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This enzyme, which forms part of the aerobic cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP-dependent. It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST. Hydrogenobyrinic acid is a very poor substrate. ATP can be replaced by dATP or CTP but the reaction proceeds more slowly. CobN exhibits a high affinity for hydrogenobyrinic acid a,c-diamide. The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding. Once the Co2+ is inserted, the next step in the pathway ensures that the cobalt is ligated securely by reducing Co(II) to Co(I). This step is carried out by EC 1.16.8.1, cob(II)yrinic acid a,c-diamide reductase. Group: Enzymes. Synonyms: hydrogenobyrinic acid a,c-diamide cobaltochelatase; CobNST; CobNCobST. Enzyme Commission Number: EC 6.6.1.2. CAS No. 81295-49-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5828; cobaltochelatase; EC 6.6.1.2; 81295-49-0; hydrogenobyrinic acid a,c-diamide cobaltochelatase; CobNST; CobNCobST. Cat No: EXWM-5828.
Cobaltous chloride co 57
Cobaltous chloride co 57. CAS No. 16413-89-1. Product ID: ACM16413891. Alfa Chemistry - ISO 9001:32057 Certified.
Cobalt Oxide
Cobalt Oxide. CAS No. 1308-06-1. Molecular Formula Co3O4. Chemical Reagents
Cobalt pellets 1/4x1/4. Grades: 99.95% Extremely High (>=99%). CAS No. 7440-48-4. Pack Sizes: Gram Quantities: 100 gm , 500 gm. Order Number: 1482.
www.prochemonline.com
Cobalt pellets 1/8x1/8
Cobalt pellets 1/8x1/8. Grades: 99.95% Extremely High (>=99%). CAS No. 7440-48-4. Pack Sizes: Gram Quantities: 100 gm, 500 gm. Order Number: 1482-2.
www.prochemonline.com
Cobalt pieces
Cobalt pieces. Grades: 99.9+% Extremely High (>=99%). CAS No. 7440-48-4. Pack Sizes: Gram Quantities: 100 gm , 500 gm. Order Number: 1483.
www.prochemonline.com
cobalt-precorrin-4 methyltransferase
Part of the anaerobic route to adenosylcobalamin. Group: Enzymes. Synonyms: CbiF. Enzyme Commission Number: EC 2.1.1.271. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1877; cobalt-precorrin-4 methyltransferase; EC 2.1.1.271; CbiF. Cat No: EXWM-1877.
cobalt-precorrin 5A hydrolase
This enzyme hydrolyses the ring A acetate Δ-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde. This is a key reaction in the contraction of the porphyrin-type tetrapyrrole ring and its conversion to a corrin ring in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. Group: Enzymes. Synonyms: CbiG (gene name). Enzyme Commission Number: EC 3.7.1.12. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4721; cobalt-precorrin 5A hydrolase; EC 3.7.1.12; CbiG (gene name). Cat No: EXWM-4721.
cobalt-precorrin-5B (C1)-methyltransferase
This enzyme catalyses the C-1 methylation of cobalt-precorrin-5B in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. Group: Enzymes. Synonyms: cobalt-precorrin-6A synthase; CbiD. Enzyme Commission Number: EC 2.1.1.195. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1794; cobalt-precorrin-5B (C1)-methyltransferase; EC 2.1.1.195; cobalt-precorrin-6A synthase; CbiD. Cat No: EXWM-1794.
cobalt-precorrin-6A reductase
The enzyme catalyses a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. The enzyme from the bacterium Bacillus megaterium has no activity with NADPH. The equivalent enzyme in the aerobic pathway is EC 1.3.1.54, precorrin-6A reductase. Group: Enzymes. Synonyms: cbiJ (gene name). Enzyme Commission Number: EC 1.3.1.106. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1278; cobalt-precorrin-6A reductase; EC 1.3.1.106; cbiJ (gene name). Cat No: EXWM-1278.
