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A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB). Group: Fluorescence/luminescence spectroscopy.
BQ-3020
BQ-3020. Group: Biochemicals. Grades: Purified. CAS No. 143113-45-5. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
BQ-3020
BQ-3020 is a potent and selective ETB endothelin receptor agonist (Ki = 0.18 and 970 nM at human ETB and ETA receptors, respectively). Synonyms: endothelin receptor antagonist; Acetyl-(Ala11·15)-Endothelin-1 (6-21). CAS No. 143113-45-5. Molecular formula: C96H140N20O25S. Mole weight: 2006.3.
BQ-610
A highly selective ETA receptor antagonist (IC?? = 20 nM) that attenuates ET-induced reduction in cardiac output. Group: Fluorescence/luminescence spectroscopy.
BQ-788 is a potent, selective ETB receptor antagonist with IC 50 of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC 50 of 1300 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 173326-37-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-15894A.
BQ-788
BQ-788 is a potent and selective ETB receptor antagonist with an IC50 of 1.2 nM. Synonyms: BQ-788 free acid; D-Norleucine, N-((cis-2,6-dimethyl-1-piperidinyl)carbonyl)-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-; N-cis-2,6-Dimethylpiperidinocarbonyl-β-tBu-Ala-D-Trp(1-methoxycarbonyl)-D-Nle-OH. Grade: 95%. CAS No. 173326-37-9. Molecular formula: C34H51N5O7. Mole weight: 641.80.
BQ 788 sodium salt
BQ 788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM) without significant activity on ETA receptor (IC50= 1300 nM). Uses: Antihypertensive agents. Synonyms: cis-N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine Monosodium Salt; N-[[(2R,6S)-2,6-Dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; (R)-2-((R)-2-((S)-2-((2S,6R)-2,6-Dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoic Acid Sodium Salt. Grade: 95%. CAS No. 156161-89-6. Molecular formula: C34H50N5NaO7. Mole weight: 663.78.
BQ-788 sodium salt
BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC 50 of 1.2 nM in human Girrardi heart cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 156161-89-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15894.
BQ-788 Sodium Salt
Highly selective ETB-receptor antagonist (IC50=1.2nM). BQ 788 is an endothelin type B (ETB) receptor antagonist and is a potential antidote for the cardiovascular toxicity with hypotension and bradycardia. Group: Biochemicals. Alternative Names: cis-N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine Monosodium Salt; N-[[(2R,6S)-2,6-Dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine Monosodium Salt; (R) -2- ( (R) -2- ( (S) -2- ( (2S, 6R) -2, 6-Dimethylpiperidine-1-carboxamido) -4, 4-dimethylpentanamido) -3- (1- (methoxycarbonyl) -1H-indol-3-yl) propanamido) hexanoic Acid Sodium Salt; N-cis-2, 6-Di methyl piperidinocarbonyl-BETA-tBu-Ala-D-Trp (1-methoxycarbonyl) -D-Nle; BQ 788. Grades: Highly Purified. CAS No. 156161-89-6. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
BQCA
BQCA a highly selective allosteric modulator of the M1 mAChR. Uses: Scientific research. Group: Signaling pathways. CAS No. 338747-41-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101858.
BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M1 receptor. Uses: A highly selective positive allosteric modulator of the m1 muscarinic acetylcholine receptor (machr). Synonyms: 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; 1,4-Dihydro-1-[(4-methoxyphenyl)methyl]-4-oxo-3-quinolinecarboxylic Acid. Grade: ≥98%. CAS No. 338747-41-4. Molecular formula: C18H15NO4. Mole weight: 309.32.
BQR695
BQR695 is a potent and selective PI4K inhibitor exhibiting potency against both human PI4KIIIβ and Plasmodium falciparum asexual blood stages (IC50?values of 90?nM and 71 nM, respectively). Uses: Antimalarial. Synonyms: NVP-BQR695; NVP-BQR-695; NVP-BQR 695; BQR695; BQR-695; BQR 695. NVP-BQR695; CS-8070; HY-18748; CS 8070; HY 18748; CS8070; HY18748; 2-[[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]amino]-N-methylacetamide. Grade: 99%. CAS No. 1513879-21-4. Molecular formula: C19H20N4O3. Mole weight: 352.39.
