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| Product | Description | |
|---|---|---|
| CF53 | CF53 is a selective, highly potent and orally active BET protein inhibitor, with a Ki of <1 nM, Kd of 2.2 nM and IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. It has potent antitumor activity in vitro and in vivo. Synonyms: N-(3-Cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-amine; BET inhibitor CF53; 9H-Pyrimido[4,5-b]indol-4-amine, N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethyl-4-isoxazolyl)-6-methoxy-2-methyl-; CF53 free base. Grade: ≥98%. CAS No. 1808160-52-2. Molecular formula: C24H25N7O2. Mole weight: 443.50. |  |
| CFDA-SE | CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus[1]. CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester. CAS No. 150347-59-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-D0938. |  |
| CFG920 | CFG920 is a Steroid 17-alpha-hydroxylase inhibitor originated by Novartis. It has potential antiandrogen and antineoplastic activities. It may inhibit cell proliferation of androgen-dependent tumor cells. In Jan 2013, Phase-I clinical trials in Prostate cancer in Spain was on-going, but now clinical trials for Prostate cancer is discontinued. Uses: Prostate cancer. Synonyms: CFG920; CFG 920; CFG-920; 1-(2-chloropyridin-4-yl)-3-(4-methylpyridin-3-yl)imidazolidin-2-one. Grade: 98%. CAS No. 1260006-20-9. Molecular formula: C14H13ClN4O. Mole weight: 288.73. | |
| CFI-400936 | CFI-400936 is a selective proteine kinase TTK inhibitor with IC50 value of 3.6nM. It demonstrates good activity in cell based assay and selectivity against a panel of human kinases. CFI-400936 shows potential anticancer activity. Uses: Anticancer. Synonyms: CFI400936; CFI 400936; CFI-400936. 2-(dimethylamino)-2-(2-ethylphenyl)-N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)acetamide. Grade: 98%. CAS No. 1338793-07-9. Molecular formula: C25H27N5O3S. Mole weight: 477.58. | |
| CFI-401870 | CFI-401870 is a TTK (tyrosine threonine kinase) Inhibitor with IC50 value < 10 nM. CFI-401870 showed low off-target activity (>500×) and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing. It has been selected for preclinical evaluation. Uses: Anti-tumor. Synonyms: CFI-401870; CFI 401870; CFI401870; N-((R)-cyclopropyl(pyridin-2-yl)methyl)-3-(4-((1R,3R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5-carboxamide. Grade: 98%. CAS No. 1430741-35-7. Molecular formula: C30H31N5O2. Mole weight: 493.61. | |
| CFI-401980 | CFI-401980, a pyrazolotriazin derivative, has been found to be a TTK inhibitor that could exhibit good antiproliferative activity in some human cancer cell lines. Ki = 0.8 nM. Synonyms: CFI-401980; CFI 401980; CFI401980; N-cyclopropyl-2-methyl-4-(2-phenoxy-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide. Grade: 98%. CAS No. 1610676-27-1. Molecular formula: C28H30N6O3. Mole weight: 498.59. | |
| CFLZ-171 formic acid salt | CFLZ-171 is an important intermediate to synthesis carfilzomib which is an anti-cancer drug acting as a selective proteasome inhibitor. Synonyms: CFLZ-171 formic acid salt; CFLZ 171 formic acid salt; CFLZ171 formic acid salt; carfilzomib intermediate molecule weight 171. 1Pentanone 2amino4methyl1(2R)2methyl2oxiranyl (2S) 222trifluoroacetate (1:1); 1Pentanone 2amino4methyl1(2R)2methyloxiranyl (2S) trifluoroacetate (9CI); S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one 2,2,2-trifluoroacetate. Grade: 98%. CAS No. 1140908-93-5. Molecular formula: C9H17NO2.CH2O2. Mole weight: 217.27. | |
| CFLZ-567 | CFLZ-567 is a key intermediate for making carfilzomib. carfilzomib is a selective proteasome inhibitor as an anti-cancer drug. Uses: Key intermediate for making carfilzomib. Synonyms: carfilzomib intermediate molecule weight 567; LPhenylalanine (S)2(4morpholinyl)acetylaminobenzenebutanoylLleucyl; LPhenylalanine (S)(4morpholinylacetyl)aminobenzenebutanoylLleucyl (9CI); (S)-2-((S)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic acid. Grade: 98%. CAS No. 868540-16-3. Molecular formula: C31H42N4O6. Mole weight: 566.69. | |
