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Product
Crisaborole Impurity 82 Crisaborole Impurity 82. Uses: For analytical and research use. Alternative Names: 4-(4-bromo-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)benzonitrile. CAS No. 943311-78-2. Molecular formula: C19H18BrNO3. Mole weight: 388.26. Catalog: APB943311782. Alfa Chemistry Analytical Products 4
Crisaborole (Standard) Crisaborole (Standard) is the analytical standard of Crisaborole. This product is intended for research and analytical applications. Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AN-2728 (Standard); PF-06930164 (Standard). CAS No. 906673-24-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10978R. MedChemExpress MCE
Crisamicin A It is produced by the strain of Micromonospora purpureochromogenes subsp. lalotolerans. It only has activity against gram-positive bacteria. The activity of samicin C is stronger than Crisamicin A. Synonyms: (3aS)-5β,5'β-Dimethyl-10,10'-dihydroxy-3,3',3aβ,3'aβ,5,5',6,6',11,11',11bβ,11'bβ-dodecahydro-8,8'-bi[2H-furo[3,2-b]naphtho[2,3-d]pyran]-2,2',6,6',11,11'-hexaone; (3aS,3'aS,5S,5'S,11bS,11'bS)-3,3',3a,3'a,5,5',11b,11'b-Octahydro-10,10'-dihydroxy-5,5'-dimethyl-8,8'-bi[2H-furo[3,2-b]naphtho[2,3-d]pyran]-2,2',6,6',11,11'-hexone; CRS-A; (8,8'-Bi-2H-furo(3,2-b)naphtho(2,3-d)pyran)-2,2',6,6'11,11'-hexone,3,3',3a,3'a,5,5',11b,11'b-octahydro-10,10'-dihydroxy-5,5'-dimethyl-, (3aS-(3aalpha,5alpha,8(3aR*,5R*,11bR*),11balpha))-. CAS No. 95828-47-0. Molecular formula: C32H22O12. Mole weight: 598.51. BOC Sciences 12
Crisamicin C It is produced by the strain of Micromonospora purpureochromogenes subsp. lalotolerans. It only has activity against gram-positive bacteria. The activity of samicin C is stronger than Crisamicin A. Synonyms: CRS-C. CAS No. 100630-79-3. Molecular formula: C32H22O13. Mole weight: 614.51. BOC Sciences 12
Crisdesalazine Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE2 production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AAD-2004. CAS No. 927685-43-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105005. MedChemExpress MCE
Crisdesalazine Crisdesalazine is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor potentially for the treatment of Alzheimer's type dementia, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Arthritis, Depression, Diabetes and Pancreatitis. Synonyms: AAD-2004; Benzoic acid, 2-hydroxy-5-((2-(4-(trifluoromethyl)phenyl)ethyl)amino)-. CAS No. 927685-43-6. Molecular formula: C16H14F3NO3. Mole weight: 325.28. BOC Sciences 7
Crispine A Crispine A. Group: Biochemicals. Alternative Names: 1,2,3,5,6,10b-Hexahydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline. Grades: Highly Purified. CAS No. 15889-93-7. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C14H19NO2. US Biological Life Sciences. USBiological 9
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Cristatic acid It is produced by the strain of Albaterllus cristatus. It can resist bacillus, tumor and hemolysis. Synonyms: NSC338268; NSC 338268; Cristatic acid-1. CAS No. 80557-13-7. Molecular formula: C23H28O5. Mole weight: 384.46. BOC Sciences 12
Crizanlizumab Crizanlizumab is a monoclonal antibody used for the prevention of vaso-occlusive crises (VOCs) in patients with sickle cell disease (SCD). Crizanlizumab binds to P-selectin, a cell adhesion molecule expressed on the surface of activated endothelial cells and platelets. By inhibiting P-selectin, crizanlizumab helps prevent the adhesion of sickle red blood cells to the endothelium and other blood cells, which is a key step in the initiation of VOCs in patients with SCD. It is indicated for the prevention of VOCs in patients with SCD. Vaso-occlusive crises are episodes of severe pain caused by the blockage of blood flow in small blood vessels, leading to tissue ischemia and organ damage. Crizanlizumab aims to reduce the frequency and severity of these painful episodes. Synonyms: Immunoglobulin G2, anti-(human P-selectin) (human-Mus musculus monoclonal SelG1 heavy chain), disulfide with human-Mus musculus monoclonal SelG1 light chain, dimer; Adakveo; Crizanlizumab-tmca; SEG 101; SelG 1. CAS No. 1690318-25-2. BOC Sciences 7
Crizanlizumab Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: hSel001; SEG101. CAS No. 1690318-25-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9987. MedChemExpress MCE