This enzyme catalyses both methylation at C-15 and decarboxylation of the C-12 acetate side chain of cobalt-precorrin-6B, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. Group: Enzymes. Synonyms: cbiT (gene name); S-adenosyl-L-methionine:precorrin-7 C15-methyltransferase (C-12-decarboxylating); cobalt-precorrin-7 (C15)-methyltransferase [decarboxylating]. Enzyme Commission Number: EC 2.1.1.196. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1795; cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]; EC 2.1.1.196; cbiT (gene name); S-adenosyl-L-methionine:precorrin-7 C15-methyltransferase (C-12-decarboxylating); cobalt-precorrin-7 (C15)-methyltransferase [decarboxylating]. Cat No: EXWM-1795.
cobalt-precorrin-7 (C5)-methyltransferase
This enzyme catalyses the methylation at C-5 of cobalt-precorrin-7, a step in the anaerobic (early cobalt insertion) adenosylcobalamin biosynthesis pathway. Group: Enzymes. Synonyms: CbiE. Enzyme Commission Number: EC 2.1.1.289. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1896; cobalt-precorrin-7 (C5)-methyltransferase; EC 2.1.1.289; CbiE. Cat No: EXWM-1896.
cobalt-precorrin-8 methylmutase
The enzyme catalyses the the conversion of cobalt-precorrin-8 to cobyrinate by methyl rearrangement, a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. The equivalent enzyme in the aerobic pathway is EC 5.4.99.61, precorrin-8X methylmutase. Group: Enzymes. Synonyms: cbiC (gene name). Enzyme Commission Number: EC 5.4.99.60. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5603; cobalt-precorrin-8 methylmutase; EC 5.4.99.60; cbiC (gene name). Cat No: EXWM-5603.
Cobalt Rod
Cobalt Rod. Alternative Names: Cobalt Rod, Co Rod.
Cobalt Salts
Cobalt Salts. CAS: various. Packing: Various.
New Jersey NJ
Cobalt Sheet
Cobalt Sheet. Alternative Names: Cobalt Sheet, Co Sheet. CAS No. 1315-11-3.
Cobamamide is a biologically active form of vitamin B12. It is a cofactor for various enzymes. Synonyms: Adenosine Cobalamin; Cobinamide, Co-(5'-deoxyadenosin-5'-yl)-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3); Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-Dribofuranosyl-1H-benzimidazole; Cobinamide, Co-(5'-deoxyadenosine-5') deriv., hydroxide, dihydrog. Grade: ≥95%. CAS No. 13870-90-1. Molecular formula: C72H100CoN18O17P. Mole weight: 1579.58.
Cobamamide (pyrogen Free)
1g Pack Size. Group: Biochemicals. Formula: C72H100CoN18O17P. CAS No. 13870-90-1. Prepack ID 16609610-1g. Molecular Weight 1579.58. See USA prepack pricing.
CoB-CoM heterodisulfide reductase
This enzyme is found in methanogenic archaea, particularly Methanosarcina species, and regenerates coenzyme M and coenzyme B after the action of EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. Contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters. Highly specific for both coenzyme M and coenzyme B. Reacts with various phenazine derivatives, including 2-hydroxyphenazine and 2-bromophenazine. Group: Enzymes. Synonyms: heterodisulfide reductase; soluble heterodisulfide reductase. Enzyme Commission Number: EC 1.8.98.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1682; CoB-CoM heterodisulfide reductase; EC 1.8.98.1; heterodisulfide reductase; soluble heterodisulfide reductase. Cat No: EXWM-1682.
Cobicistat
Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-9350. CAS No. 1004316-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10493.
Cobicistat
Cobicistat. Group: Biochemicals. Grades: Highly Purified. CAS No. 1004316-88-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. US Biological Life Sciences.
Worldwide
Cobicistat
Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Uses: Anti-hiv agents. Synonyms: Cobicistat, GS-9350; GS 9350; GS9350. Grade: 98%. CAS No. 1004316-88-4. Molecular formula: C40H53N7O5S2. Mole weight: 776.028.
Cobicistat-[d8]
An isotope labelled of Cobicistat. Cobicistat can be use in the treatment of human immunodeficiency virus infection. Synonyms: Cobicistat D8. Grade: > 99%. Molecular formula: C40H46D8N7O5S2. Mole weight: 784.07.
Cobicistat Impurity serves as an impurity for the drug Cobicistat, which is frequently prescribed to treat human immunodeficiency virus (HIV) infection. Synonyms: 2-Amino-4-morpholinobutanoic acid; 2-amino-4-(morpholin-4-yl)butanoic acid; 770684-35-0; 2-amino-4-morpholin-4-ylbutanoic acid; (2S)-2-Amino-4-morpholinebutanoicAcidDihydrochloride; 854893-19-9; SCHEMBL1889261; 2-Amino-4-morpholinobutanoicacid; MFCD07786927; AKOS000212411; BS-9757; 2-Amino-4-(mopholin-4-yl) butanoic acid; EN300-91881. Grade: > 95%. CAS No. 854893-19-9. Molecular formula: C8H16N2O3. Mole weight: 188.23.
