A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
CNV-2197944, a selective, state-dependent Cav2.2 calcium channel blocker, can reverse hyperalgesia associated with injury or inflammation in conjunction with the opioid. (Extracted from patent WO2017046581A1, compound 1). Synonyms: Cav 2.2 blocker 2; CNV2197944; Methanone, (2-methyl-3-pyridinyl)((2S)-2-methyl-4-((4-(trifluoromethyl)phenyl)sulfonyl)-1-piperazinyl)-; (S)-(2-Methyl-4-((4-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(2-methylpyridin-3-yl)methanone. Grade: ≥98%. CAS No. 1204535-44-3. Molecular formula: C19H20F3N3O3S. Mole weight: 427.44.
CNX-1351
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC50 of 6.8 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1276105-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16596.
CNX-1351
CNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20-400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α. Synonyms: CNX-1351; CNX 1351; CNX1351. Grade: 0.98. CAS No. 1276105-89-5. Molecular formula: C30H35N7O3S. Mole weight: 573.716.
CNX-2006
CNX-2006 is a potent and mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer. Synonyms: CNX2006; CNX 2006; N-[3-[[2-[4-[[1-(2-fluoroethyl)azetidin-3-yl]amino]-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide. Grade: 98%. CAS No. 1375465-09-0. Molecular formula: C26H27F4N7O2. Mole weight: 545.543.
CNX-2006
CNX-2006 is a mutant-selective and irreversible EGFR inhibitor with an IC50 below 20 nM for EGFRT790M. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375465-09-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13897.
CNX-500
CNX-500, a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin, still has inhibitory activity against Btk (IC50 = 0.5 nM) and forms a covalent bond with Btk. CNX-500 has a low inhibitory effect on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn. Synonyms: N1-[19-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-N5-[3-[3-[[5-methyl-4-[[3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-2-pyrimidinyl]amino]phenoxy]propyl]pentanediamide; N-(3-{3-[(4-{[3-(Acryloylamino)phenyl]amino}-5-methyl-2-pyrimidinyl)amino]phenoxy}propyl)-N'-{15-oxo-19-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10-trioxa-14-azanonadec-1-yl}pentanediamide. Grade: ≥98%. CAS No. 1202758-21-1. Molecular formula: C48H68N10O9S. Mole weight: 961.18.
CNX-774
CNX-774 is an orally active, irreversible and selective BTK inhibitor, with an IC50 of < 1 nM. CNX-774 specifically targets Cysteine 481 of Btk for covalent modification[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1202759-32-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13943.
CNX-774
CNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Synonyms: CNX-774; CNX 774; CNX774. CAS No. 1202759-32-7. Molecular formula: C26H22FN7O3. Mole weight: 499.49638.
Co 101244
Co 101244 is an N-methyl-D-aspartate NR2B subtype antagonist. Synonyms: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol; PD 174494; Ro 63-1908; Co 101244; PD 174494; Ro63-1908; Co101244; PD174494; Ro-63-1908; Co-101244. CAS No. 193359-26-1. Molecular formula: C21H27NO3. Mole weight: 341.45.
Co 101244 hydrochloride
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 174494 hydrochloride. CAS No. 193356-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107706.
Co 101244 hydrochloride
Co 101244 hydrochloride, with strongly neuroprotective effect in vivo and in vitro, is an ifenprodil-like noncompetitive, highly selective antagonist of NR2B-containing NMDA receptors (IC5= 43 nM). Synonyms: 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]piperidin-4-ol; hydrochloride; 4-hydroxy-N-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidine; Co 101244; 193359-26-1 (Co 101244 free base); Co-101244; Co101244; PD 174494; PD-174494; PD174494. Grade: >98%. CAS No. 193356-17-1. Molecular formula: C21H27NO3.HCl. Mole weight: 377.91.