Crizotinib Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinase inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptors. Category: Active pharmaceutical ingredients. CAS No. 877399-52-5. Product ID: API877399525. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.34. Protheragen
Crizotinib Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor. Uses: Antineoplastic agents. Synonyms: PF-02341066; PF 02341066; PF02341066. Grade: >98%. CAS No. 877399-52-5. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.343. BOC Sciences 7
Crizotinib Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; PF 2341066; [3-[[ (R) -1- (2, 6-Dichloro-3-fluorophenyl) ethyl]oxy]-5-[1- (piperidin-4-yl) -1H-pyrazol-4-yl]pyridin-2-yl]amine. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 9
Worldwide
Crizotinib Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878. MedChemExpress MCE
Crizotinib acetate Crizotinib, an orally bioavailable agent, belongs to the class of c-met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors with potential antineoplastic activity. Category: Active pharmaceutical ingredients. Synonyms: PF02341066. CAS No. 877399-53-6. Product ID: API877399536. Molecular formula: C23H26Cl2FN5O3. Mole weight: 510.39. Protheragen
Crizotinib-d5 Crizotinib-d5 is a deuterated compound of Crizotinib. Crizotinib has a CAS number of 877399-52-5. Crizotinib is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor. Category: Active pharmaceutical ingredients. CAS No. 1395950-84-1. Product ID: API1395950841. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37. Protheragen
Crizotinib-d5 Crizotinib-d5 is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-02341066-d5. CAS No. 1395950-84-1. Pack Sizes: 1 mg. Product ID: HY-50878S. MedChemExpress MCE
Crizotinib-[d5] Crizotinib-d5 is a labelled Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Synonyms: Crizotinib D5; 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-d4)-1H-pyrazol-4-yl]-2-pyridinamine-d5; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-ylamine-d5; PF 02341066-d5; PF 2341066-d5. Grade: 95% by HPLC; 95% atom D. CAS No. 1395950-48-7. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37. BOC Sciences 2
Crizotinib hydrochloride Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grade: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. BOC Sciences 7
Crizotinib hydrochloride Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met, with IC50 values of 20 nM and 8 nM, respectively. Category: Active pharmaceutical ingredients. Synonyms: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Product ID: API1415560698. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. Protheragen
Crizotinib hydrochloride Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878A. MedChemExpress MCE
Crizotinib Impurity 10 Crizotinib Impurity 10. Uses: For analytical and research use. Alternative Names: (R)-1-(2,6-dichloro-3-fluorophenyl)ethanol. CAS No. 330156-50-8. Molecular formula: C8H7Cl2FO. Mole weight: 209.04. Catalog: APB330156508. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 11 Crizotinib Impurity 11. Uses: For analytical and research use. Alternative Names: (R)-tert-butyl 4-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate. CAS No. 877399-51-4. Molecular formula: C26H30Cl2FN5O3. Mole weight: 550.45. Catalog: APB877399514. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 12 Crizotinib Impurity 12. Uses: For analytical and research use. Alternative Names: (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine. CAS No. 877397-71-2. Molecular formula: C13H11Cl2FN2O. Mole weight: 301.14. Catalog: APB877397712. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 13 Crizotinib Impurity 13. Uses: For analytical and research use. CAS No. 2075-45-8. Molecular formula: C3H3BrN2. Mole weight: 146.97. Catalog: APB2075458. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 13 Crizotinib Impurity 13. Uses: For analytical and research use. Alternative Names: (1-(piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid. CAS No. 1146614-42-7. Molecular formula: C8H14BN3O2. Mole weight: 195.03. Catalog: APB1146614427. