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| Product | Description | |
|---|---|---|
| Brazzein | Brazzein is a sweet-tasting protein composed of 54 amino acids and is considered as a potential sugar substitute. Uses: Brazzein, a natural sweet protein derived from the fruit of the west african plant pentadiplandra brazzeana, has garnered significant attention in recent years for its potential applications in drug discovery. this unique protein, which is approximately 2,000 times sweeter than sucrose on a weight basis, possesses several properties that make it a promising candidate for various pharmaceutical and. Grade: 90%. Mole weight: 6473. |  |
| BrBzGCp2 | BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 ?M in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S-p-Bromobenzylglutathione cyclopentyl diester. CAS No. 166038-00-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136684. |  |
| BRCA1 human | recombinant, expressed in insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| BRCA1-IN-1 | A novel small-molecule-like BRCA1 inhibitor (IC50= 0.53 μM) (Ki= 0.71 μM). Synonyms: [(3S)-1,1-difluoro-3-[3-(1H-indol-3-yl)propanoylamino]-4-oxo-4-[[2-oxo-2-(4-phenylbutylamino)ethyl]amino]butyl]phosphonic acid. CAS No. 1622262-74-1. Molecular formula: C27H33F2N4O6P. Mole weight: 578.54. | |
| BRCA1-IN-2 | BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM. It shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions. Synonyms: N-(4-Phenylbutyl)-2-[[(2S)-2-[[3-(1H-indole-3-yl)propanoyl]amino]-3-(phosphonooxy)propanoyl]amino]acetamide. Grade: 98%. CAS No. 1622262-55-8. Molecular formula: C26H33N4O7P. Mole weight: 544.54. | |
| BRD0418 | BRD0418 is a TRIB1 inducer. BRD0418 modulates expression of TRIB1 involved in cholesterol and triglyceride biosynthesis, VLDL production and in LDL uptake in HepG2 cells. Synonyms: BRD-0418; BRD 0418. Grade: >98%. CAS No. 1565827-99-7. Molecular formula: C29H32N2O5. Mole weight: 488.58. | |
| BRD0539 | BRD0539 is a cell-permeable and reversible inhibitor of Streptococcus pyogenes Cas9 (SpCas9) with IC50 of 22 μM. Synonyms: BRD 0539; BRD-0539. CAS No. 1403838-79-8. Molecular formula: C25H25FN2O3S. Mole weight: 452.54. | |
| BRD0639 | BRD0639 is a first-in-class PRMT5 inhibitor. BRD0639 can support studies of PBM-dependent PRMT5 activities and the development of novel PRMT5 inhibitors that selectively target these functions. Synonyms: BRD 0639; BRD-0639; 1(6H)-Pyridazineacetamide, 4-chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-, (αS)-; (αS)-4-Chloro-α-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-1(6H)-pyridazineacetamide; (S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide. Grade: ≥95%. CAS No. 2760881-74-9. Molecular formula: C21H22ClN5O4S. Mole weight: 475.95. | |
| BRD0639 | BRD0639 is a potent PRMT5 inhibitor. BRD0639 engages the target in cells, disrupts PRMT5-RIOK1 complexes, and reduces substrate methylation. BRD0639 is a first-in-class PBM-competitive inhibitor that can support studies of PBM-dependent PRMT5 activities and the development of novel PRMT5 inhibitors that selectively target these functions. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BRD0639; BRD 0639; BRD-0639. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2760881-74-9. Molecular formula: C21H22ClN5O4S. Mole weight: 475.95. Purity: >98%. IUPACName: (S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide. Canonical SMILES: C[C@H](N1C(C=C(Cl)C=N1)=O)C(NC2=CC=C(C)C(S(=O)(NCCC3=NC=CC=C3)=O)=C2)=O. Product ID: ACM2760881749. Alfa Chemistry ISO 9001:2015 Certified. |  |
| BRD0705 | BRD0705 is a potent, paralog selective and orally active GSK3? inhibitor with an IC50 of 66 nM and a Kd of 4.8 ?M. BRD0705 displays increased selectivity for GSK3? (8-fold) versus GSK3? (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2056261-41-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116830. | |
| BRD0705 | BRD0705 is a potent, paralog selective and orally active inhibitor of Glycogen synthase kinase 3α (GSK3α) with IC50 of 66 nM and Kd of 4.8 μM. Synonyms: BRD 0705; BRD-0705. CAS No. 2056261-41-5. Molecular formula: C20H23N3O. Mole weight: 321.42. | |
