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An adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3uM, 18.8uM, and 42nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.CAS Number:37739-05-2. Group: Biochemicals. Grades: Highly Purified. CAS No. 37739-05-2. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences.
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Adenosine A1 Receptor Antagonist I, DPCPX (8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948)
A blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9nM, 130nM, 1.0uM, 4.0uM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 102146-07-6. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?, Primary Target: A1. US Biological Life Sciences.
A blood-brain barrier-permeant indenopyrimidinone that acts as a dual A1/A2A antagonist (Ki = 48.2 and 6.5nM, respectively, against agonist-induced cAMP response in A1- or A2A-expressing CHO-K1 cells) and effectively reverses D2 antagonist haloperidol- (1mg/kg; s.c.) induced catalepsy in both rats and mice (ED50 = 0.3 and <0.1mg/kg, respectively) in vivo by simultaneously reversing A1-mediated inhibition of DA (Dopamine) release and A2A-dependent inhibition of D2 receptor response to DA. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
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Adenosine A2A Receptor Agonist I, Hydrochloride (CGS 21680)
A xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27nM). Exhibits reduced affinity for A2B receptors (Ki = 67nM), but offers greater selectivity over A1R (Ki = 290nM) and A3R (88.8uM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Group: Biochemicals. Alternative Names: CGS-21680; 3- (4- (2- ( (6-amino-9- ( (2R, 3R, 4S, 5S) -5- (ethylcarbamoyl) -3, 4-di hydroxytetra hydrofuran-2-yl) -9H-purin-2-yl) amino) ethyl) phenyl) propanoic acid). Grades: Highly Purified. CAS No. 124182-57-6. Pack Sizes: 5mg. Molecular Formula: C23H29N7O6 HCl, Molecular Weight: 536. US Biological Life Sciences.
Worldwide
Adenosine A2A Receptor Antagonist II, SCH-58261 (2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261)
A highly potent and selective antagonist of adenosine A2A receptor (Ki = 600pM). Does not affect the activity of other adenosine receptors in any significant manner (Ki = 287nM; 5uM, and > 10uM for A1, A2B, and A3 receptors, respectively). Displays neuroprotective effects in cerebral ischaemia in rats, and shown to counteract Parkinsonian-like muscle rigidity in rats. CAS Number:160098-96-4. Group: Biochemicals. Grades: Highly Purified. CAS No. 160098-96-4. Pack Sizes: 10mg. Molecular Formula: C??H??N?O, Primary Target: A2A Receptor. US Biological Life Sciences.
A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9nM for human A3R, and 113nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6uM and 2.05uM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA-induced bronchoconstriction in an allergic murine model. Group: Biochemicals. Grades: Highly Purified. CAS No. 212329-37-8. Pack Sizes: 5mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences.
Worldwide
Adenosine amine congener
Adenosine amine congener is a water-soluble and potent A1 adenosine receptor agonist. Synonyms: N-(4-(2-((4-(2-((2-Aminoethyl)amino)-2-oxoethyl)phenyl)amino)-2-oxoethyl)phenyl)adenosine. Grades: 98%. CAS No. 96760-69-9. Molecular formula: C28H32N8O6. Mole weight: 576.6.
Adenosine is a nucleoside composed of a molecule of adenine attached to a ribofuranose moiety via a Beta-N9-Glycosidic bond. It plays an important role in biochemical processes, such as energy transfer. It is associated with skin health and is well known for anti-wrinkle properties. Adenosine Content: Min 15%. Uses: Anti-aging and anti-wrinkle creams, serums, and lotions. Group: Skin actives. CAS No. 58-61-7/7585-39-9. Appearance: White powder. Catalog: CI-SC-0717.
Adenosine Cyclic 2',3'-Phosphate 5'-Phosphate can be used in biological study for 2':3'-cyclic PAP, sulfuryl group acceptor in a reaction catalyzed by phenol sulfotransferase. It can also be used in biological study for effect of adenine nucleotides on myo-inositol-1,4,5-trisphosphate-induced calcium release. Group: Biochemicals. Grades: Highly Purified. CAS No. 4527-92-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H13N5O9P2, Molecular Weight: 409.19. US Biological Life Sciences.