| CFM 1571 | CFM 1571 is a stimulator of nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 of 5.49 μM and IC50 of 2.84 μM. When adenylyl cyclase is not activated, it has no obvious inhibition on phosphodiesterases, and shows minimal inhibition of iNOS (25%) and nNOS (17%). It inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM), and has the potential to study cardiovascular and other diseases. Synonyms: 3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-1H-pyrazole-5-carboxamide; 1H-Pyrazole-5-carboxamide, 3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1-(phenylmethyl)-; 1-Benzyl-3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide; 1-benzyl-3-(3-dimethylaminopropyloxy)-5-(4-methoxyphenylaminocarbonyl)-1H-pyrazole. Grade: ≥95%. CAS No. 268725-86-6. Molecular formula: C23H28N4O3. Mole weight: 408.49. | |
| Cfm 1571 hydrochloride | Cfm 1571 hydrochloride. Alternative Names: CFM-1571; UNII-EE9FJW53Z2. CAS No. 1215548-30-3. Purity: >99 %. Product ID: ACM1215548303. Molecular formula: C23H28N4O3.HCl. Mole weight: 444.95. IUPAC Name: 2-benzyl-5-[3-(dimethylamino)propoxy]-N-(4-methoxyphenyl)pyrazole-3-carboxamide. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| CFM 1571 hydrochloride | CFM 1571 hydrochloride is a stimulator of nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 of 5.49 μM and IC50 of 2.84 μM. When adenylyl cyclase is not activated, it has no obvious inhibition on phosphodiesterases, and shows minimal inhibition of iNOS (25%) and nNOS (17%). It inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM), and has the potential to study cardiovascular and other diseases. Synonyms: 1-Benzyl-3-(3-(dimethylamino)propoxy)-N-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide Hydrochloride; 1H-Pyrazole-5-carboxamide, 3-[3-(dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-, hydrochloride (1:1); 3-[3-(Dimethylamino)propoxy]-N-(4-methoxyphenyl)-1-(phenylmethyl)-1H-pyrazole-5-carboxamide hydrochloride. Grade: ≥95%. CAS No. 1215548-30-3. Molecular formula: C23H29ClN4O3. Mole weight: 444.95. | |
| CFM 1571 hydrochloride | CFM 1571 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1215548-30-3. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CFM-2 | CFM-2. Group: Biochemicals. Grades: Purified. CAS No. 178616-26-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CFM-2 | Potent and selective AMPA antagonist. Synonyms: CFM-2; CFM 2; CFM2. Grade: >98%. CAS No. 178616-26-7. Molecular formula: C17H17N3O3. Mole weight: 311.34. | |
| CFM 4 | CFM 4 is a CARP-1 mimetic compound that inhibits CARP-1 binding to APC-2. It causes apoptosis and inhibition of cell growth in cancer cells. Synonyms: CFM-4; CFM 4; CFM4; 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one. Grade: ≥99% by HPLC. CAS No. 331458-02-7. Molecular formula: C22H16ClN3OS. Mole weight: 405.9. | |
| CFM 4 | CFM 4. Group: Biochemicals. Grades: Purified. CAS No. 331458-02-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| c-Fms-IN-1 | c-Fms-IN-1 is a c-FMS kinase inhibitor with an IC50 of 0.0008 μM. Synonyms: 5-Cyano-N-[4-(4-methyl-1-piperazinyl)-2-(1-piperidinyl)phenyl]-2-furamide; 2-Furancarboxamide, 5-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(1-piperidinyl)phenyl]-; 5-Cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide. Grade: ≥95%. CAS No. 885703-64-0. Molecular formula: C22H27N5O2. Mole weight: 393.48. | |
| c-Fms-IN-1 | c-Fms-IN-1 is a FMS kinase inhibitor with an IC50 of 0.0008 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 885703-64-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18791. | |