BQU57
BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Synonyms: BQU57; BQU 57; BQU-57. Grade: >98%. CAS No. 1637739-82-2. Molecular formula: C16H13F3N4O. Mole weight: 334.1.
Bromine is a dark reddish-brown fuming liquid with a pungent odor. Denser than water and soluble in water. Hence sinks in water. Toxic by inhalation. Accelerates the burning of combustible material. It is very corrosive to tissue and to metals.;GasVapor; Liquid;FUMING RED-TO-BROWN LIQUID WITH PUNGENT ODOUR.;Dark reddish-brown, fuming liquid with suffocating, irritating fumes.;Dark reddish-brown, fuming liquid with suffocating, irritating fumes. Group: Polymers. Product ID: molecular bromine. Molecular formula: 159.81g/mol. Mole weight: Br2;Br2. BrBr. InChI=1S/Br2/c1-2. GDTBXPJZTBHREO-UHFFFAOYSA-N.
BR-103354
BR-103354 is a fibroblast activation protein (FAP) inhibitor with IC50 of 14 nM. BR-103354 functions as an anti-diabetic and anti-NASH agent. Synonyms: BR 103354; BR103354. Grade: >98%. CAS No. 2505339-87-5. Molecular formula: C19H15F2N5O2S. Mole weight: 415.42.
brachyurin
From hepatopancreas of the fiddler crab, Uca pugilator. In peptidase family S1 (trypsin family). Other serine endopeptidases that degrade collagen, but are not listed separately here, include a second endopeptidase from Uca pugilator, digestive enzymes from other decapod crustacea, and an enzyme from the fungus Entomophthora coronata. Group: Enzymes. Synonyms: Uca pugilator collagenolytic proteinase; crab protease I; crab protease II. Enzyme Commission Number: EC 3.4.21.32. CAS No. 848900-32-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4127; brachyurin; EC 3.4.21.32; 848900-32-3; Uca pugilator collagenolytic proteinase; crab protease I; crab protease II. Cat No: EXWM-4127.
Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT), Human, Primer Pair Kit, Positive Control
Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT), Human, Primer Pair Kit, Positive Control. Group: Molecular Biology. Pack Sizes: 1Vial. US Biological Life Sciences.
Worldwide
Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT), Human, Primer Pair Kit, Primer
Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT), Human, Primer Pair Kit, Primer. Group: Molecular Biology. Pack Sizes: 1Vial. US Biological Life Sciences.
Worldwide
Braco-19
Braco-19 is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 351351-75-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523.
Braco-19
Braco-19 is a potent telomerase/telomere inhibitor that prevents telomerase catalysis. Braco-19, as a G-quadruplex (GQ) binding ligand, stabilizes GQ formation at 3V telomeric DNA overhang and produces rapid senescence or selective cell death. It is also an HAdV virus replication inhibitor. Uses: Cytostatic agents. Synonyms: N-(9-{[4-(dimethylamino)phenyl]amino}-6-[3-(pyrrolidin-1-yl)propanamido]acridin-3-yl)-3-(pyrrolidin-1-yl)propanamide; N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide; 9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyrrolodinopropionamido)acridine. Grade: ≥95%. CAS No. 351351-75-2. Molecular formula: C35H43N7O2. Mole weight: 593.76.
Braco-19 trihydrochloride is a potent telomerase/telomere inhibitor, preventing the capping and catalytic action of telomerase. Braco-19 acts as G-quadruplex (GQ) binding ligand, stabilizing G-quadruplexes formation at the 3V telomeric DNA overhang and produce rapid senescence or selective cell death. Braco-19 is also a HAdV virus replication inhibitor[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1177798-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15523A.