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 14 Crizotinib Impurity 14. Uses: For analytical and research use. CAS No. 3469-69-0. Molecular formula: C3H3IN2. Mole weight: 193.98. Catalog: APB3469690. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 16 Crizotinib Impurity 16. Uses: For analytical and research use. CAS No. 877399-73-0. Molecular formula: C13H20IN3O2. Mole weight: 377.23. Catalog: APB877399730. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 19 Crizotinib Impurity 19. Uses: For analytical and research use. CAS No. 1448326-33-7. Molecular formula: C13H10BrCl2FN2O. Mole weight: 380.04. Catalog: APB1448326337. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 24 Crizotinib Impurity 24. Uses: For analytical and research use. Molecular formula: C13H11Cl2FN2O2. Mole weight: 317.14. Catalog: APB07185. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 26 Crizotinib Impurity 26. Uses: For analytical and research use. CAS No. 1394346-24-7. Molecular formula: C13H8BrCl2FN2O3. Mole weight: 410.02. Catalog: APB1394346247. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 3 Crizotinib Impurity 3. Uses: For analytical and research use. Alternative Names: (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine. CAS No. 877397-70-1. Molecular formula: C13H9Cl2FN2O3. Mole weight: 331.13. Catalog: APB877397701. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 30 Crizotinib Impurity 30. Uses: For analytical and research use. CAS No. 704-09-6. Molecular formula: C8H7Cl2FO. Mole weight: 209.04. Catalog: APB704096. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 31 Crizotinib Impurity 31. Uses: For analytical and research use. Molecular formula: C21H22Cl2FN5O2. Mole weight: 466.34. Catalog: APB07186. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 32 Crizotinib Impurity 32. Uses: For analytical and research use. Molecular formula: C21H20Cl2FN5O3. Mole weight: 480.32. Catalog: APB07187. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 33 Crizotinib Impurity 33. Uses: For analytical and research use. Molecular formula: C16H24N6. Mole weight: 300.41. Catalog: APB07188. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 35 Crizotinib Impurity 35. Uses: For analytical and research use. Molecular formula: C8H15BClN3O2. Mole weight: 231.49. Catalog: APB07190. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 36 Crizotinib Impurity 36. Uses: For analytical and research use. Molecular formula: C13H10BrCl2FN2O. Mole weight: 380.04. Catalog: APB07191. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 37 Crizotinib Impurity 37. Uses: For analytical and research use. Molecular formula: C13H10BrCl2FN2O. Mole weight: 380.04. Catalog: APB07189. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 38 Crizotinib Impurity 38. Uses: For analytical and research use. Molecular formula: C13H10BrCl2FN2O. Mole weight: 380.04. Catalog: APB07192. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 39 Crizotinib Impurity 39. Uses: For analytical and research use. Molecular formula: C13H9Br2Cl2FN2O. Mole weight: 458.93. Catalog: APB07194. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 4 Crizotinib Impurity 4. Uses: For analytical and research use. Alternative Names: (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine. CAS No. 1233484-06-4. Molecular formula: C13H9Cl2FN2O3. Mole weight: 331.13. Catalog: APB1233484064. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 40 Crizotinib Impurity 40. Uses: For analytical and research use. Molecular formula: C13H9Br2Cl2FN2O. Mole weight: 458.93. Catalog: APB07193. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 41 Crizotinib Impurity 41. Uses: For analytical and research use. CAS No. 141699-59-4. Molecular formula: C11H21NO5S. Mole weight: 279.35. Catalog: APB141699594. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 42 Crizotinib Impurity 42. Uses: For analytical and research use. CAS No. 877397-67-6. Molecular formula: C10H9Cl2FO2. Mole weight: 251.08. Catalog: APB877397676. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 43 Crizotinib Impurity 43. Uses: For analytical and research use. CAS No. 877397-68-7. Molecular formula: C10H9Cl2FO2. Mole weight: 251.08. Catalog: APB877397687. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 44 Crizotinib Impurity 44. Uses: For analytical and research use. Molecular formula: C10H9Cl2FO2. Mole weight: 251.08. Catalog: APB07195. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 45 Crizotinib Impurity 45. Uses: For analytical and research use. Molecular formula: C9H9Cl2FO3S. Mole weight: 287.13. Catalog: APB07196. Alfa Chemistry Analytical Products 2
