avanafil Impurity 25. Uses: For analytical and research use. Alternative Names: 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylsulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide. Molecular formula: C19H19ClN6O3S. Mole weight: 446.91. Catalog: APB02777. | |
| Avanafil Impurity 26 | Avanafil Impurity 26. Uses: For analytical and research use. Alternative Names: (S)-ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate. Molecular formula: C20H25ClN4O4. Mole weight: 420.89. Catalog: APB02778. | |
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