Worldwide
Adenosine-d2
Adenosine-d 2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Adenine riboside-d2; D-Adenosine-d2. CAS No. 82741-17-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-B0228S6.
adenosine deaminase
Adenosine Deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Group: Enzymes. Synonyms: deoxyadenosine deaminase. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. ADA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4568; adenosine deaminase; EC 3.5.4.4; 9026-93-1; deoxyadenosine deaminase. Cat No: EXWM-4568.
Adenosine deaminase Bovine, Recombinant
Adenosine deaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Protein determined by biuret. Applications: Adenosine deaminase is useful in various molecular biology assays, such as glycerol release assays. adenosine deaminase is a potential target for treatments of combined immunodeficiency disease. Group: Enzymes. Synonyms: ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. ADA. Mole weight: 32.5-33 kDa. Activity: 60-130 units/mg protein; > 130 units/mg protein; 150-200 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 3.2 M (NH4)2SO4, 0.01 M potassium phosphate, pH 6.0. Source: E. coli. Species: Bovine. ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: NATE-0032.
Adenosine deaminase from Human, Recombinant
Adenosine deaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Applications: Adenosine deaminase (ada) is a key enzyme in purine metabolism and is essential for normal immune function. it is important in the study of immune system diseases such as rheumatoid arthritis. Group: Enzymes. Synonyms: ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. ADA. Activity: >1 U/mL. Storage: Store at -20°C. Source: E. coli. Species: Human. ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: NATE-1583.
Adenosine deaminase, microorganism
Adenosine deaminase (RnADA) (EC 3.5.4.4) is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RnADA. CAS No. 9026-93-1. Pack Sizes: 1 mg. Product ID: HY-114175.
Adenosine deaminase, Recombinant
Adenosine deaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system. Group: Enzymes. Synonyms: ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Enzyme Commission Number: EC 3.5.4.4. CAS No. 9026-93-1. Purity: > 90 %. ADA. Mole weight: About 53kDa (SDS-PAGE). Activity: 200U/mg protein. Appearance: White powder, lyophilized. Storage: Redissolved in 20% glycerol, 4°C, store at -20°C for long-term preservation, Avoid multiple freeze-thaw cycles. Source: E. coli. ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4. Cat No: NATE-1009.
Adenosine dialdehyde
Adenosine dialdehyde is an irreversible inhibitor of S-adenosylhomocysteine hydrolase (IC50 = 40 nM), blocking the conversion of SAH to homocysteine and adenosine. Synonyms: 2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal. Grades: ≥ 95 %. CAS No. 34240-05-6. Molecular formula: C10H11N5O4. Mole weight: 265.23.
Adenosine Ep Impurity A HCl
Adenosine Ep Impurity A HCl. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2922-28-3. Molecular Formula: C5H6ClN5. Mole Weight: 171.59. Catalog: APB2922283.
Adenosine Ep Impurity G
Adenosine Ep Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 58-63-9. Molecular Formula: C10H12N4O5. Mole Weight: 268.23. Catalog: APB58639.
Adenosine HCl
Adenosine HCl is a key component used to research various cardiac conditions acting as an antiarrhythmic compound. Synonyms: Adenosine hydrochloride; Adenosine (hydrochloride); 58056-57-8; (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol hydrochloride; 19065-22-6; (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; hydrochloride; SCHEMBL3836212; CS-0287134; EN300-215572; (2r,3r,4s,5r)-2-(6-Amino-9h-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride; (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride(1:x). CAS No. 58056-57-8. Molecular formula: C10H13N5O4·HCl. Mole weight: 303.70.
Adenosine impurities7 (Regardson impurity 8)
Adenosine impurities7 (Regardson impurity 8). Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C16H20N8O5. Mole Weight: 404.39. Catalog: APB06541.
Adenosine impurity 13
Adenosine impurity 13. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C15H22N6O5S. Mole Weight: 398.44. Catalog: APB06542.
Adenosine impurity 14
Adenosine impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 96392-15-3. Molecular Formula: C19H21N5O4. Mole Weight: 383.4. Catalog: APB96392153.
Adenosine impurity 15
Adenosine impurity 15. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C21H25N5O. Mole Weight: 363.5. Catalog: APB06543.