| BRD1 (561-668) GST tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD1 (561-668) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD2 (339-459) GST tag human | recombinant, expressed in E. coli, ?86% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD2 (339-459) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD2 (65-187) GST tag human | recombinant, expressed in E. coli, ?81% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD2 (65-187) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD2, BD1, BD2 (65-459) GST tag human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD2 Inhibitor II, BIC1 (BRD2 Bromodomain-Interactive Compound, BIC1, 1-(2-(1H-Benzimidazol-2-ylsulfanyl)ethyl)-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione, 1-(2-(1H-Benzo[d]imidazol-2-ylthio)ethyl)-3-methyl-1H-benzo[d]imidazole-2(3H)-thione) | A cell-permeable benzimidazolyl-benzimidazolothione compound that directly interacts with BRD2-BD1 bromodomain reversibly (=28uM) and blocks the transcriptional activity of BRD2 in COS7 cells expressing Histac-K12 (<10uM). Shown to selectively disrupt BRD2 bromodomain-acetylated histone H4K12 association without modulating H4K12 acetylation; only weakly affect the interaction between the BRDT bromodomain (testis-specific bromodomain-containing protein) and acetylated histone H4. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| BRD32048 | The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 with KD of 17.1 μM, which reduces p300-dependent acetylation and stability of ETV1. Synonyms: BRD-32048; BRD 32048. Grade: ≥98%. CAS No. 433694-46-3. Molecular formula: C16H22N6O. Mole weight: 314.4. | |
| BRD32048 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD3 (29-145) GST tag human | recombinant, expressed in E. coli, ?81% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD3 (29-145) His tag human | recombinant, expressed in E. coli, ?88% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD3 (306-417) GST tag human | recombinant, expressed in E. coli, ?82% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD3 (306-417) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD3308 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD3308 | BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 ?M) or HDAC2 (IC50 of 1.34 ?M). BRD3308 suppresses pancreatic ?-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release. BRD3308 activates HIV-1 transcription and disrupts HIV-1 latency[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1550053-02-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19618. | |
| BRD3308 | BRD3308 is a highly selective HDAC3 inhibitor with IC50 of 54 nM. BRD3308 inhibits pancreatic β-cell apoptosis induced by inflammatory cytokines or glycolipid toxic stress, and increases the release of functional insulin. BRD3308 activates HIV-1 transcription and destroys the HIV-1 incubation period. Synonyms: 4-Acetylamino-N-(2-Amino-4-Fluorophenyl)-Benzamide; CHEMBL4293858; SCHEMBL15551809; BDBM178100. Grade: 98%. CAS No. 1550053-02-5. Molecular formula: C15H14FN3O2. Mole weight: 287.29. | |
| BRD3731 | BRD3731 is a selective inhibitor of GSK3β, with IC50s of 15 and 215 nM for GSK3β and GSK3α, respectively. It has potential for the study of post-traumatic stress disorder (PTSD), psychiatric disorder, diabetes and neurodegenerative disorders. Synonyms: 5H-Pyrazolo[3,4-b]quinolin-5-one, 3-(2,2-dimethylpropyl)-1,2,4,6,7,8-hexahydro-4,7,7-trimethyl-4-phenyl-, (4S)-; (4S)-3-(2,2-Dimethylpropyl)-4,7,7-trimethyl-4-phenyl-1,2,4,6,7,8-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one. Grade: ≥98%. CAS No. 2056262-07-6. Molecular formula: C24H31N3O. Mole weight: 377.52. | |
| BRD4 (342-460) GST tag human | recombinant, expressed in E. coli, ?75% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4 (342-460) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4354 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD 4354 | BRD 4354 is an HDAC5 and HDAC9 inhibitor (IC50 = 0.85 and 1.88 μM, respectively) displaying >20-fold selectivity for HDAC5/9 over HDAC1/2/3. It also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Synonyms: BRD4354; BRD 4354; BRD-4354; 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol. Grade: ≥98% by HPLC. CAS No. 315698-07-8. Molecular formula: C21H23ClN4O. Mole weight: 382.89. | |