Co 101244 hydrochloride
Co 101244 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 193356-17-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Co 102862
Co 102862, also known as V102862, an orally active anticonvulsant with robust activity, is a potent, broad-spectrum state-dependent inhibitor of mammalian voltage-gated Na+ channels with ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Synonyms: CO-102862; CO 102862; CO102862; [[4-(4-fluorophenoxy)phenyl]methylideneamino]urea; 4-(4-fluorophenoxy)benzaldehyde semicarbazone; Co 102862; Co-102862; FPhOBal semicarbazone; 181144-66-1; 2-(4-(4-Fluorophenoxy)benzylidene)hydrazinecarboxamide; Hydrazinecarboxamide, 2-[[4-(4-fluorophenoxy)phenyl]methylene]-. Grade: >99 %. CAS No. 181144-66-1. Molecular formula: C14H12FN3O2. Mole weight: 273.26.
Co 102862
Co 102862. Group: Biochemicals. Grades: Purified. CAS No. 181144-66-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
CO-1686 hydrobromide
CO-1686 hydrobromide is the hydrobromide salt form of CO-1686. CO-1686, also called as Rociletinib, is an oral tyrosine kinase inhibitor that irreversibly and selectively inhibits mutation of EGFR for treating Non-small cell lung cancer.Non-small cell lun. Synonyms: N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide; hydrobromide CO-1686 (hydrobromide) CO-1686 hydrobromide HY-15729A CS-5247 KB-310894 1446700-26-0. CAS No. 1446700-26-0. Molecular formula: C27H29BrF3N7O3. Mole weight: 636.46.
CO23
CO23, a selective thyroid hormone receptor α (TRα) agonist, regulates growth and development and can be transported across the blood-brain barrier. Synonyms: 2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]-; 5-(3,5-Diiodo-4-(3-isopropyl-4-hydroxyphenoxy)benzyl)imidazolidine-2,4-dione; 5-[4-(4-Hydroxy-3-isopropylphenoxy)-3,5-diiodobenzyl]-2,4-imidazolidinedione; 5-{4-[4-hydroxy-3-(propan-2-yl)phenoxy]-3,5-diiodobenzyl}imidazolidine-2,4-dione. Grade: ≥95%. CAS No. 1370363-74-8. Molecular formula: C19H18I2N2O4. Mole weight: 592.17.
CO23
CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1370363-74-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130012.
Co3O4
Co3O4. Purity: 99%.
CoA-disulfide reductase
A flavoprotein. Not identical with EC 1.8.1.6 (cystine reductase), EC 1.8.1.7 (glutathione-disulfide reductase) or EC 1.8.1.13 (bis-γ-glutamylcystine reductase). The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH, while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes. Group: Enzymes. Synonyms: CoA-disulfide reductase (NADH2); NADH2:CoA-disulfide oxidoreductase; CoA:NAD+ oxidoreductase (misleading); CoADR; coenzyme A disulfide reductase. Enzyme Commission Number: EC 1.8.1.14. CAS No. 206770-55-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1640; CoA-disulfide reductase; EC 1.8.1.14; 206770-55-0; CoA-disulfide reductase (NADH2); NADH2:CoA-disulfide oxidoreductase; CoA:NAD+ oxidoreductase (misleading); CoADR; coenzyme A disulfide reductase. Cat No: EXWM-1640.
CoA-glutathione reductase
A flavoprotein. The substrate is a mixed disulfide. May be identical to EC 1.8.1.9, thioredoxin-disulfide reductase. Group: Enzymes. Synonyms: coenzyme A glutathione disulfide reductase; NADPH-dependent coenzyme A-SS-glutathione reductase; coenzyme A disulfide-glutathione reductase; NADPH2:CoA-glutathione oxidoreductase. Enzyme Commission Number: EC 1.8.1.10. CAS No. 37256-33-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1636; CoA-glutathione reductase; EC 1.8.1.10; 37256-33-0; coenzyme A glutathione disulfide reductase; NADPH-dependent coenzyme A-SS-glutathione reductase; coenzyme A disulfide-glutathione reductase; NADPH2:CoA-glutathione oxidoreductase. Cat No: EXWM-1636.