Adenosine impurity 16
Adenosine impurity 16. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C17H19N5. Mole Weight: 293.4. Catalog: APB06544.
Adenosine impurity 17
Adenosine impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 20859-00-1. Molecular Formula: C16H23N5O4S. Mole Weight: 381.45. Catalog: APB20859001.
Adenosine impurity 18
Adenosine impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10527-91-0. Molecular Formula: C9H9N5O2. Mole Weight: 219.2. Catalog: APB10527910.
Adenosine impurity 19
Adenosine impurity 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 149022-20-8. Molecular Formula: C10H12N5Na2O7P. Mole Weight: 391.19. Catalog: APB149022208.
Adenosine impurity 20
Adenosine impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 34369-07-8. Molecular Formula: C10H16N5Na2O14P3. Mole Weight: 569.16. Catalog: APB34369078.
Adenosine impurity 22
Adenosine impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 97540-22-2. Molecular Formula: C22H34N6O16S4. Mole Weight: 766.78. Catalog: APB97540222.
Adenosine impurity 23
Adenosine impurity 23. Uses: For analytical and research use. Group: Impurity standards. CAS No. 80791-87-3. Molecular Formula: C11H16N6O4. Mole Weight: 296.29. Catalog: APB80791873.
Adenosine impurity 24
Adenosine impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 141344-03-8. Molecular Formula: C11H14N6O3. Mole Weight: 278.27. Catalog: APB141344038.
adenosine kinase
2-Aminoadenosine can also act as acceptor. Group: Enzymes. Synonyms: adenosine kinase (phosphorylating). Enzyme Commission Number: EC 2.7.1.20. CAS No. 9027-72-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3034; adenosine kinase; EC 2.7.1.20; 9027-72-9; adenosine kinase (phosphorylating). Cat No: EXWM-3034.
Adenosine Kinase from Human, Recombinant
E.coli. Applications: Human adenosine kinase is an active and purified, 345-aa short form adk protein (39kda) cloned by rt-pcr amplification of mrna extracted from human hepatoma cells and expressed in e.coli. the sequence of the cloned adk (genbank accession number u50196) was confirmed by dna sequencing (100% identity). Group: Enzymes. Synonyms: ADK. Enzyme Commission Number: EC 2.7.1.20. CAS No. 9027-72-9. Mole weight: 39kDa. Activity: ≥ 0.200 unit/mg protein. Source: Human. Species: ADK. ADK; EC 2.7.1.20. Pack: stable lyophilized form. Cat No: NATE-1740.
Adenosine Methionine-D3
Adenosine Methionine-D3. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C15H19D3N6O5S. Mole Weight: 401.46. Catalog: APB06537.
Adenosine monophosphate
Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: AMP. CAS No. 61-19-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-A0181.
Adenosine Monophosphate (mixture of 2(3)-phosphate isomers)
An adenosine derivative that is a metabolite of adenosine-2:3-cyclic monophopshate. Group: Biochemicals. Alternative Names: 2(3')-Adenylic acid; 2(3')-AMP; Adenosine 2(3')-(Dihydrogen Phosphate); Adenosine 2(3')-Phosphate; NSC 210570. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences.
Adenosine N-benzoyl-3'-deoxy-2'-O-(1,1-difluoro-2-methoxyethyl)-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a cutting-edge and highly effective modified nucleoside utilized in advanced biomedical research. With a distinctive and intricate chemical arrangement, it possesses unparalleled potential in gene therapies and drug delivery systems. This nucleoside has shown promising outcomes in the treatment and study of various genetic disorders and diseases, including cancer. Its exceptional stability and efficiency are beneficial in advancing research in these fields. Synonyms: ( (2S, 3R, 4R, 5R) -5- (6-benzamido-9H-purin-9-yl) -4- (1, 1-difluoro-2-methoxyethoxy) -3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl (2-cyanoethyl) diisopropylphosphoramidite. CAS No. 2299279-70-0. Molecular formula: C49H55F2N8O7P. Mole weight: 936.98.
