A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It is also a central signaling component of the intracellular DNA sensing pathway. Synonyms: STING inhibitor C 176; C176; C 176. Grade: ≥98%. CAS No. 314054-00-7. Molecular formula: C11H7IN2O4. Mole weight: 358.09.
C-176
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 314054-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112906.
C-176
STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway. Group: Inhibitors. CAS No. 314054-00-7. Pack Sizes: 5mg. Product ID: S6575. Formula: C11H7IN2O4. Smiles: C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])I. Storage Conditions: 3 years -20°C powder.
United States; Europe
C-178
C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 329198-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-123963.
C-178
C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grade: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27.
C18:0 L-carnitine-d9 (HCl salt). Alternative Names: Stearoyl L-carnitine-d9 (HCl salt). CAS No. 2936622-19-2. Purity: >99%. Product ID: ALCFA2936622192. Molecular formula: C25H41D9ClNO4. Mole weight: 473.18. Alfa Chemistry - ISO 9001:32057 Certified.
C18:1-Ceramide
C18:1-Ceramide is a ceramide subspecies. C18:1-Ceramide can be used in the study of type 2 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5966-28-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141578.
C18:1 Ceramide-1-Phosphate (d18:1/18:1(9Z))
C18:1 Ceramide-1-Phosphate (d18:1/18:1(9Z)). Alternative Names: N-oleoyl-ceramide-1-phosphate (ammonium salt). CAS No. 1246304-33-5. Purity: >99%. Product ID: ALCFA1246304335. Molecular formula: C36H73N2O6P. Mole weight: 660.948. Alfa Chemistry - ISO 9001:32057 Certified.
C188 (CPD188) is a STAT3 inhibitor with anticancer effects. C188 inhibits STAT3 SH2/pY-peptide binding (IC50 of 20 μM against pY-peptide binding) and IL-6-mediated STAT3 phosphorylation. C188 is selective for STAT3 over STAT1. C188 inhibits nuclear-to-cytoplasmic translocation of Stat3. C188 shows highly active induces apoptosis in breast cancer cell lines with constitutive Stat3 activation (EC50s of 0.73 μM, 3.96 μM, and 7.01 μM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CPD188. CAS No. 823828-18-8. Pack Sizes: 5 mg. Product ID: HY-112338.
C188-9
C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TTI-101. CAS No. 432001-19-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112288.
C188-9 (TTI-101)
C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors. Group: Inhibitors. Alternative Names: TTI 101. CAS No. 432001-19-9. Pack Sizes: 5mg. Product ID: S8605. Formula: C27H21NO5S. Smiles: COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O. Storage Conditions: 2 years -80 in solvent.
United States; Europe
C18 Alkyl Acrylate
C18 Alkyl Acrylate.
C18 Alkyl Methacrylate
C18 Alkyl Methacrylate.
C18-Ceramide (d18:1/18:0)
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C18-Ceramide. CAS No. 2304-81-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100355.
C18-Ceramide-d7
C18-Ceramide-d7 is deuterium labeled C18-Ceramide. Uses: Scientific research. Category: Signaling pathways. CAS No. 1840942-14-4. Pack Sizes: 500 μg (1.75 mM * 500 μL in Methanol:Chloroform (10:90)); 1 mg; 5 mg. Product ID: HY-100355S1.
C18 dihydroceramide
C18 dihydroceramide. Group: Biochemicals. Alternative Names: N- [ (1S, 2R) -2-Hydroxy-1- (hydroxymethyl) heptadecyl] octadecanamide; Dihydroceramide; N-Stearoylsphinganine. Grades: Highly Purified. CAS No. 2304-80-5. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C36H73NO3. US Biological Life Sciences.
C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide. It can inhibit rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 8.8 μM. Synonyms: L-erythro Cer(d18:1/18:0); L-erythro Ceramide (d18:1/18:0); N-octadecanoyl-L-erythro-sphingosine. Grade: ≥98%. CAS No. 252039-52-4. Molecular formula: C36H71NO3. Mole weight: 565.95.
C18 L-threo Ceramide (d18:1/18:0)
C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.8 μM. Synonyms: N-octadecanoyl-L-threo-sphingosine; L-threo Cer(d18:1/18:0); L-threo Ceramide (d18:1/18:0). Grade: ≥98%. CAS No. 95037-06-2. Molecular formula: C36H71NO3. Mole weight: 565.95.
C-19393 E5
It is produced by the strain of Streptomyces griseus subsp. cryophilus C-19393. C-19393 E5 has anti-gram-positive and anti-gram-negative bacteria activity and strong β-lactamase inhibition. Synonyms: Antibiotic C 19393E5; C-19393 E(5). CAS No. 83310-72-9. Molecular formula: C13H16N2O6S. Mole weight: 328.34.