| c-Fms-IN-10 | c-Fms-IN-10 is a cFMS inhibitor (IC50 = 2 nM) with antitumor activity. Synonyms: 4-Amino-N-{3-methyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl}thieno[3,2-d]pyrimidine-7-carboxamide; Thieno[3,2-d]pyrimidine-7-carboxamide, 4-amino-N-[3-methyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl]-. Grade: ≥95%. CAS No. 1527517-50-5. Molecular formula: C22H19N7OS. Mole weight: 429.50. | |
| c-Fms-IN-2 | c-Fms-IN-2 is a c-FMS kinase inhibitor with an IC50 of 0.024 μM. Synonyms: 5-Cyanofuran-2-carboxylic Acid N-[5-hydroxymethyl-2-(4-methylpiperidin-1-yl)phenyl]amide; c-Fms inhibitor 2; 2-Furancarboxamide, 5-cyano-N-[5-(hydroxymethyl)-2-(4-methyl-1-piperidinyl)phenyl]-; 5-Cyano-N-[5-(hydroxymethyl)-2-(4-methyl-1-piperidinyl)phenyl]-2-furamide. Grade: ≥95%. CAS No. 791587-67-2. Molecular formula: C19H21N3O3. Mole weight: 339.39. | |
| c-Fms-IN-6 | c-Fms-IN-6 is a potent c-FMS inhibitor with an IC50 of ≤10 nM for unphosphorylated c-FMS. It weakly inhibits unphosphorylated c-KIT and PDGFR (IC50 >1 μM). It is used in the research of autoimmune diseases. Synonyms: 2-(5-{[2-(1-Ethyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy}-6-methyl-2-pyridinyl)-5-(2-methyl-2-propanyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 5-(1,1-dimethylethyl)-2-[5-[[2-(1-ethyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-6-methyl-2-pyridinyl]-2,4-dihydro-. Grade: ≥95%. CAS No. 1628574-81-1. Molecular formula: C22H25N7O2. Mole weight: 419.48. | |
| c-Fms-IN-7 | c-Fms-IN-7 is a cFMS inhibitor with an IC50 of 18.5 nM. (Extracted from patent WO2011079076A1, example159). Synonyms: N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(methylthio)imidazo[1,2-a]pyridine-3-carboxamide; N-{3-Cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl}-7-(methylsulfanyl)imidazo[1,2-a]pyridine-3-carboxamide; Imidazo[1,2-a]pyridine-3-carboxamide, N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]-1H-indazol-4-yl]-7-(methylthio)-. Grade: ≥95%. CAS No. 1313408-89-7. Molecular formula: C26H24N6OS. Mole weight: 468.57. | |
| c-Fms-IN-8 | c-Fms-IN-8 is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. Synonyms: (3-{4-[(4-Ethylbenzyl)oxy]-3-methoxyphenyl}-1-azetidinyl)[4-(2-hydroxyethoxy)-2-pyridinyl]methanone; Methanone, [3-[4-[(4-ethylphenyl)methoxy]-3-methoxyphenyl]-1-azetidinyl][4-(2-hydroxyethoxy)-2-pyridinyl]-. Grade: ≥95%. CAS No. 1255303-58-2. Molecular formula: C27H30N2O5. Mole weight: 462.54. | |
| c-Fms-IN-9 | c-Fms-IN-9, a c-FMS inhibitor, inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively. (Extracted from patent WO2014145023A1, Compound Example 7). Synonyms: 3-(tert-butyl)-1-(6-methyl-5-((2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl)oxy)pyridin-2-yl)-1H-1,2,4-triazol-5(4H)-one; 2-(6-Methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy}-2-pyridinyl)-5-(2-methyl-2-propanyl)-1,2-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 5-(1,1-dimethylethyl)-1,2-dihydro-2-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-. Grade: ≥95%. CAS No. 1628574-50-4. Molecular formula: C21H23N7O2. Mole weight: 405.45. | |
| c-FMS inhibitor | c-FMS inhibitor is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent. Synonyms: 1H-Pyrrole-2-carboxamide, 4-cyano-N-[4-(4-methyl-1-piperazinyl)-2-(4-methyl-1-piperidinyl)phenyl]-. Grade: >98%. CAS No. 885704-21-2. Molecular formula: C23H30N6O. Mole weight: 406.52. | |
| cFMS Receptor Inhibitor II | cFMS Receptor Inhibitor II is a colony stimulating factor-1 receptor (CSF1R) kinase inhibitor. CSF-1 is a cytokine. Synonyms: 3-Quinolinecarboxamide, 4-[(3,4-dimethylphenyl)amino]-7-(4-pyridinyl)-; 4-((3,4-dimethylphenyl)amino)-7-(pyridin-4-yl)quinoline-3-carboxamide; 4-[(3,4-Dimethylphenyl)amino]-7-(4-pyridinyl)-3-quinolinecarboxamide. Grade: ≥99%. CAS No. 959860-85-6. Molecular formula: C23H20N4O. Mole weight: 368.43. | |