| BRD 4354 ditrifluoroacetate | BRD 4354 ditrifluoroacetate is a moderately potent HDAC5 and HDAC9 inhibitor with IC50s of 0.85 and 1.88 μM, respectively. Synonyms: 8-Quinolinol, 5-chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-, 2,2,2-trifluoroacetate (1:2); 5-Chloro-7-[(4-ethyl-1-piperazinyl)(3-pyridinyl)methyl]-8-quinolinol trifluoroacetate (1:2). CAS No. 2444837-63-0. Molecular formula: C25H25ClF6N4O5. Mole weight: 610.93. | |
| BRD4 (49-170) GST tag human | recombinant, expressed in E. coli, ?82% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4 (49-170) His tag human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4770 | BRD4770 is a novel histone methyltransferase inhibitor. BRD4770 reduced cellular levels of di- and trimethylated H3K9 without inducing apoptosis, induced senescence, and inhibited both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. ATM-pathway activation, caused by either genetic or small-molecule inhibition of G9a, may mediate BRD4770-induced cell senescence. BRD4770 may be a useful tool to study G9a and its role in senescence and cancer cell biology. Synonyms: BRD4770; BRD-4770; BRD 4770. Grade: 0.98. CAS No. 1374601-40-7. Molecular formula: C25H23N3O3. Mole weight: 413.477. | |
| BRD4770 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4884 | BRD4884 is a selective HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 μM for HDAC1, 2, and 3. It possesses preferential binding kinetics with seven-fold longer half-life. BRD4884 crosses the blood brain barrier and has been evaluated in CK-p25 mice, a mouse model of neurodegeneration. It acts by enhancing the learning and memory processes. Synonyms: BRD-4884; BRD 4884. Grade: ≥98%. CAS No. 1404559-91-6. Molecular formula: C18H19FN2O2. Mole weight: 314.4. | |
| BRD4, BD1, BD2 (49-460) GST tag human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4, BD1, BD2 (49-460) His tag human | recombinant, expressed in E. coli, ?75% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| BRD4/CK2-IN-1 | BRD4/CK2-IN-1 is an effective and orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively. BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC). Molecular formula: C29H30ClN5O5. Mole weight: 564.03. | |
| BRD4 degrader-3 | BRD4 degrader-3 is a potent bromodomain BRD4 degrader extracted from patent WO2020055976A1, example 1a, has IC 50 s of 15.5 and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1]. PROTAC BRD4 Degrader-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413382-30-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136857. | |
| BRD4-IN-4 | BRD4-IN-4 (Compound 1) is a BRD4 inhibitor ( IC 50 =6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 304685-40-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153751. | |
| BRD4 ligand 6 TFA | BRD4 ligand 6 TFA is the TFA salt form of BRD4 ligand 6 (HY-161651). BRD4 ligand 6 TFA is a BRD4 ligand and can be used for synthesis of BRD4 PROTACs, such as PROTAC BRD4 Degrader-26 (HY-161650) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763548-61-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161651A. | |
| BRD5018 | BRD5018 is an antimalarial agent. CAS No. 2245231-51-8. Molecular formula: C33H38N4O4. Mole weight: 554.68. | |
| BRD5529 | BRD5529 is an effective dose-dependent CARD9-TRIM62 protein-protein interaction (PPI) inhibitor with an IC50 value of 8.6 ?M. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohns disease (CD) and ulcerative colitis (UC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1358488-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115497. | |
| BRD5529 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD5648 | BRD5648 is the inactive enantiomer of rac-BRD0705, which is a potent, paralog selective and orally active inhibitor of GSK3α. Synonyms: (R)-BRD0705; (R)-4-Ethyl-7,7-dimethyl-4-phenyl-6,7,8,9-tetrahydro-2H-pyrazolo[3,4-b]quinolin-5(4H)-one. Grade: 99%. CAS No. 2056261-42-6. Molecular formula: C20H23N3O. Mole weight: 321.42. | |
| BRD56491 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD6688 | BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 μM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1. It crosses the blood brain barrier and has been shown to rescue the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model of neurodegeneration. Synonyms: BRD-6688; BRD 6688. Grade: ≥98%. CAS No. 1404562-17-9. Molecular formula: C16H18N4O. Mole weight: 282.3. | |