Crizotinib Impurity 46 Crizotinib Impurity 46. Uses: For analytical and research use. CAS No. 65407-94-5. Molecular formula: C5H7ClN2O. Mole weight: 146.57. Catalog: APB65407945. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 47 Crizotinib Impurity 47. Uses: For analytical and research use. CAS No. 1675225-85-0. Molecular formula: C13H12Cl2N2O. Mole weight: 283.15. Catalog: APB1675225850. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 48 Crizotinib Impurity 48. Uses: For analytical and research use. CAS No. 2892666-62-3. Molecular formula: C26H41BN6O5. Mole weight: 528.46. Catalog: APB2892666623. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 5 Crizotinib Impurity 5. Uses: For analytical and research use. Alternative Names: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine. CAS No. 877399-00-3. Molecular formula: C13H10BrCl2FN2O. Mole weight: 380.04. Catalog: APB877399003. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 6 Crizotinib Impurity 6. Uses: For analytical and research use. Alternative Names: tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate. CAS No. 877399-74-1. Molecular formula: C19H32BN3O4. Mole weight: 377.29. Catalog: APB877399741. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 7 Crizotinib Impurity 7. Uses: For analytical and research use. Alternative Names: N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine. CAS No. 1356962-20-3. Molecular formula: C24H25ClN6O. Mole weight: 448.95. Catalog: APB1356962203. Alfa Chemistry Analytical Products 3
Crizotinib Impurity 8 Crizotinib Impurity 8. Uses: For analytical and research use. Alternative Names: 5-bromo-2-nitropyridin-3-ol. CAS No. 691872-15-8. Molecular formula: C5H3BrN2O3. Mole weight: 218.99. Catalog: APB691872158. Alfa Chemistry Analytical Products 4
Crizotinib Impurity 9 Crizotinib Impurity 9. Uses: For analytical and research use. Alternative Names: (S)-1-(2,6-dichloro-3-fluorophenyl)ethanol. CAS No. 877397-65-4. Molecular formula: C8H7Cl2FO. Mole weight: 209.04. Catalog: APB877397654. Alfa Chemistry Analytical Products 4
Crizotinib Impurity D Crizotinib Impurity D. Uses: For analytical and research use. CAS No. 877399-50-3. Molecular formula: C13H20BrN3O2. Mole weight: 330.23. Catalog: APB877399503. Alfa Chemistry Analytical Products 4
Crizotinib piperidin-1-Hydroxy Impurity An impurity of Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Grade: ≥95%. Molecular formula: C21H22Cl2FN5O2. Mole weight: 466.34. BOC Sciences 7
CRM1 Inhibitor IV, KPT-251 (KPT251, (Z) -2- (2- (3- (3, 5-bis (trifluoromethyl) phenyl) -1H-1, 2, 4-triazol-1-yl) vinyl) -1, 3, 4-oxadiazole, Exportin 1 Inhibitor IV, Chromosome Region Maintenance 1 Protein Inhibitor IV, CRM1 Inhibitor IV, XPO1 Inhibitor IV) A cell-permeable, irreversible, triazole-containing heterotricyclic CRM1 inhibitor that effectively blocks CRM1-mediated nuclear export (4h 1uM in U2OS cells) via covalent interaction with CRM1 NES- (nuclear export signal) binding groove cysteine (Cys528 in human). Exhibits antileukemic activity against primary human CD19+ CLL (IC50 <500nM) via apoptosis induction even in the presence of stroma cells or other known CLL survival stimuli, while exhibiting little cytotoxicity toward CD56+ NK cells from healthy donors (1uM; up to 72h). Reported to prolong the survival of SCID mice (75mg/kg p.o.) engrafted with murine E-mu-TCL1 or human MV4-11 leukemia in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H?F?N?O. US Biological Life Sciences. USBiological 9
Worldwide
CRM-51005 It is a phospholipase C (PLC) inhibitor originally isolated from fungal MT51005. Synonyms: Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-((1E)-1-methyl-1-pentenyl)-; Benzaldehyde, 3-ethyl-2,4-dihydroxy-6-(1-methyl-1-pentenyl)-, (E)-; 3-ethyl-6-[(E)-hex-2-en-2-yl]-2,4-dihydroxybenzaldehyde. CAS No. 203051-01-8. Molecular formula: C15H20O3. Mole weight: 248.32. BOC Sciences 12