| c-Fos Antibody [B8E19] | c-Fos Antibody [B8E19]. Group: Antibodies. Alternative Names: Protein c-Fos; Cellular oncogene fos; Fos proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 7; Proto-oncogene c-Fos; Transcription factor AP-1 subunit c-Fos; FOS; G0S7. CAS No. Pack Sizes: 20uL. Product ID: F4131. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| c-Fos-IN-1 | c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3125025-31-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-168895. | |
| CFSE | CFSE Inhibitor. Uses: Scientific use. Product Category: T6802. CAS No. 150347-59-4. |  |
| CFSE (CFDA-SE) | Carboxyfluorescein succinimidyl ester (CFSE, 5(6)-Carboxyfluorescein diacetate succinimidyl ester, CFDA-SE, 5(6)-CFDA N-succinmidyl ester) is a fluorescent cell staining dye. CFSE is frequently used in cell proliferation assay and motility assays. CFSE is cell permeable and covalently couples, via its succinimidyl group, to intracellular molecules, notably, to intracellular lysine residues and other amine sources. Group: Inhibitors. Alternative Names: Carboxyfluorescein succinimidyl ester, 5(6)-Carboxyfluorescein diacetate succinimidyl ester, CFDA-SE, 5(6)-CFDA N-succinmidyl ester. CAS No. 150347-59-4. Pack Sizes: 10mg. Product ID: S8269. Formula: C29H19NO11. Smiles: CC(=O)OC1=CC=C2C(=C1)OC3=C(C=CC(=C3)OC(C)=O)C24OC(=O)C5=CC(=CC=C45)C(=O)ON6C(=O)CCC6=O.CC(=O)OC7=CC=C8C(=C7)OC9=C(C=CC(=C9)OC(C)=O)C8%10OC(=O)C%11=CC=C(C=C%10%11)C(=O)ON%12C(=O)CCC%12=O. Storage Conditions: 3 years -20°C(in the dark) powder. | United States; Europe |
| CFT-1297 | CFT-1297 is a BET PROTAC degrader that can degrade BRD4[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2154353-03-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168546. | |
| CFT7455 | CFT7455 is an orally bioavailable MonoDAC targeting IKZF1/3 for the treatment of multiple myeloma (MM) and non-Hodgkin's lymphomas (NHL), including peripheral T-cell lymphoma (PTCL) and mantle cell lymphoma (MCL). Synonyms: Cemsidomide; CFT-7455; CFT 7455; (3S)-3-(6-((4-(Morpholin-4-ylmethyl)phenyl)methyl)-2-oxobenzo(cd)indol-1-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-(6-((4-(4-morpholinylmethyl)phenyl)methyl)-2-oxobenz(cd)indol-1(2H)-yl)-, (3S)-; (3S)-3-[6-[[4-(morpholin-4-ylmethyl)phenyl]methyl]-2-oxobenzo[cd]indol-1-yl]piperidine-2,6-dione; GTPL11961; GLXC-26095; (S)-CFT7455; EX-A6043; NSC840579; AKOS040758857; NSC-840579; BP-28982; MS-28680; HY-144841; CS-0435593; EN300-43393872; (3S)-3-(6-{[4-(morpholin-4-ylmethyl)phenyl]methyl}-2-oxobenz[cd]indol-1(2H)-yl]piperidine-2,6-dione; (3S)-3-[9-({4-[(morpholin-4-yl)methyl]phenyl}methyl)-3-oxo-2-azatricyclo[6.3.1.0,4,12]dodeca-1(12),4,6,8,10-pentaen-2-yl]piperidine-2,6-dione. CAS No. 2504235-67-8. Molecular formula: C28H27N3O4. Mole weight: 469.53. | |
| CFT8634 | CFT8634 is a BiDAC degrader targeting BRD9 for the treatment of cancers that are dependent on BRD9, as synovial sarcoma and SMARCB1 deleted cancers. Molecular formula: C37H45F3N6O5. Mole weight: 710.79. | |
| CFT8634 | CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991). CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers (such as synovial sarcoma and malignant rhabdoid tumor)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2704617-96-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145925B. | |
| CFTR activator 1 | CFTR activator 1 is a potent and selective CFTR activator, with an EC50 of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768261-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152264. | |
| CFTR corrector 4 | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1918142-34-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135279. | |