| BRD-6929 | BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 849234-64-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100719. | |
| BRD6989 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD 6989 | BRD 6989 is a small molecule inhibitor with high selectivity for CDK8 over CDK19. It is an analog of the natural product cortistatin A (dCA), which inhibits CDK8 and upregulates IL-10. BRD 6989 selectively binds a complex of CDK8 with an IC50 of 200 nM. It also inhibits IFNγ-induced phosphorylation of STAT1 at Ser 727 site in BMDCs. It may be useful for inflammatory disorders. Synonyms: 2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile; BRD-6989; BRD6989. Grade: ≥98%. CAS No. 642008-81-9. Molecular formula: C16H16N4. Mole weight: 264.33. | |
| BRD7116 | BRD7116 is an inhibitor of leukemia stem cell (LSC) activity (EC50 = 200 nM) but does not affect normal hematopoietic stem cells or AML cells. Synonyms: BRD-7116; 2,2,3,3-tetramethyl-N-[4-[4-[(2,2,3,3-tetramethylcyclopropanecarbonyl)amino]phenyl]sulfonylphenyl]cyclopropane-1-carboxamide. Grade: >98%. CAS No. 329059-55-4. Molecular formula: C28H36N2O4S. Mole weight: 496.66. | |
| BRD7116 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD7389 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD 7389 | BRD 7389. Group: Biochemicals. Grades: Purified. CAS No. 376382-11-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| BRD 7389 | BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2, respectively). It upregulates insulin expression in mouse αTC1 pancreatic α cells. Synonyms: BRD7389; BRD-7389; BRD 7389; BAS 05532738; BAS05532738; BAS-05532738; 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione. Grade: ≥97% by HPLC. CAS No. 376382-11-5. Molecular formula: C24H18N2O2. Mole weight: 366.41. | |
| BRD73954 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD73954 | BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. Synonyms: BRD73954; BRD-73954; BRD 73954. Grade: >98%. CAS No. 1440209-96-0. Molecular formula: C16H16N2O3. Mole weight: 284.31. | |
| BRD7552 | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. Synonyms: BRD-7552; BRD 7552; BRD7552. Grade: 95%. CAS No. 1137359-47-7. Molecular formula: C33H33N3O15. Mole weight: 711.63. | |
| BRD7552 | BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and ? cell function[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1137359-47-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-19694. | |
| BRD7552 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD 7552 | PDX1 transcription factor inducer; up regulates PDX1 expression in both primary human islets and ductal cells. Induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. Increases insulin expression in PANC-1 cells, primary human islets and human duct-derived cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1137359-47-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BRD7-IN-1 | BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) and binds to a VHL ligand via a linker to form a PROTAC VZ185. Synonyms: 4-[3,5-Dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-2,7-naphthyridin-1(2H)-one dihydrochloride; 2,7-Naphthyridin-1(2H)-one, 4-[3,5-dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-, hydrochloride (1:2). Grade: ≥95%. CAS No. 2448414-48-8. Molecular formula: C22H28Cl2N4O3. Mole weight: 467.39. | |
| BRD7-IN-1 free base | BRD7-IN-1 free base is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185. Synonyms: 2,7-Naphthyridin-1(2H)-one, 4-[3,5-dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-; 4-[3,5-Dimethoxy-4-(1-piperazinylmethyl)phenyl]-2-methyl-2,7-naphthyridin-1(2H)-one. Grade: ≥95%. CAS No. 2305379-66-0. Molecular formula: C22H26N4O3. Mole weight: 394.47. | |
| BRD9539 | BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2) with an IC50 value of 6.3 μM. It is selective for G9a and PRC2 over SU39H1 and NDMT1 up to a concentration of 40 μM. BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. Synonyms: BRD-9539; BRD 9539. Grade: ≥98%. CAS No. 1374601-41-8. Molecular formula: C24H21N3O3. Mole weight: 399.4. | |
| BRD9539 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| BRD9757 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
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