BRACO 19 trihydrochloride
BRACO 19 trihydrochloride is a telomerase inhibitor (IC50 = 115 nM) that suppresses the expression of human telomerase reverse transcriptase (hTERT) and induces cellular senescence. BRACO 19 was shown to inhibit growth of uterine cancer cells in vitro and growth of uterine tumor xenografts in mice. Synonyms: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride. Grade: ≥95% by HPLC. CAS No. 1177798-88-7. Molecular formula: C35H43N7O2.3HCl. Mole weight: 703.14.
Bractoppin
Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain. Bractoppin interrupts BRCA1 tBRCT-dependent cellular signals evoked by DNA damage. Bractoppin selectively inhibits substrate binding with nanomolar potency in vitro. Grade: 99%. CAS No. 2290527-07-8. Molecular formula: C25H23FN4O. Mole weight: 414.47.
Bractoppin
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2290527-07-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126020.
Bradanicline
Bradanicline acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studies, and was used as a potential treatment for schizophrenia and attention deficit disorder. It was used for Alzheimer's disease and cognitive impairment, but was discontinued. It was being developed by Targacept and was in phase II trials, but now it is terminated. Uses: Bradanicline was used as a potential treatment for schizophrenia and attention deficit disorder. it was used for alzheimer's disease and cognitive impairment. Synonyms: TC-5619; TC 5619; TC5619; N-[(2S,3R)-2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]-1-benzofuran-2-carboxamide; TC-5619-023; TC5619-023. Grade: 98%. CAS No. 639489-84-2. Molecular formula: C22H23N3O2. Mole weight: 361.44.
Bradanicline
Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC 50 =17 nM; K i = 1.4 nM). Bradanicline is used for the research of cognitive disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TC-5619. CAS No. 639489-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18060.
Bradanicline hydrochloride
Bradanicline hydrochloride is Alpha-7 Nicotinic Receptor Agonist. It showed cognitive enhancing effects in animal studies, and was being developed as a potential treatment for schizophrenia and attention deficit disorder. It was discontinued for Alzheimer's disease and cognitive impairment in schizophrenia in late 2013. It was also discontinued for ADHD, and no longer seems to be being developed. Uses: Bradanicline hydrochloride was being developed as a potential treatment for schizophrenia and attention deficit disorder. Synonyms: TC-5619; TC5619; TC-5619-023; TC5619-023; N-((2S,3R)-2-(pyridin-3-ylmethyl)quinuclidin-3-yl)benzofuran-2-carboxamide hydrochloride. Grade: >98%. CAS No. 1111941-90-2. Molecular formula: C22H24ClN3O2. Mole weight: 397.90.
Bradykinin
Bradykinin is a nonapeptide messenger produced from kallidin in the blood. Bradykinin has the selectivity for B2 over B1 receptors. It exhibits hypotensive and anti-inflammatory properties. Uses: Hypotensive agent. Synonyms: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine; L-Bradykinin; Kallidin I; Callidin I; Kallidin 9. Grade: ≥95%. CAS No. 58-82-2. Molecular formula: C50H73N15O11. Mole weight: 1060.21.
Bradykinin
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Peptides. CAS No. 58-82-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0206.
Bradykinin 1-3
Bradykinin 1-3, a 3-amino acid residue peptide fragment of Bradykinin, is an amino-truncated Bradykinin cleaved by Prolyl endopeptidase. Synonyms: Bradykinin (1-3); Arginyl-prolyl-proline; arginylprolylproline; L-Arginyl-L-prolyl-L-proline; H-RPP-OH. Grade: 95%. CAS No. 23815-91-0. Molecular formula: C16H28N6O4. Mole weight: 368.43.
Bradykinin(1-3)
Bradykinin(1-3). Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-ARG-PRO-PRO-OH SULFATE;H-ARG-PRO-PRO-OH SULFATE SALT;H-Arg-Pro-Pro-OH;arginyl-prolyl-proline;L-Proline, 1-(1-L-arginyl-L-prolyl)-. Product Category: Heterocyclic Organic Compound. CAS No. 23815-91-0. Molecular formula: C16H28N6O4. Mole weight: 466.51. Product ID: ACM23815910. Alfa Chemistry ISO 9001:2015 Certified.