Adenosine, N-benzoyl-3'-deoxy-2'-O-(2-methoxyethyl)-3'-[[(4-methoxyphenyl)diphenylmethyl]amino] is a versatile and noteworthy biochemical compound extensively employed within the biomedical industry for the research of diverse ailments such as cancers. Synonyms: N-Benzoyl-3'-deoxy-2'-O- (2-methoxyethyl) -3'-[[ (4-methoxyphenyl) diphenylmethyl]amino]adenosine. CAS No. 2299278-12-7. Molecular formula: C40H40N6O6. Mole weight: 700.78.
Adenosine, N-benzoyl-3'-deoxy-2'-O-(2-methoxyethyl)-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is a potent phosphoramidite recompound widely employed for the research of modified oligonucleotides, particularly in the development of nucleotide-based drugs targeting specific diseases such as cancer, viral infections and genetic disorders. Synonyms: ( (2S, 3R, 4R, 5R) -5- (6-benzamido-9H-purin-9-yl) -4- (2-methoxyethoxy) -3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl (2-cyanoethyl) diisopropylphosphoramidite. CAS No. 2299277-93-1. Molecular formula: C49H57N8O7P. Mole weight: 901.
Adenosine, N-benzoyl-3'-deoxy-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-2'-O-2-propen-1-yl-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] is an exceptional compound used in the research of formidable malignancies, such as lymphoma and leukemia. Its utilization in the pursuit of innovative antiviral therapeutics that specifically target RNA viruses denotes its indispensable role. Synonyms: ( (2S, 3R, 4R, 5R) -4- (allyloxy) -5- (6-benzamido-9H-purin-9-yl) -3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl (2-cyanoethyl) diisopropylphosphoramidite. CAS No. 2299282-94-1. Molecular formula: C49H55N8O6P. Mole weight: 882.98.
Adenosine, N-benzoyl-3'-deoxy-3'-[[(4-methoxyphenyl)diphenylmethyl]amino]-2'-O-methyl-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI) is a complex chemical entity employed in the synthesis of oligonucleotides targeting viral infections and various cancers. The versatility of this remarkable molecule extends beyond biomedical research and treatment; it has the potential to alter genetic sequences, thereby opening new therapeutic avenues for myriad hitherto enigmatic human ailments. Its designation as a universally valuable synthetic building block in both academic and clinical milieus underscores its indispensability in biomedicine. Synonyms: ( (2S, 3R, 4R, 5R) -5- (6-benzamido-9H-purin-9-yl) -4-methoxy-3- ( ( (4-methoxyphenyl) diphenylmethyl) amino) tetrahydrofuran-2-yl) methyl (2-cyanoethyl) diisopropylphosphoramidite. CAS No. 329773-22-0. Molecular formula: C47H53N8O6P. Mole weight: 856.95.
Adenosine (N-Bz)
Adenosine (N-Bz) is an essential biomedical compound widely employed in the research of numerous cardiovascular disorders, comprising arrhythmias and angina pectoris. It can interact with adenosine receptors. Grades: ≥ 98% by HPLC. Molecular formula: C17H17N5O5. Mole weight: 371.35.
Adenosine (N-PAC)
Adenosine (N-PAC), a pharmaceutical-grade compound, is a multifaceted agent, possessing the ability to treat various cardiovascular disorders: arrhythmias, angina, and hypertension. Mechanistically, its mechanism of action lies in selectively inducing the activation of specific receptors in the heart. Its downstream effects manifest as a non-negligible reduction in heart rate, accompanied by a reciprocal elevation in blood flow. Additionally, Adenosine (N-PAC) has utility in the diagnosis and treatment of certain types of irregular heartbeats, serving as an invaluable tool in the evaluation of blood circulation in cardiac imaging. Grades: ≥ 98% by HPLC. Molecular formula: C18H19N5O6. Mole weight: 401.37.
adenosine nucleosidase
Also acts on adenosine N-oxide. Group: Enzymes. Synonyms: adenosinase; N-ribosyladenine ribohydrolase; adenosine hydrolase; ANase. Enzyme Commission Number: EC 3.2.2.7. CAS No. 9075-41-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3989; adenosine nucleosidase; EC 3.2.2.7; 9075-41-6; adenosinase; N-ribosyladenine ribohydrolase; adenosine hydrolase; ANase. Cat No: EXWM-3989.
