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CZC24832 is the first selective inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with efficacy in in vitro and in vivo models of inflammation. Extensive target- and cell-based profiling of CZC24832 revealed regulation of interleukin-17-producing T helper cell (T(H)17) differentiation by PI3Kγ, thus reinforcing selective inhibition of PI3Kγ as a potential treatment for inflammatory and autoimmune diseases. Synonyms: CZC24832; CZC-24832; CZC 24832. Grade: 0.98. CAS No. 1159824-67-5. Molecular formula: C15H17FN6O2S. Mole weight: 364.399.
Selective inhibitor of PI 3-Kinase gamma (IC50 = 1.0um in a PI 3-Kgamma-dependent fMLP-induced neutrophil migration assay). Exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins. Orally effective in a rodent model of inflammatory disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 1159824-67-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
CZC-25146
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons. Synonyms: CZC25146; CZC 25146. Grade: >98%. CAS No. 1191911-26-8. Molecular formula: C22H25FN6O4S. Mole weight: 488.54.
CZC-25146 hydrochloride
CZC-25146 is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons's disease, and is ATP-competitive. Synonyms: CZC25146 hydrochloride; CZC 25146 hydrochloride. Grade: 0.98. CAS No. 1330003-04-7. Molecular formula: C22H26ClFN6O4S. Mole weight: 524.996.
Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Synonyms: CZC-54252; CZC 54252; CZC54252. Grade: >98%. CAS No. 1191911-27-9. Molecular formula: C22H25ClN6O4S. Mole weight: 504.99.
CZC-54252 HCl
CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) with IC50 values 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively. CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM). Activating mutations in leucine-rich repeat kinase 2 (LRRK2) are present in a subset of Parkinson's disease (PD) patients and may represent an attractive therapeutic target. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CZC-54252 HCl; CZC-54252 hydrochloride; CZC-54252; CZC 54252; CZC54252. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45. Purity: >98%. IUPACName: N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide hydrochloride. Canonical SMILES: CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl. Product ID: ACM1784253059. Alfa Chemistry ISO 9001:2015 Certified.
CZC 54252 hydrochloride
CZC 54252 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1191911-27-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
CZC-54252 hydrochloride
CZC-54252 hydrochloride is a potent and selective inhibitor of LRRK2 with IC50s of 1.28 and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM. It has a neuroprotective activity. Synonyms: Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-, hydrochloride (1:1); N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride. Grade: ≥95%. CAS No. 1784253-05-9. Molecular formula: C22H26Cl2N6O4S. Mole weight: 541.45.
CZC-8004
CZC-8004 is an aminopyrimidine which is a pan-kinase inhibitor that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. Synonyms: Dianilinopyrimidine-01; CZC-00008004. Grade: ≥98%. CAS No. 916603-07-1. Molecular formula: C17H16FN5. Mole weight: 309.3.
CzDBA
CzDBA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5,10-Bis(4-(9H-carbazol-9-yl)-2,6-dimethylphenyl)-5,10-dihydroboranthrene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2171334-43-1. Molecular formula: C52H40B2N2. Mole weight: 714.51 g/mol. Product ID: ACM2171334431. Alfa Chemistry ISO 9001:2015 Certified. Categories: Czaban, Steve.
CzFCN
CzFCN. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(9-Phenyl-9H-carbazol-3-yl)-9-p-tolyl-9H-fluorene-3-carbonitrile. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1448222-38-5. Molecular formula: C39H26N2. Mole weight: 522.64 g/mol. Product ID: ACM1448222385. Alfa Chemistry ISO 9001:2015 Certified. Categories: CFCN-DT.
CzPA
CzPA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-[4-(10-phenylanthracen-9-yl)phenyl]carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 910647-23-3. Molecular formula: C38H25N. Mole weight: 495.61 g/mol. Product ID: ACM910647233. Alfa Chemistry ISO 9001:2015 Certified. Categories: Czpaski Family.
CzPhDCN in
CzPhDCN in. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4'-(9H-Carbazol-9-yl)biphenyl-2,6-dicarbonitrile. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2279125-23-2. Molecular formula: C26H15N3. Mole weight: 369.42 g/mol. Product ID: ACM2279125232. Alfa Chemistry ISO 9001:2015 Certified.
Cz-Ph-DRZ
Cz-Ph-DRZ. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(4-(4,6-Diphenylpyrimidin-2-yl)phenyl)-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1106729-87-6. Molecular formula: C34H23N3. Mole weight: 473.57 g/mol. Product ID: ACM1106729876. Alfa Chemistry ISO 9001:2015 Certified.
CzPO2
CzPO2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(3,5-Bis(diphenylphosphoryl)phenyl)-9H -carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1256573-07-5. Molecular formula: C42H31NO2P2. Mole weight: 643.65 g/mol. Product ID: ACM1256573075. Alfa Chemistry ISO 9001:2015 Certified.
CzPPQ
CzPPQ. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(4-(4-Phenylquinolin-2-yl)phenyl)-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1617494-49-1. Molecular formula: C33H22N2. Mole weight: 446.54 g/mol. Product ID: ACM1617494491. Alfa Chemistry ISO 9001:2015 Certified.
CZ-PS
CZ-PS. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-(4,4'-Sulfonylbis(4,1-phenylene))bis(3,6-di-tert -butyl-9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 1396165-20-0. Molecular formula: C52H56N2O2S. Mole weight: 773.08 g/mol. Product ID: ACM1396165200. Alfa Chemistry ISO 9001:2015 Certified. Categories: CZ P-10 C.
CzTP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,6-Bis[(3,5-diphenyl)phenyl]-9-phenyl-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1201649-79-7. Molecular formula: C54H37N. Mole weight: 699.88 g/mol. Product ID: ACM1201649797. Alfa Chemistry ISO 9001:2015 Certified. Categories: CZTS.
Cz-TRZ2
Cz-TRZ2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(4-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)-1,3,6,8-tetramethyl-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2061376-82-5. Molecular formula: C37H30N4. Mole weight: 530.66 g/mol. Product ID: ACM2061376825. Alfa Chemistry ISO 9001:2015 Certified.
Cz-TRZ3
Cz-TRZ3. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(4-(4,6-Diphenyl-1,3,5-triazin-2-yl)-2-methylphenyl)-3,6-dimethyl-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2061376-83-6. Molecular formula: C36H28N4. Mole weight: 516.63 g/mol. Product ID: ACM2061376836. Alfa Chemistry ISO 9001:2015 Certified.
Cz-TRZ4
Cz-TRZ4. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(4-(4,6-Diphenyl-1,3,5-triazin-2-yl)-2,6-dimethylphenyl)-3,6-dimethyl-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2061376-84-7. Molecular formula: C37H30N4. Mole weight: 530.66 g/mol. Product ID: ACM2061376847. Alfa Chemistry ISO 9001:2015 Certified.
CzTRZ / Cz-m2Ph-TRZ
CzTRZ / Cz-m2Ph-TRZ. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(3'-(4,6-diphenyl-1,3,5-triazin-2-yl)biphenyl-3-yl)-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1106730-56-6. Molecular formula: C39H26N4. Mole weight: 550.65 g/mol. Product ID: ACM1106730566. Alfa Chemistry ISO 9001:2015 Certified.
Cz-VPN
Cz-VPN. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,6-Dibenzoyl-4,5-di(1-methyl-9-phenyl-9H-carbazoyl)-2-ethynylbenzonitrile. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1883400-30-3. Molecular formula: C58H38N4. Mole weight: 790.97 g/mol. Product ID: ACM1883400303. Alfa Chemistry ISO 9001:2015 Certified. Categories: Czapnik, Eric.