Bradykinin (1-5)
Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE). Uses: Scientific research. Group: Peptides. CAS No. 23815-89-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1488.
Bradykinin 1-5
Bradykinin 1-5 is the main stable metabolite of Bradykinin and is formed by proteolysis of angiotensin-converting enzyme (ACE). Synonyms: H-RPPGF-OH; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanine; Bradykinin (1-5); Bradykinin Fragment 1-5; 1-5-Bradykinin (9Cl); N-[2-({[1-(Arginylprolyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-1-hydroxyethylidene]phenylalanine. Grade: ≥95%. CAS No. 23815-89-6. Molecular formula: C27H40N8O6. Mole weight: 572.66.
Bradykinin 1-6
Bradykinin 1-6, a stable metabolite of Bradykinin, is an amino-truncated Bradykinin peptide cleaved by carboxypeptidase Y (CPY). Synonyms: H-Arg-Pro-Pro-Gly-Phe-Ser-OH; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-serine; (S)-2-((S)-2-(2-((S)-1-((S)-1-((S)-2-amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoic acid; Bradykinin (1-6). Grade: 95%. CAS No. 23815-88-5. Molecular formula: C30H45N9O8. Mole weight: 659.73.
Bradykinin (2-9)
Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P. Uses: Scientific research. Group: Peptides. Alternative Names: Des-Arg1-bradykinin. CAS No. 16875-11-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1490.
Bradykinin 2-9
Bradykinin 2-9, a metabolite of Bradykinin, is an amino-truncated Bradykinin peptide cleaved by Aminopeptidase P. Synonyms: Des-Arg1-bradykinin; H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH; L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine; Bradykinin fragment 2-9; 2-9-Bradykinin. Grade: ≥95%. CAS No. 16875-11-9. Molecular formula: C44H61N11O10. Mole weight: 904.02.
Bradykinin acetate salt
Bradykinin Acetate is a physiologically and pharmacologically active peptide of kinin histone, which is composed of nine amino acids. The pharmacological properties of bradykinin include smooth muscle contraction, vasodilation and hypotension, increased capillary permeability, edema formation and pain induction. It can cause bronchoconstriction and rhinitis symptoms of nasal irritation in asthmatics. Synonyms: Bradykinin, acetate (1:x); Bradykinin, acetate (salt); H 1970; H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH.xCH3CO2H; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine acetate salt; L-Bradykinin acetate salt; Arginine, N2-[N-[1-[N-[N-[N-[1-(1-arginyl-L-prolyl)-L-prolyl]glycyl]-3-phenylalanyl]seryl]prolyl]-3-phenylalanyl]-, acetate salt; Bradykinin acetate. Grade: ≥95%. CAS No. 6846-3-3. Molecular formula: C50H73N15O11.xC2H4O2. Mole weight: 1060.21 (free base).
Bradykinin acetate salt
analytical standard. Group: Amino acid, peptide & protein standards.
Bradykinin Fragment 1-7 is a seven-membered oligopeptide. Synonyms: Arg-Pro-Pro-Gly-Phe-Ser-Pro; Des-8,9-BK. Grade: ≥97% by HPLC. CAS No. 23815-87-4. Molecular formula: C35H52N10O9. Mole weight: 756.85.
Bradykinin-GN_4 antimicrobial peptide precursor
Bradykinin-GN_4 antimicrobial peptide precursor is originally from Amolops granulosus.
Induces the release of nitric oxide. Other physiological functions include stimulation of pain receptors, inhibition of cAMP accumulation, and induction of smooth muscle contraction and vasodilation. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of heart via a nitric oxide-dependent mechanism. Group: Biochemicals. Grades: Highly Purified. CAS No. 58-82-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N??O??. US Biological Life Sciences.
Bradykinin-TR1 bradykinin-related peptide precursor is originally from Amolops granulosus.