CRM646-A It is originally isolated from Acremonium sp. MT70646. CRM646-A had a strong inhibitory effect on the movement of B16-H10 melanoma cells with IC50 of 15 μmol/L. Synonyms: CRM-646-A; CHEMBL3347523. Molecular formula: C36H50O13. Mole weight: 690.77. BOC Sciences 12
CRM646-B It is originally isolated from Acremonium sp. MT70646. CRM646-B had a strong inhibitory effect on the movement of B16-H10 melanoma cells with IC50 of 30 μmol/L. Synonyms: CRM-646-B; 4-[(4-Carboxy-3-hydroxy-5-methylphenoxy)carbonyl]-3-hydroxy-5-pentadecylphenyl methyl β-D-glucopyranosiduronate. Molecular formula: C37H52O13. Mole weight: 704.80. BOC Sciences 12
CrNiSiMoVAl High-Entropy Alloy Ingots We are engaged in the development, production, and sales of CrNiSiMoVAl High-Entropy Alloy Ingots and provide personalized customization service for high-quality metal powder. CrNiSiMoVAl High-Entropy Alloy is a new alloy with very unique properties. Purity: 0.99. Alfa Chemistry Materials 6
CrNiSiMoVAl High-Entropy Alloys Spherical Powder We are engaged in the development, production, and sales of CrNiSiMoVAl high entropy alloy spherical powder and provide personalized customization service for high-quality metal powder. CrNiSiMoVAl high entropy alloy spherical powder is a new alloy with very unique properties. Alfa Chemistry Materials 6
Crocacin A It is produced by the strain of Chondromyces crocatus sp. Cm c3. It has anti-yeast and filamentous fungal activity. It can inhibit mouse fibroblasts L929 (MIC is 0.2 ng). In the microsomes of the calf's heart, it can interrupt the bc1 segment of electronic transmission, causes redshift of 569nm peak in cytochrome B reduction spectrum. Synonyms: (+)-CrocainA; [(2Z,5Z)-6-((6S,7S,8S,9S)-(2E,4E,10E)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenyl-undeca-2,4,10-trienoylamino)-hexa-2,5-dienoylamino]-acetic acid, methyl ester; Methyl 2-[6-((2E,4E,10E)(6S,7S,9S,8R)-7,9-dimethoxy-3,6,8-trimethyl-11-phenylundeca-2,4,10-trienoylamino)(2Z,5Z)hexa-2,5-dienoylamino]acetate. CAS No. 157698-34-5. Molecular formula: C31H42N2O6. Mole weight: 538.67. BOC Sciences 12
Crocacin B It is produced by the strain of Chondromyces crocatus sp. Cm c3. It has anti-yeast and filamentous fungal activity. It can inhibit mouse fibroblasts L929 (MIC is 0.2 ng). In the microsomes of the calf's heart, it can interrupt the bc1 segment of electronic transmission, causes redshift of 569nm peak in cytochrome B reduction spectrum. Synonyms: [[(2Z,5Z)-6-[[(2E,4E,6S,7S,8R,9S,10E)-7,9-Dimethoxy-3,6,8-trimethyl-1-oxo-11-phenyl-2,4,10-undecatrienyl]amino]-1-oxo-2,5-hexadienyl]amino]acetic acid; 2-[6-((2E,4E,10E)(6S,7S,9S,8R)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenylundeca-2,4,10-trienoylamino)(2Z,5Z)hexa-2,5-dienoylamino]acetic acid. CAS No. 237425-37-5. Molecular formula: C30H40N2O6. Mole weight: 524.65. BOC Sciences 12
Crocacin C It is produced by the strain of Chondromyces crocatus sp. Cm c3. It has anti-yeast and filamentous fungal activity. It can inhibit mouse fibroblasts L929 (MIC is 0.2 ng). In the microsomes of the calf's heart, it can interrupt the bc1 segment of electronic transmission, causes redshift of 569nm peak in cytochrome B reduction spectrum. Synonyms: (+)-Crocacin C; (2E,4E,10E)(6S,7S,9S,8R)-7,9-Dimethoxy-3,6,8-trimethyl-11-phenylundeca-2,4,10-trienamide; 7,9-dimethoxy-3,6,8-trimethyl-11-phenyl-(2E,4E,6S,7S,8R,9S,10E)-2,4,10-undecatrienamide. CAS No. 237425-38-6. Molecular formula: C22H31NO3. Mole weight: 357.49. BOC Sciences 12
Crocacin D It is produced by the strain of Chondromyces crocatus sp. Cm c3. It has anti-yeast and filamentous fungal activity. It can inhibit mouse fibroblasts L929 (MIC is 0.2 ng). In the microsomes of the calf's heart, it can interrupt the bc1 segment of electronic transmission, causes redshift of 569nm peak in cytochrome B reduction spectrum. Synonyms: (+)-Crocacin D. CAS No. 237425-39-7. Molecular formula: C31H44N2O6. Mole weight: 540.69. BOC Sciences 12
Crocein Orange G Crocein Orange G. Group: Biochemicals. Alternative Names: Acid Orange 12; CI 1597. Grades: Highly Purified. CAS No. 1934-20-9. Pack Sizes: 100g, 250g, 500g, 1kg. US Biological Life Sciences. USBiological 9
Worldwide
Crocein Orange G ≥91% (Dye content) Crocein Orange G ≥91% (Dye content). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg. US Biological Life Sciences. USBiological 9
Worldwide

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