| CFTR corrector 4 | CFTR corrector 4, an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase the level of CFTR on the cell surface and has the potential to treat cystic fibrosis. Synonyms: 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[(2R,4R)-2-(3,4-dimethoxyphenyl)-7-methoxy-3,4-dihydro-2H-chromen-4-yl]cyclopropanecarboxamide; Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[(2R,4R)-2-(3,4-dimethoxyphenyl)-3,4-dihydro-7-methoxy-2H-1-benzopyran-4-yl]-. Grade: ≥95%. CAS No. 1918142-34-3. Molecular formula: C29H27F2NO7. Mole weight: 539.52. | |
| CFTR corrector 6 | CFTR corrector 6, a potent cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, has the potential for cystic fibrosis (CF) and other CFTR associated disorders research. Synonyms: 4-amino-7-((1-(2-fluorophenyl)-1H-pyrazol-4-yl)methyl)-5-(2-(trifluoromethyl)pyrimidin-5-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carbonitrile. Grade: ≥95%. CAS No. 2226970-01-8. Molecular formula: C22H13F4N9. Mole weight: 479.39. | |
| CFTR corrector 6 | CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226970-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136939. | |
| CFTR corrector 8 | CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1918142-35-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147249. | |
| CFTR(inh)-172 | CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 307510-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16671. | |
| CFTRinh 172 | CFTRinh 172. Group: Biochemicals. Grades: Purified. CAS No. 307510-92-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CFTRinh-172 | CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. Synonyms: CFTR Inh-172; CFTR Inh 172; CFTR Inh172; CFTR(Inh)-172; CFTR(Inh) 172; CFTR(Inh)172; CFTR Inhibitor-172; CFTR Inhibitor 172; CFTR Inhibitor172. Grade: >98%. CAS No. 307510-92-5. Molecular formula: C18H10F3NO3S2. Mole weight: 409.4. | |
| CFTRinh-172 | CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. Group: Inhibitors. Alternative Names: CFTR inhibitor 172. CAS No. 307510-92-5. Pack Sizes: 10mg. Product ID: S7139. Formula: C18H10F3NO3S2. Smiles: C1=CC(=CC(=C1)N2C(=O)C(=CC3=CC=C(C=C3)C(=O)O)SC2=S)C(F)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| CFTR Inhibitor-172 (CFTRinh-172, 3-[ (3-Trifluoromethyl) phenyl]-5-[ (4-carboxyphenyl) methylene]-2-thioxo-4-thiazolidinone) | A cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~300nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5uM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Group: Biochemicals. Grades: Highly Purified. CAS No. 307510-92-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CFZ | An antimycobacterial compound used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease. Synonyms: clofazimine; Lamprene; Lampren; Chlofazimine; N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine. Grade: 98%. CAS No. 2030-63-9. Molecular formula: C27H22Cl2N4. Mole weight: 473.4. | |
| CG200745 | CG200745 is a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI). Like other inhibitors, CG200745 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibited deacetylation of histone H3 and tubulin as much as vorinostat and belinostat did. CG200745 also inhibited growth of prostate cancer cells, increased sub-G1 population, and activated caspase-9, -3 and -8 in LNCaP, DU145 and PC3 cells. These results indicate that CG200745 induces apoptosis. The preclinical results show that combination treatment with docetaxel and new HDACI, CG200745, potentiated anti-tumor effect in hormone-refractory prostate cancer (HRPC) cells via activation of apoptosis. Synonyms: Ivaltinostat; CG-200745; CG-2; (E)-N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalen-1-yloxy)methyl)oct-2-enediamide. CAS No. 936221-33-9. Molecular formula: C24H33N3O4. Mole weight: 427.55. | |