Coagulation and Anticoagulation Compound Library
A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS); - Structurally diverse, medicinally active, and cell permeable; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7500. Categories: Coagulation and Anticoagulation Compounds Libraries.
coagulation factor IXa
A chymotrypsin homologue, and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI. Enzyme Commission Number: EC 3.4.21.22. CAS No. 37316-87-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4122; coagulation factor IXa; EC 3.4.21.22; 37316-87-3; activated Christmas factor; blood-coagulation factor IXa; activated blood-coagulation factor IX; autoprothrombin II; blood platelet cofactor II; activated blood coagulation factor XI. Cat No: EXWM-4122.
coagulation factor VIIa
Formed from the precursor factor VII. The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: blood-coagulation factor VIIa; activated blood coagulation factor VII. Enzyme Commission Number: EC 3.4.21.21. CAS No. 65312-43-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4121; coagulation factor VIIa; EC 3.4.21.21; 65312-43-8; blood-coagulation factor VIIa; activated blood coagulation factor VII. Cat No: EXWM-4121.
coagulation factor Xa
A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca2+ and phospholipids. Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. Group: Enzymes. Synonyms: thrombokinase; prothrombase; prothrombinase; activated blood-coagulation factor X; autoprothrombin C; thromboplastin; plasma thromboplastin; factor Xa; activated Stuart-Prower factor; activated factor X. Enzyme Commission Number: EC 3.4.21.6. CAS No. 9002-5-5. Factor Xa. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4150; coagulation factor Xa; EC 3.4.21.6; 9002-05-5; thrombokinase; prothrombase; prothrombinase; activated blood-coagulation factor X; autoprothrombin C; thromboplastin; plasma thromboplastin; factor Xa; activated Stuart-Prower factor; activated factor X. Cat No: EXWM-4150.
coagulation factor XIa
In peptidase family S1 (trypsin family), and one of the γ-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor XI is activated by factor XIIa. Group: Enzymes. Synonyms: blood-coagulation factor XIa; activated blood-coagulation factor XI; activated plasma thromboplastin antecedent. Enzyme Commission Number: EC 3.4.21.27. CAS No. 37203-61-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4125; coagulation factor XIa; EC 3.4.21.27; 37203-61-5; blood-coagulation factor XIa; activated blood-coagulation factor XI; activated plasma thromboplastin antecedent. Cat No: EXWM-4125.
coagulation factor XIIa
Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator. Enzyme Commission Number: EC 3.4.21.38. CAS No. 75216-42-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4132; coagulation factor XIIa; EC 3.4.21.38; 75216-42-1; Hageman factor (activated); blood-coagulation factor XIIf; activated β blood-coagulation factor XII; prealbumin activator; Hageman factor β-fragment; Hageman factor fragment HFf; blood-coagulation factor XIIaβ; prekallikrein activator; kallikreinogen activator. Cat No: EXWM-4132.
Coagulin
Coagulin is a new antilisterial bacteriocin in the pediocin family of bacteriocins produced by Bacillus coagulans I4.
CoA:oxalate CoA-transferase
The enzymes characterized from the bacteria Escherichia coli and Acetobacter aceti can also use formyl-CoA and oxalate (EC 2.8.3.16, formyl-CoA transferase) or formyl-CoA and acetate, with significantly reduced specific activities. Group: Enzymes. Synonyms: acetyl-coenzyme A transferase; acetyl-CoA oxalate CoA-transferase; ACOCT; YfdE; UctC. Enzyme Commission Number: EC 2.8.3.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3414; CoA:oxalate CoA-transferase; EC 2.8.3.19; acetyl-coenzyme A transferase; acetyl-CoA oxalate CoA-transferase; ACOCT; YfdE; UctC. Cat No: EXWM-3414.
CoA-S-acetyl-tryptamine
CoA-S-acetyl-tryptamine is a biomedical product exerting vital influence over specialized receptors implicated in neurotransmission. Molecular formula: C33H48N9O17P3S. Mole weight: 967.77.
Coated Calcium Carbonate
Coated Calcium Carbonate.