Adenosine phosphate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 61-19-8. Molecular Formula: C10H14N5O7P. Mole Weight: 347.22. Catalog: APB61198.
adenosine-phosphate deaminase
Acts on AMP, ADP, ATP, NAD+ and adenosine, in decreasing order of activity. The bacterial enzyme can also accept the deoxy derivatives. cf. EC 3.5.4.6, AMP deaminase. Group: Enzymes. Synonyms: adenylate deaminase; adenine nucleotide deaminase; adenosine (phosphate) deaminase. Enzyme Commission Number: EC 3.5.4.17. CAS No. 37289-20-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4543; adenosine-phosphate deaminase; EC 3.5.4.17; 37289-20-6; adenylate deaminase; adenine nucleotide deaminase; adenosine (phosphate) deaminase. Cat No: EXWM-4543.
A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14nM, 20nM, 2.4uM and 6.2nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1uM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 35920-39-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Adenosine receptor antagonist 2
Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC 50 s of 1 nM and 3 nM, respectively. Adenosine receptor antagonist 2 has anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2703054-47-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144064.
Adenosine receptor antagonist 3
Adenosine receptor antagonist 3 is a potent antagonist of adenosine receptor. Adenosine receptor antagonist 3 has the potential for the research of cancer disease (extracted from patent WO2019233994A1, compound 1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2400864-80-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144419.
Adenosine receptor inhibitor 1
Adenosine receptor inhibitor 1 is a potent and selective adenosine receptor (AR) inhibitor with K i values of >1000, 68.5, >1000, >1000 nM for A 1 AR, A 2A AR, A 2B AR, A 3 AR, respectively. Adenosine receptor inhibitor 1 shows antinociceptive activity, anti-inflammatory effect and peripheral analgesic effect. Adenosine receptor inhibitor 1 has the potential for the research of cancer or neurodegenerative diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2550400-52-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-147907.
Adenosine (Ribose-1-D)
Nucleoside2H Labeled Compounds. CAS No. 119540-53-3. Molecular formula: C10H12DN5O4. Mole weight: 268.25. Appearance: White solid. Catalog: ACM119540533.
Adenosine (Standard)
Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 58-61-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0228R.
adenosine-tetraphosphatase
Also acts on inosine tetraphosphate and tripolyphosphate but shows little or no activity with other nucleotides or polyphosphates. Group: Enzymes. Enzyme Commission Number: EC 3.6.1.14. CAS No. 37289-26-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4598; adenosine-tetraphosphatase; EC 3.6.1.14; 37289-26-2. Cat No: EXWM-4598.
adenosinetriphosphatase
Many enzymes previously listed under this number are now listed separately under EC 3.6.3 and EC 3.6.4. Group: Enzymes. Synonyms: adenylpyrophosphatase; ATP monophosphatase; triphosphatase; ATPase (ambiguous); SV40 T-antigen; adenosine 5'-triphosphatase; ATP hydrolase; complex V (mitochondrial electron transport); (Ca2+ + Mg2+)-ATPase; HCO3--ATPase; adenosine triphosphatase. Enzyme Commission Number: EC 3.6.1.3. CAS No. 9000-83-3. Adenosine 5'-Triphosphatase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4614; adenosinetriphosphatase; EC 3.6.1.3; 9000-83-3; adenylpyrophosphatase; ATP monophosphatase; triphosphatase; ATPase (ambiguous); SV40 T-antigen; adenosine 5'-triphosphatase; ATP hydrolase; complex V (mitochondrial electron transport); (Ca2+ + Mg2+)-ATPase; HCO3--ATPase; adenosine triphosphatase. Cat No: EXWM-4614.
Adenosine Triphosphate, Disodium Salt (ATP-2Na)
UV Spectral Analysis: Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10g. US Biological Life Sciences.
Worldwide
adenosyl-chloride synthase
This enzyme, isolated from the marine bacterium Salinispora tropica, catalyses an early step in the pathway leading to biosynthesis of the proteosome inhibitor salinosporamide A. The enzyme is very similar to EC 2.5.1.63, adenosyl-fluoride synthase, but does not accept fluoride. Group: Enzymes. Synonyms: chlorinase; 5'-chloro-5'-deoxyadenosine synthase. Enzyme Commission Number: EC 2.5.1.94. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2833; adenosyl-chloride synthase; EC 2.5.1.94; chlorinase; 5'-chloro-5'-deoxyadenosine synthase. Cat No: EXWM-2833.