| c[G(2',5')p-2'-AHC-A(3',5')p] | c[G(2',5')p-2'-AHC-A(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator, which can be used as a ligand for affinity chromatography or for coupling of labelling structures such as fluorophores. Synonyms: Cyclic (guanosine- (2' -≥ 5')- monophosphate- 2'- O- (6- aminohexylcarbamoyl)adenosine- (3' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C27H38N12O14P2 (free acid). Mole weight: 816.6 (free acid). | |
| c[G(2',5')p-2'-Biotin-16-A(3',5')p] | c[G(2',5')p-2'-Biotin-16-A(3',5')p] is an analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator. It is a potential tracer in immunoassays and commonly used for affinity chromatography and pull-down assays. Grade: ≥ 95% by HPLC. Molecular formula: C43H63N15O17P2S (free acid). Mole weight: 1156.1 (free acid). | |
| c[G(2',5')p-2'-dA(3',5')p] | c[G(2',5')p-2'-dA(3',5')p] is a 2'-deoxy analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING stimulator, which can be used for studying ligand-receptor interactions. Synonyms: Cyclic (guanosine- (2' -≥ 5')- monophosphate- 2'- deoxyadenosine- (3' -≥ 5')- monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H24N10O12P2 (free acid). Mole weight: 658.4 (free acid). | |
| c[G(2',5')p-2'-Fluo-AHC-A(3',5')p] | c[G(2',5')p-2'-Fluo-AHC-A(3',5')p] is a fluorescent analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger and STING activator. Synonyms: Cyclic(guanosine-(2'→5')-monophosphate-2'-O-(6-[fluoresceinyl]aminohexylcarbamoyl)adenosine-(3'→5')-monophosphate), sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C48H48N12O20P2. Mole weight: 1174.9. | |
| c[G(2',5')p-ε-A(3',5')p] | c[G(2',5')p-ε-A(3',5')p] is a fluorescent analogue of c[G(2',5')pA(3',5')p]. Grade: ≥ 95% by HPLC. Molecular formula: C22H24N10O13P2 (free acid). Mole weight: 698.4 (free acid). | |
| c[G(2',5')pG(2',5')p] | c[G(2',5')pG(2',5')p] is a cyclic dinucleotide analogue of c-diGMP, the bacterial second messenger. Synonyms: Cyclic diguanosine- (2' -≥ 5')- monophosphate / cyclic bis (2' -≥ 5') diguanylic acid, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 389873-75-0. Molecular formula: C20H24N10O14P2 (free acid). Mole weight: 690.4 (free acid). | |
| c[G(2',5')pS-A(3',5')pS], isomer 1 and isomer 2 | c[G(2',5')pS-A(3',5')pS] is an isomeric di-thiophosphate analogue of c[G(2',5')pA(3',5')p], the metazoan cyclic dinucleotide second messenger. It is resistant against the 2'3'-cGAMP hydrolysing enzyme ENPP1, and compared to natural 2'3'-cGAMP, it exhibits higher potency in inducing IFN-β secretion from human THP1 monocytes. Grade: ≥ 95% by HPLC. CAS No. 1638242-56-4 / 1638243-00-1. Molecular formula: C20H24N10O11P2S2 (free acid). Mole weight: 706.6 (free acid). | |
| CG347B | CG347B is a selective inhibitor of histone deacetylase 6 (HDAC6). Synonyms: 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester; 5-Pyrimidinecarboxylic acid, 2-[(1-phenylcyclopropyl)amino]-, ethyl ester; Ethyl 2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxylate. Grade: ≥98%. CAS No. 1598426-03-9. Molecular formula: C16H17N3O2. Mole weight: 283.33. | |
| CG428 | CG428 is a potent and selective CRBN-dependent tropomyosin receptor kinase (TRK) PROTAC degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 TPM3-TRKA fusion protein in KM12 colorectal carcinoma cells (DC50 = 0.36 nM) and inhibits downstream PLCγ1 phosphorylation (IC50 = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (Kd = 1 nM, 28 nM and 4.2 nM, respectively). CG428 can be used for the research of colorectal carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2412055-93-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-137465. | |
| CGA 41-60 | CGA 41-60 has antifungal activity. The source of CGA 41-60 is synthetic construct. Synonyms: chromogranin A 41-60. Grade: >95% by HPLC. | |