Bradykinin triacetate
Bradykinin triacetate is a non-peptide messenger that is enzymatically produced from KALLIDIN in the blood. It is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Synonyms: Bradykinin, acetate (1:3); Bradykinin, triacetate (salt); Arginine, N2-[N-[1-[N-[N-[N-[1-(1-L-arginyl-L-prolyl)-L-prolyl]glycyl]-3-phenyl-L-alanyl]-L-seryl]-L-prolyl]-3-phenyl-L-alanyl]-, triacetate; Bradykinin acetate; H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH.3CH3CO2H; L-arginyl-L-prolyl-L-prolyl-glycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine acetic acid. Grade: ≥95%. CAS No. 5979-11-3. Molecular formula: C50H73N15O11.3C2H4O2. Mole weight: 1240.38.
B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor. It was equipotent against c-Raf. Synonyms: B-Raf-IN-1; B-Raf-IN 1; B-Raf-IN1; MDK36057; MDK-36057; MDK 36057. Grade: >98%. CAS No. 950736-05-7. Molecular formula: C29H24F3N5O. Mole weight: 515.53.
B-Raf IN 2
B-Raf IN 2 is a potent and selective BRAF inhibitor extracted from patent WO2021116055A1, compound Ia. CAS No. 2649372-20-1. Molecular formula: C20H17F2N5O4S. Mole weight: 461.44.
B-Raf inhibitor
aA B-Raf inhibitor, pyrazine and pyrrolo[2,3-b]pyridine derivatives, useful in the treatment of cancer and proliferative diseases. Synonyms: Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]-. Grade: >98%. CAS No. 1315330-11-0. Molecular formula: C29H31F3N6O2. Mole weight: 552.59.
BRAF inhibitor
BRAF inhibitor is a B-Raf inhibitor with anti-tumor activity extracted from patent WO/2011103196 A1, Compound P-0850. Uses: Scientific research. Group: Signaling pathways. CAS No. 918505-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10247.
B-Raf inhibitor 1
B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 μM and 2 nM for A375 proliferation and A375 p-ERK respectively. Synonyms: B-Raf Inhibitor 1; B-Raf-Inhibitor 1; B-Raf-Inhibitor-1; MDK0403; MDK-0403; MDK 0403. Grade: >98%. CAS No. 1093100-40-3. Molecular formula: C26H19ClN8. Mole weight: 478.94.
B-Raf inhibitor 1 dihydrochloride
B-Raf inhibitor 1 is an inhibitor of B-Raf kinase with IC50 values of 0.31μM and 0.72μM for cell proliferation, respectively in A375 and HCT116. B-Raf is important in signal transduction and some mutant B-Raf occurs in cancer cells. The most common mutation of these is V600E, which makes B-Raf kinase constitutively active. B-Raf inhibitor 1 belongs to the type IIA inhibitors and binds to the DFG-out ATP-binding site of B-Raf. The selectivity of B-Raf inhibitor 1 is less than of other type inhibitors. Besides mutant B-Raf, it can also inhibit wild type B-Raf and other tyrosine kinase. In cells with wild type B-Raf, B-Raf inhibitor 1 can activate the RAF-MEK-ERK signaling pathway via Raf dimerization. The preclinical toxicity test shows B-Raf inhibitor 1 can induce hyperplasia in a mouse model. Synonyms: 1,5-Isoquinolinediamine, N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-, hydrochloride (1:2). Grade: >98%. CAS No. 1191385-19-9. Molecular formula: C26H21Cl3N8. Mole weight: 551.86.
Br-AFP1
Br-AFP1 is originally from Brassica rapa subsp. chinensis.
Braftide
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF G469A with IC 50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells ( EC 50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence [1]. Uses: Scientific research. Group: Peptides. CAS No. 2411851-64-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10436.
Brahmawood. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Brahmawood;beta,2,2,3-Tetramethylcyclopent-3-ene-1-butanol. Product Category: Heterocyclic Organic Compound. CAS No. 72089-08-8. Molecular formula: C13H24O. Mole weight: 196.329060 [g/mol]. Purity: 0.96. IUPACName: 2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)butan-1-ol. Product ID: ACM72089088. Alfa Chemistry ISO 9001:2015 Certified.