Adenosylcobalamin
Adenosylcobalamin (Coenzyme B12;Cobamamide;AdoCbl) is an active form of Vitamin B 12 which is a cofactor for methylmalonyl CoA mutase [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Coenzyme B12; Cobamamide; AdoCbl. CAS No. 13870-90-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-112790.
adenosylcobalamin/α-ribazole phosphatase
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica.It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin. Group: Enzymes. Synonyms: CobC; adenosylcobalamin phosphatase; α-ribazole phosphatase. Enzyme Commission Number: EC 3.1.3.73. CAS No. 251991-06-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3678; adenosylcobalamin/α-ribazole phosphatase; EC 3.1.3.73; 251991-06-7; CobC; adenosylcobalamin phosphatase; α-ribazole phosphatase. Cat No: EXWM-3678.
adenosylcobinamide-GDP ribazoletransferase
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. CobS catalyses the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with α-ribazole to yield adenosylcobalamin. Group: Enzymes. Synonyms: CobS; cobalamin synthase; cobalamin-5'-phosphate synthase; cobalamin (5'-phosphate) synthase. Enzyme Commission Number: EC 2.7.8.26. CAS No. 137672-85-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3325; adenosylcobinamide-GDP ribazoletransferase; EC 2.7.8.26; 137672-85-6; CobS; cobalamin synthase; cobalamin-5'-phosphate synthase; cobalamin (5'-phosphate) synthase. Cat No: EXWM-3325.
adenosylcobinamide hydrolase
Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB). Group: Enzymes. Synonyms: CbiZ; AdoCbi amidohydrolase. Enzyme Commission Number: EC 3.5.1.90. CAS No. 905988-16-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4482; adenosylcobinamide hydrolase; EC 3.5.1.90; 905988-16-1; CbiZ; AdoCbi amidohydrolase. Cat No: EXWM-4482.
adenosylcobinamide kinase
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin ...erase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin. Group: Enzymes. Synonyms: CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Enzyme Commission Number: EC 2.7.1.156. CAS No. 169592-51-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2985; adenosylcobinamide kinase; EC 2.7.1.156; 169592-51-2; CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Cat No: EXWM-2985.
adenosylcobinamide-phosphate guanylyltransferase
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, α-ribazole. The second branch of the nuclotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme Cob U. Th...s a two-stage reaction with formation of a CobU-GMP intermediate. Guanylylation takes place at histidine-46. Group: Enzymes. Synonyms: CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. Enzyme Commission Number: EC 2.7.7.62. CAS No. 169592-55-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3274; adenosylcobinamide-phosphate guanylyltransferase; EC 2.7.7.62; 169592-55-6; CobU; adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; AdoCbi kinase/AdoCbi-phosphate guanylyltransferas
adenosylcobinamide-phosphate synthase
One of the substrates for this reaction, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81, threonine-phosphate decarboxylase). Group: Enzymes. Synonyms: CbiB. Enzyme Commission Number: EC 6.3.1.10. CAS No. 905988-16-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5713; adenosylcobinamide-phosphate synthase; EC 6.3.1.10; 905988-16-1; CbiB. Cat No: EXWM-5713.
Requires Mg2+. NH3 can act instead of glutamine. This enzyme catalyses the four-step amidation sequence from cobyrinic acid a,c-diamide to cobyric acid via the formation of cobyrinic acid triamide, tetraamide and pentaamide intermediates. Group: Enzymes. Synonyms: CobQ; cobyric acid synthase; 5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase; Ado-cobyric acid synthase [glutamine hydrolyzing]. Enzyme Commission Number: EC 6.3.5.10. CAS No. 137672-90-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5803; adenosylcobyric acid synthase (glutamine-hydrolysing); EC 6.3.5.10; 137672-90-3; CobQ; cobyric acid synthase; 5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase; Ado-cobyric acid synthase [glutamine hydrolyzing]. Cat No: EXWM-5803.