| CGA 41-70 | The source of CGA 41-70 is synthetic construct. CGA 41-70 has antifungal activity against N.crassa (MIC=7 microM), A. brassicicola (MIC=7 microM), N.hematococca (MIC=7 microM), F.culmorum (MIC=10 microM), F.oxyporum (MIC=30 microM), and T.mentagrophytes (MIC=30 microM). Synonyms: chromogranin A 41-70. | |
| CGA 47-60 | CGA 47-60 has antifungal activity. The source of CGA 47-60 is synthetic construct. Synonyms: chromogranin A 47-60. Grade: >98% by HPLC. | |
| CGA 47-70 | The source of CGA 47-70 is synthetic construct. It has antifungal activity against N.crassa (MIC=5 microM), A.fumigatus (MIC=30 microM), A. brassicicola (MIC=10 microM), N.hematococca (MIC=7 microM), F.culmorum (MIC=10 microM), F.oxyporum (MIC=30 microM), and T.mentagrophytes (MIC=30 microM). Synonyms: chromogranin A 47-70. | |
| cGAMP | cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclic GMP-AMP; 3',3'-cGAMP. CAS No. 849214-04-6. Pack Sizes: 10 mM * 1 mL in Water; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12512. | |
| cGAMP disodium | cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium. CAS No. 2407516-83-8. Pack Sizes: 10 mM * 1 mL in Water; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-110385. | |
| cGAMP disodium | cGAMP diammonium activates stimulator of interferon genes (STING). cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. Synonyms: 3',3'-cGAMP disodium salt; 3'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide, disodium salt; 2',3'-CGAMP disodium salt; 3',3'-Cyclic guanosine adenosine monophosphate disodium salt; Cyclic [G(3',5')pA(3',5')p] disodium salt; Cyclic AMP-GMP disodium salt; Cyclic GMP-AMP disodium salt; Cyclic (adenosine monophosphate-guanosine monophosphate) disodium salt. Grade: 98%. CAS No. 2407516-83-8. Molecular formula: C20H22N10Na2O13P2. Mole weight: 718.37. | |
| cGAS Antibody [L20A17] | cGAS Antibody [L20A17]. Group: Antibodies. Alternative Names: Cyclic GMP-AMP synthase; cGAMP synthase; cGAS; m-cGAS; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1; Cgas; Mb21d1. Pack Sizes: 20uL. Product ID: F4205. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| cGAS-IN-2 | cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with IC50 of 0.01512 μM for h-cGAS[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765273-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160546. | |
| cGAS-IN-4 | cGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC50 of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC50 of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149)-induced acute liver injury in mouse models[1].orally active, THP-1, C57Bl/6 mouse, orally active. Uses: Scientific research. Category: Signaling pathways. CAS No. 2987886-49-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-170362. | |
| CGC-11047 | CGC-11047 is a second generation polyamine analogue, synthesized through the restriction of molecular conformations of parent polyamine compounds, with potential antineoplastic activity. Polyamine analogue PG11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth. Synonyms: CGC 11047; CGC11047; SL 11047; SL 47; SL47. CAS No. 206991-64-2. Molecular formula: C14H36Cl4N4. Mole weight: 402.27. | |
| CGEHSDYKHY | CGEHSDYKHY. Synonyms: Cys-Gly-Glu-His-Ser-Asp-Tyr-Lys-His-Tyr. | |
| CGGRGD acetate | CGGRGD acetate is a RGD derivative with cysteine as the n-terminal. CGGRGD was synthesized by solid phase peptide synthesis technology, and amino2-cyanobenzothiazole (2-cyanobenzothiazole) (2-cyanobenzothiazole (CBT) was added on the surface of PCL fiber for ammoniation. Molecular formula: C21H37N9O11S. Mole weight: 623.65. | |
| CGH 2466 dihydrochloride | CGH 2466 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1177618-54-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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