Cobicistat Impurity HCl
α,α-Dimethyl-4-[(methylamino)methyl]-2-thiazolemethanol Hydrochloride is a Cobicistat impurity. Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir as a pharmacoenhancer, significantly increasing their plasma concentrations. Synonyms: α,α-Dimethyl-4-[(methylamino)methyl]-2-thiazolemethanol Hydrochloride. Grade: > 95%. Molecular formula: C8H15ClN2OS. Mole weight: 222.74.
cob(II)alamin reductase
A flavoprotein. Group: Enzymes. Synonyms: vitamin B12r reductase; B12r reductase; NADH2:cob(II)alamin oxidoreductase. Enzyme Commission Number: EC 1.16.1.4. CAS No. 37256-40-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1069; cob(II)alamin reductase; EC 1.16.1.4; 37256-40-9; vitamin B12r reductase; B12r reductase; NADH2:cob(II)alamin oxidoreductase. Cat No: EXWM-1069.
cob(II)yrinic acid a,c-diamide reductase
This enzyme also catalyses the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate. Also uses FAD and NADH but not NADPH. Group: Enzymes. Synonyms: cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect). Enzyme Commission Number: EC 1.16.8.1. CAS No. 145539-93-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1078; cob(II)yrinic acid a,c-diamide reductase; EC 1.16.8.1; 145539-93-1; cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect). Cat No: EXWM-1078.
Cobimetinib
Cobimetinib (GDC-0973, RG7420) is a potent, orally available and highly selective MEK1 inhibitor with IC50 of 4.2 nM. It shows more than 100-fold selectively for MEK1 over MEK2 when tested against a panel of more than 100 serine-threonine and tyrosine kinases and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Synonyms: XL518; GDC-0973; RG7420. Grade: ≥98%. CAS No. 934660-93-2. Molecular formula: C21H21F3IN3O2. Mole weight: 531.31.
Cobimetinib
Cobimetinib (GDC-0973) is a MEK1 inhibitor (IC50=4.2 nM) with selective and oral activity. Cobimetinib exhibits antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis. Category: Active pharmaceutical ingredients. Synonyms: RG7420, XL518, GDC-0973. CAS No. 934660-93-2. Product ID: API934660932. Molecular formula: C21H21F3IN3O2. Mole weight: 531.31.
Cobimetinib
Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0973; XL518. CAS No. 934660-93-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13064.
Cobimetinib (GDC-0973)
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, and showing no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3. Group: Inhibitors. Alternative Names: RG7420,XL518. CAS No. 934660-93-2. Pack Sizes: 5mg. Product ID: S8041. Formula: C21H21F3IN3O2. Smiles: C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Cobimetinib hemifumarate
Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0973 hemifumarate; XL-518 hemifumarate. CAS No. 1369665-02-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13064A.
Cobimetinib hemifumarate
Cobimetinib, also known as GDC-0973 and XL-518, is a novel selective MEK inhibitor, and the IC50value against MEK1 is 4.2 nM, with potential antineoplastic activity. Synonyms: Methanone, [3,?4-difluoro-2-[(2-fluoro-4-iodophenyl)?amino]?phenyl]?[3-hydroxy-3-(2S)?-2-piperidinyl-1-azetidinyl]?-, (2E)?-2-butenedioate (2:1). CAS No. 1369665-02-0. Molecular formula: C21H21F3IN3O2.1/2C4H4O4. Mole weight: 589.35.
Cobimetinib hemifumarate
Cobimetinib hemifumarate is a potent and selective MEK1 inhibitor with an IC50 value of 4.2 nM for MEK1. Category: Active pharmaceutical ingredients. CAS No. 1369665-02-0. Product ID: API1369665020. Molecular formula: C46H46F6I2N6O8. Mole weight: 1178.707.
Cobimetinib racemate
Cobimetinib racemate is a selective inhibitor of MEK. It is also known as mitogen activated protein kinase kinase (MAPKK) and is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors. Synonyms: GDC-0973 racemate; XL-518; GDC 0973 racemate; XL 518; GDC0973 racemate; XL518. Grade: >98%. CAS No. 934662-91-6. Molecular formula: C21H21F3IN3O2. Mole weight: 531.31.
Cobimetinib racemate
Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0973 racemate; XL518 racemate. CAS No. 934662-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13078.