Brain Microvascular Endothelial Cells, Human (Frozen)
Passage 2 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplements is recommended for culture. Cells have an average population doubling level of >15 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences.
Worldwide
Brain Microvascular Endothelial Cells, Human (T-25 flask)
Passage 2 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplements is recommended for culture. Cells have an average population doubling level of >15 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences.
Worldwide
Brain natriuretic peptide
Brain natriuretic peptide inhibits angiotensin II-induced blood pressure. Brain natriuretic peptide can be used in the control of blood pressure [1]. Uses: Scientific research. Group: Peptides. Alternative Names: BNP (1-32), human. CAS No. 114471-18-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-129067.
Brain natriuretic peptide
A brain natriuretic peptide secreted by the human heart in response to cardiac volume or pressure. Synonyms: Natriuretic factor, brain; Atrial natriuretic peptide B; B-Type natriuretic peptide; BNP; Brain natriuretic factor. Grade: ≥98%. CAS No. 114471-18-0. Molecular formula: C145H248N50O44S4. Mole weight: 3524.1.
Brain natriuretic peptide (1-32) (human)
An agonist at atrial natriuretic peptide (ANP) receptor A (NRP1) which is secreted from cardiac ventricles in response to volume increase and pressure overload. It exhibits natriuretic, vasodilatory and lusitropic activity and suppresses sympathetic and renin-angiotensin-aldosterone systems in vivo, and decreases de novo collagen synthesis as well as increases MMP gene expression in vitro. Synonyms: Brain Natriuretic Peptide-32 human; BNP-32 (human); Nesiritide; H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys(1)-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys(1)-Lys-Val-Leu-Arg-Arg-His-OH; L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminyl-glycyl-L-seryl-glycyl-L-cysteinyl-L-phenylalanyl-glycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-L-histidine (10->26)-disulfide. Grade: ≥99% by HPLC. CAS No. 124584-08-3. Molecular formula: C143H244N50O42S4. Mole weight: 3464.04.
Brain Natriuretic Peptide (1-32) (human) trifluoroacetate salt
Brain natriuretic peptide (BNP) (1-32) is an endogenous peptide that has cardiovascular functions and belongs to the family of natriuretic peptides. It is an agonist of natriuretic peptide receptors (NPRs) 1 and 3 with Kd values of 7.3 and 13 pM, respectively. It also binds to human recombinant NPR1 and NPR3 with IC50 values of 8 and 2.6 nM, respectively. It also relaxes contractions induced by prostaglandin F2α (PGF2α) in isolated porcine coronary artery and rat aortic strips (IC50s = 0.02 and 12.1 nM, respectively). Synonyms: BNP (1-32) (human). Grade: ≥95%. Molecular formula: C143H244N50O42S4·xCF3COOH. Mole weight: 3464.04.
Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a circulating form of mouse brain natriuretic peptide isolated from mouse heart with potent hypotensive and natriuretic potency [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: BNP-45, mouse. CAS No. 1816939-52-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2469.
Brain Natriuretic Peptide (BNP) (1-32), rat
Brain Natriuretic Peptide (BNP) (1-32), rat is a 32-amino acid polypeptide secreted by the ventricle in response to overstretching of cardiomyocytes. Synonyms: Brain Natriuretic Peptide-32 (rat); BNP (1-32), rat; H-Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys(1)-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys(1)-Asp-Gly-Leu-Arg-Leu-Phe-OH; L-asparagyl-L-seryl-L-lysyl-L-methionyl-L-alanyl-L-histidyl-L-seryl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-L-glutaminyl-L-lysyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-valyl-L-seryl-L-arginyl-L-leucyl-glycyl-L-cysteinyl-L-alpha-aspartyl-glycyl-L-leucyl-L-arginyl-L-leucyl-L-phenylalanine (10->26)-disulfide. Grade: 95%. CAS No. 133448-20-1. Molecular formula: C146H239N47O44S3. Mole weight: 3452.94.