Cobalamin
One of the analog of Vitamin B12, which has been found to be related to the metabolism of cells in human body, especially DNA synthesis, amino acid as well as fatty acid metabolism. Synonyms: Cobinamide, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3), ion(1+); Cobinamide, hydroxide, ion(1+), dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole; Cobinamide, hydroxide, ion(1+), dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosylbenzimidazole; Cobinamide, ion(1+), dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole; Cobalamine. Grade: 95%. CAS No. 13408-78-1. Molecular formula: C62H88CoN13O14P. Mole weight: 1329.35.
Cobalt acetate
Cobalt acetate is a red-violet crystalline solid. Vinegar-like odor. (USCG, 1999);PelletsLargeCrystals, Liquid;RED CRYSTALS. Alternative Names: COBALT(II) ACETATE;COBALT ACETATE;acetatecobalteux;Aceticacid,cobalt(2+)salt;aceticacid,cobalt(2++)salt;bis(acetato)cobalt;cobalt(2+)acetate;cobaltacetate(co(oac)2). CAS No. 71-48-7. Molecular formula: C4H6CoO4.4H2O;Co(C2H3O2)2;C4H6CoO4. Mole weight: 177.02g/mol. IUPAC Name: cobalt(2+);diacetate. SMILES: CC(=O)[O-].CC(=O)[O-].[Co+2]. InChI: InChI=1S/2C2H4O2.Co/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2.
Cobalt Acetate
Red crystalline solid. Uses: drying agent, catalyst. Group: organic salt. Alternative Names: Cobalt(II) Acetate. CAS No. 71-48-7.
Cobalt acetate, 98%
Cobalt acetate is a red-violet crystalline solid. Vinegar-like odor. (USCG, 1999);PelletsLargeCrystals, Liquid;RED CRYSTALS. CAS No. 71-48-7. Molecular formula: C4H6CoO4.4H2O;Co(C2H3O2)2;C4H6CoO4. Mole weight: 177.02g/mol. IUPAC Name: cobalt(2+);diacetate. SMILES: CC(=O)[O-].CC(=O)[O-].[Co+2]. InChI: InChI=1S/2C2H4O2.Co/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2.
Cobalt acetate, 99.99% trace metals basis
Cobalt acetate is a red-violet crystalline solid. Vinegar-like odor. (USCG, 1999);PelletsLargeCrystals, Liquid;RED CRYSTALS. CAS No. 71-48-7. Molecular formula: C4H6CoO4.4H2O;Co(C2H3O2)2;C4H6CoO4. Mole weight: 177.02g/mol. IUPAC Name: cobalt(2+);diacetate. SMILES: CC(=O)[O-].CC(=O)[O-].[Co+2]. InChI: InChI=1S/2C2H4O2.Co/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2.
Cobalt Acetate Tetrahydrate
Cobalt Acetate Tetrahydrate. CAS No. 6147-53-1. Molecular Formula Co(CH3COO)2 * 4H2O. Chemical Reagents
Pink powder, insoluble in water. Uses: pigments, ceramics, animal feed supplement. Group: carbonate salt. Alternative Names: Cobalt(II) Carbonate. CAS No. 513-79-1.
Cobalt Carbonate
Cobalt Carbonate - Agriculture Chemicals. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
North America & APAC
Cobalt Carbon-Coated nanoparticles
Cobalt Carbon-Coated nanoparticles.
Cobalt Carbon Nanotubes / CNTs Doped with 50wt% Co Nanopowder
Cobalt Carbon Nanotubes / CNTs Doped with 50wt% Co Nanopowder. Purity: 97%.
Cobalt Carbonyl
Cobalt Carbonyl is a metal carbonyl used as a reagent and catalyst in organometallic chemistry and organic synthesis. Cobalt Carbonyl is commonly used as a hydroformylation catalyst for the conversion of alkenes to aldehydes. Group: Biochemicals. Alternative Names: Cobalt octacarbonyl (Co2(CO)8); Cobalt Tetracarbonyl Dimer; Di- μ -carbonyl hexacarbonyl dicobalt; Dicobalt Carbonyl; Dicobalt Octacarbonyl; Octacarbonyldicobalt. Grades: Highly Purified. CAS No. 10210-68-1. Pack Sizes: 1g. US Biological Life Sciences.