C19 3'-Sulfo galactosylceramide (d18:1/19:0)
C19 3'-Sulfo Galactosylceramide (d18:1/19:0) is a synthetic derivative of sulfatide[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (3'-Sulfo)Galβ-ger(d18:1/19:0); C19 Sulfatide. CAS No. 2692623-78-0. Pack Sizes: 1 mg. Product ID: HY-159251.
C-19 steroid 1α-hydroxylase
The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione. Group: Enzymes. Synonyms: CYP260A1. Enzyme Commission Number: EC 1.14.15.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0944; C-19 steroid 1α-hydroxylase; EC 1.14.15.19; CYP260A1. Cat No: EXWM-0944.
C-(1-Bromo-1-deoxy-2,3,4,6-tetra-O-benzoyl-b-D-glucopyranosyl)formamide is a vital component in the development of novel antiviral drugs. Through its unique chemical structure, it exhibits potent antiviral activity against a range of infectious diseases, including influenza and herpes viruses. Synonyms: C-(2,3,4,6-Tetra-O-benzoyl-1-bromo-1-deoxy-b-D-glucopyranosyl)formamide. CAS No. 262849-68-3. Molecular formula: C35H28BrNO10. Mole weight: 702.50.
c-(1-Cyclopentyl-piperidin-4-yl)-methylamine
c-(1-Cyclopentyl-piperidin-4-yl)-methylamine. CAS No. 132864-60-9. Product ID: ACM132864609. Molecular formula: C11H22N2. Mole weight: 182.31. Alfa Chemistry - ISO 9001:32057 Certified.
c-(1-Methyl-pyrrolidin-3-yl)-methylamine. Alternative Names: C-(1-METHYL-PYRROLIDIN-3-YL)-METHYLAMINE;CHEMBRDG-BB 4003800;AKOS BC-1213;Dimethylaminopyrrolidine;3-(Aminomethyl)-1-methylpyrrolidine;N,1-Dimethylpyrrolidin-3-amine. CAS No. 13005-11-3. Product ID: ACM13005113. Molecular formula: C6H14N2. Mole weight: 114.19. Alfa Chemistry - ISO 9001:32057 Certified.
C1s-IN-1 trihydrochloride
C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the Ki of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the Ki of 51.2 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1376162-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg. Product ID: HY-W371165.
C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM) with 5-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1. Synonyms: C21; C-21; N-Acetyl-L-serylglycyl-N5-(2-chloroethanimidoyl)-L-ornithylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-arginyl-L-lysyl-L-valine. Grade: >98%. CAS No. 1229236-78-5. Molecular formula: C90H161ClN36O24. Mole weight: 2166.92.
C22-Ceramide
C22-Ceramide. Group: Biochemicals. Alternative Names: N-[(3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecenyl]-docosanamide. Grades: Highly Purified. CAS No. 869501-30-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C40H79NO3. US Biological Life Sciences.
C-(2,3,4,6-Tetra-O-acetyl-1-azido-1-deoxy-a-D-galactopyranosyl)formamide is a valuable compound utilized in the biomedical industry for its potential in treating infectious diseases caused by specific bacteria or viruses. Its structure and chemical properties make it an effective candidate for the development of antiviral or antibacterial drugs. Synonyms: C-(2,3,4,6-Tetra-O-acetyl-1-azido-1-deoxy-alpha-D-galactopyranosyl)formamide. CAS No. 180904-09-0. Molecular formula: C15H20N4O10. Mole weight: 416.34.
C-(2,3,4,6-Tetra-O-acetyl-1-bromo-1-deoxy-b-D-galactopyranosyl)formamide, an extensively researched and promising biomedical compound, exhibits immense potential for therapeutic applications. With its commendable prowess as a glycosylation reagent in synthesizing glycosides, oligosaccharides, and bioactive molecules, this exceptional product assumes a pivotal role in drug development. Synonyms: α-D-galacto-2-Heptulopyranosonamide, 2-bromo-2-deoxy-, 3,4,5,7-tetraacetate. CAS No. 159895-07-5. Molecular formula: C15H20BrNO10. Mole weight: 454.22.
C-(2,3,4,6-Tetra-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide is a compound used in the research of various diseases playing a crucial role in targeting specific cellular pathways associated with compound resistance and cancer progression. Synonyms: C-(2,3,4,6-Tetra-O-acetyl-1-hydroxy-beta-D-galactopyranosyl)formamide. CAS No. 189633-60-1. Molecular formula: C15H21NO11. Mole weight: 391.33.
C-(2,3,4-Tri-O-acetyl-1-azido-1-deoxy-b-D-galactopyranosyl)formamide, a renowned compound extensively applied within the biomedical industry, emerges as an indubitably vital asset enhancing drug development and research endeavors. It manifests considerable potential in ameliorating an array of ailments, predominantly those entrenched in the realms of cellular and molecular biology. Synonyms: α-D-arabino-2-Hexulopyranosonamide, 2-azido-2-deoxy-, 3,4,5-triacetate (9CI). CAS No. 189633-67-8. Molecular formula: C12H16N4O8. Mole weight: 344.28.
C-(2,3,4-Tri-O-acetyl-1-hydroxy-b-D-galactopyranosyl)formamide is a biomedical product used for the study of certain diseases. It acts as a formamide derivative of galactose, which exhibits potential antitumor activity against various cancer types. Synonyms: β-D-arabino-2-Hexulopyranosonamide, 3,4,5-triacetate (9CI). CAS No. 189633-66-7. Molecular formula: C12H17NO9. Mole weight: 319.26.
C24:1 b-D-Galactosyl ceramide
C24:1 b-D-Galactosyl ceramide is a renowned compound prevalent in the ever-evolving biomedical realm, specifically tailored for the research of diverse afflictions, including Gaucher disease and Fabry disease. Synonyms: Galactosyl-b-1,1 N-nervonoyl-D-erythro-sphingosine. Grade: >99%. CAS No. 17283-91-9. Molecular formula: C48H91NO8. Mole weight: 810.24.
C24:1Ceramide
C24:1Ceramide. Group: Biochemicals. Alternative Names: Nervonic ceramide. Grades: Highly Purified. CAS No. 54165-50-0. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C42H81NO3. US Biological Life Sciences.
Worldwide
C24:1-Ceramide
C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 54164-50-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-134575.
C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt
C24:1 Mono-sulfo galactosyl (alpha) ceramide (d18:1/24:1) Ammonium salt is a valuable compound serving as a formidable biomarker facilitating the comprehensive investigation of ceramide involvement in diverse pathological conditions, spanning from malignancies such as cancer, to metabolic disorders like diabetes is and even neurodegenerative ailments. Synonyms: 3-O-Sulfo-D-galactosyl-alpha-1,1'-N-Nervonoyl-D-erythro-sphingsoine (ammonium salt); 3-O-sulfo-alpha-D-C24:1-galactosylceramide (ammonium salt); ammonium (2S,3R,4S,5S,6R)-3,5-dihydroxy-2-(((2S,3R,E)-3-hydroxy-2-((Z)-tetracos-15-enamido)octadec-4-en-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl sulfate; Ammonium (2S,3R,4E)-3-hydroxy-2-[(15Z)-15-tetracosenoylamino]-4-octadecen-1-yl 3-O-sulfonato-α-D-threo-hexopyranoside; 15-Tetracosenamide, N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-α-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-, ammonium salt (1:1), (15Z)-. Grade: >99%. CAS No. 2260670-38-8. Molecular formula: C48H94N2O11S. Mole weight: 907.33.
C24-Ceramide
C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34435-05-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-134508.
C24-Ceramide
C24-Ceramide. Group: Biochemicals. Alternative Names: Lignoceric ceramide. Grades: Highly Purified. CAS No. 34435-05-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C42H83NO3. US Biological Life Sciences.
Worldwide
C24 Ceramide-1-Phosphate (d18:1/24:0)
C24 Ceramide-1-Phosphate (d18:1/24:0). Alternative Names: N-(tetracosanoyl)-sphing-4-enine-1-phosphate CerP(d18:1/24:0). CAS No. 1246303-20-7. Purity: >99%. Product ID: ALCFA1246303207. Molecular formula: C42H87N2O6P. Mole weight: 747.124. Alfa Chemistry - ISO 9001:32057 Certified.
C24-Ceramide (d18:1/24:0)
C24-Ceramide (d18:1/24:0) is a sphingolipid that can be used for the lipid membranes composed. C24-Ceramide (d18:1/24:0) induces time-dependent changes in membrane properties. C24-Ceramide (d18:1/24:0) induces membrane reorganization[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 102917-80-6. Pack Sizes: 1 mg. Product ID: HY-134508A.
C24 Dihydroceramide-1-Phosphate (d18:0/24:0)
C24 Dihydroceramide-1-Phosphate (d18:0/24:0). Alternative Names: 24:0 Sphinganine-1-phosphate (ammonium salt)CerP(d18:0/24:0). CAS No. 1246303-18-3. Purity: >99%. Product ID: ALCFA1246303183. Molecular formula: C42H89N2O6P. Mole weight: 749.14. Alfa Chemistry - ISO 9001:32057 Certified.
C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 was found to impede NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. CAS No. 1358099-18-9. Molecular formula: C26H31N7O. Mole weight: 457.57.
C25-140
C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1358099-18-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120934.